1. A system for modeling dose distribution, the system comprising:
an input operable to receive functional imaging information representing metabolic or biochemical activity of a tumor;
a processor operable to apply a model of tumor response to a treatment dose, the tumor response being different for different regions of the tumor as a function of the functional imaging information; and
a display operable to output an image as a function of the tumor response.
2. The system of claim 1 wherein the input comprises a data interface operable to receive the functional imaging information.
3. The system of claim 1 wherein the functional imaging information comprises positron emission tomography imaging with fluorodeoxyglucose, the metabolic or biochemical activity comprising glucose metabolism, and the tumor being a tumor of a non-small cell lung cancer.
4. The system of claim 1 wherein the model is a machine-learned model.
5. The system of claim 1 wherein the model represents a probability of residual disease in each of the different regions given the functional imaging information and the treatment dose for the respective region.
6. The system of claim 5 wherein the probability is a function of data from other patients representing functional imaging information before and after radiation therapy at known dosages.
7. The system of claim 6 wherein residual disease corresponds to functional imaging information, from after radiation therapy, greater than a threshold standard uptake value for the respective patient, the threshold standard uptake value for each patient being a function of the functional imaging information for that patient.
8. The system of claim 1 wherein the model uses a feature vector comprising age, gender, WHO performance, and tumor size.
9. The system of claim 1 wherein the model uses a feature vector for each of the different regions, the feature vector comprising functional imaging information from neighboring ones of the different regions.
10. The system of claim 1 wherein the processor is operable to determine radiation level differently for different ones of the different regions.
11. The system of claim 1 wherein the processor is operable to redistribute the treatment dose amongst the different regions as a function of the tumor response.
12. In a computer readable storage medium having stored therein data representing instructions executable by a programmed processor for distributing dose for tumor treatment, the instructions comprising:
receiving positron emission information showing variance of standardized uptake of different locations in a cancer region;
predicting therapy responses of the cancer region at the different locations as a function of the standardized uptake for the respective different locations;
determining an increase or decrease in a location specific dose as a function of the predicted therapy response; and
outputting the location specific dose for each of the different locations of the cancer region.
13. The computer readable medium of claim 12 wherein receiving positron emission information comprises receiving positron emission information showing the variance of standardized uptake of fluorine-18 deoxyglucose.
14. The computer readable medium of claim 12 wherein predicting comprises modeling as a function of a probability of residual disease given the standardized uptake and the location specific dose.
15. The computer readable medium of claim 14 wherein modeling comprises modeling as a function of the standardized uptake at neighboring ones of different locations, a patient age, a patient gender, and size of the cancer region.
16. The computer readable medium of claim 12 wherein outputting comprises outputting different location specific doses for the different locations.
17. A method for modeling dose distribution, the method comprising:
determining uptake of an agent at different portions of a tumor in a patient from emission tomography information;
classifying radiation response of the different portions of the tumor as a function of the uptake for the different portions and control probabilities of residual disease given a dose, the control probabilities having been machine-learned from a dataset for other patients having uptake information before and after treatment by radiation;
determining dose information as a function of the radiation response, the dose information varying between the different portions of the tumor; and
outputting the dose information for use with a linear accelerator to treat the patient.
18. The method of claim 17 wherein determining uptake comprises determining uptake of fluorodeoxyglucose from a positron emission tomography image of the patient’s lung, wherein classifying comprises modeling a tumor control probability as a function of dose and range of uptake, and a normal tissue control probability as a function of dose, wherein determining dose information comprises determining dose levels with sufficient probability of success and probability of harm to normal tissue as a function of the uptake at the different portions.
19. The method of claim 17 wherein the uptake is from a time before treatment of the patient.
20. The method of claim 17 wherein classifying comprises classifying for each of the different portions with a feature vector comprising the uptake for the portion, uptake for surrounding ones of the different portions, a size of the tumor, and at least one clinical factor.
21. The method of claim 17 wherein classifying comprises classifying as a function of probabilities of proper application of dose.
22. The system of claim 1 wherein the model comprises dose probabilities.
23. The computer readable medium of claim 12 wherein predicting comprises predicting as a function of a dose uncertainty.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A portable information processing unit to be used by a storage medium storing at least program data being connected thereto, comprising:
an information processing circuit for performing data processing based on the program data stored in said storage medium;
a liquid crystal display for displaying data processed by said information processing circuit;
a transflective-type reflection plate laminated on a back surface of said liquid crystal display;
a backlight emitter, in a shape of a sheet, having the same flat form as said liquid crystal display and laminated on a back surface of said transflective-type reflection plate;
backlight drive means for driving said backlight emitter;
a power supply portion for supplying power; and
a power switch capable of being switched among a first group of contacts, a second group of contacts and a third group of contacts,
said power switch:
stopping all power supply when said first group of contacts is selected;
supplying power from said power supply portion only to said information processing circuit and said liquid crystal display when said second group of contacts is selected; and
supplying power from said power supply portion to all of said information processing circuit, said liquid crystal display, and said backlight drive means when said third group of contacts is selected.
2. The portable information processing unit according to claim 1, wherein said transflective-type reflection plate is made of a material in which reflectance is higher than transmittance.
3. The portable information processing unit according to claim 1, wherein said backlight drive means includes power converting means for converting a DC power supplied by said power supply portion into an AC power of a voltage and a frequency suitable for driving said backlight emitter.
4. The portable information processing unit according to claim 1, further comprising:
power-supply-voltage detecting means for detecting whether a voltage of said power supply portion is more than or equal to a given value; and
backlight-drive control means for controlling said backlight drive means based on a result detected by said power-supply-voltage detecting means, and
wherein said backlight-drive control means places said backlight drive means in an inactive state in response to the result detected by said power-supply-voltage detecting means that the voltage of said power supply portion is less than the given value, and thereby stops power supply to said backlight emitter.
5. The portable information processing unit according to claim 1, further comprising:
intensity control means for controlling intensity of said backlight emitter; and
voltage adjusting means connected in relation to said third group of contacts of said power switch, for adjusting a voltage value in an analog fashion, and
wherein said intensity control means adjusts the intensity of said backlight emitter based on a position of said voltage adjusting means.
6. The portable information processing unit according to claim 1, wherein said power switch is a three-position switch capable of being switched among a first position for selecting said first group of contacts, a second position for selecting said second group of contacts, and a third position for selecting said third group of contacts.
7. The portable information processing unit according to claim 1, wherein said power switch is a two-position switch with a pushbutton having a first position for selecting said first group of contacts and a second position for selecting said second group of contacts, and selecting said third group of contacts when the pushbutton is pushed at the second position.