Author: claimsbot

1. An LED light source module, comprising:
a constant-current unit, comprising:
a voltage stabilizing unit having an input end, a first output end, and a second output end, the input end receiving a DC voltage, and the first output end outputting a constant current; and
a resistor parallel-connected between the first output end and the second output end; and

an LED set electrically connected to the first output end.
2. The LED light source module of claim 1, wherein the LED set comprises a single LED.
3. The LED light source module of claim 1, wherein the LED set comprises a plurality of LEDs connected to one another in series.
4. The LED light source module of claim 1, wherein the LED set comprises a plurality of first LED sets connected to one another in parallel, each said first LED set comprising a plurality of LEDs connected to one another in series.
5. LED light source module of claim 1, further comprising an ACDC rectifying unit for converting an AC voltage into the DC voltage.
6. A constant-current unit structure for use with an LED light source module, comprising:
a constant-current unit comprising a voltage stabilizing unit having an input end, a first output end, and a second output end, the input end receiving a DC voltage, and the first output end outputting a constant current; and
a resistor parallel-connected between the first output end and the second output end.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An apparatus, comprising:
a substrate having a plurality of through-holes therethrough; and
an integrated circuit (IC) socket frame to mount to the substrate, the IC socket frame having a plurality of beam features, each extending from a socket frame body and corresponding in arrangement to the plurality of through-holes through the substrate.
2. The apparatus of claim 1, wherein at least one of the plurality of beam features includes an orientation feature to orientate the substrate to the IC socket.
3. The apparatus of claim 1, wherein the plurality of through-holes are shaped and sized to receive the plurality of beam features therethrough.
4. The apparatus of claim 1, wherein the plurality of through-holes and the plurality of beam features have corresponding mating shapes selected from the group of: an \u201cL\u201d shape, a circular shape, a triangular shape, a rectangular shape, and a combination of different shapes.
5. The apparatus of claim 1, wherein the plurality of beam features have a through-hole extending therethrough from a first end of the beam feature, to a second end of the beam feature, and through the socket frame body.
6. The apparatus of claim 1, wherein the plurality of beam features provide a mechanism to facilitate at least one of the following: alignment and support of the substrate, alignment of an IC socket retention mechanism to the apparatus, and alignment of a thermal management mechanism to the apparatus.
7. The apparatus of claim 1, wherein the substrate further comprises at least one orientation feature to correspond to the orientation feature of the at least one of the plurality of beam features.
8. The apparatus of claim 1, further comprising an array of pin contacts on an upper region of the socket frame body to engage with a plurality of pins on the substrate.
9. The apparatus of claim 1, further comprising a plurality of conductive contacts on a lower surface of the socket frame body.
10. An integrated circuit (IC) socket to connect to a substrate, comprising:
a socket frame body; and
a plurality of beam features extending from the socket frame body, each of the plurality of beam features spaced apart from the others of the plurality of beam features and having a first end connected to an upper surface of the socket frame and a second end spaced apart from the socket frame body.
11. The IC socket of claim 10, wherein the plurality of beam features have a through-hole extending therethrough from the first end thereof to the second end thereof.
12. The IC socket of claim 11, wherein through-hole further extends through the socket frame body.
13. The IC socket of claim 10, wherein the plurality of beam features have an exterior shape selected from the group of: an \u201cL\u201d shape, a circular shape, a triangular shape, a rectangular shape, and a combination of different shapes.
14. The IC socket of claim 10, wherein at least one of the plurality of beam features includes an orientation feature.
15. The IC socket of claim 14, wherein the orientation feature is selected from the group of: a shape of the beam feature, a size of the beam feature, and combinations thereof.
16. The IC socket of claim 10, further comprising an array of pin contacts on an upper region of the socket frame body to engage with a plurality of pins of an IC.
17. A substrate to connect to an IC socket frame, comprising:
an substrate material; and
a plurality of through-holes through the substrate material, the plurality of through-holes to receive a corresponding plurality of beam features of an IC socket frame therein.
18. The substrate of claim 17, wherein the plurality of through-holes define an opening having a shape selected from the group of: an \u201cL\u201d shape, a circular shape, a triangular shape, a rectangular shape, and a combination of different shapes.
19. The substrate of claim 17, wherein at least one of the plurality of through-holes includes an orientation feature.
20. The substrate of claim 19, wherein the orientation feature is selected from the group of: a shape of the through-hole, a size of the through-hole, and combinations thereof.
21. A system comprising:
an integrated circuit (IC) substrate having a plurality of through-holes therethrough;
an socket frame to mount to the IC substrate, the socket frame having a plurality of beam features extending from a socket frame body and corresponding to the plurality of through-holes through the IC substrate; and
a double data rate memory electrically coupled to the IC substrate.
22. The system of claim 21, wherein at least one of the plurality of beam features includes an orientation feature.
23. The system of claim 21, further comprising a mechanism to retain the IC substrate in a fixed relationship with the socket frame.

1. A proteovesicle comprising, a recombinant glypican polypeptide embedded in a lipid vesicle, wherein the lipid vesicle is formed from detergent extraction of the recombinant glypican polypeptide from a cell.
2. The proteovesicle of claim 1, wherein the glypican is selected from the group consisting of glypican-1, glypican-2, glypican-3, glypican-4, glypican-5, and glypican-6.
3. The proteovesicle of claim 1, wherein the lipid vesicle comprises a micelle.
4. A composition comprising, a biodegradable microcapsule or microbead encapsulating therein effective amounts of a growth factor and a proteovesicle comprising a recombinant glypican polypeptide embedded in a lipid vesicle.
5. The composition of claim 4, wherein the proteovesicle is the proteovesicle of claim 1.
6. The composition of claim 4, wherein the microcapsule or microbead comprises a biocompatible hydrogel.
7. The composition of claim 6, wherein the biocompatible hydrogel comprises a polysaccharide.
8. The composition of claim 7, wherein the biocompatible hydrogel comprises alginate.
9. The composition of claim 4, wherein the microcapsule or microbead is from 1 \u03bcm in diameter up to 3 mm in diameter.
10. The composition of claim 4, wherein the proteovesicle is present in an amount effective to enhance the activity of the growth factor.
11. The composition of claim 4, wherein the growth factor is a heparin-binding growth factor.
12. The composition of claim 4, wherein the growth factor is an angiogenesis-related or wound healing-related growth factor.
13. The composition of claim 12, wherein the angiogenesis-related heparin-binding growth factor comprises a fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and Placental growth factor (PlGF).
14. The composition of claim 4, wherein the heparin-binding growth factor is a neurotrophic heparin-binding growth factor.
15. The composition of claim 14, wherein the neurotrophic heparin-binding growth factor is selected from the group consisting of a nerve growth factor (NGF), FGF, brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF), ciliary neurotrophic factor (CNTF), and neurotrophic factor-45 (NT-45).
16. A method for enhancing the angiogenic or wound healing activity of a growth factor in a subject, comprising administering to a subject in need thereof the proteovesicle of claim 1.
17. The method of claim 16, wherein the subject has been diagnosed with peripheral arterial disease (PAD), a chronic wounds, or an ischemic cardiovascular or cerebrovascular disorder.
18. A method for promoting angiogenesis in a subject, comprising administering to a subject in need thereof therapeutically effective amount of the composition claim 12.
19. The method of claim 18, wherein the subject has been diagnosed with peripheral arterial disease (PAD), a chronic wounds, or an ischemic cardiovascular or cerebrovascular disorder.
20. A method for promoting nerve regeneration in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of the composition of claim 14.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An assembly for guiding insertion of a medical device into a target area of a vertebrate comprising:
a first elongate member, said first elongate member having:
a first end;
a shaft portion coupled to and extending from said first end of said first elongate member; and
a substantially C-shaped second end coupled to and extending from said shaft portion of said first elongate member and disposed opposite said first end of said first elongate member, said substantially C-shaped second end dimensioned to guide said medical device into said target area in a desired direction;

a second elongate member, said second elongate member having:
a first end;
a shaft portion defining a bore extending therethrough and said shaft portion being coupled to and extending from said first end of said second elongate member, said shaft portion dimensioned to permit a medical device to be inserted therethrough; and
a second end coupled to and extending from said shaft portion of said second elongate member and disposed opposite said first end of said second elongate member, said second end of said second elongate member dimensioned to be removably coupled to said substantially C-shaped second end of said first elongate member.
2. The assembly of claim 1 further comprising a housing, said housing dimensioned to be coupled to said second elongate member and said housing dimensioned to be coupled to said first elongate member so that said substantially C-shaped second end of said first elongate member and said second end of said second elongate member form an angle of less than ninety degrees.
3. The assembly of claim 1 further comprising a neck portion coupled to and extending from said shaft portion of said first elongate member.
4. The assembly of claim 1 further comprising a substantially half-cylindrical neck portion coupled to and extending from said shaft portion of said second elongate member.
5. The assembly of claim 1 wherein said second end of said second elongate member being substantially flat.
6. The assembly of claim 1 wherein said vertebrate being a mammal.
7. The assembly of claim 1 wherein said vertebrate being a human being.
8. The assembly of claim 1 wherein said target area being a subdural space.
9. The assembly of claim 8 wherein said desired direction being substantially tangent to a curvature of a brain.
10. The assembly of claim 1 wherein said medical device being at least one of a lead, a guide wire, a catheter, a stent, a filter, a needle, a guide pin, and a cannula.
11. The assembly of claim 1 wherein said medical device being comprised of a shape memory alloy.
12. The assembly of claim 11 wherein said shape memory alloy being a super elastic nitinol alloy.
13. The assembly of claim 1 wherein said substantially C-shaped second end of said first elongate member defining a groove extending along said substantially C-shaped second end of said first elongate member.
14. The assembly of claim 13 wherein said substantially flat second end of said second elongate member providing a roof for enclosing at least a portion of said groove defined by and extending along said substantially C-shaped second end of said first elongate member.
15. The assembly of claim 14 further comprising at least two clasps coupled to and curving substantially inwardly from said roof of said second end of said second elongate member, said clasps being dimensioned to engage said substantially C-shaped second end of said first elongate member.
16. The assembly of claim 2 wherein said housing defining at least two bores extending therethrough, each of said at least two bores dimensioned to receive one of said shaft portion of said first elongate member and said shaft portion of said second elongate member.
17. The assembly of claim 16 wherein said at least two bores being a first bore and a second bore, said first bore extending through said housing proximate a first side of said housing and said second bore extending through said housing proximate a second side of said housing at an approximately forty-five degree angle from said first bore.
18. The assembly of claim 2 wherein said housing defining at least two grooves, each of said at least two grooves dimensioned to snap fit one of said shaft portion of said first elongate member and said shaft portion of said second elongate member.
19. The assembly of claim 18 wherein said at least two grooves being a first groove and a second groove, said first groove extending along a first side of said housing and said second groove extending along a second side of said housing at an approximately forty-five degree angle from said first groove.
20. The assembly of claim 2 wherein said housing defining:
a bore extending therethrough, said bore dimensioned to receive one of said shaft portion of said first elongate member and said shaft portion of said second elongate member; and
a groove, said groove dimensioned to snap fit the other of said shaft portion of said first elongate member and said shaft portion of said second elongate member.
21. The assembly of claim 20 wherein said bore extending through said housing proximate a first side of said housing and said groove extending along a second side of said housing at an approximately forty-five degree angle from said bore.
22. The assembly of claim 1 wherein said medical device having a substantially bulbous insertion end.
23. An assembly for guiding insertion of a medical device into a subdural space comprising:
a first elongate member, said first elongate member having:
a first end;
a shaft portion coupled to and extending from said first end of said first elongate member;
a neck portion coupled to and extending from said shaft portion of said first elongate member;
a substantially C-shaped second end coupled to and extending from said neck portion of said first elongate member and disposed opposite said first end of said first elongate member, said substantially C-shaped second end dimensioned to guide said medical device into said subdural space in a direction substantially tangent to a curvature of a brain; and
a groove defined by and extending along said substantially C-shaped second end of said first elongate member, said groove dimensioned to permit a medical device to pass therethrough;

a second elongate member, said second elongate member having:
a first end;
a shaft portion defining a bore extending therethrough and said shaft portion being coupled to and extending from said first end of said second elongate member, said shaft portion dimensioned to permit a medical device to be inserted therethrough;
a substantially half-cylindrical neck portion coupled to and extending from said shaft portion of said second elongate member;
a substantially flat second end coupled to and extending from said substantially half-cylindrical neck portion of said second elongate member and disposed opposite said first end of said second elongate member, said substantially flat second end providing a roof for enclosing at least a portion of said groove defined by and extending along said substantially C-shaped second end of said first elongate member; and
at least two clasps coupled to and curving inwardly from said roof of said substantially flat second end of said second elongate member, said clasps being dimensioned to engage said substantially C-shaped second end of said first elongate member; and

a housing, said housing defining:
a bore extending therethrough proximate a first side of said housing, said bore dimensioned to receive said shaft portion of said first elongate member; and
a groove extending along a second side of said housing, said groove dimensioned to snap fit said shaft portion of said second elongate member wherein said housing being dimensioned to maintain said second elongate member at an approximately forty-five degree angle to said first elongate member.
24. An assembly for guiding insertion of a medical device into a subdural space comprising an elongate member having:
a first end;
a shaft portion defining a bore extending therethrough and said shaft portion being coupled to and extending from said first end, said shaft portion dimensioned to permit a medical device to be inserted therethrough;
a neck portion coupled to and extending from said shaft portion; and
a substantially C-shaped second end coupled to and extending from said neck portion and disposed opposite said first end, said substantially C-shaped second end dimensioned to guide said medical device into said subdural space in a direction substantially tangent to a curvature of a brain.
25. The assembly of claim 24 wherein said substantially C-shaped second end defining a groove extending along said substantially C-shaped second end, said groove dimensioned to permit a medical device to pass therethrough.
26. The assembly of claim 24 wherein said substantially C-shaped second end defining a roof for enclosing at least a portion of said groove defined by and extending along said substantially C-shaped second end.
27. A method for guiding insertion of a medical device into a target area of a vertebrate comprising, in combination, the steps of:
providing an assembly having:
a first elongate member, said first elongate member having:
a first end;
a shaft portion coupled to and extending from said first end of said first elongate member;
a neck portion coupled to and extending from said shaft portion of said first elongate member;
a substantially C-shaped second end coupled to and extending from said neck portion of said first elongate member and disposed opposite said first end of said first elongate member, said substantially C-shaped second end dimensioned to guide said medical device into said target area in a desired direction; and
a groove defined by and extending along said substantially C-shaped second end of said first elongate member, said groove dimensioned to permit a medical device to pass therethrough;

a second elongate member, said second elongate member having:
a first end;
a shaft portion defining a bore extending therethrough and said shaft portion being coupled to and extending from said first end of said second elongate member;
a substantially half-cylindrical neck portion coupled to and extending from said shaft portion of said second elongate member;
a substantially flat second end coupled to and extending from said substantially half-cylindrical neck portion of said second elongate member and disposed opposite said first end of said second elongate member, said substantially flat second end providing a roof for enclosing at least a portion of said groove defined by and extending along said substantially C-shaped second end of said first elongate member; and
at least two clasps coupled to and curving inwardly from said roof of said substantially flat second end of said second elongate member, said clasps being dimensioned to engage said substantially C-shaped second end of said first elongate member; and

a housing, said housing defining: a bore extending therethrough proximate a first side of said housing, said bore dimensioned to receive said shaft portion of said first elongate member; and
a groove extending along a second side of said housing, said groove dimensioned to snap fit said shaft portion of said second elongate member wherein said housing being dimensioned to maintain said second elongate member at an approximately forty-five degree angle to said first elongate member;
inserting said substantially C-shaped second end of said first elongate member into said target area of said vertebrate;
guiding said medical device substantially downwardly through said bore extending through said shaft portion of said second elongate member;
guiding said medical device along said groove defined by and extending along said substantially C-shaped second end of said first elongate member; and
inserting said medical device into said target area of said vertebrate in said desired direction.
28. The method of claim 27 further comprising the step of inserting said assembly into a subdural space.
29. The method of claim 27 wherein said desired direction being substantially tangent to a curvature of a brain.
30. The method of claim 27 further comprising the steps of:
detaching said second elongate member from said groove extending along said second side of said housing;
sliding said second elongate member away from said target area while said medical device passing therethrough while at the same time said medical device maintaining its position within said target area; and
removing said substantially C-shaped second end of said first elongate member from said target area while at the same time said medical device maintaining its position within said target area.
31. The method of claim 27 wherein said medical device being at least one of a lead, a guide wire, a catheter, a stent, a filter, a needle, a guide pin, and a cannula.
32. The method of claim 27 wherein said medical device comprising a super elastic nitinol alloy.
33. A method for guiding insertion of a super elastic nitinol guide wire into a subdural space comprising, in combination, the steps of:
providing an assembly having:
a first elongate member, said first elongate member having:
a first end;
a shaft portion coupled to and extending from said first end of said first elongate member;
a neck portion coupled to and extending from said shaft portion of said first elongate member;
a substantially C-shaped second end coupled to and extending from said neck portion of said first elongate member and disposed opposite said first end of said first elongate member, said substantially C-shaped second end dimensioned to guide said super elastic nitinol guide wire into said subdural space in a direction substantially tangent to a curvature of a brain; and
a groove defined by and extending along said substantially C-shaped second end of said first elongate member;

a second elongate member, said second elongate member having:
a first end;
a shaft portion defining a bore extending therethrough and said shaft portion being coupled to and extending from said first end of said second elongate member;
a substantially half-cylindrical neck portion coupled to and extending from said shaft portion of said second elongate member;
a substantially flat second end coupled to and extending from said substantially half-cylindrical neck portion of said second elongate member and disposed opposite said first end of said second elongate member, said substantially flat second end providing a roof for enclosing at least a portion of said groove defined by and extending along said substantially C-shaped second end of said first elongate member; and
at least two clasps coupled to and curving inwardly from said roof of said substantially flat second end of said second elongate member, said clasps being dimensioned to engage said substantially C-shaped second end of said first elongate member; and

a housing, said housing defining: a bore extending therethrough proximate a first side of said housing, said bore dimensioned to receive said shaft portion of said first elongate member; and
a groove extending along a second side of said housing, said groove dimensioned to snap fit said shaft portion of said second elongate member wherein said housing being dimensioned to maintain said second elongate member at an approximately forty-five degree angle to said first elongate member;
inserting said substantially C-shaped second end of said first elongate member into said subdural space;
guiding said super elastic nitinol guide wire substantially downwardly through said bore extending through said shaft portion of said second elongate member;
guiding said super elastic nitinol guide wire along said groove defined by and extending along said substantially C-shaped second end of said first elongate member;
inserting said super elastic nitinol guide wire into said subdural space in said direction substantially tangent to said curvature of said brain;
detaching said second elongate member from said groove extending along said second side of said housing;
sliding said second elongate member away from said target area while said super elastic nitinol guide wire passing therethrough while at the same time said super elastic nitinol guide wire maintaining its position within said subdural space; and
removing said substantially C-shaped second end of said first elongate member from said subdural space while at the same time said super elastic nitinol guide wire maintaining its position within said subdural space.
34. A method for guiding insertion of a super elastic nitinol guide wire into a subdural space comprising, in combination, the steps of:
providing an elongate member having:
a first end;
a shaft portion defining a bore extending therethrough and said shaft portion being coupled to and extending from said first end, said shaft portion dimensioned to permit a medical device to be inserted therethrough;
a neck portion coupled to and extending from said shaft portion; and
a substantially C-shaped second end coupled to and extending from said neck portion and disposed opposite said first end, said substantially C-shaped second end defining a groove extending along said substantially C-shaped second end and dimensioned to permit a medical device to pass therethrough, and said substantially C-shaped second end defining a roof for enclosing at least a portion of said groove defined by and extending along said substantially C-shaped second end;

inserting said substantially C-shaped second end into said subdural space;
guiding said super elastic nitinol guide wire substantially downwardly through said bore;
guiding said super elastic nitinol guide wire along said groove;
inserting said super elastic nitinol guide wire into said subdural space in a direction substantially tangent to a curvature of a brain;
removing said substantially C-shaped second end from said target area while said super elastic nitinol guide wire passing therethrough while at the same time said super elastic nitinol guide wire maintaining its position within said subdural space; and
sliding said elongate member away from said target area while said super elastic nitinol guide wire passing therethrough while at the same time said super elastic nitinol guide wire maintaining its position within said subdural space.