1. A wireless communications apparatus, comprising:
a memory that retains instructions related to scheduling a first mobile device for uplink transmission from a first sector on a first channel during a first time slot based on a first interference budget level, scheduling a second mobile device for uplink transmission from the first sector on the first channel during a second time slot based on a second interference budget level, and transmitting assignments to the first mobile device and the second mobile device related to the scheduled uplink transmissions, wherein the first interference budget level and the second interference budget level are determined as a function of time from a time varying interference budget pattern; and
a processor, coupled to the memory, configured to execute the instructions retained in the memory.
2. The wireless communications apparatus of claim 1, wherein the memory further retains instructions related to obtaining channel quality reports from one or more mobile device, the channel quality reports include a measurement of an interference ratio between a signal strength from a serving base station to a respective mobile device and a weighted sum of signal strengths from interfering base stations.
3. The wireless communications apparatus of claim 1, wherein the memory further retains instructions related to scheduling a third mobile device for uplink transmission from the first sector on a second channel during the first time slot based on a third interference budget level and scheduling a fourth mobile device for uplink transmission from the first sector on the second channel during the second time slot based on a fourth interference budget level, the third and fourth interference budget levels being determined from a second interference budget pattern.
4. The wireless communications apparatus of claim 1, wherein the memory further retains instructions related to scheduling a fifth mobile device for uplink transmission from a second sector on the first channel during the first time slot based on a fifth interference budget level and scheduling a sixth mobile device for uplink transmission from the second sector on the first channel during the second time slot based on a sixth interference budget level, the fifth and sixth interference budget levels being determined from a third interference budget pattern and the first and third interference budget patterns being periodical.
5. The wireless communications apparatus of claim 4, wherein a wireless communication base station includes the first sector and the second sector.
6. The wireless communications apparatus of claim 4, wherein a first wireless communication base station includes the first sector and a second wireless communication base station includes the second sector.
7. A wireless communications apparatus that enables scheduling uplink transmissions by utilizing a dynamic interference budget, comprising:
means for scheduling a first mobile device for uplink transmission from a first sector on a first channel during a first time slot based on a first interference budget level, the first interference budget level being determined from an interference budget pattern that varies over time, said means for scheduling a first mobile device being implemented in hardware;
means for scheduling a second mobile device for uplink transmission from the first sector on the first channel during a second time slot based on a second interference budget level, the second interference budget lever being determined from the interference budget pattern, said means for scheduling a second mobile device being implemented in hardware; and
means for sending assignments related to the uplink transmissions to the scheduled mobile devices, said means for sending assignments being implemented in hardware.
8. The wireless communications apparatus of claim 7, further comprising:
means for scheduling a third mobile device for uplink transmission from the first sector on a second channel during the first time slot based on a third interference budget level, the third interference budget level being determined from a second interference budget pattern that varies over time, said means for scheduling a third mobile device being implemented in hardware; and
means for scheduling a fourth mobile device for uplink transmission from the first sector on the second channel during the second time slot based on a fourth interference budget level, the fourth interference budget levels being determined from the second interference budget pattern, said means for scheduling a fourth mobile device being implemented in hardware.
9. The wireless communications apparatus of claim 7, further comprising:
means for scheduling a fifth mobile device for uplink transmission from a second sector on the first channel during the first time slot based on a fifth interference budget level, the fifth interference budget level being determined from a third interference budget pattern that varies over time, said means for scheduling a fifth mobile device being implemented in hardware; and
means for scheduling a sixth mobile device for uplink transmission from the second sector on the first channel during the second time slot based on a sixth interference budget level, the sixth interference budget levels being determined from the third interference budget pattern, said means for scheduling a sixth mobile device being implemented in hardware.
10. In a wireless communications system, an apparatus comprising:
a processor configured to:
schedule a first mobile device for uplink transmission from a first sector on a first channel during a first time slot based on a first interference budget level; and
schedule a second mobile device for uplink transmission from the first sector on the first channel during a second time slot based on a second interference budget level, the first interference budget level and the second interference budget level being identified as a function of time based upon a time varying first interference budget pattern.
11. A wireless communications method, comprising:
scheduling a first mobile device for uplink transmission from a first sector on a first channel during a first time slot based on a first interference budget level;
scheduling a second mobile device for uplink transmission from the first sector on the first channel during a second time slot based on a second interference budget level, said first interference budget level and said second interference budget level are determined as a function of time from a time varying interference budget pattern; and
transmitting assignments to the first mobile device and the second mobile device related to the scheduled uplink transmissions.
12. The method of claim 11, further comprising:
obtaining channel quality reports from one or more mobile device, the channel quality reports include a measurement of an interference ratio between a signal strength from a serving base station to a respective mobile device and a weighted sum of signal strengths from interfering base stations.
13. The method of claim 11, further comprising:
scheduling a third mobile device for uplink transmission from the first sector on a second channel during the first time slot based on a third interference budget level; and
scheduling a fourth mobile device for uplink transmission from the first sector on the second channel during the second time slot based on a fourth interference budget level, the third and fourth interference budget levels being determined from a second interference budget pattern.
14. The method of claim 11, further comprising:
scheduling a fifth mobile device for uplink transmission from a second sector on the first channel during the first time slot based on a fifth interference budget level; and
scheduling a sixth mobile device for uplink transmission from the second sector on the first channel during the second time slot based on a sixth interference budget level, the fifth and sixth interference budget levels being determined from a third interference budget pattern and the first and third interference budget patterns being periodical.
15. A non-transitory machine readable medium having stored thereon machine executable instructions which when executed by a processor control the processor to:
schedule a first mobile device for uplink transmission from a first sector on a first channel during a first time slot based on a first interference budget level;
schedule a second mobile device for uplink transmission from the first sector on the first channel during a second time slot based on a second interference budget level, said first interference budget level and said second interference budget level are determined as a function of time from a time varying interference budget pattern; and
transmit assignments to the first mobile device and the second mobile device related to the scheduled uplink transmissions.
16. The non-transitory machine readable medium of claim 15, further comprising machine executable instructions which when executed by said processor control the processor to:
schedule a third mobile device for uplink transmission from the first sector on a second channel during the first time slot based on-a third interference budget level; and
schedule a fourth mobile device for uplink transmission from the first sector on the second channel during the second time slot based on a fourth interference budget level, the third and fourth interference budget levels being determined from a second interference budget pattern.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A combination comprising:
(i) a compound of Structure (I):
or a pharmaceutically acceptable salt thereof; and
(ii) a compound of Structure (II):
or a pharmaceutically acceptable salt thereof;
where the compound of Structure (I) and the compound of Structure (II) are in synergistic amounts.
2. A combination according to claim 1 where the compound of Structure (I) is in the form of a monohydrochloride salt.
3. A combination according to claim 1 further comprising a compound of Structure (III):
4. A combination kit comprising a combination according to claim 1 together with a pharmaceutically acceptable carrier or carriers.
5. A combination according to claim 1 where the amount of the compound of Structure (I) is an amount from 100 mg to 800 mg, and that amount is administered once per day in one or more tablets, and the amount of the compound of Structure (II) is an amount from 100 mg to 800 mg, and that amount is administered once per day.
6. A combination according to claim 3 where the amount of the compound of Structure (Ill) is in an amount of from 5 mgm2 to 200 mgm2, and that amount is administered once per week.
7. A method of treating ovarian cancer in a female human in need thereof, comprising the in vivo administration of a synergistic amount of a combination of 5-4-(2,3-dimethyl-2H-indazol-6-yl)methylamino-2-pyrimidinylamino-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and 2-(5-chloro-2-3-methyl-1-(1-methylethyl)-1H-pyrazol-5-ylamino-4-pyridinyl)amino-N-methoxybenzamide, or a pharmaceutically acceptable salt thereof, to such human, wherein the combination is administered within a specified period, and wherein the combination is administered for a duration of time.
8. A method according to claim 7 wherein the amount of 5-4-(2,3-dimethyl-2H-indazol-6-yl)methylamino-2-pyrimidinylamino-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, is from about 100 mg to about 800 mg, and that amount is administered once per day.
9. A method according to claim 7 wherein the amount of 2-(5-chloro-2-3-methyl-1-(1-methylethyl)-1H-pyrazol-5-ylamino-4-pyridinyl)amino-N-methoxybenzamide, or a pharmaceutically acceptable salt thereof, is from about 100 mg to about 800 mg, and that amount is administered once per day.
10. A method according to claim 7 wherein the combination further comprises 1,7\u03b2,10\u03b2-trihydroxy-9-oxo-5\u03b2,20-epoxytax-11-ene-2\u03b1,4,13\u03b1-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-(tert-butoxycarbonyl)amino-2-hydroxy-3-phenylpropanoate}.
11. A method according to claim 10, wherein the amount of 1,7\u03b2,10\u03b2-trihydroxy-9-oxo-5\u03b2,20-epoxytax-11-ene-2\u03b1,4,13\u03b1-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-(tert-butoxycarbonyl)amino-2-hydroxy-3-phenylpropanoate} is from 5 mgm2 to 200 mgm2, and that amount is administered once per week.
12. A method according to claim 7 wherein the specified period is within about 1 to about 12 hours.
13. A method according to claim 7 wherein the duration of time is for from 1 to 30 consecutive days.
14. A method according to claim 7 wherein 5-4-(2,3-dimethyl-2H-indazol-6-yl)methylamino-2-pyrimidinylamino-2-methylbenzenesulfonamide is in the form of a monohydrochloride salt.
15. A method treating ovarian cancer in a female human in need thereof, comprising the in vivo administration of a synergistic amount of a combination of 5-4-(2,3-dimethyl-2H-indazol-6-yl)methylamino-2-pyrimidinylamino-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and 2-(5-chloro-2-3-methyl-1-(1-methylethyl)-1H-pyrazol-5-ylamino-4-pyridinyl)amino-N-methoxybenzamide, or a pharmaceutically acceptable salt thereof, to such human, wherein the compounds of the combination are administered sequentially.
16. A method according to claim 15, wherein the amount of 5-4-(2,3-dimethyl-2H-indazol-6-yl)methylamino-2-pyrimidinylamino-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, is from about 100 mg to about 800 mg, and that amount is administered once per day.
17. A method according to claim 15 wherein the amount of 2-(5-chloro-2-3-methyl-1-(1-methylethyl)-1H-pyrazol-5-ylamino-4-pyridinyl)amino-N-methoxybenzamide, or a pharmaceutically acceptable salt thereof, is from about 100 mg to about 800 mg, and that amount is administered once per day.
18. A method according to claim 15 wherein the combination further comprises 1,7\u03b2,10\u03b2-trihydroxy-9-oxo-5\u03b2,20-epoxytax-11-ene-2\u03b1,4,13\u03b1-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-(tert-butoxycarbonyl)amino-2-hydroxy-3-phenylpropanoate}.
19. A method of treating ovarian cancer which comprises administering a combination according to claim 1.