1. A pharmaceutical composition that is suitable for oral administration and that releases substantially all of the drug substance, wherein the drug substance is {1S-1\u03b1,2\u03b1,3\u03b2(1S*,2R*),5\u03b2}-3-(7-{2-(3,4-difluorophenyl)cyclopropylamino}-5-(propylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol.
2. A pharmaceutical composition comprising:
{1S-1\u03b1,2\u03b1,3\u03b2(1S*,2R*),5\u03b2}-3-(7-{2-(3,4-difluorophenyl)cyclopropylamino}-5-(propylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;
one or more fillers selected from mannitol, sorbitol, maltodextrin, maltose, dextrin, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, partially pre-gelled starch, and tribasic calcium phosphate, or any mixture thereof;
one or more binders selected from hydroxypropyl cellulose, hydroxypropyl methylcellulose, alginic acid, carboxymethylcellulose sodium, copovidone, and methylcellulose, or any mixture thereof,
optionally one or more disintegrants selected from sodium starch glycollate, croscarmellose sodium, and crospovidone, or any mixture thereof, and
optionally one or more lubricants.
3. A pharmaceutical composition according to claim 2 wherein the filler is a mixture of mannitol and dibasic calcium phosphate dihydrate.
4. A pharmaceutical composition according to claim 2 wherein the binder is hydroxypropyl cellulose.
5. A pharmaceutical composition according to claim 2 wherein the disintegrant is sodium starch glycollate.
6. A pharmaceutical composition according to claim 2 wherein the lubricant is magnesium stearate or sodium stearyl fumarate.
7. A pharmaceutical composition according to claim 2 wherein {1S-1\u03b1,2\u03b1,3\u03b2(1S*,2R*),5\u03b2}-3-(7-{2-(3,4-difluorophenyl)cyclopropylamino}-5-(propylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol is present in an amount of 20 to 45% by weight.
8. A pharmaceutical composition according to claim 2 wherein the filler is present in an amount of 20 to 70% by weight.
9. A pharmaceutical composition according to claim 2 wherein the binder is present in an amount of 3 to 6% by weight.
10. A pharmaceutical composition according to claim 2 wherein the disintegrant is present in an amount of 2 to 6% by weight.
11. A pharmaceutical composition according to claim 2 wherein the lubricant is present in an amount of 0.5 to 1% by weight.
12. A pharmaceutical composition according to claim 2 wherein {1S-1\u03b1,2\u03b1,3\u03b2(1S*,2R*),5\u03b2}-3-(7-{2-(3,4-difluorophenyl)cyclopropylamino}-5-(propylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol is substantially present in the form of Polymorph II.
13. A pharmaceutical composition according to claim 2 wherein {1S-1\u03b1,2\u03b1,3\u03b2(1S*,2R*),5\u03b2}-3-(7-{2-(3,4-difluorophenyl)cyclopropylamino}-5-(propylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol is substantially present in the form of Polymorph III.
14. A pharmaceutical composition according to claim 1 wherein:
the filler is a mixture of mannitol and dibasic calcium phosphate dehydrate;
the binder is hydroxypropyl cellulose;
the disintegrant is sodium starch glycollate; and
the lubricant is magnesium stearate or sodium stearyl fumarate.
15. A pharmaceutical composition according to claim 2 comprising:
{1S-1\u03b1,2\u03b1,3\u03b2(1S*,2R*),5\u03b2}-3-(7-{2-(3,4-difluorophenyl)cyclopropylamino}-5-(propylthio)-3H-1,2,3-triazolo4,5-dpyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol in an amount of 20 to 45% by weight;
mannitol in an amount of 20 to 45% by weight;
dibasic calcium phosphate dihydrate in an amount of 10 to 30% by weight;
hydroxypropylcellulose in an amount of 3 to 6% by weight;
sodium starch glycolate in an amount of 2 to 6% by weight; and
one or more lubricants in an amount of 0.5 to 3% by weight.
16. A pharmaceutical composition according to claim 1 which has been prepared by a wet granulation process.
17. A pharmaceutical composition according to claim 1 which has been prepared by a high shear wet granulation process.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A fuse, comprising:
an electrically insulating substrate with an upper surface;
a thick film fusible conductor applied in a serpentine shape to the upper surface of the substrate;
a cover layer comprising an electrically insulating material of good thermal conductivity applied directly above the thick film fusible conductor and adjoining regions of the upper surface of the substrate;
a window in the cover layer, the window located above and near the center of the thick film fusible conductor;
a layer of a fusible metal in the window; and
a protective layer atop the cover layer, the window and the layer, wherein the fuse is suitable for surface mounted devices (SMD).
2. The fuse according to claim 1, wherein the cover layer is a sintered layer.
3. The fuse according to claim 1, wherein the serpentine shape comprises a plurality of straight portions connected by a plurality of rounded arcuate portions.
4. The fuse according to claim 1, wherein the serpentine shape comprises a plurality of straight portions connected by a plurality of rounded arcuate portions, wherein two of the straight portions are shorter than a remainder of the plurality of straight portions.
5. A fuse, comprising:
an electrically insulating substrate with an upper surface;
a thick film fusible conductor applied in a serpentine shape to the upper surface of the substrate;
a cover layer comprising an electrically insulating material of good thermal conductivity applied directly above the thick film fusible conductor and adjoining regions of the upper surface of the substrate, wherein the specific thermal conductivity of the material of the cover layer is greater than 2 WmK;
a window in the cover layer, the window located above and near the center of the thick film fusible conductor, the window located above a portion of the thick film fusible conductor with both straight and arcuate sections;
a layer of a fusible metal in the window; and
a protective layer atop the cover layer, the window and the layer.
6. The fuse according to claim 5, further comprising connectors on ends of the electrically insulating substrate, wherein the connectors are electrically connected to the thick film fusible conductor but are not integral with the thick film fusible conductor.
7. The fuse according to claim 5, wherein the window is about 1 mm long and about 1.5 mm wide.
8. The fuse according to claim 5, wherein the electrically insulating substrate is about 0.5 to about 0.7 mm thick and the fuse is configured for use as a surface mounted device (SMD).
9. The fuse according to claim 5, wherein the layer of fusible metal in the window is a partially-melted paste.