1. A method of monitoring an image forming apparatus, comprising the steps of:
receiving, at a location which is remote from the image forming machine, first parameters representing a condition of at least one part of said image forming apparatus;
storing said first parameters;
receiving, at the location which is remote from the image forming apparatus, second parameters after at least one image forming operation is executed by the image forming machine, said second parameters representing said condition of said at least one part of said image forming apparatus related to at least one of said first parameters;
comparing said first parameters and said second parameters; and
controlling a display of said condition on a terminal that is remote from said image forming apparatus using a result of the comparing step.
2. The method of claim 1, further comprising the steps of:
storing a tolerance of said condition;
comparing said tolerance to said second parameter; and
controlling a display of said condition represented by said second parameter in a highlighted manner on said terminal, when the second parameter is determined to be outside of said tolerance by said comparing step.
3. The method of claim 1, wherein said step of receiving said first parameter comprises:
receiving said first parameter from said image forming apparatus after said image forming apparatus is operated to execute a test operation when said image forming apparatus is installed at a user site so that said first parameter represents an acceptable condition existing at a time of installation.
4. The method of claim 1, further comprising the steps of:
receiving, at the location which is remote from the image forming apparatus, a message indicating an occurrence of an error in said image forming apparatus; and
sending at least one email from the location which is remote to at least one email address which has been stored in a memory to indicate that said message has been received from said image forming apparatus.
5. The method of claim 4, further comprising the steps of:
receiving said email at said remote terminal;
instructing, at the remote terminal, that at least said second parameter is to be transmitted to the remote terminal;
transmitting the second parameter to the remote terminal; and
displaying said second parameter on said remote terminal.
6. The method of claim 5, further comprising the steps of:
adjusting, at the remote terminal, said second parameter to form an updated second parameter;
sending, to said image machine, said updated parameter; and
whereby said updated second parameter modifies said condition of said image forming apparatus.
7. An image forming machine monitoring system, comprising:
means for receiving, at a location which is remote from the image forming machine, a first parameter representing a condition of at least one part of said image forming apparatus;
means for storing said first parameter;
means for receiving, at the location which is remote from the image forming apparatus, a second parameter after at least one image forming operation is executed by the image forming machine, said second parameter representing said condition of said at least one part of said image forming apparatus related to at least one of said first parameter;
means for comparing said first parameter and said second parameter to form compared data; and
means for controlling a display of said condition on a terminal that is remote from said image forming apparatus based on said compared data.
8. The system of claim 7, further comprising means for storing a tolerance of said condition;
means for comparing said tolerance to said second parameter to form compared data; and
means for controlling a display of said condition represented by said second parameter in a highlighted manner on said terminal, when said compared data indicates the second parameter is determined to be outside of said tolerance.
9. The system of claim 7, wherein said first parameter is transmitted from said image forming apparatus after said image forming apparatus is operated to execute a test operation when said image forming apparatus is installed at a user site so that said first parameter represents an acceptable condition existing at a time of installation.
10. The system of claim 7 further comprising, means for receiving, at the location which is remote from the image forming apparatus, a message indicating an occurrence of an error in said image forming apparatus; and
means for sending at least one email from the location which is remote to at least one email address which has been stored in a memory to indicate that said message has been received from said image forming apparatus.
11. The system of claim 10 further comprising means for receiving said email at said remote terminal;
means for instructing, at the remote terminal, that at least said second parameter is to be transmitted to the remote terminal;
means for transmitting the second parameter to the remote terminal; and
means for displaying said second parameter on said remote terminal.
12. The system of claim 11 further comprising means for adjusting, at the remote terminal, said second parameter to form an updated second parameter;
means for sending, to said image machine, said updated parameter; and
wherein said updated second parameter modifies said condition of said image forming apparatus.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I)
or a salt or N-oxide thereof;
wherein R3 is aryl or heteroaryl, each optionally substituted; X3 and X4 are
independently CH or N;
X5 is selected from the group consisting of CR12R13, O, S, SO, SO2, and NR14 wherein R12 and R13 are independently selected from H, OH, and lower alkyl, or together form an oxo group;
R4 is selected from the group consisting of OH, acyl, formyl, sulfonyl, alkoxy, carboxylate, haloalkyl, halogen, cyano, nitro, trifluoromethoxy, difluoromethoxy, and fluoromethoxy;
R\u2032, R5, R6 and R14 are independently selected from the group consisting of H, lower alkyl, Rp, cycloalkyl and aryl, and wherein at least one of R\u2032, R5, R6 and R14 is Rp linked via \u2014C(O)O\u2014, \u2014C(S)O\u2014, -C(O)S\u2014, \u2014C(S)S\u2014, \u2014C(O)NH\u2014 or \u2014C(S)NH\u2014;
Rp is \u2014(CR1R2)n\u2014R;
R is selected from the group consisting of acetate, amino, dialkylamino, \u2014C(O)OH, alkyl, allyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, phenylalkaryl and heteroarylalkyl, each of which is optionally substituted;
R1 and R2 are each independently selected from the group consisting of H, OH, \u2014OR11, NR15R15, halo, lower alkyl, C(O)O-alkyl, \u2014C(O)OH, \u2014OP(\u2550O)(OR11)2, \u2014OC(\u2550O)OR11, \u2014OC(\u2550O)R11, cycloalkyl, aryl, and heteroaryl or together form an oxo, wherein each R15 is independently selected from the group consisting of H, lower alkyl, prenyl, allyl, \u2014C(O))-alkyl, cycloalkyl, aryl, heteroaryl, alkaryl and alkheteroaryl, or two of R15 combine to form an optionally substituted cycloheteroalkyl;
each R11 is independently H or lower alkyl;
n is an integer from 0 to 10;
R7 and R8 are independently selected from the group consisting of H, halogen, lower alkyl, cycloalkyl, aryl, and heteroaryl; and
R9 and R10 are independently selected from the group consisting of H, halogen, \u2014OH, -alkoxy, lower alkyl, cycloalkyl, aryl, and heteroaryl wherein R7 and R8, or R9 and R10 together form an oxo group, and wherein R9 or R10 are not \u2014OH or alkoxy when X5 is NR14.
2. A compound of formula (II)
or a salt andor N-oxide thereof,
wherein X1 is selected from the group consisting of O, S, and NR11 wherein R11 is H or lower alkyl;
X2 is O or S;
X3 and X4 are independently CH or N;
X5 is selected from the group consisting of CR12R13, O, S , SO, SO2, and NR14 wherein R12 and R13 are independently selected from H, OH, and lower alkyl, or together form an oxo group, and R14 is H or lower alkyl;
R is selected from the group consisting of acetate, amino, dialkylamino, \u2014C(O)OH, alkyl, allyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, phenylalkaryl and heteroarylalkyl, each of which is optionally substituted;
R1 and R2 are each independently selected from the group consisting of H, OH, \u2014OR11, NR15R15, halo, lower alkyl, \u2014C(O)O-alkyl, \u2014C(O)OH, \u2014OP(\u2550O)(OR11)2, \u2014OC(\u2550O) OR11, \u2014OC(\u2550O)R11, cycloalkyl, aryl, and heteroaryl or together form an oxo, wherein each R15 is independently selected from the group consisting of H, lower alkyl, prenyl, allyl \u2014C(O)O-alkyl, cycloalkyl, aryl, heteroaryl, alkaryl and alkheteroaryl, or two of R15 combine to form an optionally substituted cycloheteroalkyl;
R3 is aryl or heteroaryl, each optionally substituted;
R4 is selected from the group consisting of OH, acyl, formyl, sulfonyl, alkoxy, carboxylate, haloalkyl, halogen, cyano, nitro, trifluoromethoxy, difluoromethoxy, and fluoromethoxy;
R5 and R6 are independently selected from H, lower alkyl, cycloalkyl or aryl;
R7, R8, R9, and R10 are independently selected from the group consisting of H, OH, halogen, lower alkyl, cycloalkyl, aryl, and heteroaryl, or wherein R7 and R8 or R9 and R10 together form an oxo group; and
n is an integer from 0 to 10.
3. The compound of claim 2, wherein X1 is 0.
4. The compound of claim 3, wherein X2 is 0.
5. The compound of claim 2, wherein R3 is optionally substituted aryl.
6. The compound of claim 5, wherein aryl is alkoxyphenyl, dialkoxyphenyl, or trialkoxyphenyl.
7. The compound of claim 6, wherein trialkoxyphenyl is trimethoxyphenyl.
8. The compound of claim 2, wherein R4 is OH, halogen, cyano, nitro, trifluoromethyl, difluoromethyl, fluoromethyl, trifluoromethoxy, difluoromethoxy, or fluoromethoxy.
9. The compound of claim 8, wherein R4 is F.
10. The compound of claim 2, wherein R5 and R6 are H.
11. The compound of claim 2, wherein X4 is CH.
12. The compound of claim 2, wherein X4 is N.
13. The compound of claim 2, wherein X5 is CH2 or O.
14. The compound of claim 2, wherein R7 and R8 are H or together form the oxo group.
15. The compound of claim 2, wherein R9 and R10 are methyl.
16. The compound of claim 2, wherein R is cycloheteroalkyl.
17. The compound of claim 16, wherein R is substituted or unsubstituted morpholine, or substituted or unsubstituted pyrrolidine.
18. The compound of claim 2, wherein R is heteroaryl.
19. The compound of claim 18, wherein heteroaryl is substituted or unsubstituted indole.
20. The compound of claim 2, wherein R is selected from the group consisting of acetate, amino, and dialkylamino.
21. The compound of claim 2, wherein n is 1, 2, or 3.
22. The compound of claim 1, wherein X1 is NR11.
23. The compound of claim 22, wherein X2 is O.
24. The compound of claim 22, wherein X2 is S.
25. The compound of claim 1, wherein X1 is S.
26. The compound of claim 25, wherein X2 is O.
27. A compound of formula (III):
or a salt and or N-oxide thereof;
wherein R is selected from the group consisting of acetate, amino, dialkylamino, \u2014C(O)OH, straight or branched, saturated or unsaturated alkyl, allyl, cycloalkyl, cycloheteroalkyl, aryl, and heteroaryl, each of which is optionally substituted;
X1 is O or NR11;
R11 is H or lower alkyl; and
n is and integer between 0 and 10.
28. The compound of claim 27, wherein R is morpholine.
29. The compound of claim 27, wherein R is 1-methylpiperidine.
30. The compound of claim 27 , wherein R is piperazine or 3- piperazinepropane sulfonate.
31. The compound of claim 27, wherein R is dimethylamine.
32. The compound of claim 27, wherein R is tryptamine or N-tert-butylaceyltryptamine.
33. The compound of claim 27, wherein n is 0, 1, 2, or 3.
34. A method for of treating breast cancer, the method comprising:
administering to a subject an effective amount of a compound of claim 1 or a acceptable salt or N-oxide thereof and pharmaceutically-acceptable carrier or diluent.
35. The method of claim 34, wherein the subject is a domestic animal.
36. The method of claim 34 , wherein the subject is a human.