1. A heterocycle-containing carboxylic acid derivative represented by the following formula (I):
wherein A is a group represented by the following formula (i)
in which (1) E1 is a nitrogen atom and F1, G1, H1 and I1, are carbon atoms which may have a substituent; or (2) F1 is a nitrogen atom and E1, G1, H1 and I1 are carbon atoms which may have a substituent; or (3) H1 is a nitrogen atom and E1, F1, G1 and I1 are carbon atoms which may have a substituent, R1 and R2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group which may have a substituent, a cycloalkyl group which may have a substituent; a lower alkoxy group which may have a substituent; a cycloalkyloxy group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, an aryloxy group which may have a substituent, a heteroaryloxy group which may have a substituent, a cycloalkylalkyl group which may have a substituent, an arylalkyl group which may have a substituent, a heteroarylalkyl group which may have a substituent, a cycloalkylalkyloxy group which may have a substituent, an arylalkyloxy group which may have a substituent, a heteroarylalkyloxy group which may have a substituent, an alkenyl group which may have a substituent or an alkynyl group which may have a substituent, or R1 and R2 are coupled together to form a cycloalkylene group which may have a substituent, a carbon group forming said cycloalkylene group may be substituted by a sulfur atom, an oxygen atom, a sulfinyl group, a sulfonyl group or >NR4, R4 representing a hydrogen atom or a lower alkyl group;
B is a heteroarylene group which may have a substituent, an arylene group which may have a substituent, or a group represented by the following formula:
wherein R5 represents a hydrogen atom or a lower alkyl group; and m2 stands for 0 to 2; R8 to R15 are the same or different and each independently represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom, a sulfur atom or >NR4, R4 having the same meaning as defined above;
D is an arylene group which may have a substituent;
n1 is one;
M is a hydroxyl group, a lower alkoxy group or a group represented by the following formula: \u2014NR16R17 in which R16 and R17 are the same or different and each independently represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a R17 lower alkoxy group, a hydroxyalkyl group, an aryl group or a heteroaryl group or R16 and are coupled together with the adjacent nitrogen atom to form an oxygen- or sulfur-containing ring; and
represents a single bond or double bond; or a physiologically acceptable salt thereof.
2. The compound of claim 1 wherein A is
3. The compound of claim 1 wherein B is an arylene group which may have a substituent, a heteroarylene group which may have a substituent or a group represented by the following formula:
wherein R5 represents a hydrogen atom or a lower alkyl group.
4. The compound of claim 1 wherein B is a heteroarylene group which may have a substituent, a group represented by the formula \u2014CONH\u2014.
5. A pharmaceutical composition comprising a pharmaceutically effective amount of the heterocycle-containing carboxylic acid derivative or physiologically acceptable salts thereof as claimed in claim 1 and a pharmaceutically acceptable carrier.
6. A method for treating acute promyelocytic leukemia by administering a pharmaceutically effective dose of the heterocycle-containing carboxylic acid derivative or physiologically acceptable salts thereof as claimed in claim 1 to a person suffering from acute promyelocytic leukemia.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-13. (canceled)
14. Computer-readable code embodied on computer-readable media for conducting materialization forecasting with respect to reservations made by persons for the potential purchase of a particular perishable commodity, comprising:
first subprocesses for gathering past system-wide reservation information relating to past system-wide reservations for perishable commodities that have already perished, said system-wide past reservation information including information unrelated to said particular perishable commodity;
second subprocesses for gathering current reservation information relating to current reservations for said particular perishable commodity, which current reservation has not yet perished;
third subprocesses for comparing said gathered past system-wide reservation information and said current reservation information;
fourth subprocesses for calculating, based on said comparison, the likelihood that said current reservations will materialize; and
fifth subprocesses for outputting materialization forecast results based on said calculated likelihood.
15. The computer-readable code as set forth in claim 14, wherein said past system-wide reservation information includes historical commodity details unrelated to said particular perishable commodity.
16. The computer-readable code as set forth in claim 15, wherein said past system-wide reservation information further includes Point-of-Sale (POS) information included in said past system-wide reservation information that is unrelated to said potential purchase of said particular perishable commodity.
17. The computer-readable code as set forth in claim 16, wherein said past system-wide reservation information further includes materialization information unrelated to said potential purchase of said particular perishable commodity.
18. The computer-readable code as set forth in claim 17, wherein said past system-wide reservation information includes demographic information about persons who made said past reservations.
19. The computer-readable code as set forth in claim 18, wherein said demographic information includes one or more of the following pertaining to said persons making said past reservations: age, sex, national origin, citizenship, country of residence, occupation, education, annual income, marital status, reservation frequency.
20. The computer-readable code as set forth in claim 19, wherein said current reservation information further includes current-commodity details regarding said particular perishable commodity.
21. The computer-readable code as set forth in claim 20, wherein said current reservation information further includes POS information pertaining to said particular perishable commodity.
22. The computer-readable code as set forth in claim 21, wherein said current reservation information includes demographic information about persons making said current reservations for said particular perishable commodity.
23. The computer-readable code as set forth in claim 22, wherein said demographic information includes one or more of the following pertaining to said persons making said current reservations: age, sex, national origin, citizenship, country of residence, occupation, education, annual income, marital status, reservation frequency.
24. The computer-readable code as set forth in claim 23, wherein said perishable commodities comprise airline seats, and wherein said historical commodity details include information related to one or more of the following regarding said airline seats: carrier name, flight origin, flight destination, booking class, flight distance, departure time, connection time, arrival time, departure date, arrival date, flight duration, number of distinct legs comprising a complete one-way itinerary, aircraft type, aircraft capacity.
25. The computer-readable code as set forth in claim 24, wherein said POS information includes one or more of the following: POS type, POS country, booking carrier, booking recency, change recency, fare code, number of passengers traveling with said persons making said past reservations, length of stay associated with the reservation, time between booking date and flight date, payment status.
26. The computer-readable code as set forth in claim 25, wherein said current-commodity details include information related to one or more of the following: carrier name, flight origin, flight destination, booking class, flight distance, departure time, connection time, arrival time, departure date, arrival date, flight duration, number of distinct legs comprising a complete one-way itinerary, aircraft type, aircraft capacity.