1. A liner for a shaped charge having a composition formed from 90% or more by weight of powdered tungsten and 10% or less by weight of a powdered binder, the composition being formed into a substantially conically shaped body and having a crystal structure of substantially equi-axed grains with a grain size of between 25 nano-meters and 100 nanometers.
2. A shaped charge comprising a housing, a quantity of high explosive inserted into the housing and a liner according to claim 1 inserted into the housing so that the high explosive is positioned between the liner and the housing.
3. A liner as claimed in claim 1 wherein the liner composition is sintered.
4. A method of making a liner for a shaped charge having a composition formed from 90% or more by weight of powdered tungsten and 10% or less by weight of a powdered binder, the composition being formed into a substantially conically shaped body and having a crystal structure of substantially equi-axed grains with a grain size of between 25 nano-meters and 1 micron, wherein the composition is formed from starting materials comprising ultra-fine powders comprising nano-crystalline particles of less than 100 nano-meters, said starting materials comprising nano-crystalline powdered tungsten and nano-crystalline powdered binder material, and the liner is formed either by pressing the composition to form a green compact or by sintering the composition.
5. A method of making a liner as claimed in claim 4 wherein the liner composition is compressively formed as a green compact.
6. A method of making a liner as claimed in claim 5 wherein the binder comprises a nano-crystalline powdered metal.
7. A method of making a liner as claimed in claim 6 wherein the binder is selected from the group consisting of lead, copper, tantalum, molybdenum and combinations thereof.
8. A method of making a liner as claimed in claim 5 wherein the binder comprises a nano-crystalline powdered non-metal.
9. A method of making a liner as claimed in claim 8 wherein the binder is a polymeric non-metal material.
10. A method of making a liner as claimed in claim 4 wherein the binder material coats the tungsten.
11. A method of making a liner as claimed in claim 4 wherein the liner composition is sintered.
12. A method of making a liner as claimed in claim 11 wherein the binder comprises nano-crystalline powdered copper, nickel, iron, cobalt and combinations thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound having the formula (I),
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein,
R1 is \u2014Xa\u2014Ra;
R2 is \u2014Xb\u2014Rb;
Xa is a 3-7 membered heterocyclyl selected from aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, thiomorpholinyl, 1,1-dioxo-thiomorphonyl and morpholinyl, any of which is optionally substituted with 1-3 times with R3;
R3, in each occurrence is selected independently from halogen, hydroxy, \u2014(C1-C6)alkyl, \u2014(C1-C6)alkoxy and halo(C1-C6)alkoxy;
Ra is a phenyl ring optionally substituted 1-3 times with R4;
R4, in each occurrence is selected independently from halogen, \u2014(C1-C6)alkyl and \u2014O\u2014R5;
Alternatively, two R4, on adjacent carbon atoms, together with the carbon atoms to which they are attached may form a 5-6 membered heterocyclyl or a 5-6 membered heteroaryl ring;
R5 is selected from \u2014(C1-C6)alkyl, halo(C1-C6)alkyl and 5-6 membered heterocyclyl;
Xb is selected from \u2014CO\u2014, \u2014CONR6\u2014, \u2014NR6CO\u2014, \u2014C(\u2550N\u2014OR6)\u2014, \u2014CONR6\u2014SO2\u2014, \u2014CONR6\u2014SO2\u2014NR6\u2014, and \u2014R6N\u2014CO\u2014NR6;
Rb is selected from
(i) alkyl, optionally substituted with 1-3 substituents selected independently from halogen, \u2014(C1-C6)alkoxy, hydroxyl and \u2014CO\u2014(CR7R8)p\u2014OR9;
(ii) aryl, heteroaryl or cycloalkyl, any of which is optionally substituted with 1-3 substituents selected independently from halogen, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, \u2014(C1-C6)alkoxy, hydroxyl, \u2014(C1-C6)alkyl and \u2014R10;
(iii) heterocyclyl, optionally substituted with 1-3 substituents selected independently from halogen, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, \u2014(C1-C6)alkoxy, hydroxyl, \u2014(C1-C6)alkyl, and N(Ri)2, wherein Ri, in each occurrence, independently selected from hydrogen, \u2014(C1-C6)alkyl or \u2014(C3-C6)alkyl;
Alternatively, R6 and Rb together with Nitrogen atom to which they are attached, may form a 3-10 membered heterocyclic ring optionally substituted 1-3 times with R11;
R6, in each occurrence, is independently selected from hydrogen, \u2014(C1-C6)alkyl and \u2014(C1-C6)alkyl-(C3-C6)cycloalkyl;
R7, R8 or R9, in each occurrence, is independently selected from hydrogen and \u2014(C1-C6)alkyl;
R10 is a 5-6 membered heterocyclyl or a 5-6 membered heteroaryl, any of which is optionally substituted with 1-2 substituents selected independently from \u2014(C1-C6)alkyl, halogen, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, \u2014(C1-C6)alkoxy and hydroxyl;
R11 is selected from halogen, hydroxyl, alkyl and NH2; and
p is 0, 1, 2 or 3.
2. The compound according to claim 1, having the formula (Ia):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein
\u2018n\u2019 is 1, 2 or 3;
\u2018m\u2019 is 1, 2 or 3;
\u2018q\u2019 is 0, 1, 2 or 3;
R2, R3, and R4 are as described in claim 1.
3. The compound according to claim 1, having the formula (Id):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein
\u2018m\u2019 is 1 or 2;
\u2018n\u2019 is 1, 2 or 3;
\u2018q\u2019 is 0 or 1;
R2, R3, and R4 are as described in claim 1.
4. The compound according to claim 1, having the formula (Ie):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein
\u2018m\u2019 is 1 or 2;
\u2018n\u2019 is 1, 2 or 3;
\u2018q\u2019 is 0 or 1;
R2, R3, and R4 are as described in claim 1.
5. The compound according to claim 1, having the formula (Ig):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein
R3 is halogen;
\u2018q\u2019 is 0 or 1;
R2 and R4 are as described in claim 1.
6. The compound according to claim 1, having the formula (Ij):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein
\u2018q\u2019 is 0 or 1;
R2 and R4 are as described in claim 1.
7. The compound according to claim 1, having the formula (Ik):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein
R2 and R5 are as described in claim 1.
8. The compound according to claim 1, having the formula (Il):
or pharmaceutically acceptable salts thereof, or pharmaceutically acceptable solvates thereof or stereoisomers thereof,
wherein
R3 is halogen;
\u2018m\u2019 is 1 or 2;
\u2018q\u2019 is 0 or 1;
R2 is as described in claim 1.
9. The compound according to claim 1, wherein R2 is \u2014CO\u2014Rb, \u2014CONH\u2014Rb, \u2014CONCH3\u2014Rb, \u2014NHCO\u2014Rb, \u2014C(\u2550N\u2014OH)\u2014Rb, \u2014CONH\u2014SO2\u2014Rb, \u2014CON(CH3)\u2014SO2\u2014Rb, \u2014CONH\u2014SO2\u2014NH\u2014Rb, \u2014CONH\u2014SO2\u2014N(CH3)\u2014Rb, \u2014CONH\u2014SO2\u2014N(CH2CH3)\u2014Rb, \u2014CONH\u2014SO2\u2014N(CH2CH2CH3)\u2014Rb, \u2014CONH\u2014SO2\u2014N(cyclopropylmethyl)-Rb or \u2014NH\u2014CO\u2014NH\u2014Rb.
10. The compound according to claim 1, wherein
Rb is
(i) methyl, ethyl, propyl, tert-butyl, isobutyl, propan-2-yl or 2-methylpropan-2-yl, any of which is optionally substituted with 1-3 substituents independently selected from fluorine, methoxy, hydroxyl, \u2014COOCH2CH3 and \u2014COOH;
(ii) phenyl, pyridin-2-yl, pyridin-3-yl, pyrazin-2-yl, pyridazin-3-yl, thiazol-2-yl, 1,3,4-thiadiazol-2-yl, 1H-pyrazol-3-yl, cyclopropyl, cyclohexyl or amantan-1-yl, any of which is optionally substituted with 1-3 substituents independently selected from fluorine, fluoromethyl, difluoromethyl, trifluoromethyl, fluoromethoxy, methoxy, ethoxy, hydroxyl, methyl, 3-hydroxypyrrolidin-1-yl, piperidin-1-yl, 1,2,4-triazol-1-yl and 1H-imidazol-1-yl; or
(iii) pyrrolidin-1-yl, azetidin-1-yl, piperidin-1-yl, morpholino, piperazin-1-yl, azepan-1-yl or tetrahydro-2H-pyran-4-yl, optionally substituted with 1-3 substituents independently selected from fluorine, fluoromethyl, difluoromethyl, trifluoromethyl, fluoromethoxy, methoxy, hydroxyl, \u2014NH2 and methyl.
11. The compound according to claim 1, wherein R4 is independently selected from fluorine, methoxy, 2-fluoroethoxy, (tetrahydrofuranyl)oxy, (tetrahydropyranyl)oxy, (tetrahydrofuran-3-yl)oxy, (tetrahydro-2H-pyran-4-yl)oxy or (R)-(tetrahydrofuran-3-yl)oxy; or R4 on two carbon adjacent atoms, together with the carbon atoms to which they are attached form a 1,4-dioxine ring.
12. The compound according to claim 1, wherein
R1 is \u2014Xa\u2014Ra;
R2 is \u2014CO\u2014Rb, \u2014CONH\u2014Rb, \u2014CONCH3\u2014Rb, \u2014NHCO\u2014Rb, \u2014C(\u2550N\u2014OH)\u2014Rb, \u2014CONH\u2014SO2\u2014Rb, \u2014CON(CH3)\u2014SO2\u2014Rb, \u2014CONH\u2014SO2\u2014NH\u2014Rb, \u2014CONH\u2014SO2\u2014N(CH3)\u2014Rb, \u2014CONH\u2014SO2\u2014N(CH2CH3)\u2014Rb, \u2014CONH\u2014SO2\u2014N(CH2CH2CH3)\u2014Rb, \u2014CONH\u2014SO2\u2014N(cyclopropylmethyl)-Rb or \u2014NH\u2014CO\u2014NH\u2014Rb;
Xa is pyrrolidinyl or piperidinyl ring, optionally substituted with fluorine;
Ra is a phenyl ring optionally substituted 2-3 times with R4;
R4 is independently selected from fluorine, methoxy, 2-fluoroethoxy, (tetrahydrofuranyl)oxy, (tetrahydropyranyl)oxy, (tetrahydrofuran-3-yl)oxy, (tetrahydro-2H-pyran-4-yl)oxy or (R)-(tetrahydrofuran-3-yl)oxy; or
R4 on two adjacent carbon atoms, together with the carbon atoms to which they are attached form a 1,4-dioxine ring.
Rb is methyl, ethyl, propyl, tert-butyl, \u2014CH2C(O)OCH2CH3, \u2014CH2C(O)OH, 2-hydroxyethyl, 1,3-dihydroxypropan-2-yl, 1,3-dihydroxy-2-methylpropan-2-yl, 1-hydroxy-2-methylpropan-2-yl, (S)-2,3-dihydroxypropyl, (S)-1-hydroxypropan-2-yl, 2-fluoroethyl, 2,2-difluoroethyl, 2-fluoro-2-methylpropyl, 2,2,2-trifluoroethyl, 2-methoxyethyl, 2-ethoxyethyl, cyclopropyl, 1-methylcyclopropyl, (1r,4r)-4-hydroxycyclohexyl, 3-hydroxyadamantan-1-yl, 3-hydroxyazetidin-1-yl, 3-hydroxy-3-methylazetidin-1-yl, (S)-3-aminopyrrolidin-1-yl), (S)-3-hydroxypyrrolidin-1-yl, piperidin-1-yl, 4-hydroxypiperidin-1-yl, morpholinyl, 4-methylpiperazinyl, tetrahydro-2H-pyran-4-yl, 4-hydroxyazepan-1-yl, thiazol-2-yl, 5-methyl-1,3,4-thiadiazol-2-yl, 1,3,4-thiadiazol-2-yl, 1H-1,2,4-triazol-1-yl, (1-methyl-1H-pyrazol-3-yl), 1H-imidazol-1-yl, 6-methylpyridazin-3-yl, pyridin-2-yl, pyridin-3-yl, pyrazin-2-yl, 4-fluorophenyl, ((S)-3-hydroxypyrrolidin-1-yl)phenyl or ((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl.
13. The compound according to claim 1, selected from
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)imidazo1,2-apyridine-3-carboxamide;
N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(3-hydroxypyrrolidin-1-yl)methanone;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(3-hydroxyazetidin-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1,3-dihydroxypropan-2-yl)imidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(morpholino)methanone;
N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)morpholine-4-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N,N-dimethylimidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-methylpiperazin-1-yl)methanone;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-fluorophenyl)methanone;
3-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)-1,1-dimethylurea;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(3-hydroxypyrrolidin-1-yl)methanone;
N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)acetamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-fluorophenyl)methanone oxime;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-hydroxycyclohexyl)imidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-hydroxypiperidin-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carbonyl)glycine;
2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamido)acetic acid;
(3-aminopyrrolidin-1-yl)(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-fluorophenyl)methanone oxime;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,4R)-4-hydroxycyclohexyl)imidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-hydroxypiperidin-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo1,2-apyridine-3-carboxamide;
Ethyl 2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamido)acetate;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carbonyl)glycine;
2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamido)acetic acid;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-hydroxyazepan-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1,3-dihydroxy-2-methylpropan-2-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014((S)-2,3-dihydroxypropyl)imidazo1,2-apyridine-3-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(3-hydroxy-3-methylazetidin-1-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014((S)-1-hydroxypropan-2-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1-hydroxy-2-methylpropan-2-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(tetrahydro-2H-pyran-4-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-ethyl-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N-((4-(1H-1,2,4-triazol-1-yl)phenyl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-ethyl-N-(2-fluoroethyl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(2,2,2-trifluoroethyl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-(cyclopropylmethyl)-N-(pyridin-3-yl)sulfamoyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-(3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-((2S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(4-fluoro-2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N\u2014(N-ethyl-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
1-(6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)-N-(2-fluoroethyl)-N-methyl-1-oxomethanesulfonamide;
(tert-butylsulfonyl)(6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)methanone;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N,N-diethylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-(2-ethoxyethyl)-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N,N-diethylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N,N-dimethylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-cyclopropyl-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-(2,2-difluoroethyl)-N-methylsulfamoyl)-6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-(4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide; and
N\u2014(N,N-diethylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.
14. The compound according to claim 1, selected from
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo1,2-apyridine-3-carboxamide;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo1,2-apyridine-3-carboxamide;
(3S)\u2014N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;
(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone;
(6-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone;
(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)((S)-3-hydroxypyrrolidin-1-yl)methanone;
(ZE)(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-fluorophenyl)methanone oxime;
(EZ)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-fluorophenyl)methanone oxime;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo1,2-apyridine-3-carboxamide;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-fluorophenyl)-N-methylimidazo1,2-apyridine-3-carboxamide;
6-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,4S)-4-hydroxycyclohexyl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,4R)-4-hydroxycyclohexyl)imidazo1,2-apyridine-3-carboxamide;
(S)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-hydroxypiperidin-1-yl)methanone;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-hydroxypiperidin-1-yl)methanone;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo1,2-apyridine-3-carboxamide;
Ethyl(S)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamido)acetate;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(3-ethoxy-2-oxopropyl)imidazo1,2-apyridine-3-carboxamide;
Ethyl(R)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamido)acetate;
(S)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carbonyl)glycine;
(S)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamido)acetic acid;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carbonyl)glycine;
(R)-2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamido)acetic acid;
((S)-3-aminopyrrolidin-1-yl)(6-((S)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)methanone;
((S)-3-aminopyrrolidin-1-yl)(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)methanone;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo1,2-apyridine-3-carboxamide;
(S)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(2-hydroxyethyl)imidazo1,2-apyridine-3-carboxamide;
(6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(4-hydroxyazepan-1-yl)methanone;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1,3-dihydroxy-2-methylpropan-2-yl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014((S)-2,3-dihydroxypropyl)imidazo1,2-apyridine-3-carboxamide;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(3-hydroxy-3-methylazetidin-1-yl)methanone;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014((S)-1-hydroxypropan-2-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(1-hydroxy-2-methylpropan-2-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(tetrahydro-2H-pyran-4-yl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N-(tert-butylsulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-ethyl-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N-((4-(1H-1,2,4-triazol-1-yl)phenyl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-ethyl-N-(2-fluoroethyl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(2,2,2-trifluoroethyl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N\u2014(N-(cyclopropylmethyl)-N-(pyridin-3-yl)sulfamoyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-(S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((4-(S)-3-hydroxypyrrolidin-1-yl)phenyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(2,5-difluorophenyl)piperidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl)pyridin-3-yl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-(2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)piperidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(7-fluoro-2,3-dihydrobenzob1,4dioxin-5-yl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
1-(6-((2S,4R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)-N-(2-fluoroethyl)-N-methyl-1-oxomethanesulfonamide;
(tert-butylsulfonyl)(6-((2S,4R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)methanone;
(S)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(3-hydroxyazetidin-1-yl)methanone;
(R)-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridin-3-yl)(3-hydroxyazetidin-1-yl)methanone;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyrazin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N-((6-(1H-imidazol-1-yl)pyridin-3-yl)sulfonyl)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N,N-diethylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide
(R)\u2014N-(tert-butylsulfonyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N\u2014(N-ethyl-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)\u2014N\u2014(N-(2-ethoxyethyl)-N-methylsulfamoyl)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(6-methylpyridazin-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
(R)-6-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N-(tert-butylsulfonyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N,N-diethylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(thiazol-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-(2-fluoroethyl)sulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-(pyridin-2-yl)sulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-methoxyethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N,N-dimethylsulfamoyl)-6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-cyclopropyl-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-(2,2-difluoroethyl)-N-methylsulfamoyl)-6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((2R,4S)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoro-2-methylpropyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N\u2014(N-(2-fluoroethyl)-N-methylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N,N-diethylsulfamoyl)-6-((R)-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-((2S,4R)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide;
6-((2S,4R)-4-fluoro-2-(5-fluoro-2-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)imidazo1,2-apyridine-3-carboxamide;
N\u2014(N-ethyl-N-methylsulfamoyl)-6-((2S,4R)-4-fluoro-2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)imidazo1,2-apyridine-3-carboxamide; and
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N\u2014(N-methyl-N-propylsulfamoyl)imidazo1,2-apyridine-3-carboxamide;
or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.
15. A pharmaceutical composition comprising at least one compound as claimed in the claim 1 and at least one pharmaceutically acceptable excipient.
16. A method of treating or preventing conditions, diseases andor disorders associated with tropomyosin receptor kinase A (TrkA) by inhibiting tropomyosin receptor kinase A (TrkA) activity in a patient comprising administering to said patient a therapeutically effective amount of a compound as claimed in claim 1.
17. The method of treating conditions, diseases andor disorders treatable or preventable by inhibition of Trk kinase activity as claimed in claim 16, wherein the conditions, diseases andor disorders selected from pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, psoriatic arthritis, rheumatoid arthritis, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, fibrosis, neurodegenerative disease, a disease, disorder, injury relating to dysmyelination or demyelination, infectious diseases, and infection caused by Trypanosoma Cruzi or any combination hereof.
18. The method as claimed in claim 17, wherein pain includes chronic and acute pain.
19. The method as claimed in claim 17, wherein the pain related to cancer, surgery, bone fracture, skeletal pain caused by tumor metastasis, osteoarthritis, psoriatic arthritis, rheumatoid arthritis, interstitial cystitits, chronic pancreatitis, visceral pain, inflammatory pain, migraine, chronic lower back pain, bladder pain syndrome and neuropathic pain.
20. The compound of claim 1 having TrkA inhibitory activity using TR-FRET assay of less than about 1 \u03bcM.