1. A compound of Formula I:
or a pharmaceutically acceptable salt or ester thereof, wherein:
R1 is H or methyl; and
R2 is (C1-C6)alkyl;
wherein each alkyl represents a straight or branched chain.
2. The compound of claim 1 wherein the compound of formula (I) is a compound of formula (Ia) or I(b)
3. The compound of claim 1 wherein the compound of formula (I) is a compound selected from formula (Ic)-(If):
4. The compound of claim 1 wherein R1 is H.
5. The compound of claim 1 wherein R1 is methyl.
6. The compound of claim 3 which is a compound of formula (Ic):
or a pharmaceutically acceptable salt or ester thereof.
7. The compound of claim 1 wherein R2 is isopropyl.
8. The compound of claim 1, selected from the group consisting of:
and pharmaceutically acceptable salts and esters thereof.
9. The compound of claim 1 selected from:
and pharmaceutically acceptable salts and esters thereof.
10. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
11. The pharmaceutical composition of claim 10 further comprising at least one additional therapeutic agent selected from the group consisting of an interferon, ribavirin or an analog thereof, an HCV NS3 protease inhibitor, an NS5A inhibitor, an alpha-glucosidase 1 inhibitor, a hepatoprotectant, a mevalonate decarboxylase antagonist, an antagonist of the renin-angiotensin system, an endothelin antagonist, other anti-fibrotic agents, a nucleoside or nucleotide inhibitor of HCV NS5B polymerase, a non-nucleoside inhibitor of HCV NS5B polymerase, an HCV NS4B inhibitor, an inhibitor of viral entry andor assembly, an TLR-7 agonist, cyclophilin inhibitor, an HCV IRES inhibitor, a pharmacokinetic enhancer and other drugs for treating HCV; or a mixture thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-15. (canceled)
16. An adhesive composition comprising:
at least one polyamide noted A, with a mean number of carbon atoms per nitrogen atom, noted CA, of between 4 and 8.5;
at least one polyamide noted B, with a melting point of greater than or equal to 180\xb0 C. and a mean number of carbon atoms per nitrogen atom, noted CB, of between 7 and 10;
at least one polyamide noted C, with a mean number of carbon atoms per nitrogen atom, noted CC, of between 9 and 18;
wherein at least 50% by weight of the composition is formed from polyamides A, B and C,
wherein said polyamides in the composition have a mass-weighted mean of heats of fusion of greater than 25 Jg (DSC), and wherein polyamide A comprises from 8% to 33% by weight of the total weight of polyamides present in the composition, polyamide B comprises from 34% to 84% by weight of the total weight of polyamides present in the composition, and polyamide C comprises from 8% to 33% by weight of the total weight of polyamides present in the composition and
wherein additionally the mean number of carbon atoms per nitrogen atom of each polyamides A, B and C also satisfying the following:
CA<CB<CC and
(CB\u2212CA) andor (CC\u2212CB) is between 1 and 4.
17. The composition according to claim 16, wherein polyamide A has a melting point greater than or equal to 210\xb0 C. and polyamide C has a melting point that is less than 200\xb0 C.
18. The composition according to claim 16, wherein polyamide A is chosen from PA6, PA4.6 and PA6.6, polyamide B is chosen from PA6.10 and PA6.12, and polyamide C is chosen from PA10.10, PA11, PA12, PA10.12 and PA6.18.
19. The adhesive composition of claim 16, wherein the polyamide noted A has a mean number of carbon atoms per nitrogen atom, noted CA, of between 4 and 7.
20. The adhesive composition of claim 16, wherein the polyamide noted B has a mean number of carbon atoms per nitrogen atom, noted CB, of between 7.5 and 9.5.
21. The adhesive composition of claim 16, wherein the polyamide noted C has a mean number of carbon atoms per nitrogen atom, noted CC, of between 10 and 18.
22. The adhesive composition of claim 16 wherein (CB\u2212CA) andor (CC\u2212CB) is between 2 and 3.
23. The adhesive composition of claim 16, which comprises from 50% to 76% by weight of polyamide B relative to the total weight of polyamides present in the composition.
24. A method for transferring or storing a fluid comprising transferring or storing a fluid in a structure prepared, at least in part, from an adhesive composition according to claim 16.
25. The method according to claim 24, wherein the fluid is an oil, a brake fluid, a urea solution, a glycol-based coolant liquid, a non-biofuel, or a biofuel.