1. A microporous crystalline material of zeolitic nature with a X-ray diffraction pattern concordant with that established in tables I and II for the material as synthesized and after calcination, respectively, and with a chemical composition in calcinated and anhydrous state which may be represented by the following empirical formula
x(M1nXO2):yYO2:SiO2
wherein x has a value lower than 0.1 whereby it may be equal to zero; y has a value lower than 0.1 and may as well be equal to zero; M is H or an inorganic cation of a charge n; X is a chemical element with oxidation state 3 (as for example Al, Ga, B, Cr) and Y is a chemical element with oxidation state 4 (as for example Ti, Ge, V).
2. A zeolite according to claim 1, the chemical composition of which, in calcinated and anhydrous state, may be represented by the empirical formula
x(HXO2):yYO2:SiO2
wherein X is a trivalent element (Al, B, Ga, Cr, . . . ), Y is a tetravalent element other than Si (Ti, Ge, V, . . . ), x has a value lower than 0.1 whereby it may be equal to zero; y has a value lower than 0.1 and may also be equal to zero.
3. A zeolite according to claim 1 the composition of which in calcinated and anhydrous state may be represented as SiO2.
4. A method for synthesizing zeolites, wherein a reaction mixture containing a source of SiO2, 1,4-diquinuclidinium butane, a source of fluorine F, a source of one or several tetravalent elements Y other than Si, a source of one or several trivalent elements X and water, is subjected to heating with or without agitation to a temperature between 80 and 200 C., preferably between 130 and 200 C. until achieving crystallization, and wherein the reaction mixture has a composition in terms of molar oxide ratios, comprised between the ranges
R(OH)2SiO20.01-1.0, preferably 0.1-1.0
HFSiO20.01-1.0, preferably 0.1-1.0
X2O3SiO20-0.05
YO2SiO20-0.1
H2OSiO20-100, preferably 1-50, more preferably 1-15.
5. A method for synthesizing the zeolite of the previous claims, wherein a reaction mixture containing a source of SiO2, 1,4-diquinuclidinium butane organic cation, a source of fluoride anions, a source of one or several trivalent elements X and water, is subjected to heating with or without agitation to a temperature between 80 and 200 C., preferably between 130 and 200 C. until achieving crystallization, and wherein the reaction mixture has a composition in terms of molar oxide ratios, comprised between the ranges
R(OH)2SiO20.01-1.0, preferably 0.1-1.0
FSiO20.01-1.0, preferably 0.1-1.0
X2O3SiO20-0.05
H2OSiO20-100, preferably 1-50, more preferably 1-15.
6. A method for synthesizing the zeolite of claims 1 and 2, wherein a reaction mixture containing a source of SiO2, 1,4-diquinuclidinium butane organic cation, a source of fluoride anions, a source of Al and water, is subjected to heating with or without agitation to a temperature between 80 and 200 C., preferably between 130 and 200 C. until achieving crystallization, and wherein the reaction mixture has a composition in terms of molar oxide ratios, comprised between the ranges
RF(OH)2SiO20.01-1.0, preferably 0.1-1.0
FSiO20-1.0, preferably 0.1-1.0
Al2O3SiO20-0.05
H2OSiO20-100, preferably 1-50, more preferably 1-15.
7. A method for synthesizing the zeolite of claims 1 and 3, wherein a reaction mixture containing a source of SiO2, 1,4-diquinuclidinium butane organic cation, a source of fluoride anions and water, is subjected to heating with our without agitation to a temperature between 80 and 200 C., preferably between 130 and 200 C. until achieving crystallization, and wherein the reaction mixture has a composition in terms of molar oxide ratios, comprised between the ranges
R(OH)2SiO20.01-1.0, preferably 0.1-1.0
FSiO20.01-1.0, preferably 0.1-1.0
H2OSiO20-100, preferably 1-50, more preferably 1-15.
8. A method for synthesizing zeolites of claims 1 and 2, wherein a reaction mixture containing a source of SiO2, 1,4-diquinuclidinium butane, a source of fluoride anion, a source of one or several tetravalent elements Y other than Si and water, is subjected to heating with or without agitation to a temperature between 80 and 200 C., preferably between 130 and 200 C. until achieving crystallization, and wherein the reaction mixture has a composition in terms of molar oxide ratios, comprised between the ranges
R(OH)2SiO20.01-1.0, preferably 0.1-1.0
HFSiO20.01-1.0, preferably 0.1-1.0
YO2SiO20-0.1
H2OSiO20-100, preferably 1-50, more preferably 1-15.
9. A method of synthesizing a microporous crystalline material according to claims 4-8, of synthesizing the zeolite of claims 1 and 3, wherein the 1,4-diquinuclidinium butane organic cation is added in hydroxide form or in the form of a mixture of hydroxide and another salt, preferably a halide and the fluoride anion is added in the form of hydrofluoric acid or of a salt, preferably ammonium fluoride, in such manner that the pH of the mixture is equal to or lower than 12, preferably lower than 11, and it may be even neutral or slightly acid.
10. A method of synthesizing a microporous crystalline material according to claim 9 and previous ones, wherein such crystalline material has a X-ray diffraction pattern substantially concordant with that established in tables I and II for the material as synthesized and after calcination, respectively, and with a chemical composition in calcinated and anhydrous state which may be represented by the following empirical formula
x(M1nXO2):yYO2:zR:wH2O
wherein x has a value lower than 0.1 whereby it may be equal to zero; y has a value lower than 0.1 and may as well be equal to zero; M is H or an inorganic cation of a charge n; X is a chemical element with oxidation state 3 (as for example Al, Ga, B, Cr) and Y is a chemical element with oxidation state 4 (as for example Ti, Ge, V).
11. A method for synthesizing the zeolite according to claims 1-3 and 10 in accordance with the process of claims 4-9 and 11, wherein an amount of crystalline material (preferably with the characteristics of the material of claims 1-4 and 11) is added to the reaction mixture as crystallization promoter, said amount being comprised in the range 0.01 to 15% by weight with respect to the whole of added silica, preferably 0.05 to 5%.
12. A method for synthesizing the zeolite according to claims 1-3 and 10 in accordance with the process of claims 4-9, wherein no alkaline cations are added to the reaction mixture.
13. A method for synthesizing the zeolite according to claims 1, 2 and 10 in accordance with the process of claims 4, 5, 6, 8, 9 and 11, wherein a source of a tetravalent element other than Si, or of a trivalent element, is added during an intermediate step during heating of the reaction mixture.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An oral composition comprising a polymer attached to a sweetening agent via a cleavable linker, wherein the polymer is capable of attaching to a surface in an oral cavity, and the cleavable linker is cleavable in the oral cavity to release the sweetening agent.
2. The oral composition according to claim 1, wherein the polymer is capable of attaching to the surface in the oral cavity selected from teeth, mucous membrane, gingival, cheek, tongue and lips.
3. The oral composition according to claim 1, wherein the polymer comprises a muco-adhesive polymer.
4. The oral composition according to claim 1, wherein the polymer is selected from a copolymer of maleic anhydride and methyl vinyl ether.
5. The oral composition according to claim 1, wherein the polymer is present in an amount of between 0.001% and 10%.
6. The oral composition according to claim 1, wherein the cleavable linker comprises a covalent bond.
7. The oral composition according to claim 6, wherein the linker comprises an ester bond or an amide bond.
8. The oral composition according to claim 1, wherein the cleavable linker is cleavable by hydrolysis.
9. The oral composition according to claim 1, wherein the cleavable linker is cleavable by an enzyme.
10. The oral composition according to claim 1, wherein the sweetening agent is selected from dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup, partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof, sucralose, dipeptide-based sweeteners, cyclamates, dihydrochalcones, and mixtures thereof.
11. The oral composition according to claim 1, wherein the sweetening agent is present in an amount from 0.005% to 5%.
12. The oral composition according to claim 1, wherein oral composition is adapted to release the sweetening agent from the polymer at a rate which provides enhancement of flavour sensation in the oral cavity for at least five minutes.
13. The oral composition according to claim 1, wherein the composition comprises an orally acceptable carrier for a toothpaste, a dental cream, a mouthwash, a chewing gum or a denture adhesive.
14. The oral composition according to claim 1, wherein the composition comprises one or more further agents selected from an anti-plaque agent, a whitening agent, antibacterial agent and a cleaning agent.
15. The oral composition according to claim 1, which further comprises a flavouring agent.
16. A portable dose article comprising the oral composition according to claim 1, wherein the portable dose article is selected from a lozenge, a mint, a bead, a wafer, a small portable nebulizer containing said composition in liquid formulated for oral application as a spray, a small portable bottle containing said composition in liquid formulated for oral application as a drop, and a soft pliable tablet.
17. A method for making the oral composition of claim 1, the method including attaching the polymer to the sweetening agent via the cleavable linker.
18. The method according to claim 17, wherein the polymer is attached to the sweetening agent by esterification.
19. A method for controlling the release of a sweetening agent in an oral cavity, comprising applying to the oral cavity the oral composition of claim 1.
20. Use of a polymer for enhancing andor sustaining the sensation of flavour in an oral cavity, wherein the polymer is attached to a sweetening agent via a cleavable linker, wherein the polymer is capable of attaching to a surface in the oral cavity and the cleavable linker is cleavable in the oral cavity to release the sweetening agent, so that the sensation of flavour is enhanced andor sustained.
21. Use according to claim 20, wherein the polymer is capable of attaching to the surface in the oral cavity selected from teeth, mucous membrane, gingival, cheek, tongue and lips.
22. Use according to claim 20, wherein the polymer is administered to the oral cavity in the oral composition comprising an orally acceptable carrier for a toothpaste, a dental cream, a mouthwash, a chewing gum or a denture adhesive.
23. A method for enhancing andor sustaining the sensation of flavour in an oral cavity, comprising applying to the oral cavity the oral composition of claim 1.
24. A method for controlling the release of a sweetening agent in an oral cavity, comprising applying to the oral cavity the oral composition the portable dose article of claim 16, wherein the cleavable linker is cleaved in the oral cavity to release the sweetening agent.
25. A method for enhancing andor sustaining the sensation of flavour in an oral cavity, comprising applying to the oral cavity the portable dose article of claim 16.