Author: claimsbot

1. A method of calibrating a vehicular camera installed in a vehicle, wherein the camera has an imager and a camera microcontroller, said method comprising:
(a) determining whether the contrast in images received by the imager is beyond a selected threshold value;
(b) searching for a reference point in the images depending on the result of step (a) using the camera microcontroller; and
(c) adjusting the position of an overlay applied by the microcontroller to the images depending on the result of step (b).
2. The method as claimed in claim 1, wherein step (b) includes:
(d) selecting a search window within the images;
(e) dividing the search window into a plurality of bars, wherein each bar corresponds to a plurality of pixels on the imager;
(f) receiving data relating to brightness levels of the bars; and
(g) detecting the position of the reference point based on changes in brightness levels from bar to bar.
3. The method as claimed in claim 2, wherein the search window selected in step (d) is a vertical position search window and wherein step (b) further includes:
(h) selecting a rotation angle detection search window;
(i) searching for the positions of a plurality of rotation angle reference points; and
(j) determining whether to adjust the position of the overlay rotationally based on the results of step (i).
4. The method as claimed in claim 1, wherein step (b) includes:
(d) selecting a search window within the images;
(e) selecting a rotation angle detection search window;
(f) searching for the positions of a plurality of rotation angle reference points; and
(g) determining whether to adjust the position of the overlay rotationally based on the results of step (f).
5. The method as claimed in claim 1, wherein step (b) includes determining the reference point iteratively using data from the camera.
6. The method as claimed in claim 1, wherein step (b) includes determining the reference point and determining an offset amount with which to shift the overlay on the images.
7. The method as claimed in claim 6, wherein the reference point is at an edge of the bumper of the vehicle.
8. The method as claimed in claim 1, comprising determining a rotation angle of the camera and adjusting the position of the overlay based on the determined rotation angle.
9. The method as claimed in claim 8, comprising emitting near-infrared light via a near-infrared light source towards a location where the reference point may be determined.
10. The method as claimed in claim 9, wherein the reference point is at an edge of the bumper of the vehicle, and wherein near-infrared light is emitted towards the bumper of the vehicle.
11. The method as claimed in claim 1, comprising providing images captured by said camera to an in-vehicle display.
12. The method as claimed in claim 11, comprising applying the adjusted overlay to images displayed at the in-vehicle display.
13. A method of calibrating a vehicular camera installed in a vehicle, wherein the camera has an imager and a camera microcontroller, said method comprising:
(a) searching for a reference point in images captured by the camera using the camera microcontroller;
(b) providing the images to an in-vehicle display;
(c) applying an overlay to images displayed at the in-vehicle display;
(d) determining the reference point and determining an offset amount with which to shift the overlay on the images displayed at the in-vehicle display; and
(e) adjusting the position of the overlay applied to the images displayed at the in-vehicle display responsive to the result of steps (a) and (d).
14. The method as claimed in claim 13, wherein step (a) includes:
(f) selecting a search window within the images;
(g) selecting a rotation angle detection search window;
(h) searching for the positions of a plurality of rotation angle reference points; and
(i) determining whether to adjust the position of the overlay rotationally based on the results of step (h).
15. The method as claimed in claim 13, wherein step (a) includes determining the reference point iteratively using data from the camera.
16. The method as claimed in claim 13, comprising determining a rotation angle of the camera and adjusting the position of the overlay based on the determined rotation angle.
17. A method of calibrating a vehicular camera installed in a vehicle, wherein the camera has an imager and a camera microcontroller, said method comprising:
(a) determining a reference point in images captured by the camera using the camera microcontroller;
(b) comparing the determined reference point’s actual position to its expected position;
(c) providing the images to an in-vehicle display;
(d) applying an overlay to images displayed at the in-vehicle display;
(e) determining an offset amount with which to shift the overlay on the images displayed at the in-vehicle display responsive to step (b); and
(f) adjusting the position of an overlay applied to the images displayed at the in-vehicle display responsive to the result of step (e).
18. The method as claimed in claim 17, comprising determining a rotational offset in the images responsive to step (b) and adjusting the position of the overlay based on the determined rotational offset.
19. The method as claimed in claim 17, wherein step (a) includes determining the reference point iteratively using data from the camera.
20. The method as claimed in claim 17, wherein step (a) includes:
(f) selecting a search window within the images;
(g) selecting a rotation angle detection search window;
(h) searching for the positions of a plurality of rotation angle reference points; and
(i) determining whether to adjust the position of the overlay rotationally based on the results of step (h).

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method implemented in a computer infrastructure comprising a combination of hardware and software, the method comprising:
receiving a request from a local computing device to save data on a network comprising a plurality of data storage locations in a plurality of different geographic regions;
determining a specified geographic region of the plurality of different geographic regions by analyzing at least one of: (i) file attributes associated with the data, and (ii) predefined rules;
identifying one of the plurality of data storage locations within the specified geographic region based on the determining step; and
routing the data to the identified one of the plurality of data storage locations within the specified geographic region.
2. The method of claim 1, wherein:
the local computing device is using a service provider’s application running on network infrastructure remote from the local computing device; and
the data is associated with the application.
3. The method of claim 2, wherein the local computing device is accessing the service provider’s application via a web browser.
4. The method of claim 1, wherein:
the local computing device is running an application or an operating system on a service provider’s hardware remote from the local computing device; and
the data is associated with the application or the operating system.
5. The method of claim 1, wherein:
the determining the specified geographic region comprises analyzing the file attributes associated with the data; and
the file attributes were created in response to a selection of a user at the local computing device.
6. The method of claim 1, wherein the identifying comprises comparing the specified geographic region to a mapping database that associates geographic regions with the plurality of data storage locations.
7. The method of claim 1, wherein:
the determining the specified geographic region comprises analyzing the predefined rules; and
the predefined rules are based on at least one of: file content, semantic data, user identity, group association, and local computing device location.
8. The method of claim 1, further comprising presenting a plurality of selectable geographic regions to the local computing device.
9. The method of claim 8, further comprising determining the plurality of selectable geographic regions based on the predefined rules, wherein at least one of the plurality of different geographic regions is omitted from the plurality of selectable geographic regions based on the predefined rules.
10. The method of claim 1, wherein a service provider at least one of creates, maintains, deploys and supports the computer infrastructure.
11. The method of claim 1, wherein steps of claim 1 are provided by the service provider on a subscription, advertising, andor fee basis.
12. A computer system for saving data on a network, the system comprising:
a CPU, a computer readable memory and a computer readable storage media;
first program instructions to present a plurality of geographic regions to a local computing device, wherein the plurality of geographic regions are associated with a plurality of data storage locations in a network, and the local computing device is accessing the network;
second program instructions to receive a specification of at least one of the plurality of geographic regions from the local computing device; and
third program instructions to cause data associated with the local computing device to be physically stored at a device located within the specified at least one of the plurality of geographic regions,
wherein the first, second and third program instructions are stored on the computer readable storage media for execution by the CPU via the computer readable memory.
13. The system of claim 12, wherein:
the network comprises a cloud computing infrastructure;
the local computing device is using a service provider’s application running on the cloud computing infrastructure at a location remote from the local computing device; and
the data is associated with the application.
14. The system of claim 12, wherein:
the network comprises computing resources of at least one service provider; and
the computing resources are pooled to serve multiple consumers using a multi-tenant model, with different physical and virtual resources dynamically assigned and reassigned according to demand.
15. The system of claim 12, wherein:
the network comprises a cloud computing infrastructure;
the local computing device is running an application or an operating system on a service provider’s hardware in the cloud computing infrastructure and remote from the local computing device; and
the data is associated with the application or the operating system.
16. The system of claim 12, wherein an intelligent routing system interfaced between the local computing device and the network performs the presenting, the receiving, and the causing the data to be physically stored.
17. The system of claim 12, wherein the specification of at least one of the plurality of geographic regions comprises a file attribute.
18. The system of claim 17, further comprising creating the file attribute based on a selection of a user.
19. The system of claim 17, further comprising comparing the file attribute to a mapping database for determining a network identity of a storage location corresponding to the specified at least one of the plurality of geographic regions.
20. The system of claim 12, wherein the presenting the plurality of geographic regions is based on at least one predefined rule.
21. The system of claim 20, wherein the at least one predefined rule is based on at least one of: file content, semantic data, user identity, group association, and local computing device location.
22. A computer program product comprising a computer usable storage medium having readable program code embodied in the storage medium, the computer program product includes at least one component operable to:
receive a request to save data on a network, wherein the network comprises a plurality of data storage locations in a plurality of different geographic regions;
determine a specified geographic region by analyzing at least one of: (i) file attributes associated with the data, and (ii) predefined rules;
identify one of the plurality of data storage locations within the specified geographic region; and
cause the data to be saved at the identified one of the plurality of data storage locations within the specified geographic region by routing the data to the identified one of the plurality of data storage locations within the specified geographic region.
23. A system, comprising:
an intelligent routing system interfaced between a local computing device and a network, wherein the network comprises a plurality of data storage locations in a plurality of different geographic regions, and wherein the intelligent routing system is configured to:
receive a request from the local computing device to save data on the network;
determine a specified geographic region by analyzing at least one of: (i) file attributes associated with the data, and (ii) predefined rules;
identify one of the plurality of data storage locations within the specified geographic region; and
cause the data to be saved at the identified one of the plurality of data storage locations within the specified geographic region by routing the data to the identified one of the plurality of data storage locations within the specified geographic region.

1. A clamping assembly for selectively retaining a stack of pages, said assembly comprising:
a bottom disk configured to be positioned proximate the stack of pages;
a tube operationally coupled to said bottom disk;
a top disk operationally coupled to said tube wherein said top disk selectively compresses the stack of pages between said top and bottom disks;
a retainer operationally coupled to said top disk wherein said retainer retains said top disk on the stack of pages; and
a release operationally coupled to said top disk wherein said release is configured to selectively release said top disk from the stack of pages; and
a shaft slidably positioned within said tube wherein a bottom end of said shaft is positioned proximate a bottom end of said tube.
2. The assembly according to claim 1 further comprising a lip coupled to and extending upwardly from a top side of said bottom disk wherein said lip is coextensive with an outer edge of said bottom disk.
3. The assembly according to claim 1 further comprising a bottom engaging disk coupled to a top edge of a lip on said bottom disk wherein an outer edge of said bottom engaging disk is coextensive with said lip on said bottom disk.
4. The assembly according to claim 1 further comprising a tube aperture extending through a top side and a bottom side of a bottom engaging disk proximate an outer edge of said bottom engaging disk.
5. The assembly according to claim 1 further comprising said tube extending downwardly through a tube aperture wherein a bottom end of said tube is coupled to a top side of said bottom disk.
6. (canceled)
7. The assembly according to claim 1 further comprising a primary spring biasing member positioned within said tube wherein said primary spring biasing member is positioned between a top side of said bottom disk and a bottom end of said shaft wherein said primary spring biasing member biases said shaft upwardly in said tube.
8. The assembly according to claim 1 further comprising:
of an outer edge of said top disk having a flat portion wherein said top disk forms a circle segment; and
a lip coupled to and extending upwardly from a top side of said top disk wherein said lip is coextensive with said outer edge of said top disk.
9. A clamping assembly for selectively retaining a stack of pages, said assembly comprising:
a bottom disk configured to be positioned proximate the stack of pages;
a tube operationally coupled to said bottom disk;
a top disk operationally coupled to said tube wherein said top disk selectively compresses the stack of pages between said top and bottom disks;
a retainer operationally coupled to said top disk wherein said retainer retains said top disk on the stack of pages;
a release operationally coupled to said top disk wherein said release is configured to selectively release said top disk from the stack of pages; and
a primary shaft aperture extending through a top side and a bottom side of said top disk proximate a flat portion of an outer edge of said top disk.
10. The assembly according to claim 9 further comprising a shaft extending upwardly through a primary shaft aperture in said top disk wherein said top disk is coupled to said shaft.
11. A clamping assembly for selectively retaining a stack of pages, said assembly comprising:
a bottom disk configured to be positioned proximate the stack of pages;
a tube operationally coupled to said bottom disk;
a top disk operationally coupled to said tube wherein said top disk selectively compresses the stack of pages between said top and bottom disks;
a retainer operationally coupled to said top disk wherein said retainer retains said top disk on the stack of pages;
a release operationally coupled to said top disk wherein said release is configured to selectively release said top disk from the stack of pages;
a rounded portion of said retainer coupled to a second end of a straight portion of said retainer wherein said retainer has a T-shape;
a first end of a straight portion of said retainer being hingedly coupled to a top side of said top disk wherein said straight portion of said retainer extends outwardly through an opening in a lip on said top disk wherein a rounded portion of said retainer is positioned outside of said lip on said top disk; and
a secondary shaft aperture extending through a top side and a bottom side of a straight portion of said retainer wherein a shaft extends upwardly through said secondary shaft aperture in said straight portion of said retainer.
12. The assembly according to claim 7, further comprising a secondary spring biasing member positioned around a shaft wherein said secondary spring biasing member is positioned between a bottom side of said retainer and a top side of said top disk wherein said secondary spring biasing member biases said retainer into a retaining position wherein an outer edge of a secondary shaft aperture in a straight portion of said retainer engages an outer surface of said shaft.
13. A clamping assembly for selectively retaining a stack of pages, said assembly comprising:
a bottom disk configured to be positioned proximate the stack of pages;
a tube operationally coupled to said bottom disk;
a top disk operationally coupled to said tube wherein said top disk selectively compresses the stack of pages between said top and bottom disks;
a retainer operationally coupled to said top disk wherein said retainer retains said top disk on the stack of pages;
a release operationally coupled to said top disk wherein said release is configured to selectively release said top disk from the stack of pages; and
a cover coupled to a top edge of a lip on said top disk wherein an outer edge of said cover is coextensive with said lip on said top disk.
14. A clamping assembly for selectively retaining a stack of pages, said assembly comprising:
a bottom disk configured to be positioned proximate the stack of pages;
a tube operationally coupled to said bottom disk;
a top disk operationally coupled to said tube wherein said top disk selectively compresses the stack of pages between said top and bottom disks;
a retainer operationally coupled to said top disk wherein said retainer retains said top disk on the stack of pages;
a release operationally coupled to said top disk wherein said release is configured to selectively release said top disk from the stack of pages;
an outer edge of said release having a flat portion wherein said release forms a circle segment;
a lip coupled to and extending upwardly from a top side of said release wherein said lip on said release is coextensive with said outer edge of said release;
said release being operationally coupled to said top side wherein said flat portion of said outer edge of said release abuts a flat portion of an outer edge of said top disk wherein said release and said top disk forms a complete circle;
a cover coupled to a top edge of said lip on said release wherein said cover is coextensive with said lip on said release; and
a rounded portion of said retainer being positioned with said release wherein an outer edge of said rounded portion of said retainer is coextensive with an inner edge of said lip on said release.
15. The assembly according to claim 1 further comprising the stack of pages being selectively positioned between said top and bottom disks wherein said top disk is urged downwardly wherein the stack of paper is compressed between a top surface of a bottom engaging disk and a bottom side of said top disk wherein said retainer is positioned in a retaining position wherein the stack of pages is retained between said top and bottom disks.
16. The assembly according to claim 7, further comprising said release being selectively depressed wherein said retainer is urged into a releasing position wherein a shaft freely moves in a secondary shaft aperture in said retainer wherein a primary spring biasing member biases said top disk upwardly away from the stack of pages wherein the stack of pages are removable from said assembly.
17. The assembly according to claim 1, further comprising:
a lip coupled to and extending upwardly from a top side of said bottom disk wherein said lip is coextensive with an outer edge of said bottom disk;
a bottom engaging disk coupled to a top edge of said lip on said bottom disk wherein an outer edge of said bottom engaging disk is coextensive with said lip on said bottom disk;
a tube aperture extending through a top side and a bottom side of said bottom engaging disk proximate an outer edge of said bottom engaging disk;
said tube extending downwardly through said tube aperture wherein a bottom end of said tube is coupled to said top side of said bottom disk;
a primary spring biasing member positioned within said tube wherein said primary spring biasing member is positioned between said top side of said bottom disk and said bottom end of said shaft wherein said primary spring biasing member biases said shaft upwardly in said tube;
said top disk comprising an outer edge of said top disk having a flat portion wherein said top disk forms a circle segment;
a lip coupled to and extending upwardly from a top side of said top disk wherein said lip is coextensive with said outer edge of said top disk;
a primary shaft aperture extending through a top side and a bottom side of said top disk proximate said flat portion of said outer edge of said top disk, said shaft extending upwardly through said primary shaft aperture in said top disk wherein said top disk is coupled to said shaft;
said retainer comprising a rounded portion of said retainer coupled to a second end of a straight portion of said retainer wherein said retainer has a T-shape, a first end of said straight portion of said retainer being hingedly coupled to said top side of said top disk wherein said straight portion of said retainer extends outwardly through an opening in said lip on said top disk wherein said rounded portion of said retainer is positioned outside of said lip on said top disk; and
a secondary shaft aperture extending through a top side and a bottom side of said straight portion of said retainer wherein said shaft extends upwardly through said secondary shaft aperture in said straight portion of said retainer;
a secondary spring biasing member positioned around said shaft wherein said secondary spring biasing member is positioned between a bottom side of said retainer and said top side of said top disk wherein said secondary spring biasing member biases said retainer into a retaining position wherein an outer edge of said secondary shaft aperture in said straight portion of said retainer engages an outer surface of said shaft;
a cover coupled to a top edge of said lip on said top disk wherein an outer edge of said cover is coextensive with said lip on said top disk;
said release comprising an outer edge of said release having a flat portion wherein said release forms a circle segment, said release being operationally coupled to said top disk wherein said flat portion of said outer edge of said release abuts said flat portion of said outer edge of said top disk wherein said release and said top disk forms a complete circle;
a lip coupled to and extending upwardly from a top side of said release wherein said lip on said release is coextensive with said outer edge of said release;
a cover coupled to a top edge of said lip on said release wherein said cover is coextensive with said lip on said release;
said rounded portion of said retainer being positioned with said release wherein an outer edge of said rounded portion of said retainer is coextensive with an inner edge of said lip on said release;
the stack of pages being selectively positioned between said top and bottom disks wherein said top disk is urged downwardly wherein the stack of paper is compressed between a top surface of said bottom engaging disk and said bottom side of said top disk wherein said retainer is positioned in a retaining position wherein the stack of pages is retained between said top and bottom disks; and
said release being selectively depressed wherein said retainer is urged into a releasing position wherein said shaft freely moves in said secondary shaft aperture in said retainer wherein said primary spring biasing member biases said top disk upwardly away from the stack of pages wherein the stack of pages are removable from said assembly.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of preventing or reducing hypersensitivity or allergic reactions in a human patient undergoing taxane therapy for a taxane-responsive disease condition, comprising orally co-administering to the patient a taxane and an oral bioavailability enhancing agent comprising an inhibitor of P-glycoprotein, without prior administration of medication to prevent the hypersensitivity or allergic reactions, wherein the taxane reaches therapeutic blood or plasma levels in said patient.
2. The method of claim 1, wherein the taxane is selected from the group consisting of paclitaxel and analogs, derivatives and prodrugs thereof.
3. The method of claim 1 wherein the taxane is a analog of paclitaxel.
4. The method of claim 3, wherein the analog of paclitaxel is docetaxel.
5. The method of claim 1, wherein the enhancing agent is administered either
a) about 0.5-72 hrs. before,
b) less than 0.5 hr. before, together with or less than 0.5 hr. after, or
c) both about 0.5-72 hrs. before and again less than 0.5 hr. before, together with or less than 0.5 hr. after, the administration of the taxane.
6. The method of claim 1, wherein the taxane and the enhancing agent are administered in separate oral dosage forms.
7. The method of claim 1, wherein the taxane and the enhancing agent are administered together in a combination oral dosage form.
8. The method of claim 1, wherein the taxane is paclitaxel.
9. The method of claim 1, wherein the enhancing agent is administered in an amount of from about 0.1 to 20 mgkg of patient body weight.
10. The method of claim 8, wherein the paclitaxel and the enhancing agent are orally co-administered once a week.
11. The method of claim 10, wherein the paclitaxel is administered in a divided dose.
12. The method of claim 5, wherein the taxane is docetaxel.
13. The method of claim 1, wherein two or more doses of the taxane are administered after a single dose of the enhancing agent.
14. The method of claim 1, wherein the patient is administered about 20-1,000 mgm2 of the taxane based on patient body surface area.
15. The method of claim 14, wherein the patient is administered about 50-200 mgm2 of the taxane based on patient body weight.
16. The method of claim 1, wherein the patient is administered about 2-30 mgkg of paclitaxel based on patient body weight.
17. The method of claim 16, wherein the patient is administered about 2-6 mgkg of paclitaxel.
18. The method of claim 1, wherein the taxane, the enhancing agent or both is each administered in a dosage form selected from the group consisting of tablets, softgel capsules, hardgel capsules, caplets, gelcaps, pills, lozenges, powders, micronized particles, osmotic delivery systems, and liquid solutions, suspensions and elixirs.
19. The method of claim 8, wherein paclitaxel is administered in a formulation further comprising a polyethoxylated castor oil, alcohol or polyoxyethylated sorbitan mono-oleate.
20. The method of claim 1, wherein the disease condition is a cancer, tumor, malignancy, uncontrolled tissue or cellular proliferation secondary to tissue injury, or an inflammatory disease.
21. The method of claim 1, wherein the disease condition is selected from the group consisting of gastrointestinal tract cancers, lung cancers, pancreatic cancer, prostate cancer, hepatocellular carcinoma, liver metastases, genito-urinary and gastrointestinal tract cancers, Kaposi’s sarcoma, polycystic kidney disease and malaria.
22. The method of claim 1, wherein the disease condition is cancer.
23. The method of claim 22, wherein the taxane is paclitaxel.
24. The method of claim 23, wherein the patient is administered about 50-200 mgm2 of paclitaxel based on patient body weight.
25. The method of claim 24, wherein paclitaxel and the enhancing agent are orally co-administered about once per week.
26. The method of claim 25, wherein paclitaxel is administered in a divided dose.
27. The method of claim 1, wherein the taxane is docetaxel.
28. The method of claim 1, wherein the disease condition is lung cancer.
29. The method of claim 28, wherein the taxane is paclitaxel.
30. The method of claim 29, wherein the patient is administered about 50-200 mgm2 of paclitaxel based on patient body weight.
31. The method of claim 30, wherein paclitaxel and the enhancing agent are orally co-administered about once per week.
32. The method of claim 31, wherein paclitaxel is administered in a divided dose.
33. The method of claim 28, wherein the taxane is docetaxel.
34. The method of claim 33, wherein from about 0.1 to about 20 mgkg of the enhancing agent are orally administered to the patient.
35. The method of claim 1, wherein the disease condition is a cancer of the gastrointestinal tract.
36. The method of claim 35, wherein the taxane is paclitaxel.
37. The method of claim 36, wherein the patient is administered about 50-200 mgm2 of paclitaxel based on patient body weight.
38. The method of claim 37, wherein paclitaxel and the enhancing agent are orally co-administered about once per week.
39. The method of claim 38, wherein paclitaxel is administered in a divided dose.
40. The method of claim 35, wherein the taxane is docetaxel.
41. The method of claim 40, wherein from about 0.1 to about 20 mgkg of the enhancing agent are orally administered to the patient.
42. The method of claim 1, wherein the disease condition is ovarian cancer.
43. The method of claim 42, wherein the taxane is paclitaxel.
44. The method of claim 43, wherein the patient is administered about 50-200 mgm2 of paclitaxel based on patient body weight.
45. The method of claim 44, wherein paclitaxel and the enhancing agent are orally co-administered about once per week.
46. The method of claim 45, wherein paclitaxel is administered in a divided dose.
47. The method of claim 3, wherein the taxane is docetaxel.
48. The method of claim 47, wherein from about 0.1 to about 20 mgkg of the enhancing agent are orally administered to the patient.
49. The method of claim 1, wherein the disease condition is breast cancer.
50. The method of claim 49, wherein the taxane is paclitaxel.
51. The method of claim 50, wherein the patient is administered about 50-200 mgm2 of paclitaxel based on patient body weight.
52. The method of claim 51, wherein paclitaxel and the enhancing agent are orally co-administered about once per week.
53. The method of claim 52, wherein paclitaxel is administered in a divided dose.
54. The method of claim 49, wherein the taxane is docetaxel.
55. The method of claim 54, wherein from about 0.1 to a out 20 mgkg of the enhancing agent are orally administered to the patient.