1. A machine tool receptacle, having a slaving device (12, 14, 16, 300), by way of which an insert tool can be operatively connected to a drive shaft (54), wherein the insert tool is operatively connectable to the slaving device (14, 16, 300) via at least one detent element (24, 26, 302), supported movably counter to a spring element (20, 22), which detent element snaps into place in an operating position of the insert tool and fixes the insert tool by positive engagement, characterized in that the insert tool is a circular saw blade (18, 32).
2. The machine tool receptacle of claim 1, characterized in that the detent element (24, 26, 302) is displaceable in the axial direction (44) counter to the spring element (20, 22).
3. The machine tool receptacle of claim 1 or 2, characterized in that a drive moment can be transmitted via a positive-engagement connection between the circular saw blade (18, 32) and the slaving device (12, 14, 16, 300).
4. The machine tool receptacle of one of the foregoing claims, characterized in that the detent element (24, 26, 300) can be released from its detent position by an unlocking button (28, 30).
5. The machine tool receptacle of one of the foregoing claims, characterized in that the circular saw blade (32) is connectable to the slaving device (16) via a tongue-and-groove connection, which is secured by positive engagement via at least one detent element (26) in an operating position of the circular saw blade (32).
6. The machine tool receptacle of claims 1-4, characterized in that the circular saw blade (8) is connected to the slaving device (12, 14, 300) in the circumferential direction (34, 36) via at least a first element (24, 302) and in the axial direction (38) via at least a second element (40, 42, 306).
7. The machine tool receptacle of claim 6, characterized in that at least one detent element (24, 302), extending in the axial direction (38), snaps into a recess (46, 48, 50), corresponding to the detent element (24, 302), of a tool hub (52) of the circular saw blade (18) in an operating position of the circular saw blade (18) and fixes the circular saw blade (18) in the circumferential direction (34, 36) by positive engagement.
8. The machine tool receptacle of claim 6, characterized in that at least one detent element (24) extending in the axial direction (38) is secured in a component (56) supported displaceably on the drive shaft (54) counter to the spring element (20).
9. The machine tool receptacle of one of claims 6-8, characterized in that the slaving device (12, 14, 300) has at least one fastening element (40, 42, 306), extending in the axial direction (38), which can be passed through at least one region (58, 60, 62) of an elongated slot (64, 66, 68) of the circular saw blade (18) and in the elongated slot (64, 66, 68) is displaceable in a narrowed region (70, 72, 74) of the elongated slot (64, 66, 68), and by way of which the circular saw blade (18) is axially fixable in the elongated slot (64, 66, 68) via a contact face (76, 78, 310a) disposed on the fastening element (40, 42, 306).
10. The machine tool receptacle of claim 9, characterized in that a component (82) forming a bearing face (80) for the circular saw blade (18), in the fastened state of the circular saw blade (18), has a recess (84) in the region of the elongated slot (64, 66, 68), into which recess part of the circular saw blade (18) is pressed elastically, in an operating position of the circular saw blade (18).
11. The machine tool receptacle of claim 9 or 10, characterized in that the fastening element (42, 306) extending in the axial direction (38) is supported elastically displaceably in the axial direction (38) counter to a spring element (86, 312), for axially fixing the circular saw blade (18).
12. The machine tool receptacle of one of claims 6-11, characterized in that a collar (92), by way of which the circular saw blade (18) can be radially centered, is formed onto a component (90) of the slaving device 14, (300) that forms a bearing face (88) for the circular saw blade (18).
13. The machine tool receptacle of one of the foregoing claims, characterized in that at least one detent element (302) is integrally formed onto a disklike component (304).
14. The machine tool receptacle of one of the foregoing claims, characterized in that at least two elements (306) for fixing the circular saw blade (18) in the axial direction (38) are integrally formed onto a disklike component (308).
15. A circular saw blade, which can be connected by a tool hub (52, 94), via a slaving device (12, 14, 16, 300) of a machine tool receptacle, to a drive shaft (54) of a circular saw (10), characterized in that the tool hub (52, 94) is operatively connectable to the slaving device (12, 14, 16, 300) via at least one detent element (24, 26, 302), supported movably counter to a spring element (20, 22, 312), which detent element snaps into place in an operating position of the tool hub (52, 94) and fixes the tool hub (52, 94) by positive engagement.
16. The circular saw blade of claim 15, characterized in that at least a first recess (46, 48, 50) for a positive-engagement connection to the slaving device (12, 14, 300) in at least one circumferential direction (34, 36), and at least one second recess (64, 66, 68), separated from the first recess (46, 48, 50), for a positive-engagement connection in the axial direction (38) are made in the tool hub (52).
17. The circular saw blade of claim 16, characterized in that at least elongated slot (64, 66, 68) is made in the tool hub (52), which elongated slot has one wide region (58, 60, 62) and at least one narrow region (70, 72, 74).
18. A method for producing a circular saw blade (18, 32) of claim 14 or 15, characterized in that in one production operation of an outer contour of the circular saw blade (18, 32), at least one recess (46, 48, 50, 64, 66, 68) for the machine tool receptacle (12, 14, 16, 300) is made in the circular saw blade (18, 32).
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A method of treating alcoholism or alcohol abuse, comprising extinguishing an alcohol-drinking response by administering to a subject a pharmaceutically effective amount of an opioid antagonist before imminent drinking.
2. The method according to claim 1, wherein the opioid antagonist is selected from the group consisting of nalmefene, naloxone, naltrexone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, and nalorphine, or a pharmaceutically acceptable salt thereof.
3. The method according to claim 2, wherein the opioid antagonist is selected from the group consisting of nalmefene, naloxone and naltrexone, or a pharmaceutically acceptable salt thereof.
4. The method according to claim 3, wherein the opioid antagonist is nalmefene or a pharmaceutically acceptable salt thereof.
5. A method of treating alcoholism or alcohol abuse, comprising extinguishing an alcohol-drinking response by administering to a subject transmucosally a pharmaceutically effective amount of an opioid antagonist before imminent drinking.
6. The method according to claim 5, wherein the opioid antagonist is selected from the group consisting of nalmefene, naloxone, naltrexone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, and nalorphine, or a pharmaceutically acceptable salt thereof.
7. The method according to claim 6, wherein the opioid antagonist is selected from the group consisting of nalmefene, naloxone and naltrexone, or a pharmaceutically acceptable salt thereof.
8. The method according to claim 7, wherein the opioid antagonist is nalmefene or a pharmaceutically acceptable salt thereof.
9. A method of treating alcoholism or alcohol abuse, comprising extinguishing an alcohol-drinking response by administering to a subject before imminent drinking a transmucosal preparation comprising a pharmaceutically effective amount of an opioid antagonist, wherein the transmucosal preparation has rapid onset of action.
10. The method according to claim 9, wherein the opioid antagonist is selected from the group consisting of nalmefene, naloxone, naltrexone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, and nalorphine, or a pharmaceutically acceptable salt thereof.
11. The method according to claim 10, wherein the opioid antagonist is selected from the group consisting of nalmefene, naloxone and naltrexone, or a pharmaceutically acceptable salt thereof.
12. The method according to claim 11, wherein the opioid antagonist is nalmefene or a pharmaceutically acceptable salt thereof.
13. The method according to claim 8 or 12, wherein the dose is about 1 to about 50 mg.
14. The method according to claim 13, wherein the dose is about 5 to about 20 mg.
15. The method according to claim 9, wherein the transmucosal preparation is administered orally.
16. The method according to claim 15, wherein the transmucosal preparation comprises a backing layer and a mucoadhesive layer, and wherein the mucoadhesive layer comprises an opioid antagonist.
17. The method according to claim 15, wherein the transmucosal preparation is a rapidly disintegrating capsule or tablet.
18. The method according to claim 15, wherein the pH of the transmucosal preparation is within the range of about 6 to about 8.
19. The method according to claim 18, wherein the pH of the transmucosal preparation is within the range of about 6.5 to about 7.5.
20. The method of claim 1 or 5, wherein said method is repeated prior to each episode of alcohol consumption by the subject.
21. The method according to any one of claims 1, 5, or 9, wherein the subject is a FAH subject.
22. A method of treating alcoholism or alcohol abuse of a FAH subject, comprising extinguishing an alcohol-drinking response by administering to the FAH subject a pharmaceutically effective amount of an opioid antagonist.
23. The method according to claim 22, wherein a pharmaceutically effective amount of nalmefene or a pharmaceutically acceptable salt thereof is administered.