1. A non-transitory computer-readable medium embodying program code executable in a computing device, the program code being configured to cause the computing device to:
obtain a search query from an application executed by a client device associated with a user account, the user account being associated with a group of users within an enterprise;
identify, independent of a plurality of search results returned to the application by a search engine in response to the search query, a resource stored in a resource repository accessible to the computing device that is relevant to the search query, the resource repository further being independent from the search engine; and
transmit the resource to the client device, the resource being transmitted independent of the plurality of search results returned to the application by the search engine.
2. The non-transitory computer-readable medium of claim 1, wherein the resource repository is a private resource repository associated with the enterprise.
3. The non-transitory computer-readable medium of claim 1, the program code being further configured to cause the computing device to at least:
identify a plurality of search queries obtained from a plurality of user accounts associated with the enterprise;
determine that a threshold number of the plurality of search queries correspond to the search query; and
generate an administrator notification to obtain or generate at least one resource corresponding to the search query in response to the threshold number of the plurality of search queries corresponding to the search query.
4. The non-transitory computer-readable medium of claim 1, the program code being further configured to cause the computing device to at least:
identify a plurality of search queries obtained from a plurality of user accounts associated with the enterprise;
identify a highest ranked subset of the plurality of search queries; and
generate an administrator notification to obtain or generate at least one resource corresponding to the highest ranked subset of the plurality of search queries.
5. The non-transitory computer-readable medium of claim 1, the program code being further configured to cause the computing device to at least:
determine whether the search query corresponds to a previous search query associated with the user account; and
generate an administrator notification to obtain or generate content corresponding to the search query.
6. The non-transitory computer-readable medium of claim 1, wherein the program code identifies the at least one resource item stored on the resource repository accessible to the computing device that is relevant to the search query based at least in part upon at least one of a device type or a role within the enterprise of a user associated with the user account.
7. A system, comprising:
at least one computing device;
programming code executable in the at least one computing device, the programming code being configured to cause the at least one computing device to at least:
obtain a search query associated with a user account within an enterprise, the user account being associated with at least one client device;
identify at least one resource item relevant to the search query independent of a search engine accessible by a browser executed by the at least one client device;
associate the at least one resource item with the user account;
generate a notification comprising a reference to the at least one resource item; and
transmit the notification to the at least one client device independent of the search engine accessible by the browser, the notification being transmitted independent of the search engine accessible by the browser.
8. The system of claim 7, wherein the programming code that generates the notification is further configured to cause the at least one computing device to at least transmit the at least one resource item to the client device.
9. The system of claim 8, wherein the programming code that generates the notification is further configured to cause the at least one computing device to at least:
determine whether the client device is out of compliance with at least one compliance rule; and
include information about the at least one compliance rule into the notification.
10. The system of claim 7, wherein the programming code is further configured to cause the at least one computing device to at least:
identify the at least one resource item subsequent to a search performed via the search engine accessible by the browser; and
transmit the notification to another application executed by the client device subsequent to the search performed via the search engine accessible by the browser.
11. The system of claim 7, wherein the search query is based at least in part upon content associated with an email message accessible via a mail client executed by the client device.
12. The system of claim 7, wherein the search query is based at least in part upon content associated with a calendar event associated with a calendar of the user.
13. The system of claim 7, wherein the at least one resource item is stored in a resource repository associated with the enterprise and accessible using credentials associated with the user account.
14. The system of claim 13, wherein the resource repository comprises an application distribution environment.
15. The system of claim 13, wherein the resource repository includes a storage space associated with the user account.
16. A method, comprising:
obtaining, in at least one computing device, a search signal from a client device;
identifying, by the at least one computing device, at least one resource item relevant to the search signal independent of a search engine accessible by a browser executed by the at least one client device;
associating, by the at least one computing device, the at least one resource item with a user account corresponding to the client device; and
transmitting, from the at least one computing device, a reference to the at least one content item to the client device independent of the search engine accessible by the browser.
17. The method of claim 16, wherein the search signal comprises a user group to which the user account corresponding to the client device is associated within an enterprise.
18. The method of claim 16, wherein the search signal comprises at least one of a device type or a location of the client device.
19. The method of claim 16, wherein the search signal comprises a search query obtained on behalf of another user account within an enterprise that is associated with a same user group as the user account corresponding to the client device.
20. The method of claim 19, further comprising transmitting the reference to a plurality of client devices associated with a respective plurality of user accounts associated with a same user group as the user account corresponding to the client device.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for producing an antibiotic bone cement, comprising:
step A), mixing a bone cement base powder with a water content of less than or equal to 1.0% by weight with trometamol-fosfomycin to form a bone cement powder, and,
step X), drying the bone cement powder to a water content of less than or equal to 1.0% by weight.
2. The method according to claim 1, wherein the bone cement base powder is a polymer powder comprising a polymer selected from the group consisting of poly(methacrylic acid methylester), poly(methacrylic acid ethylester), poly(methylmethacrylic acid propylester), poly(methacrylic acid isopropylester), poly(methyl-methacrylate-co-methylacrylate), poly(styrene-co-methylmethacrylate), and a mixture of at least two of said polymers.
3. The method according to claim 1, wherein, in step A), the amount of bone cement base powder that is admixed to the bone cement powder ranges from 70 to 99.5% by weight.
4. The method according to claim 1, wherein a radiopaquer is additionally admixed to the bone cement powder in step A).
5. The method according to claim 4, wherein the amount of admixed radiopaquer is in the range from 3 to 30% by weight.
6. The method according to claim 1, wherein an initiator is additionally admixed to the bone cement powder in step A).
7. The method according to claim 6, wherein the initiator is a peroxide.
8. The method according to claim 6, wherein the amount of admixed initiator is in the range of 0.01 to 10% by weight relative to the total weight of the bone cement powder.
9. The method according to claim 1, wherein a further pharmaceutical agent is additionally admixed in step A).
10. The method according to claim 9, wherein the pharmaceutical agent is an antibiotic that has a water content of maximally 15.0% by weight.
11. The method according to claim 9, wherein the admixed amount of the further pharmaceutical agent is in the range from 0.1 to 15% by weight, relative to the total weight of the bone cement powder.
12. The method according to claim 1, wherein the bone cement powder is sterilised in a step E) that proceeds after step A) and before step X).
13. The method according to claim 12, wherein the bone cement powder produced in step A) is packaged in a sterile packaging material in a step D) preceding step E).
14. A bone cement powder produced according to the method according to claim 1 which comprises a bone cement base powder and trometamol-fosfomycin, whereby the bone cement powder has a water content of less than or equal to 1.0% by weight.
15. The bone cement powder according to claim 14, comprising:
75.0-90.0% by weight of at least one particulate polymethylmethacrylate or polymethylmethacrylate copolymer, relative to the total weight of the bone cement powder,
5.0-20.0% by weight of a particulate radiopaquer, relative to the total weight of the bone cement powder,
0.5-2.0 wt. % water-phlegmatised dibenzoylperoxide, relative to the total weight of the bone cement powder, having a water content of less than or equal to 30% by weight, and
0.5-15.0 wt. % trometamol-fosfomycin, relative to the total weight of the bone cement powder, whereby the total water content of the bone cement powder is less than or equal to 1.0% by weight.
16. The bone cement powder according to claim 15, comprising an additional antibiotic selected from the group consisting of aminoglycoside antibiotics, glycopeptide antibiotics, lincosamide antibiotics, and oxazolidinone antibiotics, whereby the antibiotic has a water content of maximally 15.0% by weight.
17. A spacer or implantable local active substance release systems comprising U a bone cement powder according claim 14 as a component of polymethylmethacrylate bone cements.
18. The method according to claim 3, wherein, in step A), the amount of bone cement base powder that is admixed to the bone cement powder ranges from 80.0 to 94% by weight.
19. The method according to claim 5, wherein the amount of admixed radiopaquer is in the range from 5.0 to 20% by weight.
20. The method according to claim 7, wherein the initiator is a a water phlegmatised dibenzoylperoxide with a water content of less than 28.0% by weight.