1. A hand-transportable container capable of holding a quantity of liquid and a plurality of tools, said container comprising:
a bottom which allows said container to rest stably on a flat horizontal surface,
at least one substantially planar wall that is oriented in a near vertical position when the container is sitting on its bottom and resting normally on a horizontal surface; this substantially planar wall may be referred to herein as the \u2018rear wall\u2019,
an open top side, which is at least partially surrounded by a substantially horizontal flange protruding outwards from near the top edge of said open top side, said flange containing holes andor recesses and for having substantially vertical portions for receiving and holding a tool or a plurality of tools.
2. The container of claim 1, additionally comprising a lip extending vertically upward around the periphery of the open top when the container is resting on a horizontal surface, said lip being capable of receiving an at least partially sealing lid.
3. The container of claim 1, additionally comprising a pivoting handle formed of a rigid material such as wire with an enlarged diameter gripping portion in the central section of the handle, said container having stops for limiting the handle motion such that the handle grip is securely positioned by a downward force in a location approximately 1 to 4 inches above the flange of the container when the handle engages the stops; this arrangement can provide a convenient and ergonomic hand hold comprising both the handle grip and the container flange.
4. The container of claim 1, additionally comprising a pivoting handle formed of a rigid material such as wire with an enlarged diameter gripping portion in its central section, and where the handle bail element and the grip element are configured to provide convenient means of securely attaching a detachable connector to the handle near its middle; the detachable connector may be integrally joined to a flexible element and to a ladder hook, which enables suspending the container from a ladder rung or other structural member; or the connector may be joined to a hoisting element such as a cord or rope for securing or elevating the container invention.
5. The container of claim 1, additionally configured and sized to fit entirely within an empty standard five-gallon paint pail, or its metric equivalent, in such a way that the sealing top of the paint pail can be put into a closed position, thus providing a protective storage or travel environment for the present container invention.
6. The container of claim 1, additionally comprising two substantially planar side walls; said side walls are not required to, but may beneficially converge together as they depart from their respective corners proximal to the substantially planar rear wall, thus reducing the width of the front of the container relative to the width of the back; said corners are not required to, but may beneficially be radiused with a radius of between approximately \xbc to \xbe inch, thus making the container easier to clean, yet not interfering with a paint roller tool that is positioned proximal to the rear substantially planar wall.
7. The container of claim 1, where additionally at least one of the tool-holding areas is configured to retain a cleaning cloth; the form of the cloth holder is not limited to, but may be, a curved and approximately \u2018V\u2019 shaped slot in a downwardly turned portion of the invention’s tool-holding flange; in the lower part of the \u2018V\u2019, the sides of the slot may beneficially become parallel or nearly so, to prevent the cloth from working upward and falling out.
8. The container of claim 1, where additionally a portion of the tool-holding flange is configured to hold a quantity of painter’s putty; the form of the putty holding area is not limited to but may be formed by a pair of shallow recesses located symmetrically on the front flange of the container.
9. The container of claim 1, where additionally a portion of the tool-holding flange is configured to hold a screwdriver with interchangeable tips; the form of this screwdriver holder is not limited to, but may be formed by: a circular hole of at least 0.4 inch diameter located in a substantially horizontal portion of the container’s outwardly extending flange; though not limited to the following arrangement, a plurality of such holes may be provided in a rear, substantially horizontal, flange of the container invention.
10. The container of claim 1, where additionally a portion of the tool-holding flange is configured to hold a standard carpenter’s pencil, when said pencil has had a snugly fitting stop element placed around its cylindrical shaft; the form of this pencil holder is not limited to, but may be an elongated rectangular hole (\u215c inch\xd7\u215d inch) with rounded corners placed in the substantially horizontal portion of the container’s rear flange.
11. The container of claim 1, where additionally a portion of the tool-holding flange is configured to hold a variety of tools, such as pencils and screwdrivers. The tools may be secured by a variety of substantially circular holes of varying diameter, some of which have a diameter of at least \u215c inch to accept a standard pencil fitted with a suitable stop.
12. The container of claim 1, where additionally a portion of the tool-holding flange is configured to hold a clip-on tool such as a tape measure; the form of this region of the tool-holding flange is not limited to, but can be a downwardly turned, substantially vertical portion of the container’s tool flange in an area where the horizontal portion of the flange is cut away by an elongated hole; two such areas may be provided on either side of the invention, and the elongated hole may also provide means of supporting a scraper or putty knife.
13. The container of claim 1, where additionally the rear portion of the tool-holding flange is configured with an outward extending substantially horizontal portion that joins to a downwardly extending substantially vertical portion; said flange portion enabling the invention to be securely hung on a horizontal edge, such as an open cupboard door or a chair back; though not limited to this form, the bottom edge of the substantially vertical portion of the flange may be provided with a wide and shallow notch (approximately 1.2 inches wide and 0.4 inches deep); this notch can help to center the container when hung on a coat hook, doorknob, or the like.
14. The container of claim 1, where additionally the front wall of the container is formed of two outwardly convex cylindrical surfaces that meet in a near-vertical central indentation.
15. A hand-transportable container capable of holding a quantity of liquid andor a plurality of tools, said container including:
a bottom which allows said container to rest stably on a flat horizontal surface,
at least one substantially planar wall, which is oriented in a near vertical position when the container is sitting on its bottom and resting normally on a horizontal surface,
an angled open top, the rim of which is higher on the side proximal to said substantially planar wall and lower on the side opposite said wall, the angle defining said open top being approximately between 15 and 45 degrees from horizontal when the container is resting normally on a horizontal surface,
a flange protruding outwards from the upper edge of the top opening, said flange being between either approximately horizontal or approximately in the plane defining the open top, said flange containing holes andor recesses for receiving and holding tools,
at least one substantially vertical section of flange attached to the outer portion of the substantially horizontal flange.
16. The container of claim 15 where the side wall opposite to the said substantially planar wall is formed by two outwardly convex cylindrical surfaces that join along the vertical centerline of the wall in a shallow trough or recess.
17. The container of claim 15 where the side wall opposite to the said substantially planar wall has two lips on its upper edge, an outer lip being contiguous with lips on the adjacent walls and a free-standing inner lip, said inner lip being separated from said outer lip by a narrow trough which can drain liquid back into the main reservoir internal to the container invention; said inner lip can provide a convenient edge for removing excess paint from a brush.
18. A hand-transportable container capable of holding a quantity of liquid andor a plurality of tools, said container comprising a magnet or plurality of magnets contained within the walls of the container, at least one magnet being capable of independently holding magnetically attractable tools both on the inside and on the outside of the container.
19. The container of claim 18 where in a position approximately above at least one of the magnets an additional supporting element is provided, said element providing additional support for a tool attracted to and held by said magnet; said supporting element can be, but is not limited to being, an elongated hole or slot in a flange that outwardly extends from near the top edge of the container.
20. The container of claim 18, where one or more magnet-equipped walls of the container are formed by two substantially parallel elements that are offset laterally from one another by a distance of approximately 0.1 inch to 0.25 inch, this offset distance can correspond to the approximate thickness of the magnet elements contained within the walls of the container, the offset may provide for easier molding of magnet holders within a plastic container part andor may contribute structural integrity to the walls.
21. The container of claim 18, where one or more walls of the container are provided with pockets capable of receiving magnets, said pockets being equipped with means of securely holding the magnets in position; the form of the magnet pockets and magnet-holding means is not limited to comprising, but may beneficially comprise molded plastic pockets within one or more walls, the pockets being substantially open on the bottom side; the pockets can be additionally equipped each with two downwardly extending, tapered, semi-flexible plastic \u2018ears\u2019 or extensions that will hold a magnet firmly in place after the magnet is snapped into position from below.
22. The container of claim 18, where one or a plurality of magnets are contained within the walls of the container, said magnet or magnets being positioned within the walls such that a relatively thin layer of non-magnetic material, such as plastic, covers the magnet on one or both sides. The thickness of said covering material can be in the range of approximately 0.01 inch to 0.04 inch, in order to provide sufficient structural integrity and yet provide for a sufficiently short distance between the magnet and a magnetically attracted tool; a short distance can insure providing an adequate holding force between said tool and a magnet.
23. The container of claim 18 where additionally the magnet or magnets are placed or embedded within the side wall or walls of the container in a location approximately one third of the way from the front top lip of the container to the bottom and approximately one quarter of the way from the front wall to the rear wall.
24. A lid or cover for a hand-transportable container, said container being capable of holding a quantity of liquid andor a plurality of tools, said lid including:
means of mating with the open top of said container in a secure manner while providing a substantially vapor tight seal between the container and the lid,
a notch or cutout on at least one edge of the lid, said notch being sized to allow the handle of a paint roller tool to protrude out of the container while the roller portion of the tool is within the container. Said notch can be beneficially sized to fit closely around the handle shaft of the roller tool, thus providing a substantially vapor tight seal; the location of a notch or notches is not limited to, but may beneficially be on the side of the lid that engages the substantially planar rear wall of the container; the rear wall of the container may beneficially comprise a small downwardly extending semicircular notch adjacent to the notch in the lid when the lid is installed in a closed position.
25. The lid of claim 24, being additionally configured to engage an angled open top on the container, said angled open top being fitted with a vertical upwardly extending lip around the periphery of the open top and said lid comprising a substantially vertically downward extending lip or pair of lips (inner and outer), said lid lip or lips being configured to mate with the upwardly extending lip on the container, forming a substantially vapor tight seal between the container and the lid; though not limited to the following form, the slot between said inner and outer lips of the lid may beneficially comprise a wider gap at its deeper end and a narrower gap at the entrance to the gap; the gap width near said entrance can beneficially be a snug fit on the flange extending upward on the container portion of the invention; said container flange may have parallel and vertical wall sides formed with considerable precision, so as to fit well in the gap in the lid element; the gap at the base of the slot may beneficially be wider than the width of the container flange plus twice the thickness of a removable liner; with this form the lid lips can flex to allow said container lip with a liner installed to fit in down to the base of the lid slot.
26. The lid of claim 24, additionally comprising a moveable flap, said flap being configured to removably cover said notch in the lid when no roller tool shaft is in place, thus maintaining a substantially vapor-tight seal when the lid is closed without a roller tool filling the notch; though not limited to this following form, the flap can beneficially be joined to the lid by means of a pivot or flexure attachment.
27. The lid of claim 24, additionally comprising protruding tabs, which have extensions that can engage contours in the container body and provide a \u2018snap into place\u2019 function; while not limited to the following form, said protruding tabs can beneficially extend downward from the lid when it is closed in the normal resting position of the container; said tabs can engage an outwardly extending ridge formed by the inner edge of an elongated hole in the container’s tool-holding flange.
28. The lid of claim 24, additionally comprising a tab or plurality of tabs extending outward from at least one edge of the lid, said tab or tabs being configured to insert into and be held securely in correspondingly shaped holes or slots in an extending flange extending from the main container body; while not limited to the following form, said tabs and slots can beneficially be configured to assure that the lid will lie closely along side of a planar wall on the exterior of the container when the lid is in a stowed position.
29. A paint spreading grid or screen for a hand-transportable container, said container being capable of holding a quantity of liquid, said grid being a substantially planar element, without suspension hooks; said grid can be held securely within the container in a position nearly proximal to a planar wall by slots comprised within the interior of the container; the spreader grid element can beneficially have rigid beam elements on either side of a porous central element, said beams configured to engage said slot in the interior of the container; said slots are not limited to the following form, but may beneficially be formed by the following combination: on one edge of the slot by flanges or webs that extend approximately \xbd inch inwards from the interior faces of the side walls of the container, and on the other edge of the slot by the radiused corners of the container; said flanges or webs are not required to, but may beneficially additionally perform the function of preventing jamming or locking together when multiple containers are stacked for storage (without grids in place); to effectively achieve this stack-defining function said flanges can terminate in a substantially horizontal top edge located some distance above the bottom of the container; for example: if the flange termination is located three inches above the extreme outer bottom of the container, the stacking interval will be 3 inches; it is not required, but can be beneficial to provide a slight curvature to the side beams of the grid, with the concave side proximal to the nearby wall; this feature can help to position the grid more securely and place the top edge of the grid element closer to the nearby wall; to allow for drainage of paint through the grid, it is beneficial to provide for some gap between the grid and the nearby wall, approximately 116 to 316 inch being sufficient.
30. A carrying strap for a hand-transportable container, said container being capable of holding a quantity of liquid andor a plurality of tools, said strap being formed as a complete loop; said loop form assures that a user of the invention may securely wear the strap only, without a container attached, and not have the danger of the strap slipping off; said loop form enabling a user to easily attach and detach the container from the strap element by hooking the strap loop under a suitably shaped extension of the container; though not limited to the following configuration, said extension may beneficially be configured to be formed by a outwards and then downwardly turning flange near the top of the substantially planar wall of the container; additionally, the substantially horizontal portion of said flange configuration may be provided with indentations in its outer edge near the corner where it meets the downward portion of the flange; said indentations can help to prevent the strap from slipping off the flange, yet allow easy removal of the container from the strap when required; while not essential, it can be very beneficial to provide the strap loop with means of length adjustment.
31. The carrying strap of claim 30, additionally comprising a clip or plurality of clips, said clips being attached to the lower portion of the strap in positions that enable the clips (or snap hooks) to be detachably fastened to appropriate points on the container body; the attachment points are not limited to, but may consist of holes in either side of the horizontal portion of the flange proximal to the container’s substantially planar wall.
32. A set of retractable legs for a hand-transportable container, said container being capable of holding a quantity of liquid andor a plurality of tools; four legs can be provided each one pivoting about an axis located near each of the four corners of an approximately rectangular or trapezoidal bottom of the container; though not limited to the following form, the pivot axes of the various legs can beneficially be angled in a manner providing additional stability; by making the pivot axes of the various legs converge together as the axes are extended downward, addition stability may be achieved; due to this said angling of the pivot axes the ends of the legs distal from the container body will be lower when extended, relative to their vertical position when retracted; it is desirable to have the portions of the legs distal from their respective pivot axes flush or slightly above flush with the lowest portion of the downwardly extending flange that partially surrounds the bottom of the container; when the legs are extended it is desirable to have their distal portions below flush with the plane defined by the bottom of the surrounding flange; the lower position of the distal ends of the legs when extended helps to overcome any flex or slop in the leg pivots that might otherwise cause the container to rock or wobble when resting on a flat horizontal surface.
33. A removable liner for a hand-transportable container, said container being capable of holding a quantity of liquid andor a plurality of tools, said liner being formed to fit closely within the container including fitting closely within any interior slots designed to receive a paint spreading grid; this is to assure that said grid will still fit in place with a liner installed.
34. The liner of claim 33 comprising an upper portion of said liner that is configured to fit closely over a top lip of the container in such a manner that the liner extends over the top of the lip and then downward over the outside surface of the lip, thus allowing the downward extending lips of a sealing lid to effectively engage said container top lip with or without a liner in place.
35. A resilient stop unit for a substantially cylindrical tool such as a pencil or a pen, said stop unit being formed in a wavy outline from a somewhat elastic material, and having a flexible hole sized to fit snugly around the cylindrical portion of said tool and an outer extent somewhat larger than the size of the flexible tool hole; the tool stop unit prevents a tool from passing completely through a storage receptacle consisting of a through-hole in a substantially planar support element, as may be found on the tool-holding flange of the present container invention.
36. A tape roll holder for a hand-transportable container, said container being capable of holding a quantity of liquid andor a plurality of tools, said tape roll holder being configured to hold a roll of tape, such as masking tape, or a plurality of such tape rolls; said tape roll holder comprises: a lineal flexible element with a first and a second end (such as a length of nylon cord), a magnetically attractable element (such as a ferrous fob) attached to the first end of said flexible element, means of attaching the second end of said flexible element to the container, and a magnet attached to the container, said magnet being capable of holding said fob and said magnet being located at a distance from said second end attachment point that is less than the length of said flexible element; to use said tape holder, the fob end of the flexible element can be passed though the central hole of a tape roll and then the fob can be attached to said magnet; to remove the tape, the fob can be detached from said magnet and the tape roll removed from the assembly.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method to obtain a compound of Formula (II):
wherein x is an integer of 0 to 4; and wherein said method comprises:
(a) debenzylation of a compound of Formula Ia:
wherein:
R11 represents a C1-5 straight- or branched-chain alkyl group;
R12 represents an amino protecting group; and,
v is an integer of 0 to 4;
to yield a large scale batch of at least 100 g of a compound of Formula Ib:
wherein R21, R22 and w are as defined for R11, R12 and v of Formula Ia, respectively and wherein said large scale batch is purified only by glass sinter filtration, followed by evaporation;
(b) conversion of the compound of Formula Ib obtained directly from step (a) into a compound of Formula I:
wherein R1, R2 and n are as defined for R11, R12 and v of Formula Ia, respectively; and,
X represents a leaving group selected from a halogen, or the group \u2014O\u2014SO2\u2014R3 wherein R3 is a halogen, a straight-chain or branched-chain C1-10 alkyl, a straight-chain or branched-chain C1-10 haloalkyl, and a C6-10 aryl;
wherein said conversion is carried out by reaction of said compound of Formula Ib with a suitable form of X as defined for Formula I;
(c) reaction of the compound of Formula I obtained in step (b) with a suitable source of 18F-fluoride to obtain a compound of Formula IIa:
wherein R31, R32 and y are as defined for R11, R12 and v of Formula Ia, respectively; and,
(d) deprotection of the compound of Formula IIa obtained in step (c) to remove R31 and R32; and
wherein said method provides a compound of Formula II suitable for use in in vivo imaging procedures.
2. The method as defined in claim 1 wherein X is a group represented by the group \u2014O\u2014SO2\u2014R3.
3. The method as defined in claim 2 wherein R3 is selected from the group consisting of toluenesulfonic acid, nitrobenzenesulfonic acid, benzenesulfonic acid, trifluoromethanesulfonic acid, fluorosulfonic acid, perfluoroalkylsulfonic acid, trimethylstannyl and triethylstannyl.
4. The method as defined in claim 3 wherein R3 is trifluoromethanesulfonic acid.
5. The method as defined in claim 1 wherein X is halogen.
6. The method as defined in claim 5 wherein said halogen is bromo or chloro.
7. The method as defined in claim 1 wherein R1 is ethyl.
8. The method as defined in claim 1 wherein R2 is selected from the group consisting of a t-butoxycarbonyl group, an allyloxycarbonyl group, a phthalimide group and N-benzylideneamine substituent.
9. The method as defined in claim 1 wherein said compound of Formula I is:
said compound of Formula Ia is:
and said compound of Formula Ib is:
and
wherein Et is ethyl, OTf is trifluoromethanesulfonic acid and Boc is tert-Butyloxycarbonyl.
10. The method as defined in claim 1 wherein said deprotection comprises removal of R31 followed by removal of R32.
11. The method as defined in claim 1 wherein R31 is ethyl.
12. The method as defined in claim 1 wherein R32 is a t-butoxycarbonyl group.
13. The method as defined in claim 1 wherein said compound of Formula II is:
and said compound of Formula IIa is:
and
wherein Et is ethyl and Boc is tert-Butyloxycarbonyl.
14. The method as defined in claim 13 wherein said deprotection step comprises removal of Et by basic hydrolysis and removal of Boc by acidic hydrolysis.
15. The method as defined in claim 1 wherein steps (c) and (d) are carried out on an automated synthesiser.