1. A method of treating a disease or condition mediated by oxytocin, wherein said method comprises administering (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-(4-morpholinyl)-2-oxoethyl-6-(1S)-1-methylpropyl-2,5-piperazinedione to a patient in need thereof.
2. The method of claim 1, wherein said (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-(4-morpholinyl)-2-oxoethyl-6-(1S)-1-methylpropyl-2,5-piperazinedione is administered parenterally.
3. The method of claim 1, wherein said (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-(4-morpholinyl)-2-oxoethyl-6-(1S)-1-methylpropyl-2,5-piperazinedione is administered orally.
4. The method of claim 1, wherein said (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-(4-morpholinyl)-2-oxoethyl-6-(1S)-1-methylpropyl-2,5-piperazinedione is administered as a dosage of 2-800 mg per day.
5. The method of claim 1, wherein said patient is a human patient.
6. A method of treating a disease or condition mediated by oxytocin, wherein said method comprises administering a pharmaceutical composition comprising (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-(4-morpholinyl)-2-oxoethyl-6-(1S)-1-methylpropyl-2,5-piperazinedione and at least one pharmaceutically acceptable carrier to a patient in need thereof.
7. The method of claim 1, wherein said disease or condition is endometriosis.
8. The method of claim 1, wherein said disease or condition is dysmenorrhea.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A connection device for connecting tubes comprising:
a main block having a trapezoid cross section to form two inclined surfaces, a long side and a short side, two inner threads formed in the main block and extending to one of the long side and the short side;
two pushing blocks attached respectively to the inclined surfaces of the main block, and each pushing block having
a body;
an inclined surface and an outer surface respectively formed at two sides of the body; and
two resilient tongues formed on the body and each resilient tongue having a free end and an engaging protrusion formed on and protruding from the free end of the resilient tongue; and
two fasteners inserted into the main block and each having a thread screwed with one of the inner threads in the main block.
2. The connection device as claimed in claim 1, wherein each pushing block has two flanges formed respectively a top and a bottom of the body, extending toward the main block and abutting respectively with a top and a bottom of the main block.
3. The connection device as claimed in claim 2 further comprising
two holding elements attached respectively to the outer surfaces of the bodies of the pushing blocks, and each holding element having a body and two engaging holes defined through the body of the holding element, wherein
the engaging protrusions on the pushing blocks extend respectively into and protrude respectively out of the engaging holes in the holding elements.
4. The connection device as claimed in claim 3, wherein each holding element has two side flanges formed respectively on two side edges of the body of the holding element, extending toward a corresponding one of the pushing blocks to limit a movement direction of the corresponding pushing block.
5. The connection device as claimed in claim 4, wherein the main block having two through hole defined in the short side of the main block and communicating respectively with the inner threads.
6. The connection device as claimed in claim 5, wherein
the main block has two nut holes defined in the long side of the main block;
two nuts are mounted respectively in the nut holes; and
the inner threads are formed respectively in the nuts.
7. The connection device as claimed in claim 1 further comprising
two holding elements attached respectively to the outer surfaces of the bodies of the pushing blocks, and each holding element having a body and two engaging holes defined through the body of the holding element, wherein
the engaging protrusions on the pushing blocks extend respectively into and protrude respectively out of the engaging holes in the holding elements.
8. The connection device as claimed in claim 7, wherein each holding element has two side flanges formed respectively on two side edges of the body of the holding element, extending toward a corresponding one of the pushing blocks to limit a movement direction of the corresponding pushing block.
9. The connection device as claimed in claim 8, wherein the main block having two through hole defined in the short side of the main block and communicating respectively with the inner threads.
10. The connection device as claimed in claim 9, wherein
the main block has two nut holes defined in the long side of the main block;
two nuts are mounted respectively in the nut holes; and
the inner threads are formed respectively in the nuts.
11. The connection device as claimed in claim 1, wherein the main block having two through hole defined in the short side of the main block and communicating respectively with the inner threads.
12. The connection device as claimed in claim 11, wherein
the main block has two nut holes defined in the long side of the main block;
two nuts are mounted respectively in the nut holes; and
the inner threads are formed respectively in the nuts.
13. The connection device as claimed in claim 2, wherein the main block having two through hole defined in the short side of the main block and communicating respectively with the inner threads.
14. The connection device as claimed in claim 13, wherein
the main block has two nut holes defined in the long side of the main block;
two nuts are mounted respectively in the nut holes; and
the inner threads are formed respectively in the nuts.