1. A compound having the formula (I):
or a pharmaceutically acceptable salt thereof, wherein
Ar1 is phenyl, wherein said phenyl can be unsubstituted or substituted with 1 to 3 fluoro;
Ar2 is bis(trifluoromethyl)phenyl;
X1 is \u2014O\u2014;
R1 and R2 are independently selected from the group consisting of H, C1-C6 alkyl or hydroxyl(C1-C3 alkyl), C3-C8 cycloalkyl, \u2014CH2F, \u2014CHF2, \u2014CF3;
R3 is H, C1-C6 alkyl, hydroxyl(C1-C3 alkyl), C3-C8 cycloalkyl, \u2014CH2F, \u2014CF2H, or \u2014CF3;
R6 and R7 are independently selected from H or C1-C6 alkyl;
n2 is 1 or 2;
R4 and R5 together are \u2550O;
R18 is C1-C6 alkyl, Cbz or H;
R32 and R33 are each H;
or a diaseteromer, enantiomer, stereoisomer, regioisomer, rotamer, or tautomer thereof.
2. The compound according to claim 1, wherein:
at least one of R1 or R2 is C1-C6alkyl and the other of R1 or R2 is H;
R3 is H;
R6 and R7 are H;
R18 is Cbz or H;
R32 and R33 are H; and
n2 is 2, or a pharmaceutically acceptable salt thereof.
3. The compound according to claim 1 having the formula:
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An illuminator of a door outside handle for a vehicle, comprising:
a case installed within a handle housing;
a Printed Circuit Board (PCB) installed at a rear end of the case; and
a Light Emitting Diode (LED) bulb supported while being electrically connected to the PCB and having a substantially cylindrical shape, the LED bulb being configured to perform both a function of a light source and a function of a guiding light through a length thereof extending from the PCB to a surface of the handle housing;
wherein, when a light is irradiated from the LED bulb, the light directly illuminates an outer panel.
2. The illuminator of claim 1, wherein the LED bulb is inserted within and supported by a guide aperture formed in the case and an end of the LED bulb extends to the surface of the handle housing.
3. The illuminator of claim 1, further comprising:
a top LED installed at one side of the PCB and electrically connected to the PCB; and
a light guide disposed lengthwise along an outer line contour of an inner grip of the handle housing,
wherein an end of the light guide contacts or gets close to the top LED, and the light guide is configured to have one side surface thereof exposed at a border line between the handle housing and the inner grip and to illuminate a light from the top LED to the outer panel.
4. The illuminator of claim 3, wherein the light guide includes an LED introducing part protruding from a rear side thereof at one end thereof contacting the top LED so that the light guide contacts the top LED using the LED introducing part.
5. The illuminator of claim 3, wherein the LED bulb and the top LED emit lights of different colors such that the LED bulb is turned on first when an unlocking operation is performed through a remote controller and the top LED is turned off when a locking operation is performed through the remote controller while the remote controller is within a radius of approximately 0.7 to 1 m of a vehicle.
6. The illuminator of claim 5, wherein the LED bulb emits a white light and the top LED emits an orange light.
7. The illuminator of claim 1, wherein the LED bulb emits lights of different colors.
8. The illuminator of claim 7, wherein the LED bulb emits a white light and n orange light.