1. A method for rejuvenating Leydig cells in an aged male rat having Leydig cells, the method comprising:
(a) providing an aged male rat having Leydig cells, wherein the aged male rat is 18 months of age or older; and
(b) coadministering luteinizing hormone (LH) and thyroid hormone (TH) to the rat, whereby rejuvenation of Leydig cells in the aged male rat having Leydig cells is accomplished,
wherein rejuvenation of the Leydig cells comprises enhanced Leydig cell serum testosterone production, increased Leydig cell volume and increased Leydig cell steroidogenic potential.
2. A method of enhancing testosterone production in an aged male rat having Leydig cells, the method comprising:
(a) providing an aged male rat having Leydig cells, wherein the aged male rat is 18 months of age or older; and
(b) coadministering luteinizing hormone (LH) and thyroid hormone (TH) to the rat, whereby testosterone production in the aged male rat having Leydig cells is enhanced.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-25. (canceled)
26. An interventional catheter for use in a vessel, comprising:
an elongated shaft having an exterior surface, a proximal end, and a distal end; and
an amphora-shaped filter coupled to the exterior surface of the elongated shaft, the filter comprising a plurality of expanding struts supporting a filter mesh, the struts configured to transition between a contracted position, wherein a concave portion of the struts contacts the exterior surface of the elongated shaft, and an expanded position, wherein the filter mesh is deployed to capture emboli, the filter defining a reservoir between the concave portions and a proximal portion of the struts when the plurality of struts is in the contracted position.
27. The catheter of claim 26 further comprising a sheath having a distal end slidably disposed on the elongated shaft, the sheath movable from a retracted position, wherein the distal end of the sheath is located proximal of the filter, to an extended position, wherein the distal end of the sheath collapses the filter such that the concave portions contact the exterior surface of the elongated shaft to seal the reservoir.
28. The catheter of claim 26 wherein the elongated shaft further comprises a diagnostic or therapeutic end effector located distal of the filter.
29. The catheter of claim 28 wherein the end effector comprises a balloon.
30. The catheter of claim 29 further comprising a stent disposed on the balloon.
31. The catheter of claim 26 wherein the filter mesh has a multiplicity of pores, the size of the pores sufficient to permit blood to pass through the filter, but to capture embolic material.
32. The catheter of claim 31 wherein the pore size is smaller than 500 micrometers.
33. The catheter of claim 26 wherein the plurality of struts comprises four or more struts.
34. The catheter of claim 26 further comprising one or more radiopaque markers affixed to the elongated shaft.
35. The catheter of claim 26 further comprising one or more radiopaque markers affixed to the plurality of struts.
36. The catheter of claim 27 wherein the struts self-expand upon retraction of the sheath.
37. The catheter of claim 26 wherein the plurality of struts are integrally formed with a mounting ring that couples the plurality of struts to the exterior surface of the elongated shaft.
38. The catheter of claim 37 wherein the plurality of struts and mounting ring comprise a superelastic alloy.
39. The catheter of claim 26 wherein the elongated shaft has a diameter of 5 French.
40. The catheter of claim 26 wherein the elongated shaft further comprises a guide wire lumen extending through the distal end of the elongated shaft.
41. A method of capturing emboli in a vessel, comprising:
advancing an interventional catheter into a vessel having a lesion such that the catheter is positioned adjacent to the lesion, the interventional catheter having a sheath, an elongated shaft slidably disposed within the sheath, and an amphora-shaped filter coupled to the elongated shaft;
retracting the sheath to a position proximal to the filter such that a plurality of struts supporting a filter mesh on the filter expand to capture emboli from the lesion; and
moving the sheath to a position distal to the filter such that a concave portion of the struts contacts the elongated shaft to define a reservoir between the concave portions and a proximal portion of the struts.
42. The method of claim 41 wherein the interventional catheter further comprises a balloon located distal of the filter,
wherein the advancing comprises advancing the interventional catheter into the vessel such that the balloon is disposed across the lesion.
43. The method of claim 42 further comprising inflating the balloon to compress the lesion and release emboli after the retracting and before the moving.
44. The method of claim 41 wherein the interventional catheter is advanced along a guidewire.
45. The method of claim 41 further comprising determining a position of the interventional catheter using fluoroscopic visualization of one or more radiopaque markers affixed to the interventional catheter.