1. A method for communication, the method comprising:
performing by one or more processors andor circuits in one or more of a plurality of network devices:
distributing hypervisor functions, which control operations of one or more virtual machines, across a plurality of network devices when processing data by said one or more of said plurality of network devices; and
sharing information among said plurality of network devices to enable said processing of said data by said one or more virtual machines.
2. The method according to claim 1, comprising configuring a sub-hypervisor within each of said one or more virtual machines to enable said processing of said data.
3. The method according to claim 2, comprising configuring said sub-hypervisors utilizing said hypervisor.
4. The method according to claim 2, comprising communicating load information of said plurality of network devices to said hypervisor utilizing said sub-hypervisors.
5. The method according to claim 1, wherein said one or more virtual machines executes one or more threads that enable said processing of said data.
6. The method according to claim 1, comprising balancing a load handled by said one or more virtual machines utilizing said hypervisor.
7. The method according to claim 1, comprising dynamically configuring said one or more virtual machines utilizing said hypervisor based on changes in one or more of said plurality of network devices.
8. The method according to claim 1, comprising scaling operations of said one or more virtual machines by said distribution of said one or more virtual machines across said plurality of network devices.
9. The method according to claim 1, comprising receiving resulting information of said processing of said data in said one or more virtual machines.
10. The method according to claim 1, wherein said plurality of network devices comprises one or more of: servers, switches, routers, racks, blades, mainframes, personal data assistants, smart phones, desktop computers, andor laptop devices.
11. A system for enabling data processing, the system comprising:
one or more processors andor circuits in one or more of a plurality of network devices, wherein said one or more of said processors andor circuits are operable to:
distribute hypervisor functions, which control operations of one or more virtual machines, across a plurality of network devices when processing data by said plurality of network devices; and
share information among said plurality of network devices to enable said processing of said data by said one or more virtual machines.
12. The system according to claim 11, wherein said one or more processors andor circuits are operable to configure a sub-hypervisor within each of said one or more virtual machines to enable said processing of said data.
13. The system according to claim 12, wherein said one or more processors andor circuits are operable to configure said sub-hypervisors utilizing said hypervisor.
14. The system according to claim 12, wherein said one or more processors andor circuits are operable to communicate load information of said plurality of network devices to said hypervisor utilizing said sub-hypervisors.
15. The system according to claim 11, wherein said one or more virtual machines executes one or more threads that enable said processing of said data.
16. The system according to claim 11, wherein said one or more processors andor circuits are operable to balance a load handled by said one or more virtual machines utilizing said hypervisor.
17. The system according to claim 11, wherein said one or more processors andor circuits are operable to dynamically configure said one or more virtual machines utilizing said hypervisor based on changes in one or more of said plurality of network devices.
18. The system according to claim 17, wherein said one or more processors andor circuits are operable to scale operations of said one or more virtual machines by distributing said one or more virtual machines across said plurality of network devices.
19. The system according to claim 11, wherein said one or more processors andor circuits are operable to receive resulting information of said processing of said data said in said one or more virtual machines.
20. The system according to claim 11, wherein said plurality of network devices comprises one or more of: servers, switches, routers, racks, blades, mainframes, personal data assistants, smart phones, desktop computers, andor laptop devices.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I)
or a therapeutically acceptable salt thereof, wherein
R1 is selected from the group consisting of hydrogen and alkyl;
R2 is selected from the group consisting of hydrogen, alkoxy, alkoxyalkoxy, alkyl, carboxyalkoxy, carboxyalkyl, halo, haloalkyl, heterocyclylalkoxy, hydroxy, nitro, and \u2014NRcRd; and
one of R3 and R4 is A-X\u2014R5 and the other is hydrogen; wherein A-X\u2014R5 is drawn with its left end attached to the parent molecular moiety;
R5 is selected from the group consisting of aryl, heteroaryl, and heterocyclyl;
A is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of alkyl, halo, haloalkoxy, and haloalkyl; and
X is selected from the group consisting of O, NRa, N(Ra)C(S)N(Rb), (CH2)mN(Ra)C(O)N(Rb)(CH2)n, CH2C(O)N(Ra), and N(Ra)C(O), wherein Ra and Rb are independently selected from the group consisting of hydrogen and alkyl, m and n are independently 0 or 1, and wherein each group is drawn with its left end attached to A and its right end attached to R5.
2. The compound of claim 1 wherein R3 is A-X\u2014R5 and R4 is hydrogen.
3. The compound of claim 2 wherein X is selected from the group consisting of O, NRa, N(Ra)C(S)N(Rb), CH2C(O)N(Ra), and N(Ra)C(O).
4. The compound of claim 3 selected from the group consisting of
4-(4-phenoxyphenyl)-1-isoindolinone;
4-{4-(5,7-dimethyl-1,3-benzoxazol-2-yl)amino-3-fluorophenyl}-1-isoindolinone;
4-(2-anilino-1H-benzimidazol-5-yl)-1-isoindolinone;
N-(3-methylphenyl)-2-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylacetamide;
N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-1,3-thiazole-2-carboxamide;
N-(3-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylthiourea;
4-(2,5-dimethoxyphenyl)-N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-1,3-thiazole-2-carboxamide;
4-(3-bromophenyl)-N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-1,3-thiazole-2-carboxamide;
4-(4-methoxyphenyl)-N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-1,3-thiazole-2-carboxamide; and
4-4-(1H-benzimidazol-2-ylamino)phenyl-1-isoindolinone.
5. The compound of claim 2 wherein X is (CH2)mN(Ra)C(O)N(Rb)(CH2)n.
6. The compound of claim 5 wherein R2 is other than hydrogen.
7. The compound of claim 6 selected from the group consisting of
N-(3-methylphenyl)-N\u2032-4-(7-nitro-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-(7-amino-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}acetamide;
N2,N2-dimethyl-N1-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}glycinamide;
N-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}nicotinamide;
N-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-2-phenylacetamide;
2-(2-methoxyethoxy)-N-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}acetamide;
N-{4-6-(2-methoxyethoxy)-1-oxo-2,3-dihydro-1H-isoindol-4-ylphenyl}-N\u2032-(3-methylphenyl)urea;
({7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-5-yl}oxy)acetic acid;
N-4-(7-hydroxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-4-(7-methoxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
({7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetic acid;
N-{4-7-(2-methoxyethoxy)-1-oxo-2,3-dihydro-1H-isoindol-4-ylphenyl}-N\u2032-(3-methylphenyl)urea;
benzyl 7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-5-ylcarbamate;
N-4-(6-methoxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-(3-methylphenyl)-N\u2032-(4-{7-3-(4-morpholinyl)propoxy-1-oxo-2,3-dihydro-1H-isoindol-4-yl}phenyl)urea;
N-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}benzamide;
3-(dimethylamino)-N-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}benzamide;
N-(3-methylphenyl)-N\u2032-4-(6-nitro-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-(6-amino-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea; and
N-{7-4-({(3-methylphenyl)aminocarbonyl}amino)phenyl-3-oxo-2,3-dihydro-1H-isoindol-5-yl}acetamide.
8. The compound of claim 5 wherein R2 is hydrogen.
9. The compound of claim 8 wherein R5 is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are unsubstituted.
10. The compound of claim 9 selected from the group consisting of
N-2,3-dihydro-1H-inden-5-yl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-1,3-benzodioxol-5-yl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-phenylurea; and
N-2-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-phenylurea.
11. The compound of claim 8 wherein R5 is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are monosubstituted.
12. The compound of claim 11 wherein A is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are unsubstituted.
13. The compound of claim 12 selected from the group consisting of
N-(3-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(4-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2-methoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-methoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(4-methoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2-fluorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-fluorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(4-fluorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2-chlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-chlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(4-chlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2-bromophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-bromophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(4-bromophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-4-(trifluoromethoxy)phenylurea;
N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-phenoxyphenyl)urea;
N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-4-(trifluoromethyl)phenylurea;
N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(4-phenoxyphenyl)urea;
N-3-(benzyloxy)phenyl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-3-(trifluoromethyl)phenylurea;
N-(3-ethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-cyanophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
methyl 3-({4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylamino}carbonyl)aminobenzoate;
N-(3-acetylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-methylphenyl)-N\u2032-6-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-3-pyridinylurea;
N-(5-methyl-3-pyridinyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-(2-methyl-1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-(3-methylphenyl)-N\u2032-3-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-methyl-N-(3-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-chlorophenyl)-N-methyl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-methyl-N\u2032-(3-methylphenyl)-N-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea; and
N-(3-methylphenyl)-N\u2032-5-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-2-thienylurea.
14. The compound of claim 11 wherein A is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are monosubstituted.
15. The compound of claim 14 selected from the group consisting of
N-2-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-(3-chlorophenyl)-N\u2032-2-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-2-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-4-fluoro-3-(trifluoromethyl)phenylurea;
N-(4-chlorophenyl)-N\u2032-2-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-bromophenyl)-N\u2032-2-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-2-(trifluoromethoxy)phenylurea;
N-(3-chlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-2-(trifluoromethoxy)phenylurea;
N-2-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-(3-chlorophenyl)-N\u2032-2-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-3-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-(3-chlorophenyl)-N\u2032-3-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-3-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-3-(trifluoromethyl)phenylurea;
N-2-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-2-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-chlorophenyl)urea;
N-3-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-3-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-chlorophenyl)urea;
N-3-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-3-(trifluoromethyl)phenylurea;
N-(3-chlorophenyl)-N\u2032-3-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-3-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea;
N-(3-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-2-(trifluoromethyl)phenylurea;
N-(3-chlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-2-(trifluoromethyl)phenylurea;
N-(3-chlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-3-(trifluoromethyl)phenylurea;
N-(3-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-3-(trifluoromethyl)phenylurea;
N-2-ethyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3-methylphenyl)urea; and
N-(3-chlorophenyl)-N\u2032-2-ethyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea.
16. The compound of claim 8 wherein R3 is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are disubstituted.
17. The compound of claim 16 wherein A is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are unsubstituted.
18. The compound of claim 17 selected from the group consisting of
N-(2,3-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2,4-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2,5-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,4-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2,3-dimethoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2,4-dimethoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2,5-dimethoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,4-dimethoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,5-dimethoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2,3-dichlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(2,5-dichlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,4-dichlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,5-dichlorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-chloro-3-(trifluoromethyl)phenyl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-chloro-4-methoxyphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(4-bromo-3-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-chloro-4-fluorophenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3-chloro-4-methylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-2-fluoro-5-(trifluoromethyl)phenyl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,5-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea; and
N-4-fluoro-3-(trifluoromethyl)phenyl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea.
19. The compound of claim 16 wherein A is selected from the group consisting of aryl and heteroaryl, wherein the aryl and the heteroaryl are monosubstituted.
20. The compound of claim 19 selected from the group consisting of
N-(3,4-dimethylphenyl)-N\u2032-2-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,4-dimethylphenyl)-N\u2032-2-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-fluoro-3-(trifluoromethyl)phenyl-N\u2032-2-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,4-dimethylphenyl)-N\u2032-3-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-(3,5-dimethylphenyl)-N\u2032-3-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-fluoro-3-(trifluoromethyl)phenyl-N\u2032-3-methyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-2-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3,5-dimethylphenyl)urea;
N-3-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-4-fluoro-3-(trifluoromethyl)phenylurea;
N-3-chloro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-(3,5-dimethylphenyl)urea;
N-(3,5-dimethylphenyl)-N\u2032-3-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea;
N-4-fluoro-3-(trifluoromethyl)phenyl-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-3-(trifluoromethyl)phenylurea;
N-(3,5-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-2-(trifluoromethyl)phenylurea;
N-(3,4-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-3-(trifluoromethyl)phenylurea;
N-(3,5-dimethylphenyl)-N\u2032-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-3-(trifluoromethyl)phenylurea;
N-2-ethyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl-N\u2032-4-fluoro-3-(trifluoromethyl)phenylurea; and
N-(3,5-dimethylphenyl)-N\u2032-2-ethyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenylurea.
21. A pharmaceutical composition comprising a compound of claim 1 or a therapeutically acceptable salt thereof, in combination with a therapeutically acceptable carrier.
22. A method for inhibiting a protein kinase in a patient in recognized need of such treatment comprising administering to the patient a therapeutically acceptable amount of a compound of claim 1, or a therapeutically acceptable salt thereof.
23. A method for treating cancer in a patient in recognized need of such treatment comprising administering to the patient a therapeutically acceptable amount of a compound of claim 1, or a therapeutically acceptable salt thereof.