1. A carboxylic acid compound represented by the formula (I), or a salt thereof:
wherein Ar represents a C6-10aryl group optionally having at least one substituent;
R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a hydroxyl group, a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group;
X represents an oxygen atom or a methylene group;
Y represents a group represented by the formula (II) or (III):
wherein Z represents a group represented by the formula (IV):
wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6alkoxy group;
m is 0 or 1; and
n is 0 or 1.
2. The carboxylic acid compound according to claim 1 or a salt thereof, wherein Y is a group represented by the formula (II):
wherein Z represents a group represented by the formula (IV):
wherein R9, R10, R11 and R12 are independent of each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group.
3. The carboxylic acid compound according to claim 1 or a salt thereof, wherein Y represents a group represented by the formula (III):
wherein Z represents a group represented by the formula (IV):
wherein R9, R10, R11 and R12 are independent of each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group.
4. The carboxylic acid compound according to claim 1 or a salt thereof, wherein each of R9, R10 and R11 represents a hydrogen atom; and R12 represents a C1-6 alkoxy group.
5. The carboxylic acid compound according to claim 1 or a salt thereof, wherein R12 represents an ethoxy group or an isopropoxy group.
6. The carboxylic acid compound according to claim 1 or a salt thereof, wherein X represents an oxygen atom.
7. The carboxylic acid compound according to claim 1 or a salt thereof, wherein each of m and n represents 0.
8. The carboxylic acid compound according to claim 1 or a salt thereof, wherein each of R1, R2, R3, R4, R5, R6, R7 and R8 represents a hydrogen atom.
9. The carboxylic acid compound according to claim 1 or a salt thereof, wherein Ar represents a benzene ring group optionally having at least one substituent selected from the group consisting of a halogen atom, a hydroxyl group, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-6 cycloalkyl group and a trifluoromethyl group.
10. A method for treating diabetes mellitus, syndrome X or an inflammatory disease, said method comprising administering a pharmacologically effective amount of the carboxylic acid compound according to claim 1 or a salt thereof to a patient in need thereof.
11. The carboxylic acid compound according to claim 1 or a salt thereof, wherein said at least one substituent of said Ar is selected from the group comprising an alkyl group, alkenyl group, alkynyl group and alkoxy group, wherein any of said groups is further optionally substituted with a hydroxyl group, thiol group, nitro group, morpholino group, thiomorpholino group, a halogen atom, nitrile group, azide group, formyl group, amino group, an alkylamino group, a dialkylamino group, carbamoyl group or sulfonyl group.
12. The carboxylic acid compound according to claim 1 or a salt thereof, wherein said at least one substituent of said Ar is selected from the group comprising a halogen atom, hydroxy group, C1-6 alkyl group, halogenated C1-6 alkyl group, C3-6 cycloalkyl group arid a C1-6 alkoxy group.
13. A pharmaceutical composition comprising:
a pharmacologically effective amount of the compound according to claim 1 or a salt thereof; and
a pharmaceutically acceptable carrier.
14. The method of claim 10, wherein said inflammatory disease is an inflammatory bowel disease.
15. The method of claim 10, wherein said disease is diabetes mellitus or syndrome X.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An assembly tool for assembling a lens tube in a support frame, comprising:
a main body configured for positioning the support frame; and
a top cover rotatably connected to the main body, wherein the top cover comprises a positioning plate and a fastening assembly rotatably connected to the positioning plate; the fastening assembly comprises a fastening member and a restricting member connected to the fastening member, the fastening member is threaded with the positioning plate, and the restricting member defines a penetrating hole for receiving the lens tube and comprises a plurality of engaging portions on a side wall defining the penetrating hole, and the plurality of engaging portions are configured for being engaged with the lens tube; and
wherein the restricting member is capable of engaging with the lens tube positioned on the support frame, and thus the lens tube is rotated into the support frame by rotating the fastening member.
2. The assembly tool of claim 1, wherein the fastening member comprises a fastening head, and a first threaded portion formed on the fastening head; the positioning plate defines a connecting hole, and a second threaded portion is formed on the inner surface of the connecting hole; the first threaded portion engages with the second threaded portion.
3. The assembly tool of claim 2, wherein the top cover further comprises a cover body defining an assembly hole, the fastening head extends through the assembly hole of the cover body, and the positioning plate is positioned in the cover body.
4. The assembly tool of claim 2, wherein the fastening head defines a restricting groove in an end thereof for receiving the restricting member.
5. The assembly tool of claim 1, wherein the main body comprises a support member, an assembly plate, and a pivot shaft; the support member comprise a main portion and a pivot portion formed on a side of the main portion; the main portion defines a receiving groove for receiving the assembly plate; the pivot portion is rotatably connected to the top cover via a pivot shaft.
6. The assembly tool of claim 5, wherein the assembly plate defines a restricting hole for receiving the support frame.
7. The assembly tool of claim 6, wherein the support frame defines a positioning hole, a third threaded portion is formed in the inner surface of the positioning hole; and the lens tube forms a fourth threaded portion engaging with the third threaded portion.
8. An assembly tool for assembling a lens module, comprising:
a main body; and
a top cover rotatably connected to the main body;
wherein the top cover comprises a positioning plate and a fastening assembly positioned on the positioning plate; the fastening assembly comprises a fastening member and a restricting member connected to the fastening member, the fastening member are rotatably connected to the positioning plate, the restricting member defines a penetrating hole, and a plurality of engaging portions are formed on a side wall defining the penetrating hole.
9. The assembly tool of claim 8, wherein the fastening member comprises a fastening head, and a first threaded portion is formed on the fastening head; the positioning plate defines a connecting hole, a second threaded portion is formed on the inner surface of the connecting hole; and the first threaded portion engages with the second threaded portion.
10. The assembly tool of claim 9, wherein the top cover further comprises a cover body defining an assembly hole, the fastening head extends through the assembly hole of the cover body, and the positioning plate is positioned in the cover body.
11. The assembly tool of claim 9, wherein the fastening head defines a restricting groove in an end thereof for receiving the restricting member.
12. The assembly tool of claim 8, wherein the main body comprises a support member, an assembly plate, and a pivot shaft; the support member comprise a main portion and a pivot portion formed on a side of the main portion; the main portion defines a receiving groove for receiving the assembly plate; and the pivot portion is rotatably connected to the top cover via a pivot shaft.
13. The assembly tool of claim 12, wherein the assembly plate defines a restricting hole for receiving the lens module.