1. A compound of the formula IA:
its enantiomers, diastereomers, enantiomerically enriched mixtures, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein:
ring A is a 3-13 membered carbocycle or heterocycle comprising carbon atoms, 0-3 carbonyl groups, 0-4 double bonds, and from 0-4 ring heteroatoms selected from the group consisting of O, N, NR, and S(O)p, provided that ring A contains other than a S\u2014S, O\u2014O, or S\u2014O bond;
n\u2032 is an integer from 1-3;
Z is selected from the group consisting of COR5, CO2H, \u2014CH2CO2H, \u2014CO2R6,
\u2014CONHOH, \u2014CONHOR5, \u2014CON(R6)OH, \u2014CONHOR6, \u2014NHRa, \u2014N(OH)C(O)R5, \u2014N(OH)CHO, \u2014SH, \u2014CH2SH, \u2014S(O)(\u2550NH)Ra, \u2014SN2H2Ra, \u2014PO(ORg)2, \u2014PO(OH)NHRa,
Rg is independently selected from the group consisting of H, CH2OCORa,
P is D-E-G-Q-L-T-X-Y, wherein
D is absent or is selected from the group consisting of O, NRa1, C(O), C(O)O, OC(O), C(O)NRa1, NRa1C(O), OC(O)O, OC(O)NRa1, NRa1C(O)O, NRa1C(O)NRa1, S(O)p, S(O)pNRa1, NRa1S(O)p, and NRa1SO2NRa1;
E is absent or is selected from the group consisting of C1-10alkylene, C2-10 alkenylene, and C2-10 alkynylene;
G is absent or is selected from the group consisting of O, NRa1, S(O)p, and C(O);
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb;
L is absent or is selected from the group consisting of O, NRa1, C(O), C(O)O, OC(O), C(O)NRa1, NRa1C(O), OC(O)O, OC(O)NRa1, NRa1C(O)O, NRa1C(O)NRa1, S(O)p, S(O)pNRa1, NRa1S(O)p, and NRa1SO2NRa1;
T is absent or is selected from the group consisting of C1-10 alkylene, C2-10 alkenylene, and C2-10 alkynylene;
X is absent or is selected from the group consisting of O, NRa1, S(O)p, and C(O);
Y is selected from the group consisting of H, a C3-13 carbocycle substituted with 0-5 Rc and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rc;
provided that D, E, G, Q, L, T, X and Y do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, S(O)p\u2014O, O\u2014S(O)p or S(O)p\u2014S(O)p group;
R, at each occurrence, is independently selected from (C1-10 alkylene substituted with 1-3 Rb1)-M, (C2-10 alkenylene substituted with 1-3 Rb1)-M, (C2-10 alkynylene substituted with 1-3 Rb1)-M, OH, Cl, F, Br, I, \u2014CN, NO2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCF2CF3, OCHF2, O(CRdRd1)r-M, NRa(CRdRd1)r-M, OC(O)(CRdRd1)r-M, NRaC(O)(CRdRd1)r-M, OC(O)O(CRdRd1)r-M, OC(O)NRa(CRdRd1)r-M, NRaC(O)O(CRdRd1)r-M, NRaC(O)NRa1(CRdRd1)r-M, S(O)p(CRdRd1)r-M, S(O)2NRa(CRdRd1)r-M, NRaS(O)2(CRdRd1)r-M, and NRaS(O)2NRa1(CRdRd1)r-M, (CRdRd1)rP(O)(ORa)2, (CRdRd1)rP(O)(ORa)(NRdRd1), (CRdRd1)rP(O)(NRaRa1)2, (CRdRd1)rOP(O)(ORa)2, (CRdRd1)rOP(O) (ORa)(NRaRa1), (CRdRd1)rOP(O)(NRaRa1)2, (CRdRd1)rNRaP(O)(ORa)2, (CRdRd1)rNRaP(O)(ORa)(NRaRa1), (CRdRd1)rNRaP(O)(NRaRa1)2; C(\u2550NRa)NRa1Ra2; C(\u2550CRdRd1)NRa1Ra2; a C3-13 carbocycle
substituted with 0-5 Rd, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, two R, together with a carbon atom on A, form the group CA\u2550CRdRd1, where the atom CA is said atom on A;
M is selected from the group consisting of H, C2-10 alkenylene substituted with 0-3 Rb1, C2-10 alkynylene substituted with 0-3 Rb1, ORa, Cl, F, Br, I, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, NRaC(O)Ra, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCF2CF3, OCHF2, a C3-13 carbocycle substituted with 0-5 Rd, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, R, at each occurrence, is independently selected from (CRdRd1)rO(CRdRd1)r-M1,
(CRdRd1)rNRa(CRdRd1)r-M1, (CRdRd1)rC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)(CRdRd1)r-M1,
(CRdRd1)rOC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)O(CRdRd1)r-M1, (CRdRd1)rNRaC(O)NRa1(CRdRd1)r-M1, (CRdRd1)rS(O)p(CRdRd1)r-M1, (CRdRd1)rS(O)2NRa(CRdRd1)r-M1, (CRdRd1)rNRaS(O)2(CRdRd1)r-M1, and (CRdRd1)rNRaS(O)2NRa1(CRdRd1)r-M1;
M1 is selected from the group consisting of C1-10 alkylene-M1,
C2-10 alkenylene-M1, C2-10 alkynylene-M1, ORa, Cl, F, Br, I, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCF2CF3, and a 5-14 membered non-aromatic heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd; a C3-C13 carbocycle, C4-C14 heterocycle and wherein said C3-C13 carbocycle and C4-C14 heterocycle are substituted with 1-3 Rh, and CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3;
alternatively, when two R groups are attached to adjacent ring A atoms, together with the atoms to which they are attached they may form a 3-8 membered saturated, partially saturated or unsaturated ring comprised of carbon atoms and 0-3 heteroatoms selected from the group consisting of N, NRa, O, and S(O)p, wherein said ring may be benzene-fused andor substituted with Rd;
alternatively, when two R groups are attached to the same ring A carbon, together with the carbon to which they are attached they may form a 3-8 membered saturated, partially saturated or unsaturated spiro-ring comprised of carbon atoms and 0-3 heteroatoms selected from the group consisting of N, NRa, O, and S(O)p, wherein said spiro-ring may be benzene-fused andor substituted with Rd;
provided that either two or more R or M, M1 and the atom to which they are attached do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, N-halogen, O-halogen, S-halogen, S(O)p\u2014O, O\u2014S(O)p, S(O)p\u2014S(O)p group, or C(O)F, C(O)Cl, C(O)Br, or C(O)I reactive group;
Ra, Ra1, and Ra2 at each occurrence are independently selected from the group consisting of H, C1-C8alkyl, C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are optionally substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, Br, I, \u2550O, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfinyl, alkylsulfonyl, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCF2CF3 and OCH2CF3; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of C1-C8 alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, Br, I, \u2550O, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfinyl, alkylsulfonyl, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCF2CF3 and OCH2CF3;
alternatively, Ra and Ra1 taken together with the nitrogen to which they are attached form a 4 to 8 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rb at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, Br, I, \u2550O, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3; C3-10 carbocyclic residue, and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl-(C1-8)alkyl and said C3-10 carbocyclic residue, heterocyclic system,
C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rb1 at each occurrence is independently selected from the group consisting of ORa, F, \u2550O, \u2014CN, NO2, NRaRa1 and S(O)pRa;
Rc at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, Br, I, \u2550O, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3; a C3-10 carbocyclic residue, and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl are optionally substituted with Rc1;
Rc1 at each occurrence is independently selected from the group consisting of C1-6 alkyl, ORa, Cl, F, Br, I, \u2550O, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, S(O)pRa2, CF3, and CF2CF3, CH2F, and CHF2;
Rd at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, Br, I, \u2550O, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)O Ra1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3; C3-10 carbocyclic residue, and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
Rd1 at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, Br, I, \u2550O, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)O Ra1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3; C3-10 carbocyclic residue, and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
alternatively, Rd and Rd1 taken together with the atom to which they are attached form a 4 to 8 membered ring containing from 0-1 heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rh at each occurrence is independently selected from the group consisting of ORj, NRjRa, CORj, C(O)ORj, C(O)NRjRa, NRaC(O)NRjRa1, OC(O)NRjRa, S(O)pNRjRa1, NRaS(O)pRj, NRaS(O)pNRjRa, C1-6 alkyl substituted with Rc;
Rj at each occurrence is independently selected from the group consisting of CF3, CHF2, CFH2, CF2CF3, C1-C8 alkyl substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, Br, I, \u2550O, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfinyl, alkylsulfonyl, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3; C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkenyl and alkynyl groups are optionally substituted with C1-C8alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, Br, I, \u2550O, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfinyl, alkylsulfonyl, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, Br, I, \u2550O, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfinyl, alkylsulfonyl, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCF2CF3 and OCH2CF3, with the proviso that said C3-C10 carbocycle can not be a phenyl group and C3-C10 carbocyclylalkyl can not be a benzyl group;
R3 is H or C1-6 alkyl ORa, NRaRa1, and S(O)pRa;
R4 is selected from the group consisting of H, C1-6 alkyl, ORa, NRaRa1, and S(O)pRa;
R5 at each occurrence is selected from the group consisting of C1-10 alkyl substituted with 0-2 Rb, and C1-8 alkyl substituted with 0-2 Re;
Re at each occurrence is selected from the group consisting of phenyl substituted with 0-2 Rb and biphenyl substituted with 0-2 Rb;
R6 at each occurrence is selected from the group consisting of phenyl, naphthyl, C1-10 alkyl-phenyl-C1-6 alkyl-, C3-11 cycloalkyl, C1-6 alkylcarbonyloxy-C1-3 alkyl-,
C1-6 alkoxycarbonyloxy-C1-3 alkyl-, C2-10 alkoxycarbonyl,
C3-6 cycloalkylcarbonyloxy-C1-3 alkyl-, C3-6 cycloalkoxycarbonyloxy-C1-3 alkyl-,
C3-6 cycloalkoxycarbonyl, phenoxycarbonyl, phenyloxycarbonyloxy-C1-3 alkyl-, phenylcarbonyloxy-C1-3 alkyl-, C1-6 alkoxy-C1-6 alkylcarbonyloxy-C1-3 alkyl-,
5-(C1-C5 alkyl)-1,3-dioxa-cyclopenten-2-one-ylmethyl, 5-(Ra)-1,3-dioxa-cyclopenten-2-one-ylmethyl, (5-aryl-1,3-dioxa-cyclopenten-2-one-yl)methyl, \u2014C1-10 alkyl-NR7R7a, \u2014CH(R8)OC(O)R9, and \u2014CH(R8)OC(O)OR9;
alternatively, R4 and R6 can be taken together to form a 5-10 membered ring optionally substituted with Rc;
R7 is selected from the group consisting of H, C1-10 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C1-3 alkyl-, and phenyl-C1-6 alkyl-;
R7a is selected from the group consisting of H, C1-10 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C1-3 alkyl-, and phenyl-C1-6 alkyl-;
R8 is selected from the group consisting of H and C1-4 linear alkyl;
R9 is selected from the group consisting of H, C1-8 alkyl substituted with 1-2 Rf, C3-8 cycloalkyl substituted with 1-2 Rf, and phenyl substituted with 0-2 Rb;
Rf at each occurrence is selected from the group consisting of H, C1-4 alkyl, Ca-8 cycloalkyl, C1-5 alkoxy, and phenyl substituted with 0-2 Rb;
p at each occurrence is 0, 1, and 2; and
r at each occurrence is 0, or an integer from 1 to 10.
2. A compound according to claim 1, wherein the compound is of formula IIA:
wherein ring A is a 4-10 membered non-aromatic carbocycle or heterocycle comprising carbon atoms, 0-1 carbonyl groups and from 0-2 ring heteroatoms selected from the group consisting of O, N, NR, provided that ring A contains other than a O\u2014O bond;
n\u2032 is 1 or 2;
Z is selected from the group consisting of CO2H, \u2014CH2CO2H, \u2014CONHOH, \u2014CONHOR5, \u2014NHRa, \u2014N(OH)C(O)R5, \u2014N(OH)CHO, \u2014SH, \u2014CH2SH, and
P is D-E-G-Q-L-T-X-Y, wherein
D is absent or is selected from the group consisting of O, NRa1, C(O), C(O)O, OC(O), C(O)NRa1, NRa1C(O), OC(O)NRa1, NRa1C(O)O, NRa1C(O)NRa1, S(O)p, S(O)pNRa1, and NRa1S(O)p;
E is absent or is selected from the group consisting of C1-10alkylene, C2-10 alkenylene, and
C2-10 alkynylene;
G is absent or is selected from the group consisting of O, NRa1, S(O)p, and C(O);
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb;
L is absent or is selected from the group consisting of O, NRa1, C(O), C(O)O, OC(O), C(O)NRa1, NRa1C(O), OC(O)NRa1, NRa1C(O)O, S(O)p, S(O)pNRa1, and NRa1S(O)p;
T is absent or is selected from the group consisting of C1-10 alkylene, C2-10 alkenylene, and C2-10 alkynylene;
X is absent or is selected from the group consisting of O, NRa1, S(O)p, and C(O);
Y is selected from the group consisting of H, a C3-10 carbocycle substituted with 0-5 Rc and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rc,
provided that D, E, G, Q, L, T, X and Y do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, S(O)p\u2014O, O\u2014S(O)p or S(O)p\u2014S(O)p group;
R, at each occurrence, is independently selected from (C1-10 alkylene substituted with 1-3 Rb1)-M, (C2-10 alkenylene substituted with 1-3 Rb1)-M, (C2-10 alkynylene substituted with 1-3 Rb1)-M, OH, Cl, F, Cl, \u2014CN, NO2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, O(CRdRd1)r-M, NRa(CRdRd1)r-M, OC(O)(CRdRd1)r-M, NRaC(O)(CRdRd1)r-M, OC(O)O(CRdRd1)r-M, OC(O)NRa(CRdRd1)r-M, NRaC(O)O(CRdRd1)r-M, NRaC(O)NRa1(CRdRd1)r-M, S(O)p(CRdRd1)r-M, S(O)2NRa(CRdRd1)r-M, NRaS(O)2(CRdRd1)r-M, C(\u2550NCN)NRa1Ra2; C(\u2550C(H)(NO2))NRa1Ra2; a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, two R, together with a carbon atom on A, form the group CA\u2550CRdRd1, where the atom CA is said atom on A;
M is selected from the group consisting of H, C2-10 alkenylene substituted with 0-3 Rb1, C2-10 alkynylene substituted with 0-3 Rb1, ORa, Cl, F, Br, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, NRaC(O)Ra, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, R, at each occurrence, is independently selected from C1-10 alkylene-M1,
C2-10 alkenylene-M1, C2-10 alkynylene-M1, (CRdRd1)rO(CRdRd1)r-M1,
(CRdRd1)rNRa(CRdRd1)r-M1, (CRdRd1)rC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)(CRdRd1)r-M1,
(CRdRd1)rOC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)O(CRdRd1)r-M1, (CRdRd1)rNRaC(O)NRa1(CRdRd1)r-M1, (CRdRd1)rS(O)p(CRdRd1)r-M1, (CRdRd1)rS(O)2NRa(CRdRd1)r-M1, and (CRdRd1)rNRaS(O)2(CRdRd1)r-M1;
M1 is selected from the group consisting of ORa, Cl, F, Br, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and a 5-10 membered non-aromatic heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd; a C3-C10 carbocycle, C5-C10 heterocycle and wherein said C3-C10 carbocycle and C5-C10 heterocycle are substituted with 1-3 Rh, and CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3;
alternatively, when two R groups are attached to adjacent ring A atoms, together with the atoms to which they are attached they may form a 3-8 membered saturated, partially saturated or unsaturated ring comprised of carbon atoms and 0-3 heteroatoms selected from the group consisting of N, NRa, O, and S(O)p, wherein said ring may be benzene-fused andor substituted with Rd;
alternatively, when two R groups are attached to the same ring A carbon, together with the carbon to which they are attached they may form a 3-8 membered saturated, partially saturated or unsaturated spiro-ring comprised of carbon atoms and 0-3 heteroatoms selected from the group consisting of N, NRa, O, and S(O)p, wherein said spiro-ring may be benzene-fused andor substituted with Rd;
provided that either two R or M, M1 and the atom to which they are attached do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, N-halogen, O-halogen, S-halogen, S(O)p\u2014O, O\u2014S(O)p, S(O)p\u2014S(O)p group, or C(O)F, C(O)Cl, C(O)Br, or C(O)I reactive group;
Ra, Ra1, and Ra2 at each occurrence are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are optionally substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfinyl, alkylsulfonyl, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of C1-C8 alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, Br, \u2550O, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfinyl, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3;
alternatively, Ra and Ra1 taken together with the nitrogen to which they are attached form a 3 to 8 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rb at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl-(C1-8)alkyl and said C3-10 carbocyclic residue, heterocyclic system, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rb1 at each occurrence is independently selected from the group consisting of ORa, F, \u2550O, \u2014CN, NO2, NRaRa1 and S(O)pRa;
Rc at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2,
NRaS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; a C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rc1 at each occurrence is independently selected from the group consisting of C1-6 alkyl, ORa, Cl, F, Br, \u2550O, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, and CH2F, and CHF2;
Rd at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, Br, \u2550O, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl optionally substituted with Rc1;
Rd1 at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
alternatively, Rd and Rd1 taken together with the atom to which they are attached form a 4 to 8 membered ring containing from 0-1 heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rh at each occurrence is independently selected from the group consisting of ORj, NRjRa, CORj, C(O)ORj, C(O)NRjRa, NRaC(O)NRjRa1, OC(O)NRjRa, S(O)pNRjRa1, NRaS(O)pRj, C1-6 alkyl substituted with Rc.
Rj at each occurrence is independently selected from the group consisting of CF3, CHF2, CH2F, CF2CF3, C1-C8 alkyl substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkenyl and alkynyl groups are optionally substituted with C1-C8 alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-C10 carbocycle, 5-10 membered heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3, with the proviso that said C3-C10 carbocycle can not be a phenyl group and C3-C10 carbocyclylalkyl can not be a benzyl group;
R5 at each occurrence is selected from the group consisting of C1-10 alkyl substituted with 0-2 Rb, and C1-8 alkyl substituted with 0-2 Re;
Re at each occurrence is selected from the group consisting of phenyl substituted with 0-2 Rb and biphenyl substituted with 0-2 Rb;
p at each occurrence is 0, 1, and 2; and
r at each occurrence is 0, or an integer from 1 to 10.
3. A compound according to claim 2, wherein the compound is selected from the group consisting of formula IIIA or IVA:
wherein ring A is a 5-7 membered non-aromatic carbocycle or heterocycle comprising carbon atoms, 0-1 carbonyl groups and from 0-2 ring heteroatoms selected from the group consisting of O, N, NR, provided that ring A contains other than a O\u2014O bond;
n\u2032 is 1 or 2;
P is D-E-G-Q-L-T-X-Y, wherein
D is absent or is selected from the group consisting of O, NRa1, C(O), C(O)NRa1, NRa1C(O), OC(O)NRa1, NRa1C(O)O, NRa1C(O)NRa1, S(O)p, S(O)pNRa1, and NRa1S(O)p;
E is absent or is selected from the group consisting of C1-10alkylene, C2-10 alkenylene, and
C2-10 alkynylene;
G is absent or is selected from the group consisting of O, NRa1, S(O)p, and C(O);
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb;
L is absent or is selected from the group consisting of O, NRa1, C(O), C(O)NRa1, NRa1C(O), OC(O)NRa1, NRa1C(O)O, S(O)p, S(O)pNRa1, and NRa1S(O)p;
T is absent or is selected from the group consisting of C1-10 alkylene, C2-10 alkenylene, and C2-10 alkynylene;
X is absent or is selected from the group consisting of O, NRa1, S(O)p, and C(O);
Y is selected from the group consisting of H, a C5-7 carbocycle substituted with 0-5 Rc and a 5-6 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Re;
provided that D, E, G, Q, L, T, X and Y do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, S(O)p\u2014O, O\u2014S(O)p or S(O)p\u2014S(O)p group;
R, at each occurrence, is independently selected from (C1-10 alkylene substituted with 1-3 Rb1)-M, (C2-10 alkenylene substituted with 1-3 Rb1)-M, (C2-10 alkynylene substituted with 1-3 Rb1)-M, OH, F, Cl, \u2014CN, NO2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, O(CRdRd1)r-M, NRa(CRdRd1)r-M, OC(O)(CRdRd1)r-M, NRaC(O)(CRdRd1)r-M, OC(O)O(CRdRd1)r-M, OC(O)NRa(CRdRd1)r-M, NRaC(O)O(CRdRd1)r-M, NRaC(O)NRa1(CRdRd1)r-M, S(O)p(CRdRd1)r-M, S(O)2NRa(CRdRd1)r-M, NRaS(O)2(CRdRd1)r-M, C(\u2550NCN)NRa1Ra2; C(\u2550C(H)(NO2))NRa1Ra2; a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, two R, together with a carbon atom on A, form the group CA\u2550CRdRd1, where the atom CA is said atom on A;
M is selected from the group consisting of H, C2-10 alkenylene substituted with 0-3 Rb1,
C2-10 alkynylene substituted with 0-3 Rb1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, NRaC(O)Ra, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, R, at each occurrence, is independently selected C1-10 alkylene-M1;
C2-10 alkenylene-M1, C2-10 alkynylene-M1, (CRdRd1)rO(CRdRd1)r-M1,
(CRdRd1)rNRa(CRdRd1)r-M1, (CRdRd1)rC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)(CRdRd1)r-M1,
(CRdRd1)rOC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)O(CRdRd1)r-M1, (CRdRd1)rNRaC(O)NRa(CRdRd1)r-M1, (CRdRd1)rS(O)p(CRdRd1)r-M1, (CRdRd1)rS(O)2NRa(CRdRd1)r-M1, and (CRdRd1)rNRaS(O)2(CRdRd1)r-M1;
M1 is selected from the group consisting of ORa, Cl, F, Br, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and a 5-10 membered non-aromatic heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd; a C3-C10 carbocycle, C5-C10 heterocycle and wherein said C3-C10 carbocycle and C5-C10 heterocycle are substituted with 1-3 Rh, and CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3;
provided that either two R or M, M1 and the atom to which they are attached do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, N-halogen, O-halogen, S-halogen, S(O)p\u2014O, O\u2014S(O)p, S(O)p\u2014S(O)p group, or C(O)F, C(O)Cl, C(O)Br, or C(O)I reactive group;
Ra, Ra1, and Ra2 at each occurrence are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl;
alternatively, Ra and Ra1 taken together with the nitrogen to which they are attached form a 3 to 8 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rb at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl-(C1-8)alkyl and said C3-10 carbocyclic residue, heterocyclic system,
C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rb1 at each occurrence is independently selected from the group consisting of ORa, F, \u2014CN, NRaRa1 and S(O)pRa;
Rc at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2 NW Ra1, NRaS(O)2Ra2,
NRaS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; a C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rc1 at each occurrence is independently selected from the group consisting of C1-6 alkyl, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, and CH2F, and CHF2;
Rd at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8) alkyl optionally substituted with Rc1.
Rd1 at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
alternatively, Rd and Rd1 taken together with the atom to which they are attached form a 4 to 8 membered ring containing from 0-1 heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rh at each occurrence is independently selected from the group consisting of ORj, NRjRa, CORj, C(O)ORj, C(O)NRjRa, NRaC(O)NRjRa1, OC(O)NRjRa, S(O)pNRjRa1, NRaS(O)pRj, C1-6 alkyl substituted with Rc.
Rj at each occurrence is independently selected from the group consisting of CF3, CHF2, CH2F, CF2CF3, C1-C8 alkyl substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkenyl and alkynyl groups are optionally substituted with C1-C8 alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-C10 carbocycle, 5-10 membered heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3, with the proviso that said C3-C10 carbocycle can not be a phenyl group and C3-C10 carbocyclylalkyl can not be a benzyl group;
p at each occurrence is 0, 1, and 2; and
r at each occurrence is 0, or an integer from 1 to 10.
4. A compound according to claim 3, wherein the compound is of formula III wherein:
ring A is a 5-7 membered non-aromatic carbocycle or heterocycle comprising carbon atoms, and from 1-2 ring heteroatoms selected from the group consisting of O, N, NR, provided that ring A contains other than a O\u2014O bond;
P is D-Q-L-Y, wherein
D is absent or is selected from the group consisting of O, NRa1, C(O), C(O)NRa1, NRa1C(O), S(O)p, S(O)pNRa1, and NRa1S(O)p;
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb;
L is absent or is selected from the group consisting of O, NRa1, C(O), C(O)NRa1, S(O)p, S(O)pNRa1, and NRa1S(O)p;
Y is selected from the group consisting of H, a C5-7 carbocycle substituted with 0-5 Rc and a 5-6 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rc;
provided that D, Q, L and Y do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, S(O)p\u2014O, O\u2014S(O)p or S(O)p\u2014S(O)p group;
R, at each occurrence, is independently selected from (C1-10 alkylene substituted with 1-3 Rb1)-M, (C2-10 alkenylene substituted with 1-3 Rb1)-M, (C2-10 alkynylene substituted with 1-3 Rb1)-M, OH, F, Cl, \u2014CN, NO2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, O(CRdRd1)r-M, NRa(CRdRd1)r-M, OC(O)(CRdRd1)r-M, NRaC(O)(CRdRd1)r-M, OC(O)O(CRdRd1)r-M, OC(O)NRa(CRdRd1)r-M, NRaC(O)O(CRdRd1)r-M, NRaC(O)NRa1(CRdRd1)r-M, S(O)p(CRdRd1)r-M, S(O)2NRa(CRdRd1)r-M, NRaS(O)2(CRdRd1)r-M, C(\u2550NCN)NRa1Ra2; C(\u2550C(H)(NO2))NRa1Ra2; a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, two R, together with a carbon atom on A, form the group CA\u2550CRdRd1, where the atom CA is said atom on A;
M is selected from the group consisting of H, C2-10 alkenylene substituted with 0-3 Rb1,
C2-10 alkynylene substituted with 0-3 Rb1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, NRaC(O)Ra, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, R, at each occurrence, is independently selected from C1-10 alkylene-M1,
C2-10 alkenylene-M1, C2-10 alkynylene-M1, (CRdRd1)rO(CRdRd1)r-M1,
(CRdRd1)rNRa(CRdRd1)r-M1, (CRdRd1)rC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)(CRdRd1)r-M1,
(CRdRd1)rOC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)O(CRdRd1)r-M1, (CRdRd1)rNRaC(O)NRa(CRdRd1)r-M1, (CRdRd1)rS(O)p(CRdRd1)r-M1, (CRdRd1)rS(O)2NRa(CRdRd1)r-M1, and (CRdRd1)rNRaS(O)2(CRdRd1)r-M1;
M1 is selected from the group consisting of ORa, Cl, F, Br, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and a 5-10 membered non-aromatic heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd; a C3-C10 carbocycle, C5-C10 heterocycle and wherein said C3-C10 carbocycle and C5-C10 heterocycle are substituted with 1-3 Rh, and CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3;
provided that either two R or M, M1 and the atom to which they are attached do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, N-halogen, O-halogen, S-halogen, S(O)p\u2014O, O\u2014S(O)p, S(O)p\u2014S(O)p group, or C(O)F, C(O)Cl, C(O)Br, or C(O)I reactive group;
Ra, Ra1, and Ra2 at each occurrence are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl;
alternatively, Ra and Ra1 taken together with the nitrogen to which they are attached form a 3 to 8 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rb at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl-(C1-8)alkyl and said C3-10 carbocyclic residue, heterocyclic system,
C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl are optionally substituted with V;
Rb1 at each occurrence is independently selected from the group consisting of ORa, F, \u2014CN, NRaRa1 and S(O)pRa;
Rc at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; a C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rc1 at each occurrence is independently selected from the group consisting of C1-6 alkyl, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, and CH2F, and CHF2;
Rd at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
Rd1 at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
alternatively, Rd and Rd1 taken together with the atom to which they are attached form a 4 to 8 membered ring containing from 0-1 heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rh at each occurrence is independently selected from the group consisting of ORj, NRjRa, CORj, C(O)ORj, C(O)NRjRa, NRaC(O)NRjRa1, OC(O)NRjRa, S(O)pNRjRa1, NRaS(O)pRj, C1-6 alkyl substituted with Rc;
Rj at each occurrence is independently selected from the group consisting of CF3, CHF2, CH2F, CF2CF3, C1-C8 alkyl substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkenyl and alkynyl groups are optionally substituted with C1-C8alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-C10 carbocycle, 5-10 membered heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3, with the proviso that said C3-C10 carbocycle can not be a phenyl group and C3-C10 carbocyclylalkyl can not be a benzyl group;
p at each occurrence is 0, 1, and 2; and
r at each occurrence is 0, or an integer from 1 to 10.
5. A compound according to claim 2, wherein the compound has the formula VA:
wherein J and K are independently selected from the group consisting of \u2014(CH2)n\u2014, NH, NR, O, and n=1-3; with the proviso that J and K can not be an N\u2014N, O\u2014O, or N\u2014O;
n\u2032 is 1 or 2;
P is D-Q-L-Y, wherein
D is absent or is selected from the group consisting of C(O), C(O)NRa1, NRa1C(O), S(O)p, S(O)pNRa1, and NRa1S(O)p;
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb;
L is absent or is selected from the group consisting of O;
Y is selected from the group consisting of H, a C5-7 carbocycle substituted with 0-5 Rc and a 5-6 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rc;
provided that D, Q, L and Y do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, S(O)p\u2014O, O\u2014S(O)p or S(O)p\u2014S(O)p group;
R, at each occurrence, is independently selected from OH, F, Cl, \u2014CN, NO2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, O(CRdRd1)r-M, NRa(CRdRd1)r-M, NRaC(O)(CRdRd1)r-M, OC(O)O(CRdRd1)OC(O)NRa(CRdRd1)r-M, NRaC(O)O(CRdRd1)r-M, NRaC(O)NRa1(CRdRd1)r-M, S(O)p(CRdRd1)r-M, S(O)2NRa(CRdRd1)r-M, NRaS(O)2(CRdRd1)r-M, C(\u2550NCN)NRa1Ra2; C(\u2550C(H)(NO2))NRa1Ra2; a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, two R, together with a carbon atom on the ring bearing J and K form the group CA\u2550CRdRd1, where the atom CA is said atom on the ring bearing J and K;
M is selected from the group consisting of H, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, NRaC(O)Ra, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, R, at each occurrence, is independently selected C1-10 alkylene-M1,
C2-10 alkenylene-M1, C2-10 alkynylene-M1, (CRdRd1)rO(CRdRd1)r-M1,
(CRdRd1)rNRa(CRdRd1)r-M1, (CRdRd1)rC(O)(CRdRd1)r-M1, (CRdRd1)rC(O)O(CRdRd1)r-M1, (CRdRd1)rC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)(CRdRd1)r-M1,
(CRdRd1)rOC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)O(CRdRd1)r-M1, (CRdRd1)rNRaC(O)NRa(CRdRd1)r-M1, (CRdRd1)rS(O)p(CRdRd1)r-M1, (CRdRd1)rS(O)2NRa(CRdRd1)r-M1, and (CRdRd1)rNRaS(O)2(CRdRd1)r-M1;
M1 is selected from the group consisting of ORa, Cl, F, Br, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and a 5-10 membered non-aromatic heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd; a C3-C10 carbocycle, C5-C10 heterocycle and wherein said C3-C10 carbocycle and C5-C10 heterocycle are substituted with 1-3 Rh, and CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3;
provided that either two R or M, M1 and the atom to which they are attached do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, N-halogen, O-halogen, S-halogen, S(O)p\u2014O, O\u2014S(O)p, S(O)p\u2014S(o)p group, or C(O)F, C(O)Cl, C(O)Br, or C(O)I reactive group;
Ra, Ra1, and Ra2 at each occurrence are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl;
alternatively, Ra and Ra1 taken together with the nitrogen to which they are attached form a 3 to 8 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rb at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3;
Rc at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; a C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rc1 at each occurrence is independently selected from the group consisting of C1-6 alkyl, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, and CH2F, and CHF2;
Rd at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRa S(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
Rd1 at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl optionally substituted with Rc1;
alternatively, Rd and Rd1 taken together with the atom to which they are attached form a 4 to 8 membered ring containing from 0-1 heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rh at each occurrence is independently selected from the group consisting of ORj, NRjRa, CORj, C(O)ORj, C(O)NRjRa, NRaC(O)NRjRa1, OC(O)NRjRa, S(O)pNRjRa1, NRaS(O)pRj, C1-6 alkyl substituted with Rc;
Rj at each occurrence is independently selected from the group consisting of CF3, CHF2, CH2F, CF2CF3, C1-C8 alkyl substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, alkylamido, dialkylamido, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkenyl and alkynyl groups are optionally substituted with C1-C8 alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, alkylamido, dialkylamido, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-C10 carbocycle, 5-10 membered heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylamido, dialkylamido, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3, with the proviso that said C3-C10 carbocycle can not be a phenyl group and C3-C10 carbocyclylalkyl can not be a benzyl group;
p at each occurrence is 0, 1, and 2; and
r at each occurrence is 0, or an integer from 1 to 10.
6. A compound according to claim 2, wherein the compound has the formula VIA:
wherein K and W are independently selected from the group consisting of \u2014(CH2)n\u2014, NH, NR, O, and n=1-3, with the proviso that K and W can not be N\u2014N, N\u2014O or O\u2014O;
n\u2032 is 1 or 2;
P is D-Q-L-Y, wherein
D is absent or is selected from the group consisting of C(O), C(O)NRa1, NRa1C(O), S(O)p, S(O)pNRa1, and NRa1S(O)p;
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb;
L is absent or is selected from the group consisting of O,
Y is selected from the group consisting of H, a C5-7 carbocycle substituted with 0-5 Rc and a 5-6 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rc;
provided that D, Q, L and Y do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, S(O)p\u2014O, O\u2014S(O)p or S(O)p\u2014S(O)p group;
R, at each occurrence, is independently selected from OH, F, Cl, \u2014CN, NO2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, O(CRdRd1)r-M, NRa(CRdRd1)rM, NRaC(O)(CRdRd1)r-M, OC(O)O(CRdRd1)r-M, OC(O)NRa(CRdRd1)rM, NRaC(O)O(CRdRd1)r-M, NRaC(O)NRa1(CRdRd1)r-M, S(O)p(CRdRd1)r-M, S(O)2NRa(CRdRd1)r-M, NRaS(O)2(CRdRd1)r-M, C(\u2550NCN)NRa1Ra2;
C(\u2550C(H)(NO2))NRa1Ra2; a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, two R, together with a carbon atom on the ring bearing K and W form the group CA\u2550CRdRd1, where the atom CA is said atom on the ring bearing K and W;
M is selected from the group consisting of H, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, NRaC(O)Ra, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, R, at each occurrence, is independently selected C1-10 alkylene-M1,
C2-10 alkenylene-M1, C2-10 alkynylene-M1, (CRdRd1)rO(CRdRd1)r-M1,
(CRdRd1)rNRa(CRdRd1)r-M1, (CRdRd1)rC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)O(CRdRd1)r-M1, (CRdRd1)rC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)(CRdRd1)r-M1, (CRdRd1)rOC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)O(CRdRd1)r-M1, (CRdRd1)rNRaC(O)NRa(CRdRd1)r-M1, (CRdRd1)rS(O)p(CRdRd1)r-M1, (CRdRd1)rS(O)2NRa(CRdRd1)r-M1, and (CRdRd1)rNRaS(O)2(CRdRd1)r-M1;
M1 is selected from the group consisting of ORa, Cl, F, Br, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and a 5-10 membered non-aromatic heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd; a C3-C10 carbocycle, C5-C10 heterocycle and wherein said C3-C10 carbocycle and C5-C10 heterocycle are substituted with 1-3 Rh, and CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3;
provided that either two R or M, M1 and the atom to which they are attached do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, N-halogen, O-halogen, S-halogen, S(O)p\u2014O, O\u2014S(O)p, S(O)p\u2014S(o)p group, or C(O)F, C(O)Cl, C(O)Br, or C(O)I reactive group;
Ra, Ra1, and Ra2 at each occurrence are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl;
alternatively, Ra and Ra1 taken together with the nitrogen to which they are attached form a 3 to 8 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rb at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3;
Rc at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; a C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl are optionally substituted with Rc1;
Rc1 at each occurrence is independently selected from the group consisting of C1-6 alkyl, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, and CH2F, and CHF2;
Rd at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRa S(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl optionally substituted with Rc1;
Rd1 at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NRaRa1, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl optionally substituted with Rc1;
alternatively, Rd and Rd1 taken together with the atom to which they are attached form a 4 to 8 membered ring containing from 0-1 heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rh at each occurrence is independently selected from the group consisting of ORj, NRjRa, CORj, C(O)ORj, C(O)NRjRa, NRaC(O)NRjRa1, OC(O)NRjRa, S(O)pNRjRa1, NRaS(O)pRj, C1-6 alkyl substituted with Rc;
Rj at each occurrence is independently selected from the group consisting of CF3, CHF2, CH2F, CF2CF3, C1-C8 alkyl substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, alkylamido, dialkylamido, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkenyl and alkynyl groups are optionally substituted with C1-C8 alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, alkylamido, dialkylamido, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-C10 carbocycle, 5-10 membered heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, alkylamido, dialkylamido, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3, with the proviso that said C3-C10 carbocycle can not be a phenyl group and C3-C10 carbocyclylalkyl can not be a benzyl group;
p at each occurrence is 0, 1, and 2; and
r at each occurrence is 0, or an integer from 1 to 10.
7. A compound according to claim 1, wherein the compound is selected from the group consisting of:
wherein:
P is D-Q-L-Y, wherein
D is absent or is selected from the group consisting of O, NRa1, C(O), C(O)NRa1, NRa1C(O), S(O)p, S(O)pNRa1, and NRa1S(O)p;
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb;
L is absent or is selected from the group consisting of O, NRa1, C(O), C(O)NRa1, S(O)p, S(O)pNRa1, and NRa1S(O)p;
Y is selected from the group consisting of H, a C5-7 carbocycle substituted with 0-5 Rc and a 5-6 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rc;
provided that D, Q, L and Y do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, S(O)p\u2014O, O\u2014S(O)p or S(O)p\u2014S(O)p group;
R, at each occurrence, is independently selected from (C1-10 alkylene substituted with 1-3 Rb1)-M, (C2-10 alkenylene substituted with 1-3 Rb1)-M, (C2-10 alkynylene substituted with 1-3 Rb1)-M, OH, F, Cl, \u2014CN, NO2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, O(CRdRd1)r-M, NRa(CRdRd1)r-M, OC(O)(CRdRd1)r-M, NRaC(O)(CRdRd1)r-M, OC(O)O(CRdRd1)r-M, OC(O)NRa(CRdRd1)r-M, NRaC(O)O(CRdRd1)r-M, NRaC(O)NRa1(CRdRd1)r-M, S(O)p(CRdRd1)r-M, S(O)2NRa(CRdRd1)r-M, NRaS(O)2(CRdRd1)r-M, C(\u2550NCN)NRa1Ra2; C(\u2550C(H)(NO2))NRa1Ra2; a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, when two R are located on the same carbon atom, the two R, together with the carbon atom to which they are attached form the group CA\u2550CRdRd1;
M is selected from the group consisting of H, C2-10 alkenylene substituted with 0-3 Rb1,
C2-10 alkynylene substituted with 0-3 Rb1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, NRaC(O)ORa, NRaC(O)Ra, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, a C3-10 carbocycle substituted with 0-5 Rd, and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd;
alternatively, R, at each occurrence, is independently selected C1-10 alkylene-M1;
C2-10 alkenylene-M1, C2-10 alkynylene-M1, (CRdRd1)rO(CRdRd1)r-M1,
(CRdRd1)rNRa(CRdRd1)r-M1, (CRdRd1)rC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)(CRdRd1)r-M1,
(CRdRd1)rC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)(CRdRd1)r-M1,
(CRdRd1)rOC(O)O(CRdRd1)r-M1, (CRdRd1)rOC(O)NRa(CRdRd1)r-M1, (CRdRd1)rNRaC(O)O(CRdRd1)r-M1, (CRdRd1)rNRaC(O)NRa(CRdRd1)r-M1, (CRdRd1)rS(O)p(CRdRd1)r-M1, (CRdRd1)rS(O)2NRa(CRdRd1)r-M1, and (CRdRd1)rNRaS(O)2(CRdRd1)r-M1;
M1 is selected from the group consisting of ORa, Cl, F, Br, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, OS(O)2NRaRa1, S(O)pRa2, CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and a 5-10 membered non-aromatic heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd; a C3-C10 carbocycle, C5-C10 heterocycle and wherein said C3-C10 carbocycle and C5-C10 heterocycle are substituted with 1-3 Rh, and CF3, CF2CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, OCF2CF3 and OCH2CF3;
provided that either two R or M, M1 and the atom to which they are attached do not combine to form a N\u2014N, N\u2014O, O\u2014N, O\u2014O, N-halogen, O-halogen, S-halogen, S(O)p\u2014O, O\u2014S(O)p, S(O)p\u2014S(O)p group, or C(O)F, C(O)Cl, C(O)Br, or C(O)I reactive group;
Ra, Ra1, and Ra2 at each occurrence are independently selected from the group consisting of H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl; C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl;
alternatively, Ra and Ra1 taken together with the nitrogen to which they are attached form a 3 to 8 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rb at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, NRaS(O)2NRaRa1, OS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl-(C1-8)alkyl and said C3-10 carbocyclic residue, heterocyclic system,
C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rb1 at each occurrence is independently selected from the group consisting of ORa, F, \u2014CN, NRaRa1 and S(O)pRa;
Rc at each occurrence is independently selected from the group consisting of C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2,
NRaS(O)2NRaRa1, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; a C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl are optionally substituted with Rc1;
Rc1 at each occurrence is independently selected from the group consisting of C1-6 alkyl, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, OC(O)NRaRa1, RaNC(O)ORa, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, and CH2F, and CHF2;
Rd at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with V, ORa, Cl, F, \u2014CN, NO2, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRa1, RaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1, NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
Rd1 at each occurrence is independently selected from the group consisting of H, C1-6 alkyl optionally substituted with Rc1, ORa, Cl, F, \u2014CN, NRaRa1, C(O)Ra, C(O)ORa, C(O)NRaRaNC(O)NRaRa, OC(O)NRaRa1, RaNC(O)ORa1, S(O)2NRaRa1 NRaS(O)2Ra2, S(O)pRa2, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-10 carbocyclic residue, and a 5-10 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S, C3-C10 carbocyclyl(C1-8)alkyl, and 5-10 heterocyclyl(C1-8)alkyl; said C3-10 carbocyclic residue, heterocyclic system C3-C10 carbocyclyl(C1-8)alkyl, and 5-14 heterocyclyl(C1-8) alkyl optionally substituted with Rc1;
alternatively, Rd and Rd1 taken together with the atom to which they are attached form a 4 to 8 membered ring containing from 0-1 heteroatoms selected from the group consisting of N, O, and S, wherein said ring may be substituted with Rd;
Rh at each occurrence is independently selected from the group consisting of ORj, NRjRa, CORj, C(O)ORj, C(O)NRjRa, NRaC(O)NRjRa1, OC(O)NRjRa, S(O)pNRjRa1, NRaS(O)pRj, C1-6 alkyl substituted with Re;
Rj at each occurrence is independently selected from the group consisting of CF3, CHF2, CH2F, CF2CF3, C1-C8 alkyl substituted with O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C2-C8 alkenyl, C2-C8 alkynyl, wherein said alkenyl and alkynyl groups are optionally substituted with C1-C8 alkyl, O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamidoalkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, OCHF2, and OCH2CF3; C3-C10 carbocycle, 5-10 membered heterocycles, C3-C10 carbocyclylalkyl, heterocyclylalkyl and wherein said C3-C10 carbocycle, heterocycles, C3-C10 carbocyclylalkyl, and heterocyclylalkyl may be optionally substituted with one or more substituents selected from the group consisting of O(primary, secondary, or tertiary)C1-C8, OH, Cl, F, \u2014CN, NO2, alkylamino, dialkylamino, alkarylamino, arylamino, carboxyl, alkylcarboxylate, alkylamido, dialkylamido, alkylureidoalkyl, alkylureidodialkyl, carbamoylalkyl, carbamoyldialkyl, alkylcarbamoyl, sulfonamidoalkyl, sulfonamidodialkyl, N-alkylsulfonamidoalkyl, N-alkylsulfonamido-alkyl, N-alkylsufonamidodialkyl, alkylamidosulfonate, dialkylamidosulfonate, alkylsulfonyl, CF3, CH2F, CHF2, CF2CH3, C(CH3)2F, OCF3, and OCH2CF3, with the proviso that said C3-C10 carbocycle can not be a phenyl group and C3-C10 carbocyclylalkyl can not be a benzyl group;
p at each occurrence is 0, 1, and 2; and
r at each occurrence is 0, or an integer from 1 to 10.
8. A compound according to claim 7, wherein the compound is selected from:
9. A compound according to claim 8, wherein the compound is selected from:
wherein:
M is selected from a C3-10 carbocycle substituted with 0-5 Rd and a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, S(O)p and said heterocycle being substituted with 0-5 Rd.
10. A compound according to claim 9, wherein the compound is:
wherein:
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb; and
Y is aryl substituted with 0-5 Rb.
11. A compound according to claim 9, wherein the compound is:
wherein:
Q is absent or is selected from the group consisting of a C3-13 carbocycle substituted with 0-5 Rb, and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Rb; and
Y is C3-13 carbocycle substituted with 0-5 Rc and a 5-14 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S(O)p, and said heterocycle being substituted with 0-5 Re.
12. A compound according to claim 7, wherein the compound is selected from:
13. The compound according to claim 1, wherein the compound exists in the form of a single enantiomer or diastereomer.
14. A method for treating a disease associated with unwanted metalloprotease activity in a mammalian subject, the method comprising administering to said mammal in need thereof, an effective amount of a metalloprotease inhibitor compound of claim 1.
15. A method for treating a diseases modulated by metalloproteases in a mammalian subject, wherein the disease is selected from the group consisting of arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions by administering to said mammal in need of such treatment, an effective amount of a metalloprotease inhibitor according to claim 1.
16. A method of inhibiting pathological changes mediated by elevated levels of matrix metalloproteases in mammals comprising administering to said mammal in need thereof a therapeutically effective amount of a matrix metalloprotease inhibiting compound according to claim 1.
17. A method for treating a disease associated with unwanted sheddase activity in a mammalian subject, the method comprising administering to said mammal in need thereof, an effective amount of a sheddase inhibitor compound of claim 1.
18. A method for treating a disease associated with unwanted TNF-\u03b1 converting enzyme activity in a mammalian subject, the method comprising administering to said mammal in need thereof, an effective amount of a TNF-\u03b1 converting enzyme inhibitor compound of claim 1.
19. A method for treating a disease associated with unwanted metalloprotease activity wherein said metalloprotease is selected from the group consisiting of MMP12, MMP13, MMP3, MMP2, MMP9 in a mammalian subject, the method comprising administering to said mammal in need thereof, an effective amount of a metalloprotease inhibitor compound of claim 1.
20. A method for treating a disease associated with unwanted Her2 sheddase activity, growth factors and cytokine sheddases in a mammalian subject, the method comprising administering to said mammal in need thereof, an effective amount of a sheddase inhibitor compound of claim 1.
21. A method for treating a disease associated with unwanted ADAM activity wherein said ADAM is selected from the group consisting of ADAM10, ADAM15, ADAM28, ADAM33 in a mammalian subject, the method comprising administering to said mammal in need thereof, an effective amount of a sheddase inhibitor compound of claim 1.
22. A pharmaceutical composition for use in therapy, comprising a compound of claim 1, and a pharmaceutically-acceptable diluent or carrier.
23. A compound according to claim 1 selected from the group consisting of:
(2S,3S,5R)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1 (2H)-ylcarbonyl}-N-hydroxy-5-(3R)-3-hydroxypyrrolidin-1-ylpiperidine-3-carboxamide;
(2S,3S)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1 (2H)-ylcarbonyl}-5-(2-{2-(dimethylamino)ethylamino}-2-oxoethyl)-N-hydroxypiperidine-3-carboxamide;
(2S,3S,5S)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N-hydroxy-5-{2-(3R)-3-hydroxypyrrolidin-1-yl-2-oxoethyl}piperidine-3-carboxamide;
(2S,3S,5R)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1 (2H)-ylcarbonyl}-N-hydroxy-5-{2-(3R)-3-hydroxypyrrolidin-1-yl-2-oxoethyl}piperidine-3-carboxamide;
(2S,3S,5S)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N-hydroxy-5-(2-morpholin-4-yl-2-oxoethyl)piperidine-3-carboxamide;
(2S,3S,5R)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1 (2H)-ylcarbonyl}-N-hydroxy-5-(2-morpholin-4-yl-2-oxoethyl)piperidine-3-carboxamide;
(2S,3S,5S)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N-hydroxy-5-2-(4-hydroxypiperidin-1-yl)-2-oxoethylpiperidine-3-carboxamide;
(2S,3S,5R)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1 (2H)-ylcarbonyl}-N-hydroxy-5-2-(4-hydroxypiperidin-1-yl)-2-oxoethylpiperidine-3-carboxamide;
(2S,3S,5R)-2-{4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl}-N-hydroxy-5-(methoxyacetyl)(methyl)aminopiperidine-3-carboxamide;
(2S,3S,5S)-2-{4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl}-N-hydroxy-5-(methoxyacetyl)(methyl)aminopiperidine-3-carboxamide;
(2S,3S,5S)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N-hydroxy-5-{2-(2-methoxyethyl)amino-2-oxoethyl}piperidine-3-carboxamide;
(2S,3S,5R)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N-hydroxy-5-{2-(2-methoxyethyl)amino-2-oxoethyl}piperidine-3-carboxamide;
(2S,3S,5S)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N-hydroxy-5-{2-oxo-2-(3R)-tetrahydrofuran-3-ylaminoethyl}piperidine-3-carboxamide;
(2S,3S,5R)-2-{4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N-hydroxy-5-{2-oxo-2-(3R)-tetrahydrofuran-3-ylaminoethyl}piperidine-3-carboxamide;
Methyl (3R,5S,6S)-5-(hydroxyamino)carbonyl-6-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidin-3-yl carbonate;
Methyl (3S,5S,6S)-5-(hydroxyamino)carbonyl-6-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidin-3-yl carbonate;
(2S,3S)\u2014N,5-dihydroxy-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(5S,6S)-5-(hydroxyamino)carbonyl-6-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidin-3-yl methylcarbamate;
tetrahydro-2H-pyran-4-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-1-carboxylate;
(3R)-tetrahydrofuran-3-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-1-carboxylate;
(3S)-tetrahydrofuran-3-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-1-carboxylate;
2-methoxyethyl (3R,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-1-carboxylate;
tetrahydro-2H-pyran-4-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
(3R)-tetrahydrofuran-3-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
(3S)-tetrahydrofuran-3-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
2-methoxyethyl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
tetrahydro-2H-pyran-4-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylpiperidine-1-carboxylate;
(3R)-tetrahydrofuran-3-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylpiperidine-1-carboxylate;
(3S)-tetrahydrofuran-3-yl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylpiperidine-1-carboxylate;
2-methoxyethyl (3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylpiperidine-1-carboxylate;
(1S,2S,5S)\u2014N,5-dihydroxy-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-2-{4-phenyl-3,6-dihydropyridin-1(2H)-ylcarbonyl}cyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-2-(4-phenylpiperidin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S)\u2014N-hydroxy-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}-5-pyrrolidin-1-ylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N-hydroxy-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}-5-morpholin-4-ylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}-5-morpholin-4-ylcyclohexanecarboxamide;
(1S,2S)\u2014N-hydroxy-5-(3R)-3-hydroxypyrrolidin-1-yl-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexanecarboxamide;
(1S,2S,5S)-2-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-N,5-dihydroxycyclohexanecarboxamide;
(3S)-tetrahydrofuran-3-yl ((3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl)methylcarbamate;
(3R)-tetrahydrofuran-3-yl ((3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl)methylcarbamate;
tetrahydro-2H-pyran-4-yl ((3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl)methylcarbamate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl pyrrolidine-1-carboxylate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl methylcarbamate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl dimethylcarbamate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl morpholine-4-carboxylate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl (3R)-3-hydroxypyrrolidine-1-carboxylate;
(3S)-tetrahydrofuran-3-yl (2S,3S)-3-(hydroxyamino)carbonyl-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}piperidine-1-carboxylate;
(3R)-tetrahydrofuran-3-yl (2S,3S)-3-(hydroxyamino)carbonyl-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}piperidine-1-carboxylate;
tetrahydro-2H-pyran-4-yl (2S,3S)-3-(hydroxyamino)carbonyl-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}piperidine-1-carboxylate;
(3R)-tetrahydrofuran-3-yl (2S,3S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
(3S)-tetrahydrofuran-3-yl (2S,3S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
tetrahydro-2H-pyran-4-yl (2S,3S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
Benzyl {5-({(5S,6S)-5-(hydroxyamino)carbonyl-6-(3-phenylpyrrolidin-1-yl)carbonylpiperidin-3-yl}acetyl)aminopentyl}carbamate;
(2S,3S)-5-{2(5-aminopentyl)amino-2-oxoethyl}-N-hydroxy-2-(3-phenylpyrrolidin-1-yl)carbonylpiperidine-3-carboxamide;
(1S,2S)\u2014N-Hydroxy-5-(2-oxo-2-piperidin-1-ylethyl)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S)\u2014N-Hydroxy-5-(2-oxo-2-pyrrolidin-1-ylethyl)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S)\u2014N-hydroxy-5-{2-(3R)-3-hydroxypyrrolidin-1-yl-2-oxoethyl}-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S)\u2014N(2)-hydroxy-N(1)-{4-(2-methylquinolin-4-yl)methoxyphenyl}-4-(2-oxo-2-piperidin-1-ylethyl)cyclohexane-1,2-dicarboxamide;
(2S,3S,5R)-2-{4-(3-isopropylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N,5-dihydroxypiperidine-3-carboxamide;
(2S,3S,5S)-2-{4-(3-isopropylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl}-N,5-dihydroxypiperidine-3-carboxamide;
(2S,3S,5R)\u2014N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5R)\u2014N-Hydroxy-5-(2-morpholin-4-yl-2-oxoethyl)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-Hydroxy-5-(2-morpholin-4-yl-2-oxoethyl)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N,5-dihydroxy-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}piperidine-3-carboxamide;
(2S,3S,5R)\u2014N,5-dihydroxy-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}piperidine-3-carboxamide;
(2S,3S,5R)\u2014N-hydroxy-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}-5-(2-morpholin-4-yl-2-oxoethyl)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}-5-(2-morpholin-4-yl-2-oxoethyl)piperidine-3-carboxamide;
(1S,2S)\u2014N-Hydroxy-5-2-(4-methylpiperazin-1-yl)-2-oxoethyl-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S)\u2014N-Hydroxy-5-(2-morpholin-4-yl-2-oxoethyl)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S)\u2014N-Hydroxy-5-{2-(2-methoxyethyl)amino-2-oxoethyl}-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,3S,4S)-3-(Hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl methylcarbamate;
(1S,3S,4S)-3-(Hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl dimethylcarbamate;
(1S,3S,4S)-3-(Hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate;
(1S,3S,4S)-3-(Hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl piperidine-1-carboxylate;
(1S,3S,4S)-3-(Hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl morpholine-4-carboxylate;
(1S,3S,4S)-3-(Hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (3R)-3-hydroxypyrrolidine-1-carboxylate;
(1S,3S,4S)-3-(Hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexylcyclopropylcarbamate;
(3R,4S)\u2014N-Hydroxy-1-(morpholin-4-ylcarbonyl)-4-(4-phenylpiperidin-1-yl)carbonylpiperidine-3-carboxamide;
(3S,5S,6S)-5-(Hydroxyamino)carbonyl-1-methyl-6-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidin-3-yl pyrrolidine-1-carboxylate;
(3R,5S,6S)-5-(Hydroxyamino)carbonyl-1-methyl-6-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidin-3-yl pyrrolidine-1-carboxylate;
(3S)-tetrahydrofuran-3-yl (2S,3S)-2-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylpiperidine-1-carboxylate;
(1R,3S,4 S)-3-(Hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl pyrrolidine-1-carboxylate;
(1R,3S,4 S)-3-(Hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl morpholine-4-carboxylate;
(1R,3S,4 S)-3-(Hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl dimethylcarbamate;
(1R,3S,4 S)-3-(Hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl methylcarbamate;
methyl ((1S,3S,4 S)-3-(Hydoxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl)carbamate;
(1S,2S,5S)\u2014N-Hydroxy-5-(methylsulfonyl)amino-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexanecarboxamide;
(1S,2S,5S)-5-(acetylamino)-N-hydroxy-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexanecarboxamide;
(3R,4S)\u2014N-Hydroxy-4-(4-phenylpiperidin-1-yl)carbonyl-1-(piperidin-1-ylcarbonyl)piperidine-3-carboxamide;
(3R,4S)\u2014N-Hydroxy-4-(4-phenylpiperidin-1-yl)carbonyl-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxamide;
(5S,6S)-5-(Hydroxyamino)carbonyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
(5S,6S)-5-(Hydroxyamino)carbonyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
(1S,2S,5R)\u2014N-Hydroxy-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}-5-(2-oxo-2-piperidin-1-ylethyl)cyclohexanecarboxamide;
(1S,2S,5S)\u2014N-Hydroxy-2-{4-(3-isopropylphenyl)piperidin-1-ylcarbonyl}-5-(2-oxo-2-piperidin-1-ylethyl)cyclohexanecarboxamide;
(2S,3S)\u2014N-Hydroxy-5-(2-oxo-2-piperidin-1-ylethyl)-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(2S,3S,5R)\u2014N-Hydroxy-5-(2-oxo-2-pyrrolidin-1-ylethyl)-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-Hydroxy-5-(2-oxo-2-pyrrolidin-1-ylethyl)-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-5-(2-oxo-2-pyrrolidin-1-ylethyl)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-5-(2-oxo-2-piperidin-1-ylethyl)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)\u2014N-Hydrooxy-1-methyl-5-(2-oxo-2-piperidin-1-ylethyl)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-1-methyl-5-(2-oxo-2-pyrrolidin-1-ylethyl)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-1-methyl-5-(2-oxo-2-piperidin-1-ylethyl)-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-1-methyl-5-(2-oxo-2-pyrrolidin-1-ylethyl)-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(1S,2S,5R)\u2014N-Hydroxy-5-(2-oxo-2-piperidin-1-ylethyl)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(2S,3S)\u2014N-Hydroxy-5-isobutyryl(methyl)amino-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-5-isobutyryl(methyl)amino-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-5-isobutyryl(methyl)amino-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-5-isobutyryl(methyl)amino-2-(4-phenylpiperidin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)\u2014N-Hydroxy-5-isobutyryl(methyl)amino-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(3R,4S)\u2014N-Hydroxy-4-{(3S)-3-phenylpyrrolidin-1-ylcarbonyl}-1-4-(trifluoromethoxy)benzoylpiperidine-3-carboxamide;
(3R,4S)\u2014N-Hydroxy-4-{(3S)-3-phenylpyrrolidin-1-ylcarbonyl}-1-{4-(trifluoromethoxy)phenylsulfonyl}piperidine-3-carboxamide;
(3R,4S)\u2014N-Hydroxy-4-{(3S)-3-phenylpyrrolidin-1-ylcarbonyl}-1-3-(trifluoromethoxy)benzoylpiperidine-3-carboxamide;
(3R,4S)\u2014N-Hydroxy-4-{(3S)-3-phenylpyrrolidin-1-ylcarbonyl}-1-2-(trifluoromethoxy)benzoylpiperidine-3-carboxamide;
(3R,4S)\u2014N-Hydroxy-1-4-(difluoromethoxy)benzoyl-4-{(3S)-3-phenylpyrrolidin-1-ylcarbonyl}piperidine-3-carboxamide;
(5S,6S)-5-(Hydroxyamino)carbonyl-6-{(3S)-3-phenylpyrrolidin-1-ylcarbonyl}piperidin-3-yl pyrrolidine-1-carboxylate;
(5S,6S)-5-(Hydroxyamino)carbonyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
(5S,6S)-5-(Hydroxyamino)carbonyl-6-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
methyl (2S,3S)-3-(Hydroxyamino)carbonyl-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
methyl (2S,3S)-3-(hydroxyamino)carbonyl-2-{(3S)-3-phenylpyrrolidin-1-ylcarbonyl}-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
Methyl (2S,3S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperidin-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
Methyl (2S,3S)-3-(hydroxyamino)carbonyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
Methyl (2S,3S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
(2S,3S)-5-benzoyl(methyl)amino-N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidine-3-carboxamide;
(2S,3S)-5-benzoyl(methyl)amino-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
isopropyl {(5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl}methylcarbamate;
isopropyl {(5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl}methylcarbamate;
(1S,2S,5R)\u2014N,5-dihydroxy-2-{(3R)-3-pyrrolidin-1-ylcarbonyl}-5-propylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-2-{(3R)-3-pyrrolidin-1-ylcarbonyl}-5-propylcyclohexanecarboxamide;
(1S,3S,4S)-4-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylcyclohexyl methylcarbamate;
(1S,3S,4S)-4-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylcyclohexyl dimethylcarbamate;
(1S,3S,4S)-4-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylcyclohexyl cyclopropylcarbamate;
(1S,3S,4S)-4-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylcyclohexyl pyrrolidine-1-carboxylate;
(1S,3S,4S)-4-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylcyclohexyl (3R)-3-hydroxypyrrolidine-1-carboxylate;
(1S,3S,4S)-4-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylcyclohexyl morpholine-4-carboxylate;
(1S,3S,4S)-4-{4-(4-tert-butylphenyl)piperazin-1-ylcarbonyl}-3-(hydroxyamino)carbonylcyclohexyl piperidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl methylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl dimethylcarbamate;
(1R,3S,4 S)-3-(Hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate;
methyl (2S,3S,5S)-5-(3-fluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-3-(trifluoromethyl)phenoxypiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(2,4-difluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(3-chloro-4-fluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(5-chloropyridin-3-yl)oxy-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(3-bromophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-3-yloxy)piperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-6-yloxy)piperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-(3-methylphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-(3-methoxyphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-(6-methylpyridin-2-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-(2-methylquinolin-4-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-phenoxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(3-chlorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(2,3-difluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-4-yloxy)piperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-4-yloxy)piperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-(4-methylpyridin-2-yl)oxy-2-4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(2-fluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-(2-methylphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(4-fluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(3,5-difluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(3-fluorophenoxy)-3-(hydroxyamino)carbonyl-2(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(1,3-benzothiazol-2-yloxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(3,4-difluorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyridin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(4-methylpyridin-2-yl)oxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-phenoxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)-5-(3-fluorophenoxy)-N-hydroxy-1-methyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(quinolin-6-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(2-methylquinolin-4-yl)oxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)-5-(3,5-difluorophenoxy)-N-hydroxy-1-methyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(quinolin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenylpiperidin-1-yl)carbonyl-5-(pyridin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)oxy-2-(4-phenylpiperidin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(4-methylpyridin-2-yl)oxy-2-(4-phenylpiperidin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenylpiperidin-1-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-(methylsulfonyl)-5-phenoxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(3S)-tetrahydrofuran-3-yl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-phenoxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(2-bromophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(2-chlorophenoxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
tetrahydro-2H-pyran-4-yl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-phenoxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
ethyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-phenoxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
(2S,3S,5S)\u2014N-hydroxy-5-(3-methylphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-3-(trifluoromethyl)phenoxypiperidine-3-carboxamide;
(2S,3S,5S)-5-(3-chlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(3-methoxyphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)-5-(3-fluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl piperidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl azepane-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl dimethylcarbamate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl 2,5-dihydro-1H-pyrrole-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-6-(1,3-dihydro-2H-benzoeisoindol-2-ylcarbonyl)-5-(hydroxyamino)carbonyl-1-methylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-ylpiperidine-1-carboxylate;
(3S,5S,6S)-6-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-(hydroxyamino)carbonyl-1-methylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidin-3-ylpyrrolidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-yl azepane-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-yl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-ylpiperidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-yl dimethylcarbamate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-((2S)-2-(hydroxymethyl)pyrrolidin-1-ylcarbonyloxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-2-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-3-(hydroxyamino)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(piperidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
Methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-4-phenylpiperazin-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(3-phenylpyrrolidin-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(dimethylamino)carbonyloxy-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperidin-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)oxypiperidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-ylpyrrolidine-1-carboxylate;
(3S,5S,6S)-6-(1,3-dihydro-2H-benzoeisoindol-2-ylcarbonyl)-5-(hydroxyamino)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-6-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-(hydroxyamino)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-yl azetidine-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-yl pyrrolidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-(2-oxo-2-pyrrolidin-1-ylethoxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(phenylthio)piperidine-1-carboxylate;
methyl (2S,3S,5S)-5-(allyloxy)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-propoxypiperidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-5-methoxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
(2S,3S,5S)-5-tert-butoxy-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
methyl (2S,3S,5S)-5-tert-butoxy-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-1-carboxylate;
(3R,4S)-1-(E)-(cyanoimino)(pyrrolidin-1-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(E)-azetidin-1-yl(cyanoimino)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(dimethylamino)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(cyclopropylamino)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(piperidin-1-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(Z)-(cyanoimino)(morpholin-4-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(Z)-(cyanoimino)(hydroxyamino)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(E)-azepan-1-yl(cyanoimino)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(Z)-(cyanoimino)(4-methylpiperazin-1-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(Z)-(cyanoimino)(thiomorpholin-4-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(4-methylpiperidin-1-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(Z)-(cyanoimino)(2,5-dihydro-1H-pyrrol-1-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(Z)-(cyanoimino)(1,3-dihydro-2H-isoindol-2-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(Z)-(cyanoimino)(3,4-dihydroisoquinolin-2(1H)-yl)methyl-N-hydroxy-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)\u2014N-hydroxy-1-(Z)-1-(hydroxyamino)-2-nitrovinyl-4-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(piperidin-1-yl)methyl-4-(4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(dimethylamino)methyl-4-4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-azepan-1-yl(cyanoimino)methyl-4-4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(pyrrolidin-1-yl)methyl-4-4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(cyclopropylamino)methyl-4-4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-azetidin-1-yl(cyanoimino)methyl-4-(4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(1S,2S,5E)-5-benzylidene-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5E)-5-(cyclopropylmethylene)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5S)-5-benzyl-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N,5-dihydroxy-5-phenyl-2-(4-phenylpiperazin-1-yl)carbonyl-cyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5R)-5-benzyl-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-cyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5R)\u2014N,5-dihydroxy-5-isopropyl-2-(4-phenylpiperazin-1-yl)carbonyl-cyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5R)-5-cyclopropyl-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-cyclohexanecarboxamide trifluoroacetate (salt);
(2S,3S,5R)-2-(4-(4-cyano-2-methylphenyl)piperidin-1-ylcarbonyl-N-hydroxy-5-(2-oxo-2-pyrrolidin-1-ylethyl)piperidine-3-carboxamide;
isopropyl (5S,6S)-5-(hydroxyamino)carbonyl-6-(4-phenylpiperidin-1-yl)carbonylpiperidin-3-ylmethylcarbamate;
(1S,2S)\u2014N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)cyclohexanecarboxamide;
N-cyclopropyl-N-({(3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl}methyl)morpholine-4-carboxamide;
(1S,2S,5S)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(piperidin-1-ylcarbonyl)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(piperidin-1-ylcarbonyl)cyclohexanecarboxamide;
(1S,2S,5S)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyrrolidin-1-ylcarbonyl)cyclohexanecarboxamide;
(1S,2S)\u2014N-hydroxy-5-(morpholin-4-ylcarbonyl)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
N-cyclopentyl-N-({(3S,4S,5S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl}methyl)piperidine-1-carboxamide;
N-cyclopentyl-N-({(3S,4S,5R)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl}methyl)piperidine-1-carboxamide;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl dimethylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl piperidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl methylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl dimethylcarbamate;
(1S,2S,5R)\u2014N,5-dihydroxy-2-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexanecarboxamide;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl dimethylcarbamate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl methylcarbamate;
(1S,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl morpholine-4-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl methylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-{(3R)-3-phenylpyrrolidin-1-ylcarbonyl}cyclohexyl morpholine-4-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl dimethylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl piperidine-1-carboxylate;
N-{(1R,3S,4 S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl}-N-methylazetidine-1-carboxamide;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl diethylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl methylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl methylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl dimethylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexyl morpholine-4-carboxylate;
(1S,2S,5R)\u2014N,5-dihydroxy-5-methyl-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-5-methyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1R,3R,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (3R)-3-hydroxypyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl dimethylcarbamate;
(1S,2S,5R)-5-allyl-N,5-dihydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-allyl-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)-5-allyl-N,5-dihydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)-5-allyl-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N,5-dihydroxy-5-methyl-2-(4-phenylpiperidin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-5-methyl-2-(4-phenylpiperidin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-5-methyl-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N,5-dihydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-propylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-propylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-phenoxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(6-methylpyridin-3-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(4-methylphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(2,3-difluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(6-methylpyridin-2-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(2-methylquinolin-4-yl)oxycyclohexanecarboxamide;
(1S,2S,5R)-5-(3,4-difluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(5-chloropyridin-3-yl)oxy-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-1-(methylsulfonyl)piperidin-4-yloxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(2,4-dichlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
methyl 4-((1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyloxy)piperidine-1-carboxylate;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-3-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)-5-(4-fluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(1-ethylpiperidin-4-yl)oxy-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(1-ethylpiperidin-4-yl)oxy-N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-6-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)-5-(2,3-dichlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(benzyloxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(4-methylpyridin-2-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3-fluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-4-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)-5-(1-acetylpiperidin-4-yl)oxy-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(2-methylpyridin-3-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-3,5-bis(trifluoromethyl)phenoxy-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(2-chlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(4-chlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3-bromophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(1,3-benzothiazol-2-yloxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3-chlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyrimidin-2-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-3-(trifluoromethyl)phenoxycyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-4-yloxy)cyclohexanecarboxamide, and (1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(thieno3,2-bpyridin-7-yloxy)cyclohexanecarboxamide.
24. A compound according to claim 1 selected from the group consisting of:
(1S,2S,5R)\u2014N-hydroxy-5-isobutyryl(methyl)amino-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl cyclopropylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl ethylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl methylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl isopropylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl prop-2-yn-1-ylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl piperidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl 4-methylpiperazine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperidin-1-yl)carbonylcyclohexyl carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (1-methylpiperidin-4-yl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl isobutyl(methyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl methyl(3-phenylpropyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl cyclohexyl(methyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (4-methoxyphenyl)methylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl indoline-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl 1,3-dihydro-2H-isoindole-2-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (2-phenylcyclopropyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl cyclobutylcarbamate;
ethyl 4-{({(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl}oxy)carbonylamino}piperidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl tetrahydrofuran-3-ylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (4-hydroxycyclohexyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (2-methoxyethyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (pyridin-2-ylmethyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (pyridin-3-ylmethyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (pyridin-4-ylmethyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl 2,5-dihydro-1H-pyrrole-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl cyclopentylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl cyclohexylcarbamate;
ethyl (1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl piperazine-1,4-dicarboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl 4-{2-methyl(phenyl)amino-2-oxoethyl}piperazine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl 4-hydroxypiperidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (3R)-3-(acetylamino)pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (3S)-3-(acetylamino)pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (2 S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl1-(hydroxymethyl)cyclopentylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(1R,2R)-2-hydroxycyclopentylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl2-(hydroxymethyl)cyclohexylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(2R)-2-hydroxycyclohexylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(1R)-2-hydroxy-1-phenylethylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(1R)-2-hydroxy-1-methylethylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(1R)-1-(hydroxymethyl)propylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(1R)-1-(hydroxymethyl)-2-methylpropylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(2R)-2-hydroxypropylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl (3-hydroxy-1-phenylpropyl)carbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl(1R)-1-(hydroxymethyl)-3-methylbutylcarbamate;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl 4-formylpiperazine-1-carboxylate;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-3-ylmethoxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-2-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-6-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)-5-(1-ethylpiperidin-4-yl)oxy-N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(4-hydroxyphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(4-methoxycyclohexyl)oxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(4-methoxyphenoxy)-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(4-methoxycyclohexyl)oxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-{2-(trifluoromethyl)quinolin-4-yloxy}cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-2-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-3-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-5-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-7-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-8-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyridin-2-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyridin-4-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(quinolin-6-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)-5-(1-ethylpiperidin-4-yl)oxy-N-hydroxy-2-(4-phenylpiperidin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperidin-1-yl)carbonyl-5-(pyridin-2-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperidin-1-yl)carbonyl-5-(pyridin-4-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-2-(4-phenylpiperidin-1-yl)carbonyl-5-(quinolin-6-yloxy)cyclohexanecarboxamide;
(1S,2S,5R)-5-(3-chlorophenoxy)-N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3,4-difluorophenoxy)-N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(2,3-difluorophenoxy)-N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(isoquinolin-1-yloxy)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(isoquinolin-3-yloxy)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(isoquinolin-5-yloxy)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(isoquinolin-7-yloxy)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(2-naphthyloxy)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(2,4-difluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3,5-difluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3-chloro-4-fluorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3,4-dichlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(3,5-dichlorophenoxy)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(2,5-dioxopyrrolidin-1-yl)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-(5,5-dimethyl-2,4-dioxo-1,3-oxazolidin-3-yl)-N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5R)\u2014N-hydroxy-5-(3-methyl-2,5-dioxoimidazolidin-1-yl)-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl 2,5-dihydro-1H-pyrrole-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl azepane-1-carboxylate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl dimethylcarbamate;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl azocane-1-carboxylate;
(2S,3S,5S)-5-(2-fluorophenoxy)-N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(6-methylpyridin-2-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)-5-(3-fluorophenoxy)-N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)-5-(1,3-benzothiazol-2-yloxy)-N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(3-methylphenoxy)-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(4-methylpyridin-2-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)-5-(3,4-difluorophenoxy)-N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)-5-(2-chlorophenoxy)-N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-phenylpiperazin-1-yl)carbonylpiperidin-3-yl 3,3-difluoropyrrolidine-1-carboxylate;
methyl (2S,3S,5S)-3-(hydroxyamino)carbonyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-6-yloxy)piperidine-1-carboxylate;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(pyridin-3-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(pyridin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)-5-(3-fluorophenoxy)-N-hydroxy-1-methyl-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-phenoxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(4-methylpyridin-2-yl)oxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(6-methylpyridin-2-yl)oxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-3-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(2-methylquinolin-4-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(2-methylquinolin-4-yl)oxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(4-phenylpiperazin-1-yl)carbonyl-5-(quinolin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(quinolin-6-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(quinolin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(4-phenylpiperazin-1-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-1-methyl-5-(4-methylpyridin-2-yl)oxy-2-(4-phenylpiperazin-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)-5-(5-chloropyridin-3-yl)oxy-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxy-5-(6-methylpyridin-2-yl)oxypiperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxy-5-(4-methylpyridin-2-yl)oxypiperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxy-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxy-5-phenoxypiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxy-5-(3-methyl-1H-pyrazol-5-yl)oxypiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(5-methylisoxazol-3-yl)oxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(3-methyl-1H-pyrazol-5-yl)oxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(2S,3S,5S)-5-(5-chloropyridin-3-yl)oxy-N-hydroxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(4-methylpyridin-2-yl)oxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-5-(3,4-difluorophenoxy)-N-hydroxypiperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxy-5-5-methylisoxazol-3-yl)oxypiperidine-3-carboxamide;
(2S,3S,5S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxy-5-(2-methylquinolin-4-yl)oxypiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(2-methylquinolin-4-yl)oxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(2S,3S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-5,5-difluoro-N-hydroxy-1-methylpiperidine-3-carboxamide;
(2S,3S)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-5,5-difluoro-N-hydroxypiperidine-3-carboxamide;
(2S,3S)-5,5-difluoro-N-hydroxy-2-4-(3-isopropylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-1-methylpiperidine-3-carboxamide;
(2S,3S)-5,5-difluoro-N-hydroxy-2-4-(3-isopropylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonylpiperidine-3-carboxamide;
(2S,3S)-5,5-difluoro-N(3)-hydroxy-1-methyl-N(2)-4-(2-methylquinolin-4-yl)methoxyphenylpiperidine-2,3-dicarboxamide;
(2S,3S)-5,5-difluoro-N(3)-hydroxy-N(2)-4-(2-methylquinolin-4-yl)methoxyphenylpiperidine-2,3-dicarboxamide;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-6-(4-(2-methylquinolin-4-yl)methoxyphenylamino)carbonylpiperidin-3-yl azepane-1-carboxylate;
(2S,3S,5R)-5-fluoro-N(3)-hydroxy-N(2)-4-(2-methylquinolin-4-yl)methoxyphenylpiperidine-2,3-dicarboxamide;
(3S,5S,6S)-5-(hydroxyamino)carbonyl-1-methyl-6-(4-(2-methylquinolin-4-yl)methoxyphenylamino)carbonylpiperidin-3-yl azepane-1-carboxylate;
(3S,5S,6S)-6-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-5-(hydroxyamino)carbonylpiperidin-3-yl azepane-1-carboxylate;
(2S,3S,5R)-5-fluoro-N-hydroxy-1-methyl-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(2S,3S,5R)-5-fluoro-N-hydroxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-phenoxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(pyridin-2-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(pyridin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(pyridin-3-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(6-methylpyridin-2-yl)oxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(4-methylpyridin-2-yl)oxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)-5-(3-fluorophenoxy)-N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(quinolin-6-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(quinolin-7-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl-5-(quinolin-4-yloxy)piperidine-3-carboxamide;
(2S,3S,5S)\u2014N-hydroxy-5-(2-methylquinolin-4-yl)oxy-2-(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonylpiperidine-3-carboxamide;
(2S,3S,5R)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-5-fluoro-N-hydroxypiperidine-3-carboxamide;
(2S,3S,5R)-5-fluoro-N-hydroxy-2-4-(3-isopropylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonylpiperidine-3-carboxamide;
(2S,3S,5R)-2-4-(4-cyano-3,5-dimethylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-5-fluoro-N-hydroxy-1-methylpiperidine-3-carboxamide;
(2S,3S,5R)-5-fluoro-N-hydroxy-2-4-(3-isopropylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-1-methylpiperidine-3-carboxamide;
(1S,2S,5E)-5-benzylidene-2-4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxycyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5E)-2-4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-5-(cyclopropylmethylene)-N-hydroxycyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5E)-5-benzylidene-N-hydroxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylcyclohexanecarboxamide;
(1S,2S,5S)\u2014N,5-dihydroxy-5-isobutyl-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1S,2S,5S)-5-butyl-N,5-dihydroxy-2-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonylcyclohexanecarboxamide;
(1R,3S,4S)-3-(hydroxyamino)carbonyl-1-methyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl azetidine-1-carboxylate trifluoroacetate (salt);
(1S,3S,4S)-3-(hydroxyamino)carbonyl-1-methyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate trifluoroacetate (salt);
(1S,2S,5S)\u2014N,5-dihydroxy-5-isobutyl-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5R)-5-(cyclopropylmethyl)-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide trifluoroacetate (salt);
(1S,2S,5R)-5-butyl-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide trifluoroacetate (salt);
(1R,3S,4S)-3-(hydroxyamino)carbonyl-1-methyl-4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl pyrrolidine-1-carboxylate trifluoroacetate (salt);
(1S,2S,5E)-5-(cyclopropylmethylene)-N-hydroxy-2-(3R)-3-phenylpyrrolidin-1-ylcarbonylcyclohexanecarboxamide;
(1S,2S,5R)-5-ethyl-N,5-dihydroxy-2-(4-phenylpiperazin-1-yl)carbonylcyclohexanecarboxamide trifluoroacetate (salt);
(3R,4S)-1-(E)-(cyanoimino)(cyclopropylamino)methyl-4-4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(dimethylamino)methyl-4-4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(piperidin-1-yl)methyl-4-(4-(4-cyano-2-methylphenyl)piperazin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-azetidin-1-yl(cyanoimino)methyl-4-(4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-azetidin-1-yl(cyanoimino)methyl-4-(4-(4-cyano-2-methylphenyl)piperidin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(pyrrolidin-1-yl)methyl-4-4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1(2H)-ylcarbonyl-N-hydroxypiperidine-3-carboxamide;
(3R,4S)-1-(E)-(cyanoimino)(piperidin-1-yl)methyl-4-(4-(4-cyano-2-methylphenyl)-3,6-dihydropyridin-1 (2H)-ylcarbonyl-N-hydroxypiperidine-3-carboxamide, and (3R,4S)-1-(E)-(cyanoimino)(piperidin-1-yl)methyl-4-(4-(4-cyano-2-methylphenyl)piperidin-1-ylcarbonyl-N-hydroxypiperidine-3-carboxamide.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A magneto-rheological (MR) clutch system comprising:
first and second drive members;
a first driven member spaced from the first drive member such that a first gap is present between the first drive member and the first driven member;
a second driven member spaced from the second drive member such that a second gap is present between the second drive member and the second driven member;
a drive wheel and a snow blower impeller being operably connected to the first and second driven members, respectively;
first and second quantities of MR fluid disposed in the first and second gaps, respectively; and
first and second magnetic field generation assemblies, the first magnetic field generation assembly being operable to apply a first magnetic field to the first quantity of MR fluid to engage the first drive member with the first driven member for engaging the drive wheel, and the second magnetic field generation assembly being operable to apply a second magnetic field to the second quantity of MR fluid to engage the second drive member with the second driven member for engaging the snow blower impeller, the engagement of the snow blower impeller and the engagement of the drive wheel being independently controllable.
2. The MR clutch system of claim 1 wherein the first and second drive members comprise first and second drive rotors, respectively, positioned in the first and second quantities of MR fluid, respectively.
3. The MR clutch system of claim 1 wherein the first and second driven members comprise first and second driven rotors, respectively, positioned in the first and second quantities of MR fluid, respectively.
4. The MR clutch system of claim 1 wherein the first and second magnetic field generation assemblies comprise first and second magnets, respectively, the first magnet being selectively positionable with respect to the first quantity of MR fluid for controlling engagement of the first driven member with the first drive member, and the second magnet being selectively positionable with respect to the second quantity of MR fluid for controlling engagement of the second driven member with the second drive member.
5. The MR clutch system of claim 1 wherein the first and second magnetic field generation assemblies comprise first and second electromagnets, respectively, the first electromagnet configured to apply the first magnetic field to the first quantity of MR fluid, the second electromagnet configured to apply the second magnetic field to the second quantity of MR fluid.
6. A magneto-rheological (MR) brake system comprising:
first and second driven members;
a drive wheel and a snow blower impeller being operably connected to the first and second driven members, respectively;
a first brake assembly defining a first chamber having a first quantity of MR fluid disposed therein and having a first braking structure positioned in the first chamber and connected to the first driven member;
a second brake assembly defining a second chamber having a second quantity of MR fluid disposed therein and having a second braking structure positioned in the second chamber and connected to the second driven member; and
first and second magnetic field generation assemblies, the first magnetic field generation assembly being operable to apply a first magnetic field to the first quantity of MR fluid for controlling engagement of the first braking structure with the first brake assembly to brake the drive wheel, and the second magnetic field generation assembly operable to apply a second magnetic field to the second quantity of MR fluid for controlling engagement of the second braking structure with the second brake assembly to brake the snow blower impeller.
7. The MR brake system of claim 6 wherein the first and second magnetic field generation assemblies comprise first and second magnets, respectively, the first magnet being selectively positionable with respect to the first MR fluid for controlling engagement of the first braking structure with the first brake assembly, and the second magnet being selectively positionable with respect to the second MR fluid for controlling engagement of the second braking structure with the second brake assembly.
8. The MR brake system of claim 6 wherein the first and second magnetic field generation assemblies comprise first and second electromagnets, respectively, the first electromagnet being configured to apply the first magnetic field to the first quantity of MR fluid, and the second electromagnet being configured to apply the second magnetic field to the second quantity of MR fluid.
9. A transmission apparatus for power equipment, comprising:
a prime mover, a drive wheel, and a snow blower impeller;
first and second drive members operably connected to the prime mover;
a first driven member spaced from the first drive member such that a first gap is present between the first drive member and the first driven member, the first driven member being connected to the drive wheel;
a second driven member spaced from the second drive member such that a second gap is present between the second drive member and the second driven member, the second driven member being connected to the snow blow impeller;
first and second quantities of MR fluid disposed in the first and second gaps, respectively; and
first and second magnetic field generation assemblies, the first magnetic field generation assembly being operable to apply a first magnetic field to the first quantity of MR fluid to engage the first drive member with the first driven member for engaging the drive wheel, and the second magnetic field generation assembly being operable to apply a second magnetic field to the second quantity of MR fluid to engage the second drive member with the second driven member for engaging the snow blower impeller, the engagement of the snow blower impeller and the engagement of the drive wheel being independently controllable.
10. The transmission apparatus of claim 9 comprising:
a brake assembly defining a chamber having a third quantity of MR fluid disposed therein and having a braking structure positioned in the chamber and connected to the second driven member; and
a third magnetic field generation assembly configured to selectively apply a third magnetic field to the third quantity of MR fluid to control engagement of the braking structure with the brake assembly to brake the second driven member and the snow blower impeller.
11. A magneto-rheological (MR) clutch system comprising:
a drive member;
at least one driven member spaced from the drive member such that a gap is present between the drive and driven members;
a mower blade being operably connected to the driven member;
a quantity of MR fluid disposed in the gap present between the drive and driven members; and
a magnetic field generation assembly operable to apply a magnetic field to the quantity of MR fluid to engage the drive member with the driven member for engaging the mower blade.
12. The MR clutch system of claim 11 wherein the magnetic field generation assembly comprises a magnet selectively positionable with respect to the MR fluid for controlling engagement of the driven member with the drive member.
13. The MR clutch system of claim 11 wherein the quantity of MR fluid is a first quantity of MR fluid;
wherein the MR clutch system comprises a brake assembly defining a chamber having a second quantity of MR fluid disposed therein and having a braking structure positioned in the chamber and connected to the driven member; and
wherein the magnetic field generation assembly is configured to selectively apply a magnetic field to the second quantity of MR fluid for controlling engagement of the braking structure with the brake assembly to brake the driven member.
14. A magneto-rheological (MR) brake system comprising:
a driven member;
a mower blade being operably connected to the driven member;
a brake assembly defining a chamber having a quantity of MR fluid disposed therein and having a braking structure positioned in the chamber and connected to the driven member; and
a magnetic field generation assembly operable to apply a magnetic field to the quantity of MR fluid to control engagement of the braking structure with the brake assembly to brake the mower blade.
15. The MR brake system of claim 14 wherein the magnetic field generation assembly comprises an electromagnet configured to apply the magnetic field to the quantity of MR fluid.