1. An isolated nucleic acid molecule comprising a nucleotide sequence drawn from the group consisting of SEQ ID NOS: 1, 3 and 5.
2. An isolated nucleic acid molecule comprising a nucleotide sequence that:
(a) encodes the amino acid sequence shown in SEQ ID NO: 2; and
(b) hybridizes under stringent conditions to the nucleotide sequence of SEQ ID NO: 1 or the complement thereof.
3. An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NO:2.
4. An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NO:4.
5. An isolated nucleic acid molecule comprising a nucleotide sequence that encodes the amino acid sequence shown in SEQ ID NO:6.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A retinoid ester having the formula
R\u2014O\u2014R1
where R is a retinoyl of a retinoid selected from the group consisting of
all-trans-retinoic acid,
9-cis-retinoic acid,
11-cis-retinoic acid,
13-cis-retinoic acid,
9,13-di-cis-retinoic acid,
TTNPB,
TTNN,
TTAB,
UAB8,
AM80,
AM580,
AM555S,
AGN 193836,
AGN 190299,
CD 2019,
CD 417,
Ro 48-2249,
Ro 44-4753,
Ro 10-9359,
SR 11254,
BMS 185354,
AGN 190299,
CD 437 (AHPN),
SR 11247,
SR 11217,
SR 11237,
AGN 191701,
LDG 100268,
LDG 100568,
LGD 100754,
Ro 25-7386,
BMS 188970,
SR 11004, and
SR 11203, and R1 is a highly sterically hindered functional group comprising a pinacol structure having the formula
2. The retinoid ester of claim 1 wherein R is a retinoyl of all-trans-retinoic acid.
3. A pharmaceutical composition comprising a retinoid ester as in claim 1 together with a pharmaceutically acceptable excipient.
4. The composition of claim 3 having from about 0.01 mg to about 100 mg of said retinoid ester per gram of the composition.
5. A retinoid ester having the formula:
6. A pharmaceutical composition comprising a retinoid ester having the formula:
together with a pharmaceutically acceptable excipient.
7. The composition of claim 6 having from about 0.01 mg to about 100 mg of said retinoid ester per gram of the composition.
8. A method of treating psoriasis comprising administering to a patient with psoriasis an effective amount of a retinoid ester as in claim 1.
9. The method of claim 8 wherein the retinoid ester is administered orally, parenterally, transdermally or topically.
10. The method of claim 8 wherein the retinoid ester is administered in a dosage of from about 5 mg to about 5 g per day.
11. The method of claim 8 wherein the retinoid ester has the formula:
12. A method of treating acne comprising administering to a patient with acne an effective amount of a retinoid ester as in claim 1.
13. The method of claim 12 wherein the retinoid ester is administered orally, parenterally, transdermally or topically.
14. The method of claim 12 wherein the retinoid ester is administered in a dosage of from about 5 mg to about 5 g per day.
15. The method of claim 12 wherein the retinoid ester has the formula:
16. A method of treating skin conditions selected from the group consisting of lack of skin firmness, wrinkles, lack of dermal hydration and insufficient sebum secretion which comprises administering to a patient with one of said skin conditions an effective amount of a retinoid ester as in claim 1.
17. The method of claim 16 wherein the retinoid ester is administered orally, parenterally, transdermally or topically.
18. The method of claim 16 wherein the retinoid ester is administered in a dosage of from about 5 mg to about 5 g per day.
19. The method of claim 16 wherein the retinoid ester has the formula:
20. A method of treating a disease selected from the group consisting of skin cancer, leukemia, colon cancer, breast cancer, prostate cancer, ovarian cancer, and lung cancer comprising administering to a patient with said disease an effective amount of a retinoid ester as in claim 1.
21. The method of claim 20 wherein the retinoid ester is administered orally, parenterally, transdermally or topically.
22. The method of claim 20 wherein the retinoid ester is administered in a dosage of from about 5 mg to about 5 g per day.
23. The method of claim 20 wherein the retinoid ester has the formula:
24. A method of treating a disease selected from the group consisting of dermatitis, eczema and keratosis comprising administering to a patient with said disease an effective amount of a retinoid ester as in claim 1.
25. The method of claim 24 wherein the retinoid ester is administered orally, parenterally, transdermally or topically.
26. The method of claim 24 wherein the retinoid ester is administered in a dosage of from about 5 mg to about 5 g per day.
27. The method of claim 24 wherein the retinoid ester has the formula: