1460742338-b2277ce3-3e32-487d-a4c1-7dbd4a66ed52

1. An image sensor comprising:
an array of photo-detectors formed in a semiconductor substrate;
a plurality of conductive line regions formed in the semiconductor substrate, each conductive line region formed under a respective line of photo-detectors along a first direction; and
a conductive junction region formed between the array of photo-detectors and the plurality of conductive line regions within the semiconductor substrate.
2. The image sensor of claim 1, wherein the conductive line regions are doped with a first dopant, and wherein the conductive junction region is doped with a second dopant that is of opposite conductivity from the first dopant.
3. The image sensor of claim 2, wherein each photo-detector has a respective junction region doped with a third dopant of the same conductivity type as the first dopant.
4. The image sensor of claim 3, wherein the semiconductor substrate is doped with a fourth dopant of the same conductivity type as the second dopant.
5. The image sensor of claim 4, wherein the semiconductor substrate is P type doped, wherein the conductive line regions are N+ type doped, wherein the conductive junction region is P+ type doped, and wherein the respective junction regions of the photo-detectors are N type doped.
6. The image sensor of claim 3, wherein each photo-detector has a respective top junction region doped with a fifth dopant of the opposite conductivity type as the third dopant.
7. The image sensor of claim 6, wherein the semiconductor substrate is P type doped, wherein the conductive line regions are N+ type doped, wherein the conductive junction region is P+ type doped, wherein the respective junction regions of the photo-detectors are N type doped, and wherein the respective top junction regions of the photo-detectors are P type doped.
8. The image sensor of claim 3, further comprising:
a surrounding junction that surrounds the array of photo-detectors.
9. The image sensor of claim 8, wherein the semiconductor substrate is P type doped, wherein the conductive line regions are N+ type doped, wherein the conductive junction region is P+ type doped, wherein the respective junction regions of the photo-detectors are N type doped, and wherein the surrounding junction is P+ type doped.
10. The image sensor of claim 1, wherein the conductive junction region is separated from the conductive line regions by a material of the semiconductor substrate.
11. The image sensor of claim 10, wherein the conductive junction region surrounds a portion of the conductive line regions.
12. The image sensor of claim 11, wherein the conductive junction region surrounds a respective top surface, and surrounds respective side portions of each conductive line region with inclined surfaces of the conductive junction region.
13. The image sensor of claim 1, wherein the array of photo-detectors includes:
a respective transmission transistor coupled to the respective junction region of each of the photo-detectors.
14. The image sensor of claim 13, wherein the respective transmission transistor is a respective field effect transistor.
15. The image sensor of claim 1, further comprising:
at least one respective conductive plug formed onto each of the conductive line regions for making contact to the respective conductive line region.
16. The image sensor of claim 15, further comprising:
two respective conductive plugs formed onto two ends of each conductive line region.
17. The image sensor of claim 15, further comprising:
a respective impurity diffusion layer surrounding each conductive plug.
18. The image sensor of claim 15, wherein a conductive plug is formed onto a plurality of conductive line regions.
19. The image sensor of claim 15, further comprising:
an overlying conductive line coupled to a line of conductive plugs disposed along a second direction that is perpendicular to the first direction.
20. The image sensor of claim 19, further comprising:
a surrounding junction that surrounds the array of photo-detectors, wherein the conductive plugs and the overlying conductive line are formed outside of the surrounding junction.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound having the formula:
wherein:
R1 is selected from the group consisting of hydrogen, F, Cl, Br, I, NO2, OR9, NR10R11, S(O)nR9, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, S(O)nR9, NR10R11, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R3 and R4 each independently is selected from the group consisting of hydrogen, OR9, S(O)nR9, NR10R11, C(Y)OR11, C(Y)NR10R11, optionally substituted C1\u2013C8alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R5 and R6 each independently is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R7 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R8 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R10 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, CO2R12, C(O)R12, SO2R12 and S(O)R12;
R11 and R12 each independently is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R13 is selected from the group consisting of optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C2\u2013C8 alkenyl, optionally substituted C2\u2013C8 alkynyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl;
m is selected from the group consisting of 0, 1 and 2;
n is selected from the group consisting of 0, 1 and 2;
W is selected from the group consisting of NH, N{R13}, N{C(Y)R11} and N{SO2R11};
X is O;
Z is selected from the group consisting of NH, N{R11}, N{C(Y)R11}, N{SO2R12} and N{S(O)R12}; and
Y is O;

and pharmaceutically acceptable salts thereof.
11. A compound according to claim 9, wherein R3 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
12. A compound according to claim 1, wherein R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
13. A compound according to claim 12, wherein R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl, optionally substituted C1\u2013C4 heteroalkyl, optionally substituted C2\u2013C4 alkynyl and optionally substituted C2\u2013C4 alkenyl.
14. A compound according to claim 13, wherein R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
15. A compound according to claim 12, wherein R6 is selected from the group consisting of optionally substituted aryl, optionally substituted arylalkyl and optionally substituted heteroaryl.
16. A compound according to claim 1, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6haloalkyl, optionally substituted C1\u2013C6heteroalkyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted C2\u2013C6 alkenyl.
17. A compound according to claim 16, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
18. A compound according to claim 17, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
19. A compound according to claim 18, wherein R5 is hydrogen or CF3.
20. A compound according to claim 1, wherein R7 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
21. A compound according to claim 1, wherein R8 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
22. A compound according to claim 21, wherein R7 and R8 are each hydrogen or optionally substituted C1\u2013C2 alkyl.
23. A compound according to claim 1, wherein R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
24. A compound according to claim 23, wherein R9 is selected from the group consisting of hydrogen and optionally substituted C3\u2013C4 alkyl.
25. A compound according to claim 1, wherein R10 is selected from the group consisting of hydrogen, S(O)R12, SO2R12, C(O)R12, CO2R12, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
26. A compound according to claim 25, wherein R10 is selected from the group consisting of hydrogen, S(O)R12, SO2R12, C(O)R12 and CO2R12.
27. A compound according to claim 1, wherein R4 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
28. A compound according to claim 27, wherein R4 is selected from the group consisting of hydrogen and optionally substituted C1\u2013C2 alkyl.
29. A compound according to claim 1, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C6 alkyl, optionally substituted C3\u2013C6 cycloalkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkenyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl.
30. A compound according to claim 29, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl, optionally substituted C1\u2013C4 heteroalkyl, optionally substituted C2\u2013C4 alkenyl and optionally substituted aryl.
31. A compound according to claim 30, wherein R13 is selected from the group consisting of CF3,CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, methyl, ethyl, propyl, isopropyl, isobutyl, cyclopropylmethyl, allyl.
32. A compound according to claim 1, wherein m is 0 or 1.
33. A compound according to claim 32, wherein m is 1.
34. A compound according to claim 1, wherein W is selected from the group consisting of NH, N{R13} and N{C(Y)R11}.
35. A compound according to claim 34, wherein W is NH or N{R13}.
36. A compound according to claim 1, wherein Z is NH or N{R11}.
37. A compound according to claim 1, wherein:
R1 is selected from the group consisting of hydrogen, F, Cl, OR9, S(O)nR9, NR10R11, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl;
R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl;
R3 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, C(Y)OR11 and C(Y)NR10R11;
R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl; and
R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
38. A compound according to claim 37, wherein:
R7 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl;
R8 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl; and
R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C3\u2013C6 cycloalkyl, optionally substituted C2\u2013C6 alkenyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl.
39. A compound according to claim 38, wherein:
m is 0 or 1;
W is selected from the group consisting of NH, N{R13}, N{C(Y)R11} and N{SO2R11};
X is O;
Z is NH or N{R11}.
40. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula:
wherein:
R1 is selected from the group consisting of hydrogen, F, Cl, Br, I, NO2, OR9, NR10R11, S(O)nR9, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, NR10R11, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R3 and R4 each independently is selected from the group consisting of hydrogen, OR9, S(O)nR9, NR10R11, C(Y)OR11, C(Y)NR10R11, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R5 and R6 each independently are selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2,optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R7 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 optionally substituted heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R8 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9,S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R10 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, CO2R12, C(O)R12, SO2R12 and S(O)R12;
R11 and R12 each independently is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R13 is selected from the group consisting of optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C2\u2013C8 alkenyl, optionally substituted C2\u2013C8 alkynyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl;
m is 1;
n is selected from the group consisting of 0, 1 and 2;
W is selected from the group consisting of NH, N{R13}, N{C(Y)R11} and N{SO2R11};
X is O;
Z is selected from the group consisting of NH, N{R11}, N{C(Y)R11}, N{SO2R12} and N{S(O)R12}; and
Y is O;

and pharmaceutically acceptable salts thereof; wherein:
the substituents of an optionally substituted group comprise one or more substituents independently selected from among alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, haloalkenyl,. haloalkynyl. cycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, aryloxy, haloalkoxy, amino, alkylamino, dialkylamino, alkylthio, arylthio, heteroarylthio, oxo, carboxyester, carboxamido, acyloxy, hydrogen, F, Cl, Br, I, CN, NO2, NH2, N3, NHCH3, N(CH3)2, SH, SCH3, OH, OCH3, OCF3, CH3, CF3, C(O)CH3, CO2CH3, CO2H, C(O)NH2, OR9, SR9, NR10R11, CF2CF3, CH2CH2F and CH2CF3.
41. A pharmaceutical composition according to claim 40, wherein said composition is suitable for enteral, parenteral, suppository or topical administration.
42. A pharmaceutical composition according to claim 40, wherein R1 is selected from the group consisting of hydrogen, F, Cl, OR9, NR10R11, S(O)nR9, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
43. A pharmaceutical composition according to claim 41, wherein:
R1 is selected from the group consisting of hydrogen, F and optionally substituted C1\u2013C4 alkyl; and
R2 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C2 alkyl, optionally substituted C1\u2013C2 haloalkyl and optionally substituted C1\u2013C2 heteroalkyl.
44. A pharmaceutical composition according to claim 40, wherein R3 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, C(Y)OR11 and C(Y)NR10R11.
45. A pharmaceutical composition according to claim 40, wherein R6 selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
46. A pharmaceutical composition according to claim 45, wherein R6 selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl, optionally substituted C1\u2013C4 heteroalkyl, optionally substituted C2\u2013C4 alkynyl and optionally substituted C2\u2013C4 alkenyl.
47. A pharmaceutical composition according to claim 40, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
48. A pharmaceutical composition according to claim 47, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
49. A pharmaceutical composition according to claim 40, wherein R7 and R8 each independently is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
50. A pharmaceutical composition according to claim 40, wherein:
R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, and optionally substituted C1\u2013C6 heteroalkyl; and
R10 is selected from the group consisting of hydrogen, S(O)R12, SO2R12, C(O)R12, CO2R12, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
51. A pharmaceutical composition according to claim 40, wherein R4 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
52. A pharmaceutical composition according to claim 40, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkenyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted C3\u2013C6 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl.
53. A pharmaceutical composition according to claim 52, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, methyl, ethyl, propyl, isopropyl, isobutyl, cyclopropylmethyl, and allyl.
54. A pharmaceutical composition according to claim 40, wherein:
W is selected from the group consisting of NH, N{R13} and N{C(Y)R11}; and
X is O.
55. A pharmaceutical composition according to claim 40, wherein Z is N{R11}.
56. A pharmaceutical composition comprising a compound according to claim 1, wherein R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6haloalkyl, optionally substituted C1\u2013C6heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
57. A compound selected from the group consisting of:
(3R)-2,3,4,7-Tetrahydro-3-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3,4-dimethyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-4-Ethyl-2,3,4,7-tetrahydro-3-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3 4,7-Tetrahydro-3-methyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-methyl-4-propyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-4-Allyl-2,3,4,7-tetrahydro-3-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3,4-Diethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-propyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-4-Allyl-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-isobutyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3RS)-2,3,4,7-Tetrahydro-3-propyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3RS)-2,3,4,7-Tetrahydro-4-methyl-3-propyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3RS)-4-Ethyl-2,3,4,7-tetrahydro-3-propyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3RS)-2,3,4,7-Tetrahydro-3-propyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-4-methyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3R)-4-Ethyl-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-Allyl-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-phenyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-phenyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-Cyclopropylmethyl-2,3,4,7-tetrahydro-3-phenyl-10-(trifluoromethyl)-8H-1,4oxazinol2,3-fquinolin-8-one;
(3R)-3-Benzyl-2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
2,3,4,7-Tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(7aR,10aS)-7,7a,8,9,10,10a-Hexahydro-1-(trifluoromethyl)-7-(2,2,2-trifluoroethyl)-4H-cyclopenta5,61,4oxazino2,3-fquinolin-3-one;
(7aR,10aS)-7-Ethyl-7,7a,8,9,10,10a-hexahydro-1-(trifluoromethyl)-4H-cyclopenta-5,61,4oxazino2,3-fquinolin-3-one;
(7aR,10aS)-7,7a,8,9,10,10a-Hexahydro-3-isopropoxy-1-(trifluoromethyl)-7-(2,2,2-trifluoroethyl)-4H-cyclopental5,61,4oxazino2,3-fquinolin-3-one;
(\xb1)-(2S,3R)-2,3,4,7-Tetrahydro-2,3-dimethyl-4-(2,2,2-trifluoroethyl)-10 -(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(6aR)-6a,7,8,9-Tetrahydro-4-(trifluoromethyl)-1H,6H-pyrrolo1\u2032,2\u2032:4,51,4-oxazino2,3-fquinolin-2-one;
2,3,4,7-Tetrahydro-2,2,4-trimethyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-8-Chloro-3-ethyl-3,4-dihydro-8-isopropoxy-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-2H-1,4oxazino2,3-fquinoline;
(3R)-3-Ethyl-3,4-dihydro-8-isopropoxy-8-methoxy-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-2H-1,4oxazino2,3-fquinoline;
(\xb1)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\u2212)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(+)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-4-methyl-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-4-Ethyl-2,3,4,7-tetrahydro-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-3,4-bis(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\u2212)-2,3,4,7-Tetrahydro-3,4-bis(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(+)-2,3,4,7-Tetrahydro-3,4-bis(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-4-Cyclopropylmethyl-2,3,4,7-tetrahydro-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-Cyclopropylmethyl-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-2-methyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-4-(2-hydroxy-2-methylpropyl)-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isobutyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one; and
pharmaceutically acceptable salt thereof.
58. A compound selected from the group consisting of:
(3R)-2,3,4,7-Tetrahydro-3-methyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(7aR,10aS)-7-Ethyl-7,7a,8,9,10,10a-hexahydro-1-(trifluoromethyl)-4H-cyclopenta5,61,4oxazino2,3-fquinolin-3-one;
(7aR,10aS)-7,7a,8,9,10,10a-Hexahydro-1-(trifluoromethyl)-7-(2,2,2-trifluoroethyl)-4H-cyclopenta5,61,4oxazino2,3-fquinolin-3-one;
(\xb1)-(2S,3R)-2,3,4,7-Tetrahydro-2,3-dimethyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\u2212)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(+)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one; and
a pharmaceutically acceptable salts thereof.