1. A compound represented by Formula I:
wherein:
R1 is hydrogen or \u2014C(O)ORc, where Rc is an unsubstituted alkyl, unsubstituted alkenyl, or unsubstituted alkynyl group;
R2 is hydrogen or an alkyl, alkenyl, or heteroalkyl group, unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
\u2014O\u2014; \u2014NRdRd; \u2014ORd; halogens; and an aryl group, unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
halogens; \u2014C(Rd)3; unsubstituted alkyl, alkyl-Rd, alkenyl-Rd, and aryl groups,
where Rd is one or more substituents independently selected from the group consisting of hydrogen; unsubstituted alkyl, unsubstituted alkenyl, and unsubstituted aryl groups;
R3 is hydrogen or an alkyl, alkenyl, or heteroalkyl group, unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
\u2014O\u2014; \u2014ORe; and, alkyl, aryl, cycloalkyl, and heteroaryl groups, unsubstituted or substituted with one or more substituents independently selected from the group consisting of:
halogens; \u2014OH; and aryl or heteroaryl groups, substituted with one or more Re substituents,
where Re is one or more substituents independently selected from the group consisting of halogens; hydrogen; OH; unsubstituted alkyl; and aryl unsubstituted or substituted with one or more substituents independently selected from the group consisting of halogen and alkyl;
R4 is hydrogen or an alkyl group, unsubstituted or substituted with \u2014ORf, where Rf is an unsubstituted alkyl group;
R5 is hydrogen or an alkyl group;
R6 is hydrogen or an alkyl group unsubstituted or substituted with an aryl group; or
R4 and R6 together with the N to which R6 is attached cyclize to form the following compound represented by the Formula Id:
wherein R12 and R13 are each independently hydrogen; and
n is 1;
R7 is hydrogen or an alkyl, alkenyl, or aryl group, unsubstituted or substituted with an aryl group, unsubstituted or substituted with one or more halogens;
X is C or N;
Y is C;
Z is C or N; and
there is a double bond between X and the 6-membered ring and Z and the 6-membered ring; or between X and Y; or between Y and Z; or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1, represented by Formula Ia:
wherein:
X is N
Y is C;
Z is C; and
the double bond is between Y and Z;
or a pharmaceutically acceptable salt thereof.
3. A compound according to claim 1, represented by Formula Ib:
wherein:
X is N;
Y is C;
Z is N; and
the double bond is between Y and Z;
or a pharmaceutically acceptable salt thereof.
4. A compound according to claim 1, represented by Formula Ic:
wherein:
X is C;
Y is C;
Z is N; and
the double bond is between X and Y;
or a pharmaceutically acceptable salt.
5. A compound according to claim 1, represented by Formula Ie:
wherein:
X is N;
Y is C;
Z is N; and
the double bond is between X and Y;
or a pharmaceutically acceptable salt.
6. A compound selected from the group consisting of:
1-(2,4-Difluorobenzyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-N-methyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(4-Fluorobenzyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1 -(4-Fluorobenzyl)-N-hydroxy-N-methyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
N-Benzyl-1-(4-fluorobenzyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine -5-carboxamide;
1-(3-Chloro-2,6-difluorobenzyl)-N-hydroxy-1H-pyrroto2,3-cpyridine-5-carboxamide;
1-(5-Chloro-thiophen-2-ylmethyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(3-Chloro-2-fluorobenzyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,3-Dichlorobenzyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(5-Ethoxy-1,2,3thiadiazol-4-ylmethyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-4-methyl-1H-pyrrolo2,3-clpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-3-ethoxymethyl-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-hydroxymethyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-3-dimethylaminomethyl-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
3-Benzyloxymethyl-1-(2,4-difluorobenzyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
3-(2,4-Difluorobenzyl)-N-hydroxy-3H-imidazo4,5-cpyridine-6-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-1H-imidazo4,5-cpyridine-6-carboxamide;
1-(2,4-Difluorobenzyl)-3-ethoxymethyl-N-hydroxy-N-methyl-1H-pyrrolo2,3-cpyndine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-hydroxymethyl-N-methyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-3-dimethylaminomethyl-N-hydroxy-N-methyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-methoxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-3-ethoxymethyl-N-methoxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-3-hydroxymethyl-N-methoxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-3-dimethylaminomethyl-N-methoxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
N-Benzyloxy-1-(2,4-difluorobenzyl)-1H-pyrrolo2,3-cpyridine-5-carboxamide;
N-Benzyloxy-3-(4-fluorobenzyl)-3H-imidazo4,5-cpyridine-6-carboxamide
3-(4-Fluorobenzyl)-N-methoxy-3H-imidazol-4,5-cpyridine-6-carboxamide;
3-(4-Fluorobenzyl)-N-phenoxy-3H-imidazo4,5-cpylidine-6-carboxamide;
3-(4-Fluorobenzyl)-N-(pentafluorobenzyl)oxy3H-imidazo4,5-cpyridine-6-carboxamide;
N-(Allyloxy)-3-(4-fluorobenzyl)-3H-imidazo4,5-cpyridine-6-carboxamide;
6-(2,4-Difluorobenzyl)-2-hydroxy-1,6-dihydrodipyrrolo3,2-d:3\u2032,4\u2032-bpyridin-3(2H)-one;
3-(2,3-Difluorobenzyl)-N-phenoxy-3H-imidazo4,5-cpyridine-6-carboxamide
3-(2,3-Difluorobenzyl)-N-methoxy-3H-imidazo4,5-cpyridine-6-carboxamide;
N-Allyloxy-3-(2,3-difluorobenzyl)-3H-imidazo4,5-cpyridine-6-carboxamide;
1-(4-Fluorobenzyl)-N-phenoxy-1H-imidazo4,5-cpyridine-6-carboxamide;
N-tert-Butoxy-3-(2,3-difluorobenzyl)-3H-imidazo4,5-cpyridine-6-carboxamide;
N-Methoxy-3-(3-methyl-butyl)-3H-imidazo4,5-cpyndine-6-carboxamide;
3-(3-Methyl-butyl)-N-phenoxy-3H-imidazo4,5-cpyridine-6-carboxamide;
3-(2-Cyclohexyl-ethyl)-N-phenoxy-3H-imidazo4,5-cpyridine-6-carboxamide;
3-(2-Cyclohexyl-ethy)-N-methoxy-3H-imidazo4,5-cpyridine-6-carboxamide;
N-Allyloxy-3-(2-cyclohexyl-ethyl)-3H-imidazo4,5-cpyridine-6-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-4-methoxymethyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-(2-phenylvinyl)-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-(3-phenylprop-1-enyl)-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-(2-phenylethyl)-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-(3-phenylpropyl)-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-{(2-phenylethyl)oxymethyl}-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-{(3-phenylallyl)oxymethyl}-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-3-methyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-3-ethyl-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
3-Allyl-1-(2,4-difluorobenzyl)-N-hydroxy-1H-pyrrolo2,3-cpyridine-5-carboxamide;
1-(2,4-Difluorobenzyl)-N-hydroxy-7-methyl-1H-pyrrolo2,3-cpyridine-5-carboxamide;
Ethyl 1-(2,4-Difluorobenzyl)-5-hydroxycarbamoyl-1H-pyrrolo2,3-cpyridine-2-carboxylate;
3-(2,4-Difluoro-phenoxymethyl)-1-ethyl-N-hydroxy-1H-pyrrolo3,2-cpyridine-6-carboxamide;
3-(3,5-Difluoro-2-hydroxybenzyl)-1-ethyl-N-hydroxy-1H-pyrrolo3,2-cpyridine-6-carboxamide;
3-(2-Chloro-4-fluoro-phenoxymethyl)-1-ethyl-N-hydroxy-1H-pyrrolo3,2-cpyridine-6-carboxamide;
3-(3-Chloro-5-fluoro-2-hydroxybenzyl)-1-ethyl-N-hydroxy-1H-pyrrolo3,2-cpyridine-6-carboxamide;
1-Ethyl-3-(4-fluoro-phenoxymethyl)-N-hydroxy-1H-pyrrolo3,2-cpyridine-6-carboxamide;
1-Ethyl-3-(5-fluoro-2-hydroxybenzyl)-N-hydroxy-1H-pyrrolo3,2-cpyridine-6-carboxamide;
1-Ethyl-N-hydroxy-3-(2,3,4-trifluoro-2-phenoxymethyl)-1H-pyrrolo3,2-cpyridine-6-carboxamide;
1-Ethyl-N-hydroxy-3-(3,4,5-trifluoro-2-hydroxybenzyl)-1H-pyrrolo3,2-cpyridine-6-carboxamide;
3-(2-Chloro-phenoxymethyl)-1-ethyl-N-hydroxy-1H-pyrrolol-3,2-cpyridine-6-carboxamide; and
3-(5-Chloro-2-hydroxy-benzyl)-1-ethyl-N-hydroxy-1H-pyrrolo3,2-cpyridine-6-carboxamide; or a pharmaceutically acceptable salt thereof.
7. A composition comprising:
a therapeutically effective amount of a compound or pharmaceutically acceptable salt according to claim 1; and
a pharmaceutically acceptable carrier, diluent, or vehicle therefor.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for estimating damage to a structure, the method comprising:
collecting a plurality of damage estimates over time;
filtering the plurality of damage estimates with spatio-temporal filters;
generating an enhanced damage estimate based on the filtered damage estimate; and
storing the enhanced damage estimate.
2. The method of claim 1, wherein filtering the plurality of damage estimates comprises:
forming a filtered structure damage estimate; and
forming an actual structure damage estimate.
3. The method of claim 2, further comprising:
updating the filtered structure damage estimate; and
updating the actual structure damage estimate.
4. The method of claim 3, wherein updating the actual structure damage estimate comprises:
computing a difference between the damage estimate and the filtered structure damage estimate computed at the previous update step;
performing a first convolution of the difference between the damage estimate and the filtered structure damage estimate with a feedback gain operator;
performing a second convolution of the actual structure damage estimate computed at the previous update step with a smoothing operator; and
combining the first and second convolution results and the actual structure damage estimate computed at the previous update step to obtain an updated actual structure damage estimate.
5. The method of claim 2, wherein filtering the plurality of damage estimates with spatio-temporal filters comprises:
performing a convolution of the actual structure damage estimate with a blur operator to form a filtered damage estimate.
6. A damage estimate system, the system comprising:
at least one sensor that collects damage estimate data as scans of the structure state;
a processing unit that receives the scans from the at least one sensor and generates a damage estimate from each scan; and
wherein the processing unit applies spatio-temporal filtering to the generated damage estimates to produce an enhanced damage estimate.
7. The system of claim 6, further comprising:
at least one sensor data concentrator adapted to receive the scans from the at least one sensor and digitize the scans.
8. The system of claim 6, further comprising:
a memory adapted to receive the damage estimates for each scan from the processing unit.
9. The system of claim 6, wherein the at least one sensor uses at least one of acoustic emission sensing, ultrasonic Lamb wave sensing, electrical conductivity sensing, and strain field sensing.
10. A machine-readable medium having instructions embodied thereon for a method for estimating damage to a structure, the method comprising:
collecting a plurality of damage estimates over time;
filtering the plurality of damage estimates with spatio-temporal filters;
generating an enhanced damage estimate based on the filtered damage estimate; and
storing the enhanced damage estimate.
11. The machine-readable medium of claim 10, wherein filtering the plurality of damage estimates comprises:
forming a filtered structure damage estimate; and
forming an actual structure damage estimate.
12. The machine-readable medium of claim 11, further comprising:
updating the filtered structure damage estimate; and
updating the actual structure damage estimate.
13. The machine-readable medium of claim 12, wherein updating the actual structure damage estimate comprises:
computing a difference between the damage estimate and the filtered structure damage estimate computed at the previous update step;
performing a first convolution of the difference between the damage estimate and the filtered structure damage estimate with a feedback gain operator;
performing a second convolution of the actual structure damage estimate computed at the previous update step with a smoothing operator; and
combining the first and second convolution results and the actual structure damage estimate computed at the previous update step to obtain an updated actual structure damage estimate.
14. The machine-readable medium of claim 11, wherein filtering the plurality of damage estimates with spatio-temporal filters comprises:
performing a convolution of the actual structure damage estimate with a blur operator to form a filtered damage estimate.
15. A damage estimate system, the system comprising:
means for sensing damage in an object, the means for sensing having an output;
means for estimating the damage of the object from the output of the means for sensing; and
means for filtering multiple outputs generated by the means for estimating in order to produce an enhanced damage estimate.