What is claimed is:
1. A discussion board of a website having images associated with a portion of the text, the discussion board comprising:
(a) a discussion portion having text inserted by users of the discussion board;
(b) a text-insert section which inserts written text into the discussion portion for discussing one or more subjects; and
(c) a webpage which automatically inserts either a predetermined image or an uploaded image into the discussion portion upon command for enhancing the text upon request.
2. The discussion board as in claim 1 further comprising a link to the webpage.
3. The discussion board as in claim 1, wherein the webpage includes a plurality of pre-determined images for selection.
4. The discussion board as in claim 1, wherein the webpage includes verification of copyright ownership.
5. A method for using a discussion board, the method comprising the steps of:
(a) retrieving the discussion board from the Internet;
(b) inserting text into a discussion portion of the discussion board for discussing one or more subjects; and
(c) automatically inserting images into the discussion board upon command for providing enhancement to the text.
6. The method as in claim 5 further comprising activating a link to a webpage which uploads an image for insertion into the discussion board, or contains pre-determined images for insertion into the discussion board.
7. The method as in claim 5 further comprising selecting at least one image from a plurality of pre-determined images for insertion into the discussion board.
8. The method as in claim 5 further comprising verifying copyright ownership of downloaded images.
9. A discussion board of a website having images associated with a portion of the text, the discussion board comprising:
(a) a first set of text input on-line on a substantially real-time basis having image, if any, positioned adjacent the first text; and
(b) a second set of text input on-line on a substantially real-time basis having a corresponding image, if any, positioned adjacent the second text.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Compounds of the formula I,
10
in which
R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
or in which
R1 and R2 together are a 1-2C-alkylenedioxy group,
R3 is hydrogen or 1-4C-alkyl,
R31 is hydrogen or 1-4C-alkyl,
or in which
R3 and R31 together are a 1-4C-alkylene group,
R4 is hydrogen or 1-4C-alkyl,
R5 is hydrogen,
R51 is hydrogen,
or in which
R5 and R51 together represent an additional bond,
Het is an unsubstituted or R6- andor R7-substituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyridazinyl radical, or an unsubstituted or R6- andor R7-substituted fused bi- or tricyclic ring system comprising at least one aromatic ring and up to 4 heteroatomsselected from the group consisting of O (oxygen), S (sulphur) or N (nitrogen)which is bonded to the phenanthridinyl radical via one of the rings comprising one or more heteroatoms, where
R6 is hydroxyl, halogen, nitro, cyano, amino, aminocarbonyl, mono- or di-1-4C-alkylamino, mono- or di-1-4C-alkylaminocarbonyl, 1-4C-alkyl, trifluromethyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyloxy, 1-4C-alkylcarbonyl, 1-4C-alkoxycarbonylamino, phenyl or completely or predominantly fluorine-substituted 1-4C-alkoxy, and
R7 is hydroxyl, halogen, nitro, 1-4C-alkyl or 1-4C-alkoxy,
and the salts, the N-oxides and the salts of the N-oxides of these compounds.
2. Compounds of the formula I as claimed in claim 1, in which
R1 is 1-2C-alkoxy, 3-5C-cycloalkoxy, 3-5C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-2C-alkoxy,
R2 is 1-2C-alkoxy, 3-5C-cycloalkoxy, 3-5C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-2C-alkoxy,
R3 is hydrogen,
R31 is hydrogen,
R4 is hydrogen or 1-2C-alkyl,
R5 is hydrogen,
R51 is hydrogen,
or in which
R5 and R51 together represent an additional bond,
Het is an unsubstituted or R6- andor R7-substituted radical selected from the group consisting of benzofuran-2-yl, benzofuran-3-yl, 2,3-dihydrobenzofuran-2-yl, 2,3-dihydrobenzofuran-3-yl, benzothiophen-2-yl, benzothiophen-3-yl, 2,3-dihydrobenzothiophen-2-yl, 2,3-dihydrobenzothiophen-3-yl, chroman-2-yl, chroman-3-yl, chroman-4-yl, isochroman-1-yl, 1,4-benzodioxan-2-yl, 1,3-benzodioxol-2-yl, quinolin-2-yl, quinolin-4-yl, quinolin-3-yl, isoquinolin-3-yl, isoquinolin-1-yl, isoquinolin-4-yl, 1,2,3,4-tetrahydroacridin-9-yl, acridin-9-yl, indolizin-2-yl, indolizin-3-yl, indolizin-5-yl, indolizin-6-yl, indolizin-7-yl, indolizin-8-yl, phenanthridin-6-yl, cinnolin-3-yl, cinnolin-4-yl, quinazolin-4-yl, quinoxalin-2-yl, phthalazin-1-yl, 1,7-naphthyridin-3-yl, 1,6-naphthyridin-3-yl, 1,6-naphthyridin-4-yl, 1,6-naphthyridin-5-yl, 1,5-naphthyridin-2-yl, 1,5-naphthyridin-3-yl, 1,5-naphthyridin-4-yl, 1,5-naphthyridin-6-yl, 1,5-naphthyridin-7-yl, 1,5-naphthyridin-8-yl, indol-3-yl, indol-2-yl, indazol-3-yl, benzimidazol-2-yl, 2,3-dihydro-1H-indol-2-yl, 2,3-dihydro-1H-indol-3-yl, 2,3-dihydro-1H -isoindol-1-yl, 2,3-dihydro-1H-isoindol-3-yl, 1,2,3,4-tetrahydroquinolin-2-yl, 1,2,3,4-tetrahydroquinolin-3-yl, 1,2,3,4-tetrahydroquinolin-4-yl, 1,2,3,4-tetrahydroisoquinolin-1-yl, 1,2,3,4-tetrahydroisoquinolin-3-yl, 1,2,3,4-tetrahydroisoquinolin-4-yl, -carbolin-1-yl, -carbolin-3-yl, -carbolin-4-yl, furan-2-yl, furan-3-yl, thiophen-2-yl, thiophen-3-yl, 1H -pyrrol-2-yl, 1H -pyrrol-3-yl, pyrazol-3-yl, pyrazol-4-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,2,3thiadiazol-4-yl, 1,2,3thiadiazol-5-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-2-yl, pyridazin-4-yl, pyridazin-3-yl and pyrazin-2-yl, where
R6 is hydroxyl, halogen, nitro, amino, aminocarbonyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, 1-4C-alkoxycarbonyl or completely or predominantly fluorine-substituted 1-2C-alkoxy, and
R7 is hydroxyl, halogen, 1-4C-alkyl or 1-4C-alkoxy,
and the salts, the N-oxides and the salts of the N-oxides of these compounds.
3. Compounds of the formula I as claimed in claim 1 in which
R1 is 1-2C-alkoxy,
R2 is 1-2C-alkoxy,
R3, R31, R4, R5 and R51 are hydrogen,
Het is an unsubstituted or R6- andor R7-substituted radical selected from the group consisting of benzofuran-2-yl, benzothiophen-2-yl, quinolin-2-yl, quinolin-4-yl, isoquinolin-1-yl, indol-2-yl, furan-2-yl, furan-3-yl, thiophen-2-yl, thiophen-3-yl, 1H-pyrrol-2-yl, pyrazol-3-yl, thiazol-2-yl, thiazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, 1,2,3thiadiazol-5-yl and pyrazin-2-yl, where
R6 is halogen, 1-4C-alkyl, 1-4C-alkoxy or phenyl, and
R7 is 1-4C-alkyl,
and the salts, the N-oxides and the salts of the N-oxides of these compounds.
4. Compounds of the formula I as claimed in claim 1 in which
R1 is methoxy,
R2 is methoxy,
R3, R31, R4, R5 and R51 are hydrogen, and
Het is quinolin-4-yl, quinolin-2-yl, 3-methyl-furan-2-yl, 3-methyl-benzofuran-2-yl, 7-methoxybenzofuran-2-yl, 5-methoxy-benzofuran-2-yl, thiophen-2-yl, 5-methyl-thiophen-2-yl, thiophen-3-yl, 1H -indol-2-yl, 5-fluoro-1H-indol-2-yl, 6-methoxy-1H-indol-2-yl, and the salts, the N-oxides and the salts of the N-oxides of these compounds.
5. Compounds of the formula I as claimed in claim 1 in which
R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
or in which
R1 and R2 together are a 1-2C-alkylenedioxy group,
R3 is hydrogen or 1-4C-alkyl,
R31 is hydrogen or 1-4C-alkyl,
or in which
R3 and R31 together are a 1-4C-alkylene group,
R4 is hydrogen or 1-4C-alkyl,
R5 is hydrogen,
R51 is hydrogen,
or in which
R5 and R51 together represent an additional bond,
Het is an unsubstituted or R6- andor R7-substituted pyrimidinyl, pyrazinyl or pyridazinyl radical, or an unsubstituted or R6- andor R7-substituted fused bi- or tricyclic ring system comprising at least one aromatic ring and up to 4 heteroatomsselected from the group consisting of O (oxygen) or N (nitrogen)which is bonded to the phenanthridinyl radical via one of the rings comprising one or more heteroatoms, where
R6 is hydroxyl, halogen, nitro, cyano, amino, aminocarbonyl, mono- or di-1-4C-alkylamino, mono- or di-1-4C-alkylaminocarbonyl, 1-4C-alkyl, trifluromethyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyloxy, 1-4C-alkylcarbonyl, 1-4C-alkoxycarbonylamino or completely or predominantly fluorine-substituted 1-4C-alkoxy, and
R7 is hydroxyl, halogen, nitro, 1-4C-alkyl or 1-4C-alkoxy, and the salts, the N-oxides and the salts of the N-oxides of these compounds.
6. Compounds of the formula I as claimed in claim 1 in which R1 is 1-2C-alkoxy, 3-5C-cycloalkoxy, 3-5C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-2C-alkoxy,
R2 is 1-2C-alkoxy, 3-5C-cycloalkoxy, 3-5C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-2C-alkoxy,
R3 is hydrogen,
R31 is hydrogen,
R4 is hydrogen or 1-2C-alkyl,
R5 is hydrogen,
R51 is hydrogen,
or in which
R5 and R51 together represent an additional bond,
Het is an unsubstituted or R6- andor R7-substituted radical selected from the group consisting of benzofuran-2-yl, benzofuran-3-yl, 2,3-dihydrobenzofuran-2-yl, 2,3-dihydrobenzofuran-3-yl, chroman-2-yl, chroman-3-yl, chroman-4-yl, isochroman-1-yl, 1,4-benzodioxan-2-yl, 1,3-benzodioxol-2-yl, quinolin-2-yl, quinolin-4-yl, quinolin-3-yl, isoquinolin-3-yl, isoquinolin-1-yl, isoquinolin-4-yl, 1,2,3,4-tetrahydroacridin-9-yl, acridin-9-yl, indolizin-2-yl, indolizin-3-yl, indolizin-5-yl, indolizin-6-yl, indolizin-7-yl, indolizin-8-yl, phenanthridin-6-yl, cinnolin-3-yl, cinnolin-4-yl, quinazolin-4-yl, quinoxalin-2-yl, phthalazin-1-yl, 1,7-naphthyridin-3-yl, 1,6-naphthyridin-3-yl, 1,6-naphthyridin-4-yl, 1,6-naphthyridin-5-yl, 1,5-naphthyridin-2-yl, 1,5-naphthyridin-3-yl, 1,5-naphthyridin-4-yl, 1,5-naphthyridin-6-yl, 1,5-naphthyridin-7-yl, 1,5-naphthyridin-8-yl, indol-3-yl, indol-2-yl, indazol-3-yl, benzimidazol-2-yl, 2,3-dihydro-1H-indol-2-yl, 2,3-dihydro-1H-indol-3-yl, 2,3-dihydro-1H-isoindol-1-yl, 2,3-dihydro-1H -isoindol-3-yl, 1,2,3,4-tetrahydroquinolin-2-yl, 1,2,3,4-tetrahydroquinolin-3-yl, 1,2,3,4-tetrahydroquinolin-4-yl, 1,2,3,4-tetrahydroisoquinolin-1-yl, 1,2,3,4-tetrahydroisoquinolin-3-yl, 1,2,3,4-tetrahydroisoquinolin-4-yl, -carbolin-1-yl, -carbolin-3-yl, -carbolin-4-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-2-yl, pyridazin-4-yl, pyridazin-3-yl and pyrazin-2-yl where
R6 is hydroxyl, halogen, nitro, amino, aminocarbonyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, 1-4C-alkoxycarbonyl or completely or predominantly fluorine-substituted 1-2C-alkoxy, and
R7 is hydroxyl, halogen, 1-4C-alkyl or 1-4C-alkoxy,
and the salts, the N-oxides and the salts of the N-oxides of these compounds.
7. A compound of the formula I as claimed in one of the claims 1, 2, 3, 4, 5 or 6, which has the same absolute configuration in positions 4a and 10b as the compound ()-cis-1,2-dimethoxy-4-(2-aminocyclohexyl)benzene having the optical rotation
5
D
20
=
–
58.5
(
c
=
1
,
ethanol
)
,
which on its part can be employed as a starting material.
8. A compound of the formula I as claimed in claim 1 for use in the treatment of illnesses.
9. A medicament comprising at least one compound of the formula I as claimed in claim 1 together with pharmaceutical excipients andor vehicles.
10. The use of compounds of the formula I as claimed in claim 1 for the production of medicaments for treating airway disorders.