1. A method of modulating the level of high-density-lipoprotein cholesterol in a mammal, which comprises administering to said mammal a therapeutically effective amount of an ester derivative of fluphenazine having the formula (I)
or a pharmaceutical acceptable salt thereof, wherein \u201cR\u201d is a 2 to 18 carbon atom-containing substituent with an acyclic carbonyl-terminated linker covalently bound to the fluphenazine moiety via the carbonyl terminus.
2. The method of claim 1, wherein R is a substituent including five to fourteen carbons atoms projecting a substantially planar face.
3. The method of claim 2, wherein R is a substituent having a substantially planar geometry except for the acyclic carbonyl linker.
4. The method of 3, wherein R is a cyclic ring structure being independently selected from the group consisting of a substituted or unsubstituted aromatic ring structure, a substituted or unsubstituted non-aromatic cyclic ring structure, a substituted or unsubstituted heterocyclic ring structure, and combinations thereof.
5. The method of claim 4, wherein said cyclic ring structure is independently selected from the group consisting of a monocyclic structure, a fused bicyclic structure and a fused tricyclic ring structure and combinations thereof.
6. The method of claim 1, wherein R is selected from the group consisting of
wherein R1 and R2 are independently hydrogen, methyl or ethyl, \u201cZ\u201d is methylene, oxygen, nitrogen or sulfur; \u201cX\u201d is independently a C1-4 alkyl group, a halogen atom, a nitro group or C1-4 alkyl ether groups, and \u201cn\u201d is 0 to 5 for formula (IIa) and 0 to 7 for formula (IIb), with the proviso that if \u201cn\u201d is greater than 1, \u201cX\u201d attached to the aromatic ring is same or different.
7. The method of claim 1, wherein R is selected from the group consisting of
wherein R1 and R2 are independently hydrogen, methyl or ethyl, \u201cZ\u201d is methylene, oxygen, nitrogen or sulfur; \u201cX\u201d is independently a C1-4 alkyl group, a halogen atom, a nitro group or C1-4 alkyl ether groups, and \u201cn\u201d is 0 to 5 for formula (IIIa), 0 to 4 for formula (IIIb), and 0 to 7 for formula (IIIc), with the proviso that if \u201cn\u201d is greater than 1, \u201cX\u201d attached to the ring is the same or different.
8. The method of claim 1, wherein R is formula (IIa), R1 and R2 are methyl, Z is oxygen, X is chlorine and n is 1.
9. The method of claim 1, wherein said ester derivative of fluphenazine is fluphenazine 4-chlorophenoxyisobutyric acid ester.
10. The method of claim 1, wherein said mammal is in need of treatment.
11. The method of claim 1, wherein said mammal is a human.
12. The method of claim 1, wherein said ester derivative is administered in the amount of at least 0.1 mgkg.
13. The method of claim 12, wherein said ester derivative is administered in an amount from 0.3 mgkg.
14. The method of claim 1, wherein said ester derivative is administered in an amount that does not provide said mammal with a neuroleptic effect.
15. The method of claim 1, where said mammal exhibits at least a 10 percent increase in HDL-C levels.
16. The method of claim 1, where said mammal exhibits at least a 20 percent increase in HDL-C levels.
17. A pharmaceutical formulation for modulating the level of high-density-lipoprotein cholesterol in a mammal, which comprises:
a therapeutically effective amount of an ester derivative of fluphenazine having the formula (I)
or a pharmaceutical acceptable salt thereof, wherein \u201cR\u201d is a 2 to 18 carbon atom-containing substituent with an acyclic carbonyl-terminated linker covalently bound to the fluphenazine moiety via the carbonyl terminus; and
a pharmaceutically acceptable carrier.
18. The formulation according to claim 17, wherein said ester derivative of fluphenazine is fluphenazine 4-chlorophenoxyisobutyric acid ester.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A mortise and tenon joint adapter system for making mortises and tenons in work pieces in combination with a jig base having a base top surface, an abutting base front surface, a top hold down bar and a front hold down bar and a router having a bit and a guide bushing, said system comprising:
a template support adapted to mount on said base top surface, and including a top face having a horizontal rear portion and an upwardly spaced, horizontal front portion, said rear portion being secured by said top hold down bar, a mortise shelf including a vertical support portion and a horizontal shelf portion extending forwardly from said support portion, said support portion being adapted to mount on said base front surface with vertical adjustability and secured by said front hold down bar under said shelf portion, said mortise shelf including means for clamping a laterally extending mortise workpiece, and at least one template mountable on said front portion of said top face of said template support, and including a mortising slot and a tenoning slot with each said mortising and tenoning slot being sized to provide two sided guidance of said guide bushing.
2. The system as set forth in claim 1 wherein each said template is adjustable forwardly and rearwardly relative to said template support.
3. The system as set forth in claim 2 wherein said front portion of said top face of said template support includes two laterally spaced, upwardly projecting template guides that extend perpendicular to said base front surface, and two laterally spaced threaded template support apertures between said template guides, and
each said template is sized to fit between said template guides, and includes a pair of spaced template support slots parallel to said template guides that are located one each over a said template support aperture and a pair of threaded fasteners that each extend through a said template support slot and into a said template support aperture.
4. The system as set forth in claim 1 wherein said at least one template includes a plurality of mortising slots and a plurality of tenoning slots.
5. The system as set forth in claim 4 wherein said at least one template includes a mortise template having said mortising slots and a tenoning template having said tenoning slots.
6. The system as set forth in claim 1 wherein said template includes a plurality of first mortising slots parallel to said base front surface and a plurality of second mortising slots perpendicular to said first mortising slots.
7. The system as set forth in claim 1
wherein each said mortising slot and tenoning slot has an upwardly opening upper channel, a downwardly opening lower channel and an intermediate passage connecting said upper and lower channels, and
said template includes at least one slidably adjustable movable stop having an upper piece sized and shaped to fit into a said upper channel, a lower piece sized and shaped to fit into a said lower channel, and a screw connecting said upper and lower pieces.
8. The system as set forth in claim 1 wherein said tenoning slot includes a laterally extending lateral section and a pair of spaced end sections that extend rearwardly from opposite ends of said lateral section.
9. The system as set forth in claim 1 wherein said shelf portion of said mortise shelf includes a pair of spaced, opposed end sections that extend laterally beyond jig base, said support portion includes a raised section that extends above said shelf portion, and said means for clamping includes a shelf hold down bar on each said end section and a sliding clamp opposite said raised section, said sliding clamp being forwardly and rearwardly adjustable, and having a raised portion that, in combination with said raised section of said support portion, clamps said mortise workpiece.
10. The system as set forth in claim 1 including a layout guide having a front edge and a plurality of spaced guide lines at selected precise distances from and parallel to said front edge, with said distances being selected as the radius of said guide bushing and the difference between the radius of said guide bushing and the radius of said bit, for different said guide bushing and bit sizes.
11. A mortise and tenon joint adapter system for making mortises and tenons in work pieces in combination with a jig base having a base top surface, an abutting base front surface, a top hold down bar and a front hold down bar and a router having a bit and a guide bushing, said system comprising:
a template support adapted to mount on said base top surface, and including a top face having a horizontal rear portion and an upwardly spaced, horizontal front portion, with said rear portion being secured by said top hold down bar, said front portion including two laterally spaced, upwardly projecting template guides that extend perpendicular to said base front surface and two laterally spaced threaded template support apertures between said template guides,
a mortise shelf including a vertical support portion and a horizontal shelf portion extending forwardly from said support portion, said support portion being adapted to mount on said base front surface with vertical adjustability and to be secured by said front hold down bar under said shelf portion, said support portion including a raised section that extends above said shelf portion, said shelf portion including a pair of spaced, opposed end sections that extend laterally beyond jig base with each said end section having a shelf hold down bar, said shelf portion including a sliding clamp opposite said raised section, said sliding clamp being forwardly and rearwardly adjustable, and having a raised portion that, in combination with said raised section of said support portion and further in conjunction with one of said shelf hold down bars, clamps a mortise workpiece,
a mortise template sized and shaped to mount on said front portion of said top face of said template support between said template guides, and having a pair of spaced elongated mortise template support slots extending parallel to said template guides and located one each over a said template support aperture, and a machine screw extending through each said mortise template support slot into a said template support aperture, said mortise template including a plurality of spaced first mortising slots perpendicular to said mortise template support slots sized to provide two sided guidance of said guide bushing and a plurality of spaced second mortising slots parallel to said mortise template support slots sized to provide two sided guidance of said guide bushing, said first and second mortising slots each having an upwardly opening upper,channel, a downwardly opening lower channel and an intermediate passage connecting said upper and lower channels, and said first and second mortising slots having slidably adjustable movable stops each having an upper piece sized and shaped to fit into a said upper channel, a lower piece sized and shaped to fit into a said lower channel, and a screw connecting said upper and lower pieces,
a tenon template sized and shaped to mount on said front portion of said top face of said template support between said template guides, and having a pair of spaced elongated tenon template support slots extending parallel to said template guides and located one each over a said template support aperture, and a machine screw extending through each said tenon template support slot into a said template support aperture, said tenon template including a plurality of spaced tenoning slots sized to provide two sided guidance of said guide bushing, each said tenoning slot having a laterally extending lateral section and a pair of spaced end sections that extend rearwardly from opposite ends of said lateral section, each said tenoning slot having an upwardly opening upper channel, a downwardly opening lower channel and an intermediate passage connecting said upper and lower channels, said tenoning slots having slidably adjustable movable stops each having an upper piece sized and shaped to fit into a said upper channel, a lower piece sized and shaped to fit into a said lower channel, and a screw connecting said upper and lower pieces, and
a layout guide having a front edge and a plurality of spaced guide lines at selected precise distances from and parallel to said front edge, with said distances being selected as the radius of said guide bushing and the difference between the radius of said guide bushing and the radius of said bit, for different said guide bushing and bit sizes.