1. A method of growing III-N material on a silicon substrate comprising the steps of:
providing a single crystal silicon substrate;
epitaxially growing a single crystal rare earth oxide on the silicon substrate;
epitaxially growing a single crystal rare earth nitride on the single crystal rare earth oxide; and
epitaxially growing a layer of single crystal III-N material on the single crystal rare earth nitride.
2. The method as claimed in claim 1 wherein the step of epitaxially growing the single crystal rare earth oxide includes selecting a rare earth oxide with a cubic crystal structure.
3. The method as claimed in claim 2 wherein the step of epitaxially growing the single crystal rare earth oxide with the cubic crystal structure includes epitaxially growing single crystal erbium oxide (Er2O3).
4. The method as claimed in claim 1 wherein the step of epitaxially growing the single crystal rare earth nitride includes selecting a rare earth nitride with a cubic crystal structure.
5. The method as claimed in claim 4 wherein the step of epitaxially growing the single crystal rare earth nitride with the cubic crystal structure includes epitaxially growing single crystal erbium nitride (ErN).
6. The method as claimed in claim 1 wherein the step of epitaxially growing the single crystal rare earth oxide and the step of epitaxially growing the single crystal rare earth nitride include using the same rare earth metal.
7. The method as claimed in claim 6 wherein the step of epitaxially growing the single crystal rare earth oxide and the step of epitaxially growing the single crystal rare earth nitride using the same rare earth metal includes using erbium to form Er2O3 and ErN.
8. The method as claimed in claim 1 wherein the step of epitaxially growing the layer of single crystal III-N material includes epitaxially growing GaN.
9. A method of growing III-N material on a silicon substrate comprising the steps of:
providing a single crystal silicon substrate;
epitaxially growing a single crystal rare earth oxide with a cubic crystal structure on the silicon substrate;
epitaxially growing a single crystal rare earth nitride with a cubic crystal structure on the single crystal rare earth oxide; and
epitaxially growing a layer of single crystal III-N material on the single crystal rare earth nitride.
10. The method as claimed in claim 9 wherein the step of epitaxially growing the single crystal rare earth oxide and the step of epitaxially growing the single crystal rare earth nitride include using the same rare earth metal.
11. The method as claimed in claim 10 wherein the step of epitaxially growing the single crystal rare earth oxide and the step of epitaxially growing the single crystal rare earth nitride using the same rare earth metal includes using erbium to form Er2O3 and ErN.
12. A method of growing semiconductor REN material on a silicon substrate comprising the steps of:
providing a single crystal silicon substrate;
selecting and epitaxially growing one of a single crystal buffer including multiple layers of rare earth oxide and a single crystal buffer including a layer of rare earth oxide and a layer of rare earth oxynitride on the silicon substrate, the selected single crystal buffer having a lower portion adjacent the silicon substrate with a crystal lattice constant substantially matched to silicon and having an upper portion adjacent an upper surface with a crystal lattice constant substantially matched to a semiconductor rare earth nitride; and
epitaxially growing on the upper surface of the selected buffer a single crystal semiconductor rare earth nitride layer.
13. The method as claimed in claim 12 wherein the step of selecting and growing the buffer includes selecting and growing multiple layers of rare earth oxide, and the multiple layers of rare earth oxide include a lower layer RE01 and an upper layer REO2, the multiple layers are each further selected to have a crystal lattice conforming to the equation aREO2<aREO1.
14. The method as claimed in claim 13 wherein the step of selecting the buffer having the lower portion with the crystal lattice constant matched to silicon includes selecting a REO material for the lower portion conforming to the equation aREO1<2asi, and the step of selecting the buffer having the upper portion with the crystal lattice constant matched to the semiconductor rare earth nitride includes selecting a rare earth oxide material for the upper portion and a semiconductor rare earth nitride material so as to conform to the equation aREN<(\xbd) aREO2.
15. The method as claimed in claim 12 wherein the step of selecting and growing the buffer includes selecting and growing the layer of rare earth oxide and the layer of rare earth oxynitride, and the layer of rare earth oxide and the layer of rare earth oxynitride are each further selected to have a crystal lattice conforming to the equation aREON<aREO1.
16. The method as claimed in claim 15 wherein the step of selecting the buffer having the lower portion with the crystal lattice constant matched to silicon includes selecting a REO material for the lower portion conforming to the equation aREO1<2asi, and the step of selecting the buffer having the upper portion with the crystal lattice constant matched to the semiconductor rare earth nitride includes selecting a rare earth oxynitride material for the upper portion and the semiconductor rare earth nitride material so as to conform to the equation aREN<aREON.
17. III-N material on a silicon substrate comprising:
a single crystal silicon substrate;
a single crystal epitaxial rare earth oxide positioned on the silicon substrate;
a single crystal epitaxial rare earth nitride positioned on the single crystal rare earth oxide, wherein the single crystal epitaxial rare earth nitride includes a rare earth nitride with a cubic crystal structure; and
a layer of single crystal epitaxial III-N material positioned on the single crystal rare earth nitride.
18. The III-N material on a silicon substrate as claimed in claim 17 wherein the single crystal epitaxial rare earth nitride with the cubic crystal structure includes single crystal erbium nitride (ErN).
19. The III-N material on a silicon substrate as claimed in claim 17 wherein the layer of single crystal epitaxial III-N material includes single crystal epitaxial GaN.
20. The III-N material on a silicon substrate as claimed in claim 17 wherein the single crystal epitaxial rare earth oxide includes a rare earth oxide with a cubic crystal structure.
21. The III-N material on a silicon substrate as claimed in claim 20 wherein the single crystal epitaxial rare earth oxide with the cubic crystal structure includes single crystal erbium oxide (Er2O3).
22. The III-N material on a silicon substrate as claimed in claim 17 wherein the single crystal epitaxial rare earth oxide and the single crystal epitaxial rare earth nitride include the same rare earth metal.
23. The III-N material on a silicon substrate as claimed in claim 22 wherein the single crystal epitaxial rare earth oxide and the single crystal epitaxial rare earth nitride include erbium in the form of Er2O3 and ErN.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of general formula (I)
wherein
R1 represents a group selected from C1-C6-alkyl-, C3-C7-cycloalkyl heterocyclyl-, phenyl, heteroraryl, phenyl-C1-C3-alkyl- or heteroaryl-C1-C3-alkyl-,
wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of hydroxy, cyano, halogen, halo-C1-C3-alkyl-, C1-C6-alkoxy-, C1-C3-fluoroalkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines;
R2 represents a group selected from
R3, R4 represent, independently from each other, a group selected from a hydrogen atom, halogen atom, cyano, \u2014SF5, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R5 represents a group selected from a hydrogen atom, cyano, \u2014C(O)R9, \u2014C(O)OR9, \u2014S(O)2R9, \u2014C(O)NR10R11, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl wherein said C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R6, R7 represent, independently from each other, a group selected from a hydrogen atom, halogen atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R8 represents a group selected from
a) a C1-C6-alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl,
wherein said C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
b) a C3-C6-alkenyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl,
wherein said C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
c) a C3-C6-alkynyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl,
wherein said C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
d) a C3-C7-cycloalkyl- group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-;
e) a heterocyclyl-group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-;
f) a phenyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
g) a heteroaryl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
h) a phenyl-C1-C3-alkyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
i) a heteroaryl-C1-C3-alkyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
j) a C3-C6-cycloalkyl-C1-C3-alkyl- group, which C3-C6-cycloalkyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3 halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
k) a heterocycly-C1-C3-alkyl- group, which heterocyclyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3 alkoxy halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
l) phenyl-cyclopropyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
m) a heteroaryl-cyclopropyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
R9 represents a group selected from C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, benzyl or heteroaryl wherein said group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R10, R11 represent, independently from each other, a group selected from hydrogen, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl wherein said C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
or its enantiomers, diastereomers, salts, solvates or salts of solvates.
2. The compound of general formula (I) according to claim 1, wherein
R3 represents a group selected from a halogen atom, cyano, \u2014SF5, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy- and
R4 represents hydrogen,
or its enantiomers, diastereomers, salts, solvates or salts of solvates.
3. The compound of general formula (I) according to claim 1, wherein
R1 represents a group selected from C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroraryl, phenyl-C1-C3-alkyl- or heteroaryl-C1-C3-alkyl-,
wherein said group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of hydroxy, cyano, halogen, halo-C1-C3-alkyl-, C1-C6-alkoxy-, C1-C3-fluoroalkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines;
R2 represents a group selected from
R3, R4 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom, chloro atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R5 represents a group selected from a hydrogen atom, cyano, \u2014C(O)R9, \u2014C(O)OR9, \u2014S(O)2R9, \u2014C(O)NR10R11, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl
wherein said C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R6, R7 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom, chloro atom, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R8 represents a group selected from
a) a C1-C6-alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl,
wherein said C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, cyano, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
b) a C3-C7-cycloalkyl- group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-;
c) a heterocyclyl-group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C2-C3-alkenyl-, C2-C3-alkynyl-;
d) a phenyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
e) a heteroaryl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
f) a phenyl-C1-C3-alkyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
g) a heteroaryl-C1-C3-alkyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
h) a C3-C6-cycloalkyl-C1-C3-alkyl- group, which C3-C6-cycloalkyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
i) a heterocycly-C1-C3-alkyl- group, which heterocyclyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
j) phenyl-cyclopropyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
k) a heteroaryl-cyclopropyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, NH2, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
R9 represents a group selected from C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, benzyl or heteroaryl wherein said group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
R10, R11 represent, independently from each other, a group selected from hydrogen, C1-C6-alkyl-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl wherein said C1-C6-alkyl, C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, amino, alkylamino-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
or its salts, solvates or salts of solvates.
4. The compound of general formula (I) according to claim 1, wherein
R1 represents a group selected from C1-C6-alkyl-, C3-C5-cycloalkyl-, wherein said group is optionally substituted with one or two substituents, identically or differently, selected from the group of hydroxy, C1-C2-alkoxy-, halo-C1-C2-alkyl-, C1-C2-fluoroalkoxy-;
R2 represents a group selected from
R3 represents a hydrogen atom or fluoro atom;
R4 represents a hydrogen atom or a fluoro atom;
R5 represents a group selected from a hydrogen atom, cyano, \u2014C(O)OR9, \u2014C(O)NR10R11;
R6, R7 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom, chloro atom;
R8 represents a group selected from
a) a C1-C6-alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, hydroxy, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-, C3-C7-cycloalkyl-, heterocyclyl-, phenyl, heteroaryl,
wherein said C3-C7-cycloalkyl-, heterocyclyl-, phenyl or heteroaryl group is optionally substituted with one, two or three substituents, identically or differently, selected from halogen, hydroxy, C1-C3-alkyl-, C1-C3-alkoxy-, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
b) a phenyl-C1-C3-alkyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
c) a heteroaryl-C1-C3-alkyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
d) a C3-C6-cycloalkyl-C1-C3-alkyl- group, which C3-C6-cycloalkyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
e) a heterocyclyl-C1-C3-alkyl- group, which heterocyclyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
f) phenyl-cyclopropyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, \u2014NH2, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
g) a heteroaryl-cyclopropyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, hydroxy, \u2014NH2, dialkylamino-, acetylamino-, N-methyl-N-acetylamino-, cyclic amines, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-.
R9 represents a C1-C3-alkyl group;
R10, R11 represent, independently from each other, a group selected from hydrogen, C1-C2-alkyl-;
or its salts, solvates or salts of solvates.
5. The compound of general formula (I) according to claim 1, wherein
R1 represents a group selected from C1-C6-alkyl-, C3-C5-cycloalkyl-, wherein said group is optionally substituted with one or two substituents, identically or differently, selected from the group of C1-C2-alkoxy-, halo-C1-C2-alkyl-, C1-C2-fluoroalkoxy-;
R2 represents a group selected from
R3 represents a hydrogen atom or a fluoro atom;
R4 represents a hydrogen atom or a fluoro atom;
R5 represents a group selected from a hydrogen atom, cyano, \u2014C(O)OR9, \u2014C(O)NR10R11;
R6, R7 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom;
R8 represents a group selected from
a) a C1-C3-alkyl group, which is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, cyano, halo-C1-C3-alkyl-;
b) a phenyl-C1-C3-alkyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
c) a heteroaryl-C1-C3-alkyl- group, which heteroaryl group is optionally substituted with one or two substituents, identically or differently, selected from the group of halogen, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
d) a C3-C6-cycloalkyl-C1-C3-alkyl- group, which C3-C6-cycloalkyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
e) a heterocyclyl-C1-C3-alkyl- group, which heterocyclyl group is optionally substituted with one or two or three substituents, identically or differently, selected from halogen, C1-C3-alkyl-, C1-C3-alkoxy-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-;
f) phenyl-cyclopropyl- group, which phenyl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
g) a heteroaryl-cyclopropyl- group, which heteroaryl group is optionally substituted with one or two or three substituents, identically or differently, selected from the group of halogen, cyano, C1-C3-alkyl-, halo-C1-C3-alkyl-, C1-C3-fluoroalkoxy-, C1-C3-alkoxy-;
R9 represents a C1-C3-alkyl group;
R10, R11 represent, independently from each other, a group selected from hydrogen, C1-C2-alkyl-;
or its salts, solvates or salts of solvates.
6. The compound of general formula (I) according to claim 1, wherein
R1 represents a C1-C3-alkyl- or cyclopropyl group;
R2 represents a group selected from
R3 represents a hydrogen atom or fluoro atom;
R4 represents a hydrogen atom or fluoro atom;
R5 represents a group selected from a hydrogen atom, cyano, \u2014C(O)OR9, \u2014C(O)NR10R11;
R6, R7 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom;
R8 represents a group selected from
a) a C1-C3-alkyl group;
b) a phenyl-C1-C3-alkyl- group, which phenyl group is optionally substituted with one or two substituents, identically or differently, selected from the group of halogen;
R9 represents a C1-C2-alkyl group;
R10, R11 represent, independently from each other, a group selected from hydrogen, C1-C2-alkyl-;
or its salts, solvates or salts of solvates.
7. The compound of general formula (I) according to claim 1, wherein
R1 represents a group selected from C1-C3-alkyl- or cyclopropyl-,
R2 represents a group selected from
R3, R4 represent, independently from each other, a group selected from a hydrogen atom, a fluoro, a chloro or a bromo atom, \u2014SF5, C1-C3 alkyl C1-C2-alkoxy- or CF3\u2014,
R5 represents a group selected from a hydrogen atom, cyano, \u2014C(O)OR9 or \u2014C(O)NR10R11,
R6, R7 represent, independently from each other, a group selected from a hydrogen atom or a fluoro atom,
R8 represents a group selected from
a) a C1-C3-alkyl group, which is optionally substituted with fluorine,
b) a phenyl-C1-C2-alkyl- group, which phenyl group is optionally substituted with halogen,
R9 represents a C1-C6-alkyl-, which is optionally substituted with C1-C3-alkoxy,
R10, R11 represent, independently from each other, hydrogen or a C1-C6-alkyl-,
or its enantiomers, diastereomers, salts, solvates or salts of solvates.
8. The compound of general formula (I) according to claim 1, wherein
R1 represents a methyl group;
R2 represents a group selected from
R3 represents a group selected from a hydrogen atom, fluoro atom;
R4 represents a group selected from a hydrogen atom;
R5 represents a group selected from a hydrogen atom, cyano, \u2014C(O)OR9, \u2014C(O)NR10R11;
R6, R7 represent, independently from each other, a group selected from a hydrogen atom, fluoro atom;
R8 represents a group selected from
a) a methyl group;
b) a benzyl group;
R9 represents an ethyl group;
R10 represents a hydrogen atom;
R11 represents a methyl group;
or its salts, solvates or salts of solvates.
9. The compound according to claim 1, which is selected from
(rac)-Ethyl(3-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)(methyl)oxido sulfanylidenecarbamate
(rac)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methylphenyl}pyrimidin-2-amine
(rac)-Ethyl {3-({4-2-(benzyloxy)-4-fluorophenyl-5-fluoropyrimidin-2-yl}amino)benzyl(methyl)-oxido-\u03bb6-sulfanylidene}carbamate
(rac)-4-2-(Benzyloxy)-4-fluorophenyl-5-fluoro-N-{3-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine
(rac)-Ethyl(3-{4-(3,4-dihydro-2H-chromen-8-yl)-5-fluoropyrimidin-2-ylamino}benzyl)(methyl)-oxido-\u03bb6-sulfanylidenecarbamate
(rac)-4-(3,4-dihydro-2H-chromen-8-yl)-5-fluoro-N-{3-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine
(rac)-{3-({4-2-(Benzyloxy)-4-fluorophenyl-5-fluoropyrimidin-2-yl}amino)benzyl(methyl)oxido-\u03bb6-sulfanylidene}cyanamide
(rac)-1-(3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)(methyl)oxido-\u03bb6-sulfanylidene-3-methylurea
(rac)-Ethyl(3-fluoro-5-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)-(methyl)oxido-\u03bb6-sulfanylidenecarbamate
(rac)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-fluoro-5-(S-methylsulfonimidoyl)methyl-phenyl}pyrimidin-2-amine
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methylphenyl}pyrimidin-2-amine; enantiomer 1
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methylphenyl}pyrimidin-2-amine; enantiomer 2
4-2-(Benzyloxy)-4-fluorophenyl-5-fluoro-N-{3-(S-methylsulfonimidoyl)methylphenyl}pyrimidin-2-amine; enantiomer 1
4-2-(Benzyloxy)-4-fluorophenyl-5-fluoro-N-{3-(S-methylsulfonimidoyl)methylphenyl}pyrimidin-2-amine; enantiomer 2
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-fluoro-5-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine; enantiomer 1
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-fluoro-5-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine; enantiomer 2
(rac)-(3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)(methyl)oxido-\u03bb6-sulfanylidenecyanamide
(3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)(methyl)oxido-\u03bb6-sulfanylidenecyanamide; enantiomer 1 (3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)(methyl)oxido-\u03bb6-sulfanylidenecyanamide; enantiomer 2
(rac)-Ethyl(3-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)oxido-\u03bb6-sulfanylidenecyanamide
rac)-N-{3-(S-Ethylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine
N-{3-(S-Ethylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine; enantiomer 1
N-{3-(S-Ethylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-amine; enantiomer 2
(rac)-(2,3-Difluoro-5-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)-(methyl)oxido-\u03bb6-sulfanylidenecyanamide
(rac)-N-{3,4-Difluoro-5-(S-methylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)pyrimidin-2-amine
N-{3,4-Difluoro-5-(S-methylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine; enantiomer 1
N-{3,4-Difluoro-5-(S-methylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine; enantiomer 2
(rac)-(3-Bromo-5-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)(methyl)-oxido-\u03bb6-sulfanylidenecyanamide
(rac)-N-{3-Bromo-5-(S-methylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)pyrimidin-2-amine
N-{3-Bromo-5-(S-methylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine; enantiomer 1
N-{3-Bromo-5-(S-methylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine; enantiomer 2
(rac)-(3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}-5-methoxybenzyl)(methyl)-oxido-\u03bb6-sulfanylidenecyanamide
(rac)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-methoxy-5-(S-methylsulfonimidoyl)methyl-phenyl}pyrimidin-2-amine
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-methoxy-5-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine; enantiomer 1
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-methoxy-5-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine; enantiomer 2
(rac)-(3-{4-(2-Ethoxy-4-fluorophenyl)-5-fluoropyrimidin-2-ylamino}-5-fluorobenzyl)(methyl)oxido-\u03bb6-sulfanylidenecyanamide
(rac)-4-(2-Ethoxy-4-fluorophenyl)-5-fluoro-N-{3-fluoro-5-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine
4-(2-Ethoxy-4-fluorophenyl)-5-fluoro-N-{3-fluoro-5-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine; enantiomer 1
4-(2-Ethoxy-4-fluorophenyl)-5-fluoro-N-{3-fluoro-5-(S-methylsulfonimidoyl)methylphenyl}-pyrimidin-2-amine; enantiomer 2
(rac)-{3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}-5-(trifluoromethyl)-benzyl(methyl)oxido-\u03bb6-sulfanylidene}cyanamide
(rac)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methyl-5-(trifluoro-methyl)phenyl}pyrimidin-2-amine
(rac)-Ethyl(3-fluoro-5-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)oxido-\u03bb6-sulfanylidenecyanamide
(rac)-N-{3-(S-Ethylsulfonimidoyl)methyl-5-fluorophenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine
N-{3-(S-Ethylsulfonimidoyl)methyl-5-fluorophenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine; enantiomer 1
N-{3-(S-Ethylsulfonimidoyl)methyl-5-fluorophenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine; enantiomer 2
(rac)-{3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}-5-(pentafluoroethyl) benzyl(methyl)oxido-\u03bb6-sulfanylidene}cyanamide
(rac)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methyl-5-(pentafluoro-ethyl)phenyl}pyrimidin-2-amine
(rac)-Cyclopropyl(3-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)oxido-sulfanylidenecyanamide
(rac)-N-{3-(S-Cyclopropylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-pyrimidin-2-amine
(rac)-Cyclopropyl(3-fluoro-5-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}-benzyl)oxido-\u03bb6-sulfanylidenecyanamide
(rac)-N-{3-(S-Cyclopropylsulfonimidoyl)methyl-5-fluorophenyl}-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)pyrimidin-2-amine
N-{3-(S-Cyclopropylsulfonimidoyl)methyl-5-fluorophenyl}-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)pyrimidin-2-amine; enantiomer 1
N-{3-(S-Cyclopropylsulfonimidoyl)methyl-5-fluorophenyl}-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)pyrimidin-2-amine; enantiomer 2
(rac)-Ethyl(3-{4-(2,3-dihydro-1-benzofuran-7-yl)-5-fluoropyrimidin-2-ylamino}benzyl)(methyl)-oxido-\u03bb6-sulfanylidenecarbamate
(rac)-5-Fluoro-4-{4-fluoro-2-(4-fluorobenzyl)oxyphenyl}-N-{3-(S-methylsulfonimidoyl)methyl-phenyl}pyrimidin-2-amine
(rac)-(3-Chloro-5-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)(methyl)-oxido-\u03bb6-sulfanylidenecyanamide
(rac)-N-{3-Chloro-5-(S-methylsulfonimidoyl)methylphenyl}-5-fluoro-4-(4-fluoro-2-methoxy-phenyl)pyrimidin-2-amine
(rac)-(3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}-5-methylbenzyl)(methyl)-oxido-\u03bb6-sulfanylidenecyanamide
(rac)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-methyl-5-(S-methylsulfonimidoyl)methyl-phenyl}pyrimidin-2-amine
(rac)-{3-{5-Fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}-5-(pentafluoro-\u03bb6-sulfanyl)benzyl(methyl)oxido-\u03bb6-sulfanylidene}cyanamide
(rac)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methyl-5-(pentafluoro-\u03bb6-sulfanyl)phenyl}pyrimidin-2-amine
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methyl-5-(pentafluoro-\u03bb6-sulfanyl)phenyl}pyrimidin-2-amine; enantiomer 1
5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{3-(S-methylsulfonimidoyl)methyl-5-(pentafluoro-\u03bb6-sulfanyl)phenyl}pyrimidin-2-amine; enantiomer 2
2-Methoxyethyl(3-fluoro-5-{5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-ylamino}benzyl)-(methyl)oxido-\u03bb6-sulfanylidenecarbamate; single enantiomer
or its salts, solvates or salts of solvates.
10. (canceled)
11. (canceled)
12. A pharmaceutical combination comprising a compound according to claim 1 in combination with at least one or more further active ingredients.
13. A pharmaceutical composition comprising a compound according to claim 1 in combination with an inert, nontoxic, pharmaceutically suitable adjuvant.
14. (canceled)
15. (canceled)
16. A compound of general formula (11)
wherein R1, R3 and R4 are as defined in claim 1.
17. A compound of general formula (12)
wherein R1, R3 and R4 are as defined in claim 1.
18. A compound of general formula (4)
wherein R1, R3 and R4 are as defined in claim 1.
19. A method for the treatment andor prophylaxis of a disease or disorder selected from hyper-proliferative disorders, virally induced infectious diseases andor of cardiovascular diseases comprising administering to a patient in need thereof a compound according to claim 1.
20. A method for the treatment andor prophylaxis of a disease or disorder selected from lung carcinomas, prostate carcinomas, cervical carcinomas, colorectal carcinomas, melanomas or ovarian carcinomas comprising administering to a patient in need thereof a compound according to claim 1.
21. The method according to claim 19, wherein the disease or disorder is mediated by CDK9.
22. The method according to claim 20, wherein the disease or disorder is mediated by CDK9.