Author: claimsbot

1. A crystalline form of grapiprant selected from the group consisting of Form X, Form X2, Form X3, Form F, Form K, Form L, Form M, and Form N, wherein the crystalline form is selected from the following group:
i. Form X, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.5, about 10.1, about 14.9, about 15.3, about 19.7, about 20.3, about 21.3, about 22.7, about 23.1, and about 27.3;
ii. Form X, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 33-80\xb0 C. and at about 110-140\xb0 C.;
iii. Form X, which exhibits a thermogravimetric analysis showing a loss of mass of 12-13% when heated from about 24\xb0 to about 150\xb0 C.;
iv. Form X2, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 10.2, about 14.9, about 16.8, about 18.3, about 21.8, about 22.7, about 23.9, about 24.3 about 25.9, and about 26.4;
v. Form X2, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 25-130\xb0 C., at about 130-150\xb0 C., and at about 150-190\xb0 C.;
vi. Form X2, which exhibits a thermogravimetric analysis showing a loss of mass of 14-15% when heated from about 25\xb0 to about 150\xb0 C.;
vii. Form X3, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 13.6, about 21.0, about 24.5, and about 25.3;
viii. Form X3, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 75-115\xb0 C., at about 135-150\xb0 C., and at about 150-170\xb0 C.;
ix. Form X3, which exhibits a thermogravimetric analysis showing a loss of mass of 10-11% when heated from about 25\xb0 to about 135\xb0 C.;
x. Form F, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 9.9, about 14.8, about 15.5, about 18.0, about 19.9, about 20.4, about 21.8, about 23.5, and about 27.7;
xi. Form F, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 122\xb0 C. and at about 143\xb0 C.;
xii. Form F, which exhibits a thermogravimetric analysis showing a loss of mass of about 20.5% when heated from about 25\xb0 to about 135\xb0 C.;
xiii. Form K, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 11.3, about 15.9, about 16.6, about 18.2, about 19.0, about 21.7, about 21.9, about 25.7, and about 29.0;
xiv. Form K, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 48\xb0 C., about 95\xb0 C., and at about 155\xb0 C.;
xv. Form K, which exhibits a thermogravimetric analysis showing a loss of mass of about 8.7% when heated from about 25\xb0 to about 135\xb0 C.;
xvi. Form L, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.8, about 11.1, about 13.8, about 16.7, about 20.7, about 23.2, about 25.0, about 26.0, and about 26.3;
xvii. Form L, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 106\xb0 C.;
xviii. Form L, which exhibits a thermogravimetric analysis showing a loss of mass of about 12.9% when heated from about 25\xb0 to about 135\xb0 C.;
xix. Form M, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.2, about 6.5, about 13.0, about 18.9, about 19.5, about 27.4, about 37.9, about 38.0, and about 39.7;
xx. Form M, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 77\xb0 C., at about 99\xb0 C., and at about 138\xb0 C.;
xxi. Form M, which exhibits a thermogravimetric analysis showing a loss of mass of about 13.6% when heated from about 25\xb0 to about 135\xb0 C.;
xxii. Form N, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.5, about 9.9, about 14.2, about 14.8, about 15.4, about 17.7, about 19.7, about 20.3, and about 23.4;
xxiii. Form N, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 121\xb0 C. and at about 157\xb0 C.; and
xxiv. Form N, which exhibits a thermogravimetric analysis showing a loss of mass of about 11% when heated from about 25\xb0 to about 135\xb0 C.
2. A pharmaceutical composition, the composition comprising at least one crystalline form of grapiprant of claim 1 and at least one pharmaceutically acceptable excipient, wherein the crystalline form of grapiprant is selected from the group consisting of Form X, Form X2, Form X3, Form F, Form K, Form L, Form M, and Form N, wherein the crystalline form is selected from the following group:
i. Form X, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.5, about 10.1, about 14.9, about 15.3, about 19.7, about 20.3, about 21.3, about 22.7, about 23.1, and about 27.3;
ii. Form X, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 33-80\xb0 C. and at about 110-140\xb0 C.;
iii. Form X, which exhibits a thermogravimetric analysis showing a loss of mass of 12-13% when heated from about 24\xb0 to about 150\xb0 C.;
iv. Form X2, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 10.2, about 14.9, about 16.8, about 18.3, about 21.8, about 22.7, about 23.9, about 24.3 about 25.9, and about 26.4;
v. Form X2, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 25-130\xb0 C., at about 130-150\xb0 C., and at about 150-190\xb0 C.;
vi. Form X2, which exhibits a thermogravimetric analysis showing a loss of mass of 14-15% when heated from about 25\xb0 to about 150\xb0 C.;
vii. Form X3, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 13.6, about 21.0, about 24.5, and about 25.3;
viii. Form X3, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 75-115\xb0 C., at about 135-150\xb0 C., and at about 150-170\xb0 C.;
ix. Form X3, which exhibits a thermogravimetric analysis showing a loss of mass of 10-11% when heated from about 25\xb0 to about 135\xb0 C.;
x. Form F, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 9.9, about 14.8, about 15.5, about 18.0, about 19.9, about 20.4, about 21.8, about 23.5, and about 27.7;
xi. Form F, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 122\xb0 C. and at about 143\xb0 C.;
xii. Form F, which exhibits a thermogravimetric analysis showing a loss of mass of about 20.5% when heated from about 25\xb0 to about 135\xb0 C.;
xiii. Form K, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 11.3, about 15.9, about 16.6, about 18.2, about 19.0, about 21.7, about 21.9, about 25.7, and about 29.0;
xiv. Form K, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 48\xb0 C., about 95\xb0 C., and at about 155\xb0 C.;
xv. Form K, which exhibits a thermogravimetric analysis showing a loss of mass of about 8.7% when heated from about 25\xb0 to about 135\xb0 C.;
xvi. Form L, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.8, about 11.1, about 13.8, about 16.7, about 20.7, about 23.2, about 25.0, about 26.0, and about 26.3;
xvii. Form L, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 106\xb0 C.;
xviii. Form L, which exhibits a thermogravimetric analysis showing a loss of mass of about 12.9% when heated from about 25\xb0 to about 135\xb0 C.;
xix. Form M, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.2, about 6.5, about 13.0, about 18.9, about 19.5, about 27.4, about 37.9, about 38.0, and about 39.7;
xx. Form M, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 77\xb0 C., at about 99\xb0 C., and at about 138\xb0 C.;
xxi. Form M, which exhibits a thermogravimetric analysis showing a loss of mass of about 13.6% when heated from about 25\xb0 to about 135\xb0 C.;
xxii. Form N, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.5, about 9.9, about 14.2, about 14.8, about 15.4, about 17.7, about 19.7, about 20.3, and about 23.4;
xxiii. Form N, which exhibits a differential scanning calorimetry profile having endothermexotherm events at about 121\xb0 C. and at about 157\xb0 C.; and
xxiv. Form N, which exhibits a thermogravimetric analysis showing a loss of mass of about 11% when heated from about 25\xb0 to about 135\xb0 C.
3. A process for preparing a substantially pure crystalline Form A of grapiprant, the process comprising:
i. contacting grapiprant at ambient temperature with a solvent comprising dichloromethane and acetone to form a saturated or a near saturated solution; and
ii. forming crystals of the substantially pure crystalline Form A of grapiprant,
wherein the crystalline Form A exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 9.9, about 13.5, about 14.3, about 16.1, about 17.7, about 21.8, about 24.14, and about 25.8;
a differential scanning calorimetry profile having showed an endothermexotherm at about 155-170\xb0 C.; and
a thermogravimetric analysis showing a loss of mass of 0.5-0.6% when heated from about 30\xb0 to about 150\xb0 C.
4. The process of claim 3, wherein the solvent comprises a volume-to-volume ratio from 1:1 to 1:3 of dichloromethaneacetone.
5. The process of claim 4, wherein the solvent comprises 0 wt. % to 0.5 wt. % water.
6. A process for preparing a substantially pure crystalline Form X of grapiprant, the process comprising:
i. contacting grapiprant at 35\xb0 C. with a solvent comprising dichloromethaneacetone in a 1:0.5 to 1:5 volume-to-volume ratio to form a suspension; and
ii. forming crystals of the substantially pure crystalline Form X of grapiprant,
wherein the crystalline Form X, which exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 6.5, about 10.1, about 14.9, about 15.3, about 19.7, about 20.3, about 21.3, about 22.7, about 23.1, and about 27.3;
a differential scanning calorimetry profile having endothermexotherm events at about 33-80\xb0 C. and at about 110-140\xb0 C.; and
a thermogravimetric analysis showing a loss of mass of 12-13% when heated from about 24\xb0 C. to about 150\xb0 C.
7. The process of claim 6, wherein the solvent comprises a volume-to-volume ratio from 1:1 to 2:1.
8. The process of claim 6, further comprising converting Form X to Form A by slurry in dichloromethaneacetone with a volume-to-volume ratio of 1:1,
wherein Form A exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at about 9.9, about 13.5, about 14.3, about 16.1, about 17.7, about 21.8, about 24.14, and about 25.8;
a differential scanning calorimetry profile having showed an endothermexotherm at about 155-170\xb0 C.; and
a thermogravimetric analysis showing a loss of mass of 0.5-0.6% when heated from about 30\xb0 to about 150\xb0 C.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A device for separating solids from liquids comprising a generally cylindrical enclosure, the generally cylindrical enclosure having an axis, and a first substantially cylindrical screen member within said generally cylindrical enclosure, said substantially cylindrical screen member also having an axis, said axis being coexistent or substantially parallel to the axis of said cylindrical enclosure, said substantially cylindrical screen member comprising a convex screen and a concave screen, said convex screen and said concave screen being connected in sealed relationship and defining a space between them whereby, when said substantially cylindrical screen member is contacted with liquid containing solids, at least some solids will be retained on said screen member and said liquid will pass through said convex and concave screens to said space.
2. The device of claim 1 wherein said substantially cylindrical screen member has a substantially linear opening, said substantially linear opening being substantially parallel to its axis, whereby said substantially linear opening facilitates contact of said liquid containing solids with said convex screen.
3. The device of claim 1 wherein said cylindrical enclosure has at least one inlet for contacting said liquid containing solids with said concave screen and said convex screen of said substantially cylindrical screen.
4. The device of claim 1 wherein said concave and said convex screens are wedge wire screens.
5. The device of claim 3 wherein said screen member has an outlet for liquid.
6. The device of claim 1 including a central, substantially cylindrical, screen.
7. The device of claim 1 including a second substantially cylindrical screen member comprising convex and concave screens, said second screen member being situated within said substantially cylindrical enclosure.
8. The device of claim 7 wherein said second substantially cylindrical screen member is substantially concentrically within said first substantially cylindrical screen member.
9. A solidsliquid separator comprising a first generally cylindrical screen having a screen surface facing outwardly, a second generally cylindrical screen of a diameter smaller than that of said first screen and having a screen surface facing inwardly, said second screen being situated substantially concentrically within said first screen, said first and second screens being connected in sealed relation to form a generally C-shaped profile and a space between said first and said second screens for collecting liquid filtrate.
10. A separator of claim 9 wherein said first and second screens are wedge wire screens.
11. A separator of claim 9 including a second separator of claim 9 within the C-shaped profile of said separator of claim 9.
12. A separator of claim 11 wherein said first and second separators comprise wedge wire screens.
13. A high volume separator comprising a plurality of devices of claim 1.
14. A high volume separator comprising a plurality of separators of claim 9.
15. The separator of claim 9 including a substantially cylindrical wedge wire screen within and substantially concentric to said generally C-shaped profile.
16. A substantially cylindrical device for separating solids and liquids comprising (a) a substantially cylindrical convex wedge wire screen and (b) a substantially cylindrical concave wedge wire screen, said substantially cylindrical concave wedge wire screen being fixed and sealed substantially concentrically within and apart from said substantially cylindrical convex wedge wire screen, whereby said convex and concave screens form an interior space.
17. The substantially cylindrical device of claim 16 having a C-shaped cross section.
18. A device for screening solids from liquids comprising at least one device of claim 16 enclosed and sealed within an enclosure having an inlet for liquid containing solids, said inlet providing access for said liquid to the convex surface of said convex wedge wire screen and also the to concave surface of said concave wedge wire screen.
19. The device of claim 18 in the form of a candle filter.
20. The device of claim 1 oriented in the form of a candle filter, having an opening at the top of said defined space, said device being substantially enclosed within a vessel having means for collecting and draining solids at the bottom thereof.

1. A method for dynamically placing resources within a graphical user interface (GUI), the method comprising:
assigning a filename to a resource of the GUI, the filename having position information encoded therein, the position information relating to the location at which the resource is displayed on a graphical user interface (GUI);
allowing a user to change the position of the resource by changing the position information encoded within the filename via editing x,y coordinates prior to the extension ; and
generating the GUI by i) interpreting the filename to parse out the position information, and ii) placing displaying the resource in a position within the GUI according to the position information.
2. The method as in claim 1, further comprising:
representing, with the position information, two-dimensional (2D) coordinates of the object within the GUI.
3. The method as in claim 2, wherein the 2D coordinates are of a particular point of the resource.
4. The method as in claim 3, further comprising:
selecting the particular point of the resource from a group comprising: a geometric center of the resource, a top left corner of the resource, a top right corner of the resource, a bottom left corner of the resource, and a bottom right corner of the resource.
5. The method as in claim 2, wherein the 2D coordinates are one of either Cartesian coordinates or polar coordinates.
6. The method as in claim 1, further comprising:
representing, with the position information, three-dimensional (3D) coordinates of the resource within the GUI, wherein the GUI is 3D.
7. The method as in claim 1, further comprising:
representing, with the position information, a position of the resource within the GUI relative to another resource of the GUI.
8. The method as in claim 1, further comprising:
representing, with the position information, a position of the resource within the GUI relative to a series of resources of the GUI.
9. The method as in claim 8, further comprising:
representing, with the position information, the position of the resource within the series of resources in row and column form.
10. The method as in claim 8, further comprising:
representing, with the position information, a spacing between the resources of the series.
11. The method as in claim 10, further comprising:
adjusting the spacing between the resources of the series based on a screen size and resolution of the GUI.
12. The method as in claim 1, further comprising:
placing the resource in a default position within the GUI in the event the position information is absent from the parsed filename.
13. The method as in claim 1, further comprising:
formatting the filename of the resource as \u201c{resourcename}_{position information}.{extension},\u201d where \u201c{resourcename}\u201d is a unique predefined name of the resource, \u201c{positioninformation}\u201d is the encoded position information, and \u201c.{extension}\u201d is a file type extension of the resource.
14. The method as in claim 1, further comprising:
coding the GUI using a programming language selected from a group comprising: Visual Basic (VB), VB.NET, Perl, Hypertext Markup Language (HTML), C, C++, and Java.
15. The method as in claim 1, further comprising:
storing a plurality of resources in locations corresponding to a plurality of particular display resolutions; and
retrieving one of the plurality of resources for use when generating the GUI based on a display resolution of the GUI.
16. An apparatus for dynamically placing resources within a graphical user interface (GUI), the apparatus comprising:
a processor;
a memory adapted to store resources;
means for assigning a filename to a resource of the GUI, the filename having position information encoded therein, the position information relating to the location at which the resource is displayed on the GUI; means for allowing a user to change the position of the resource by changing the position information encoded within the filename via editing x,y coordinates prior to the extension; and
means for generating the GUI by i) interpreting the filename to parse out the position information, and ii) displaying the resource within the GUI according to the position information.
17. A tangible computer readable storage medium storing executable program instructions, the program instructions dynamically placing resources within a graphical user interface (GUI), the executable program instructions comprising program instructions for:
assigning a filename to a resource of the GUI, the filename having position information encoded therein, the position information relating to the location at which the resource is displayed on the GUI; allowing a user to change the position of the resource by changing the position information encoded within the filename via editing x,y coordinates prior to the extension; and
generating the GUI by i) interpreting the filename to parse out the position information, and ii) placing displaying the resource in a position within the GUI according to the position information.
18. A computer for dynamically placing resources within a graphical user interface (GUI), the computer comprising:
a display;
an input device;
a processor coupled to the display and input device, the processor adapted to execute software processes; and

a memory configured to store a GUI generation process executable by the processor, the GUI generation process configured to: i) interpret a filename to a resource of the GUI, the filename having position information encoded therein, the position information relating to the location at which the resource is displayed on the GUI, the filename interpreted to parse out the position information, ii) allow a user to change the position of the resource by changing the position information encoded within the filename via editing x,y coordinates prior to the extension, and ii) display the resource within the GUI according to the position information.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. In an environment comprising a plurality of sources of electromagnetic energy, an antenna system comprising:
a plurality of receiving antenna elements;
a partitioning structure:
positioned between the elements and the sources,
disposed to create at least two non-identical radio frequency fields of view; and

at least one absorber substantially lining at least wall of the partitioning structure.
2. The antenna system according to claim 1, further comprising:
a processing unit:
in electrical communication with at least two antenna elements;
operative to receive the electrical signal of each communicated antenna element;
operative to characterize the electrical signal of each communicated antenna element; and
operative to modify those electrical signals for which the characterization meets a condition.
3. The antenna system according to claim 2, wherein the characterization of the electrical signal of each communicated antenna element comprises a function of the power such electrical signal.
4. The antenna system according to claim 3, wherein the condition for modification is that the function of the power of the characterized electrical signal exceeds a threshold.
5. The antenna system according to claim 4, wherein the modification of those electrical signals for which power is greater than a threshold is attenuation.
6. The antenna system according to claim 5, wherein the modification of those electrical signals for which power is greater than a threshold is blocking.
7. The antenna system according to claim 2, further comprising, a combiner:
in electrical communication with at the processing unit; and
operative to receive at least two electrical signals from the processing unit and combine the signals.
8. The antenna system according to claim 1, further comprising an outer skin substantially covering at least a portion of the partitioning structure.
9. The antenna system according to claim 8, wherein the outer skin is a bandpass filter.
10. The antenna system according to claim 1, wherein the partitioning structure comprises a plurality of hex-shaped walls.
11. In an antenna system comprising a plurality of antenna elements, a method for improving the resistance of the antenna system to interference from electromagnetic energy sources, the method comprising:
physically partitioning, using a partitioning structure, the space between the receiving antenna array and the electromagnetic energy sources such that at least two antenna elements are characterized by nonidentical radio frequency fields of view; and
substantially coating at least one surface of the partitioning structure with an absorber.
12. The method according to claim 11, further comprising:
in response to electromagnetic energy incident on the antenna array, determining which array elements contain energy characteristic of interference; and
modifying the signal from at least one array element that contains energy characteristic of interference.
13. The method according to claim 12, wherein the step of modification comprises broadband attenuation of the signal from at least one antenna element that contains energy characteristic of interference.
14. The method according to claim 12, wherein the step of modification comprises blocking the electromagnetic energy from at least one antenna element that contains energy characteristic of interference.