1. A soldering tip comprising:
a non-wetting solder contact layer adapted to conduct heat to a solder, to melt the solder, and to be in contact with the molten solder, wherein the non-wetting solder contact layer comprises a material that is not wettable by the molten solder and is configured to be in communication with an energy generating system that causes the non-wetting solder contact layer to generate heat;
a support structure, wherein the non-wetting solder contact layer covers at least a portion of the support structure and is in thermal communication therewith; and
a protective layer between the support structure and the non-wetting solder contact layer.
2. The soldering tip of claim 1 wherein the non-wetting solder contact layer comprises at least one of a nonfusible metal, a metal nitride, a metal oxide, a metal phosphate, a refractory metal or combinations thereof.
3. The soldering tip of claim 1 wherein the non-wetting solder contact layer comprises at least one of chromium, titanium, niobium, molybdenum, tungsten, chromium nitride, aluminum nitride, titanium nitride, an aluminum phosphate compound, or a refractory metal or combinations thereof.
4. The soldering tip of claim 1 wherein the non-wetting solder contact layer consists essentially of chromium, chromium nitride, titanium, titanium nitride, or combinations thereof.
5. The soldering tip of claim 1 wherein the protective layer comprises iron.
6. A soldering iron comprising:
a non-wetting solder contact layer adapted to conduct heat to a solder, to melt the solder, and to be in contact with the molten solder, wherein the non-wetting solder contact layer comprises a material that is not wettable by the molten solder; and
an energy generating system in operative communication with the non-wetting solder contact layer, wherein the energy generating system is adapted to cause the non-wetting solder contact layer to generate heat to melt the solder;
wherein the energy generating system includes an electrical power supply in electrical communication with the non-wetting solder contact layer such that heat is generated when electricity flows through the non-wetting solder contact layer.
7. The soldering iron of claim 6 further comprising a support structure, wherein the non-wetting solder contact layer covers at least a portion of the support structure.
8. A soldering system for melting a solder to form a joint between a first workpiece and a second workpiece, the system comprising:
an energy generating system;
a soldering tip in operative communication with the energy generating system, the soldering tip comprising a non-wetting solder contact layer adapted to conduct heat to a solder, to melt the solder, and to be in contact with the molten solder, wherein the energy generating system is configured to cause the non-wetting solder contact layer to generate heat and the non-wetting solder contact layer comprises a material that is not wettable by the molten solder; and
a dispenser adapted to dispense controlled amounts of the solder to a location proximate the soldering tip or the first workpiece and optionally the second workpiece;
wherein the energy generating system includes an electrical power supply in electrical communication with the non-wetting solder contact layer such that heat is generated when electricity flows through the non-wetting solder contact layer.
9. The soldering system of claim 8 further comprising a support structure, wherein the non-wetting solder contact layer covers at least a portion of the support structure.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A liver tumor-targeting ultrasound contrast agent comprising a gas-generating core and a hyaluronic acid shell, wherein the ultrasound contrast agent comprises 100 parts by volume of the hyaluronic acid shell and 0.08 to 5 parts by volume of the gas-generating core and,
wherein the hyaluronic acid is a hydrophobically modified hyaluronic acid.
2. The liver tumor-targeting ultrasound contrast agent according to claim 1, wherein the gas-generating core is a C1-C6 perfluorocarbon compound.
3. The liver tumor-targeting ultrasound contrast agent according to claim 1, wherein the ultrasound contrast agent has an average particle diameter of 400 nm to 4 \u03bcm.
4. The liver tumor-targeting ultrasound contrast agent according to claim 1, further comprising a fluorescent marker attached to the hyaluronic acid shell.
5. A method for preparing a liver tumor-targeting ultrasound contrast agent, the method comprising:
hydrophobically modifying hyaluronic acid;
purifying and drying the modified hyaluronic acid, followed by dissolution in deionized water; and
dropping a gas-generating compound into the hyaluronic acid solution,
wherein the gas-generating compound is used in an amount of 0.08 to 5 parts by volume, based on 100 parts by volume of the hyaluronic acid.
6. The method according to claim 5, wherein the hyaluronic acid is hydrophobically modified by reaction with 5\u03b2-cholanic acid.
7. The method according to claim 5, wherein the gas-generating compound is a C1-C6 perfluorocarbon compound.
8. The method according to claim 5, further comprising subjecting the mixed solution to sonication after dropping of the gas-generating compound.