1. A delivery unit of thick orally soluble polymer:
a base medium formed as a delivery unit,
said base medium being formed at least in part from an orally soluble polymer,
said delivery unit being orally soluble such that it disintegrates relatively slowly when placed on the roof of a human mouth and licked,
at least one flavoring present in said delivery unit, said flavoring providing a strong flavor sensation to a person who places the snack on his or her tongue,
and a dosage of a desired delivery substance in said delivery unit.
2. A delivery unit as recited in claim 1 wherein said delivery unit dissolves in not less than 5 minutes when placed on the roof of a human mouth and licked.
3. A delivery unit as recited in claim 1 wherein said delivery unit dissolves in not less than 10 minutes when placed on the roof of a human mouth and licked.
4. A delivery unit as recited in claim 1 wherein said delivery substance is selected from the group consisting of medicine, medicaments, electrolytes, minerals, vitamins, nutraceuticals, and essential oils.
5. A delivery unit as recited in claim 1 having at least one exterior dimension that is >200 microns thick.
6. A delivery unit as recited in claim 1 having at least one exterior dimension that is >800 microns thick.
7. A delivery unit as recited in claim 1 having at least one exterior dimension that is >1000 microns thick.
8. A delivery unit as recited in claim 1 having at least one exterior dimension that is >1200 microns thick.
9. A delivery unit as recited in claim 1 having at least one dimension that is >2000 microns thick.
10. A delivery unit as recited in claim 1 wherein said polymer tends to stick to human gums.
11. A delivery unit as recited in claim 1 wherein said polymer tends not to stick to human gums so that said delivery unit can float in the human mouth.
12. A delivery unit as recited in claim 1 wherein said delivery unit is flexible.
13. A delivery unit as recited in claim 1 wherein said delivery unit is semi-flexible.
14. A delivery unit as recited in claim 1 wherein said base material includes a plasticizer.
15. A delivery unit as recited in claim 1 wherein said base material includes a plurality of polymers.
16. A delivery unit as recited in claim 1 wherein said polymer is pullulan.
17. A delivery unit as recited in claim 1 wherein said polymer is gelatin.
18. A delivery unit as recited in claim 1 wherein said polymer is starch.
19. A delivery unit as recited in claim 1 wherein said polymer is alginate.
20. A delivery unit as recited in claim 1 further comprising a pliability ingredient selected from the group consisting of glycerin, sorbitol, and sorbitan acid ester.
21. A delivery unit as recited in claim 1 further comprising ydroxypropylmethylcellulose.
22. A delivery unit as recited in claim 1 wherein said delivery unit is consumable by a human without simultaneously ingesting water.
23. A delivery unit as recited in claim 1 wherein said delivery substance is present in said delivery unit in a quantity that is useful to the human body.
24. A delivery unit as recited in claim 1 wherein said delivery unit includes at least two distinct flavorings.
25. A delivery unit as recited in claim 1 wherein upon disintegration in a human mouth, said delivery unit does not leave substantial residue that can which the consumer feels needs to be ejected from the mouth.
26. A delivery unit as recited in claim 1 wherein said delivery substance constitutes at least 25% of the mass of the delivery unit
27. A delivery unit as recited in claim 1 wherein said delivery unit has a dosage of a single electrolyte or mineral.
28. A delivery unit of thick orally soluble polymer:
a delivery base and a delivery substance forming the delivery unit,
said delivery unit base including an orally soluble polymer,
said delivery unit being orally soluble such that it disintegrates relatively slowly when placed on the roof of a human mouth and licked,
said delivery unit being edible so that it may pass through a human digestive system,
said delivery unit being constructed so that it may consumed without creating noise that is readily detected by a person other than the person consuming the snack,
said delivery unit being of small bulk so that it may be consumed without swallowing,
said delivery unit being of a construction that permits it to be consumed without creating debris, stickiness or mess outside of the human body,
at least one flavoring present in said delivery unit, said flavoring providing a flavor sensation to a person who places the snack on his or her tongue in order to satisfy a craving or provide flavor satisfaction to a consumer;
wherein said delivery substance is selected from the group consisting of medicine, medicaments, electrolytes, minerals, vitamins, nutraceuticals, and essential oils.
29. A delivery unit as recited in claim 27 further comprising:
at least one flavoring present in said delivery unit, said flavoring providing a flavor sensation to a person who places the snack on his or her tongue in order to satisfy a craving or provide flavor satisfaction to a consumer, said flavoring being the dominant flavoring in the snack, said dominant flavoring giving a stronger flavor sensation than other flavorings which may be present in the snack, and said dominant flavoring being a separate flavoring from any masking flavoring and enhancement flavoring that may be present in the snack, and said flavoring serving to mask any flavor which may be inherent in said delivery substance.
30. A delivery unit as recited in claim 27 wherein said delivery unit dissolves in not less than 5 minutes when placed on the roof of a human mouth and licked.
31. A delivery unit as recited in claim 27 wherein said delivery unit dissolves in not less than 10 minutes when placed on the roof of a human mouth and licked.
32. A delivery unit as recited in claim 27 wherein said delivery substance is selected from the group consisting of medicine, medicaments, electrolytes, minerals, vitamins, nutraceuticals, and essential oils.
33. A delivery unit as recited in claim 27 having at least one exterior dimension that is >200 microns thick.
34. A delivery unit as recited in claim 27 having at least one exterior dimension that is >800 microns thick.
35. A delivery unit as recited in claim 27 having at least one exterior dimension that is >1000 microns thick.
36. A delivery unit as recited in claim 27 having at least one exterior dimension that is >1200 microns thick.
37. A delivery unit as recited in claim 27 having at least one dimension that is >2000 microns thick.
38. A delivery unit as recited in claim 27 wherein said polymer tends to stick to human gums.
39. A delivery unit as recited in claim 27 wherein said polymer tends not to stick to human gums so that said delivery unit can float in the human mouth.
40. A delivery unit as recited in claim 27 wherein said delivery unit is flexible.
41. A delivery unit as recited in claim 27 wherein said delivery unit is semi-flexible.
42. A delivery unit as recited in claim 27 wherein said base material includes a plasticizer.
43. A delivery unit as recited in claim 27 wherein said base material includes a plurality of polymers.
44. A delivery unit as recited in claim 27 wherein said polymer is pullulan.
45. A delivery unit as recited in claim 27 wherein said polymer is gelatin.
46. A delivery unit as recited in claim 27 wherein said polymer is starch.
47. A delivery unit as recited in claim 27 wherein said polymer is alginate.
48. A delivery unit as recited in claim 27 further comprising a pliability ingredient selected from the group consisting of glycerin, sorbitol, and sorbitan acid ester.
49. A delivery unit as recited in claim 27 further comprising hydroxypropylmethylcellulose.
50. A delivery unit as recited in claim 27 wherein said delivery unit is consumable by a human without simultaneously ingesting water.
51. A delivery unit as recited in claim 27 wherein said delivery substance is present in said delivery unit in a quantity that is useful to the human body.
52. A delivery unit as recited in claim 27 wherein said delivery unit includes at least two distinct flavorings.
53. A delivery unit as recited in claim 27 wherein upon disintegration in a human mouth, said delivery unit does not leave substantial residue that can which the consumer feels needs to be ejected from the mouth.
54. A delivery unit as recited in claim 27 wherein said delivery substance constitutes at least 25% of the mass of the delivery unit
55. A delivery unit as recited in claim 27 wherein said delivery unit has a dosage of a single electrolyte or mineral.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula II:
wherein
R1, R2, R3 and R4 are chosen independently from the group consisting of hydrogen, halogen, loweralkyl, loweralkoxy, hydroxy, dialkylamino, cyano, acyl, perfluoroloweralkyl, and loweralkylsulfonamido;
A is a 4, 5, or 6-membered N-alkyl lactam;
n is zero, one or two;
or a salt thereof.
2. A compound according to claim 1 wherein n in formula II is zero.
3. A compound according to claim 1 wherein the compound is selected from (+\u2212)-1-Methyl-3-(6-methyl-2-p-tolyl-imidazo1,2-apyridin-3-yl)-piperidin-2-one and (+\u2212)-3-(6-Methyl-2-p-tolyl-imidazo1,2-apyridin-3-yl)-piperidin-2-one.
4. A compound according to claim 3 wherein the compound is (+)-1-Methyl-3-(6-methyl-2-p-tolyl-imidazo1,2-apyridin-3-yl)-piperidin-2-one.
5. A compound according to claim 3 wherein the compound is (\u2212)-1-Methyl-3-(6-methyl-2-p-tolyl-imidazo1,2-apyridin-3-yl)-piperidin-2-one.
6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to any of claims 2, 1, 3, 4 or 5.
7. A method for treating anxiety disorders comprising administering to a patient a therapeutically effective amount of a compound having formula II
wherein
R1, R2, R3 and R4 are chosen independently from the group consisting of hydrogen, halogen, loweralkyl, loweralkoxy, hydroxy, dialkylamino, cyano, acyl, perfluoroloweralkyl, and loweralkylsulfonamido;
A is a 4, 5, or 6-membered N-alkyl lactam;
n is zero, one or two;
or a salt thereof.