We claim:
1. An isolated vigilance nucleic acid molecule, comprising a nucleotide sequence selected from the group consisting of SEQ ID NOS:1-6 and 8-27, or modification thereof.
2. The isolated nucleic acid molecule of claim 1, attached to a solid support.
3. An isolated oligonucleotide, comprising at least 15 contiguous nucleotides of the nucleotide sequence of SEQ ID NOS:1-6 and 8-27, or the antisense strand thereof.
4. The isolated oligonucleotide of claim 3, attached to a solid support.
5. A kit, comprising two or more isolated oligonucleotides according to claim 3.
6. The kit of claim 5, comprising a PCR primer pair.
7. A kit, comprising two or more isolated vigilance nucleic acid molecules, wherein at least one vigilance nucleic acid molecule comprises a nucleotide sequence selected from the group consisting of SEQ ID NOS:1-6 and 8-27 or modification thereof.
8. The kit of claim 7, wherein said isolated vigilance nucleic acid molecules are attached to a solid support.
9. The kit of claim 7, further comprising one or more isolated nucleic acid molecules selected from the group consisting of Fas, BiP, Cyp4e2, AANAT1 (Dat), Ddc, Cytochrome P450, AA117313, aryl sulfotransferase IV, human breast tumor autoantigen homolog, KIAA313 homolog, E25, NGFI-A, NGFI-B, rlf, Arc, JunB, IER5, Cytochrome oxidase C subunit 1, Cytochrome oxidase C subunit IV, NADH dehydrogenase subunit 2, 12S rRNA F1-ATPase subunit alpha, NgRC3, bone morphogenetic protein 2, GRP78, BDNF, IL-1, dendrin, Cacalmodulin-dependent protein kinase II -subunit, orexin, orexin receptor, and PRNP.
10. A method of diagnosing a vigilance disorder in an individual, comprising:
determining a vigilance gene profile of the individual, and
comparing said profile to a control profile indicative of the vigilance disorder, wherein at least one vigilance gene profiled is selected from the group consisting of Fas, BiP, Cyp4e2, AANAT1 (Dat), Ddc, Cytochrome P450, AA117313, aryl sulfotransferase IV, human breast tumor autoantigen homolog, KIAA313 homolog, E25, and a gene comprising a nucleotide sequence of any of SEQ ID NOS:2-6, 8-14 and 16-27 or modification thereof,
wherein correspondence between said profile of said individual and said control profile indicates that said individual has said vigilance disorder.
11. A method of determining vigilance level in an individual, comprising:
determining a vigilance gene profile of the individual, and
comparing said profile to a control profile indicative of a predetermined vigilance level, wherein at least one vigilance gene profiled is selected from the group consisting of Fas, BiP, Cyp4e2, AANAT1 (Dat), Ddc, Cytochrome P450, AA117313, aryl sulfotransferase IV, human breast tumor autoantigen homolog, KIAA313 homolog, E25, and a gene comprising a nucleotide sequence of any of SEQ ID NOS:2-6, 8-14 and 16-27 or modification thereof,
wherein correspondence between said profile of said individual and said control profile indicates that said individual exhibits said vigilance level.
12. A method of determining the efficacy of a compound in ameliorating a vigilance disorder, comprising:
administering the compound to an individual having a vigilance disorder, and
determining an effect of the compound on the vigilance gene profile of the individual, wherein at least one vigilance gene profiled is selected from the group consisting of Fas, BiP, Cyp4e2, AANAT1 (Dat), Ddc, Cytochrome P450, AA117313, aryl sulfotransferase IV, human breast tumor autoantigen homolog, KIAA313 homolog, E25, and a gene comprising a nucleotide sequence of any of SEQ ID NOS:2-6, 8-14 and 16-27 or modification thereof,
wherein modulation of the vigilance gene profile of the individual to correspond to a normal vigilance profile indicates that the compound is effective in ameliorating the vigilance disorder.
13. A method of determining the efficacy of a compound in modulating vigilance, comprising:
administering the compound to an individual, and
determining an effect of the compound on the vigilance gene profile of the individual, wherein at least one vigilance gene profiled is selected from the group consisting of Fas, BiP, Cyp4e2, AANAT1 (Dat), Ddc, Cytochrome P450, AA117313, aryl sulfotransferase IV, human breast tumor autoantigen homolog, KIAA313 homolog, E25, and a gene comprising a nucleotide sequence of any of SEQ ID NOS:2-6, 8-14 and 16-27 or modification thereof,
wherein modulation of the vigilance gene profile indicates that the compound modulates vigilance.
14. A method of ameliorating a vigilance disorder in an individual, comprising:
administering to an individual having a vigilance disorder an agent that modulates the vigilance gene profile of the individual to correspond to a normal vigilance gene profile,
wherein at least one vigilance gene profiled is selected from the group consisting of Fas, BiP, Cyp4e2, AANAT1 (Dat), Ddc, Cytochrome P450, AA117313, aryl sulfotransferase IV, human breast tumor autoantigen homolog, KIAA313 homolog, E25, and a gene comprising a nucleotide sequence of any of SEQ ID NOS:2-6, 8-14 and 16-27 or modification thereof.
15. A method of modulating vigilance level in an individual, comprising:
administering to an individual an agent that modulates the vigilance gene profile of the individual to correspond to a control vigilance gene profile,
wherein at least one vigilance gene profiled is selected from the group consisting of Fas, BiP, Cyp4e2, AANAT1 (Dat), Ddc, Cytochrome P450, AA117313, aryl sulfotransferase IV, human breast tumor autoantigen homolog, KIAA313 homolog, E25, and a gene comprising a nucleotide sequence of any of SEQ ID NOS:2-6, 8-14 and 16-27 or modification thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A system for requesting modification of signal light control of a traffic grid, the system comprising:
a vehicle computer unit, wherein the vehicle computer unit is installed in a vehicle and functions to determine the vehicle’s position, direction, and velocity;
a plurality of priority detector units, wherein each priority detector unit is communicatively attached to a signal light controller within the traffic grid; and
a wireless network connecting the vehicle computer unit and the plurality of priority detector units;
wherein the vehicle computer unit uses the vehicle’s position, direction and velocity to calculate the vehicle’s estimated time of arrival to a signal light within the traffic grid and sends the vehicle’s estimated time of arrival to the signal light to a priority detector unit communicatively attached to a signal light controller associated with the signal light; and
wherein the priority detector unit communicatively attached to the signal light controller associated with the signal light receives the vehicle’s estimated time of arrival and requests modification of the signal light controller associated with the signal light based on the vehicle’s estimated time of arrival.
2. The system of claim 1, the system further comprising:
a remote traffic control center, wherein the remote traffic control center is communicatively attached to the wireless network; and
wherein the vehicle computer unit transmits information chosen from the group consisting of the vehicle’s position, direction, velocity and estimated time of arrival to the remote traffic control center; and
wherein the remote traffic control center determines which signal light controllers within the traffic grid need to be modified to keep the vehicle on schedule; and
wherein the remote traffic control center sends a signal to one or more of the plurality of priority detector units to request modification of an associated signal light controllers based on the vehicle’s estimated time of arrival.
3. The system of claim 1, wherein the vehicle computer unit sends the vehicle’s estimated time of arrival to the signal light to the priority detector unit communicatively attached to the signal light controller associated with the signal light at a plurality of advanced detection zones preceding the signal light.
4. The system of claim 3, wherein the location of the advanced detection zones in the traffic grid can be modified by a user.
5. The system of claim 1, wherein the vehicle computer unit sends its estimated time of arrival to the priority detector unit communicatively attached to the signal light controller associated with the signal light at pre-defined periods of time; and
wherein the priority detector unit communicatively attached to the signal light controller associated with the signal light receives the vehicle’s estimated time of arrival and requests modification of the signal light controller associated with the signal light at pre-defined periods of time based on the vehicle’s estimated time of arrival.
6. The system of claim 5, wherein the pre-defined periods of time can be modified by a user.
7. The system of claim 1, wherein the vehicle computer unit sends the vehicle’s estimated time of arrival to the signal light to the priority detector unit communicatively attached to the signal light controller associated with the signal light at a plurality of advanced detection zones if the vehicle reached a certain pre-defined estimated time of arrival to the signal light while the vehicle is within the advanced detection zone; and
wherein the vehicle computer unit sends its estimated time of arrival to the signal light to the priority detector associated with the signal light at a check out zone within each of the plurality of advanced detection zones.
8. The system of claim 7, wherein the vehicle is a mass transit vehicle.
9. A system for requesting modification of signal light control of a traffic grid, the system comprising:
a vehicle computer unit, wherein the vehicle computer unit is installed in a vehicle and functions to determine the vehicle’s position, direction, and velocity;
a plurality of priority detector units, wherein each priority detector unit is communicatively attached to a signal light controller within the traffic grid; and
a wireless network connecting the vehicle computer unit and the plurality of priority detector units;
wherein the vehicle computer unit transmits information chosen from the group consisting of the vehicle’s position, direction, velocity to at least one priority detector unit; and
wherein the at least one priority detector unit receives the information and calculates the vehicle’s estimated time of arrival to a signal light within the traffic grid associated with the at least one priority detector unit; and
wherein the at least one priority detector unit is communicatively attached to a signal light controller associated with the signal light and sends a signal to request modification of the signal light controller associated with the signal light based on the vehicle’s estimated time of arrival.
10. The system of claim 9, wherein the vehicle is a mass transit vehicle.
11. A system for requesting modification of signal light control of a traffic grid, the system comprising:
a vehicle computer unit, wherein the vehicle computer unit is installed in a vehicle and functions to determine the vehicle’s position, direction, and velocity;
a plurality of priority detector units, wherein each priority detector unit is communicatively attached to a signal light controller within the traffic grid;
a wireless network connecting the vehicle computer unit and the plurality of priority detector units; and
a remote traffic control center, wherein the remote traffic control center is communicatively attached to the wireless network;
wherein the vehicle computer unit transmits information chosen from the group consisting of the vehicle’s position, direction, velocity to the remote traffic control center; and
wherein the remote traffic control center receives the information and calculates the vehicle’s estimated time of arrival to a signal light within the traffic grid;
wherein the remote traffic control center sends a signal to one or more of the plurality of priority detector units requesting modification of an associated signal light controller based on the vehicle’s estimated time of arrival.
12. The system of claim 11, wherein the vehicle is a mass transit vehicle.