Author: claimsbot

1. An ink-jet ink composition comprising: a pigment, a polymer pigment dispersant, polymer particles, a hydrophilic organic solvent, water, and at least one of a water-soluble acidic compound having a molecular weight of 200 or less or a salt thereof in an amount of from 50 ppm to 1,000 ppm, wherein a hydrophobic structural unit incorporated in a polymer that forms the polymer particles comprises at least one structural unit derived from a (meth)acrylic monomer having a cyclic aliphatic group.
2. The ink jet ink composition according to claim 1, wherein the water-soluble acidic compound is a compound having a carboxy group.
3. The ink-jet ink composition according to claim 1, wherein the polymer particles are self-dispersing polymer particles.
4. The ink jet ink composition according to claim 1, wherein the polymer particles have a carboxy group.
5. The ink-jet ink composition according to claim 1, wherein the glass transition temperature of the polymer particles is from 40\xb0 C. to 180\xb0 C.
6. The ink-jet ink composition according to claim 1, wherein the polymer pigment dispersant contains a carboxy group.
7. The ink-jet ink composition according to claim 1, wherein the hydrophilic organic solvent is an (alkyleneoxy)alcohol or an (alkyleneoxy)alkyl ether.
8. An ink set comprising: the ink jet ink composition according to claim 1 and a treatment liquid that forms an aggregate when contacted with the ink-jet ink composition.
9. The ink set according to claim 8, wherein the treatment liquid contains a compound having a carboxy group.
10. An image forming method comprising: applying, onto a recording medium, a treatment liquid that forms an aggregate when contacted with the ink jet ink composition according to claim 1; and applying the ink jet ink composition onto the recording medium so as to form an image.
11. The ink-jet ink composition according to claim 1, wherein the at least one of a water-soluble acidic compound having a molecular weight of 200 or less or a salt thereof is at least one selected from the group consisting of water-soluble acidic compounds having a molecular weight of 150 or less, and salts thereof.
12. The ink-jet ink composition according to claim 1, wherein the at least one of a water-soluble acidic compound having a molecular weight of 200 or less or a salt thereof is at least one selected from the group consisting of acrylic acid, methacrylic acid, maleic acid, malic acid, tartaric acid, fumaric acid, lactic acid, succinic acid, glutaric acid, butanoic acid, acetic acid, methane sulfonic acid, p-toluene sulfonic acid, and salts thereof.
13. The ink-jet composition according to claim 1, wherein the at least one of a water-soluble acidic compound having a molecular weight of 200 or less or a salt thereof is at least one selected from the group consisting of maleic acid, malic acid, tartaric acid, succinic acid, glutaric acid, acetic acid, butanoic acid, and alkali metal salts thereof.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A detergent pourer sterilizer including a housing including a hollow portion having an open side; a detergent pourer configured to be detachably attached to the housing; and a cover member configured to open or close the open side of the hollow portion,
wherein the sterilizer comprises at least one ultraviolet light emitting diode (UV LED) configured to emit ultraviolet light toward the detergent pourer positioned in the hollow portion.
2. The detergent pourer sterilizer according to claim 1, wherein the UV LED is installed on at least one of inner surfaces of the housing to emit ultraviolet light toward the detergent pourer.
3. The detergent pourer sterilizer according to claim 1, wherein the UV LED is installed on an inner surface of the cover member to emit ultraviolet light toward the detergent pourer.
4. The detergent pourer sterilizer according to claim 3, further comprising: a power supply disposed near the housing to supply power to the UV LED,
wherein electrical contacts are installed at parts of the cover member and the housing, the parts not contacting each other when the cover member opens the hollow portion and contacting each other when the cover member closes the hollow portion,
wherein the contact of the cover member is connected to the UV LED, and the contact of the housing is connected to the power supply,
wherein the contacts of the cover member and the housing are electrically connected to each other to supply power to the UV LED only when the cover member closes the hollow portion.
5. The detergent pourer sterilizer according to claim 4, wherein the UV LED is installed on at least one of inner surfaces of the housing to emit ultraviolet light toward the detergent pourer, wherein the UV LED installed on the housing is connected to the UV LED installed on the cover member in series.
6. The detergent pourer sterilizer according to claim 1, further comprising: a switch installed at a part of the cover member, the part not contacting the housing when the cover member opens the hollow portion and contacting the housing when the cover member closes the hollow portion, wherein the switch operates to supply power to the UV LED only when the cover member closes the hollow portion.
7. The detergent pourer sterilizer according to claim 1, further comprising a nozzle installed on the housing for spraying high-pressure water toward the detergent pourer.
8. The detergent pourer sterilizer according to claim 1, wherein the housing comprises an air injection hole for injecting air toward the hollow portion therethrough and an air discharge hole for discharging the injected air.
9. The detergent pourer sterilizer according to claim 8, further comprising: a water discharge hole formed in the housing and operating as the air discharge hole.
10. The detergent pourer sterilizer according to claim 1, wherein the detergent pourer includes a material allowing ultraviolet light to be transmitted therethrough.
11. The detergent pourer sterilizer according to claim 1, wherein the detergent pourer or the housing has at least one region of an inner surface coated with photocatalytic material such that photocatalytic material causes photocatalytic reaction with ultraviolet light.
12. The detergent pourer sterilizer according to claim 1, further comprising: a reflector installed on an inner surface of the housing.
13. The detergent pourer sterilizer according to claim 1, further comprising an alarm means to alarm an open state of the cover member when the cover member is opened as power is supplied to the UV LED.
14. A method of sterilizing a detergent pourer of a washing machine including a housing including a hollow portion having an open side, a detergent pourer configured to be detachably attached to the housing, and a cover member configured to open or close the open side of the hollow portion, and a ultraviolet light emitting diode (UV LED) configure ultraviolet light toward the hollow portionNN1, the method comprising:
performing sterilizing of the detergent pourer when an operation of the washing machine is completed or an instruction from user to start the sterilization is received,
wherein the sterilizing of the detergent pourer comprises:
checking if there is no laundry in a washing tub; and
supplying power to the UV LED and turning on the UV LED only when the cover member is closed after checking that there is no laundry in the washing tub.
15. The method according to claim 14, wherein the housing comprises a nozzle for spraying high-pressure water toward the detergent pourer,
wherein the sterilizing of the detergent pourer further comprises:
spraying the high-pressure water the washing tub only when the cover member is closed after checking that there is no laundry in the washing tub,
wherein the spraying is performed before the turning on of the UV LED.
16. The method according to claim 14, wherein the housing comprises an air injection hole for injecting air toward the hollow portion and an air discharge hole for discharging the injected air,
wherein the sterilizing of the detergent pourer further comprises:
injecting the air only when the cover member is closed after checking that there is no laundry in the washing tub,
wherein the injecting of the air is performed before the turning on of the UV LED.
17. The method according to claim 15, wherein the housing comprises an air injection hole for injecting air toward the hollow portion and an air discharge hole for discharging the injected air,
wherein the sterilizing of the detergent pourer further comprises:
injecting the air only when the cover member is closed after checking that there is no laundry in the washing tub,
wherein the injecting of the air is performed after the spraying of the high-pressure water is performed and before the turning on of the UV LED.
18. The method according to claim 14, wherein the sterilizing of the detergent pourer starts automatically only when an accumulated number of uses of the washing machine after a most recent execution of the sterilizing is greater than or equal to 2.

1. A compound of Formula (I):
or a stereoisomer or a salt thereof, wherein:
(i) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O or S;
(ii) X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is O or S;
(iii) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is NH or NCH3; or
(iv) X1 is N-G2, X2 is N, and X3 is CH;
wherein the broken circle represents two non-adjacent double bonds within Ring A;
Q1 is CH, C(CH3), or CF;
Q2 is CH;
W is \u2014CH2\u2014, \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, \u2014CH2CF2\u2014, \u2014CH\u2550CH\u2014, \u2014CH2N(CH3)\u2014, \u2014CH2O\u2014, or \u2014CH2CH2O\u2014;
G1 is \u2014OH, \u2014CH2OH, \u2014CH(OH)CH2OH, \u2014(CH2)0-2COOH, \u2014CH(OH)(CH2)0-2COOH, \u2014CH2NH(CH2)1-2OH, \u2014CH2NRg(CH2)1-2COOH, \u2014CH2NRg(CH2)1-2C(O)NH2, \u2014CH2NRg(CH2)1-2OP(O)(OH)2, \u2014OCH2CH(OH)CH2OH, \u2014(CH2)0-2C(NH2)(CH3)CH2OH, \u2014(CH2)0-2CRg(NH2)C(O)OH, \u2014(CH2)0-2C(NH2)(CH3)(CH2)1-2OP(O)(OH)2, \u2014CH2CH2C(NH2)(CH2OH)2, \u2014CH2NHCH(CH2OH)2, \u2014CH2N(CH2CH2OH)2, \u2014CH2NHCH2CH(OH)CH2OH, \u2014CH(OH)C(O)NHCH2CN, \u2014CH(OH)C(O)NHCH2CH2S(O)2CH3, \u2014CRg(OH)C(O)NHCH2CH2OH, \u2014CH2(hydroxy pyrrolidinyl), \u2014CH2(hydroxymethyl pyrrolidinyl),
G2 is:
(i) pentyl;
(ii) phenyl substituted with one or two substituents independently selected from propyl, butyl, \u2014CN, \u2014CF3, cyclohexyl, \u2014OCH2CH3, andor \u2014OCH(CH3)2;
(iii) pyrazolyl, isoxazolyl, isothiazolyl, or pyrimidinyl substituted with one or two substituents independently selected from \u2014CF3, \u2014CN, butyl, methyl cyclopropyl, cyclohexyl, phenyl, chlorophenyl, pyridinyl, andor fluoropyridinyl;
(iv) cyclohexyl substituted with chlorophenyl;
(v) \u2014NHC(O)\u2014(CH2)0-2-(phenyl) or \u2014NHC(O)(pentyl);
(vi) \u2014C(O)NHCH2C(CH3)3, \u2014C(O)NRg\u2014(CHRg)0-3-A1, \u2014C(O)NRg\u2014CH2C(Rg)(A1)(A1), or \u2014C(O)NHCH2(tetrahydronaphthalenyl), wherein A1 is phenyl substituted with zero to 2 substituents independently selected from Cl, \u2014CH3, \u2014OCH3, \u2014OCH2CH3, \u2014OCH(CH3)2, andor phenoxy;
(vii)
\u2003wherein Re is naphthalenyl or \u2014(CH2)0-2(phenyl) and said phenyl is substituted with zero to 1 substituents selected from F, Cl, or OCH3; or
(viii) \u2014(CR5R5)aCReReB4, \u2014CH\u2550CH\u2014CReReB4, or \u2014(CR5R5)aO(CR5R5)aCReReB4, wherein B4 is phenyl substituted with zero to 2 substituents independently selected from F, Cl, \u2014OH, andor butyl; and each Re is independently H andor \u2014CH3, or two geminal Re along with the carbon atom to which they are attached form a C4-6spirocycloalkyl ring;

each a is independently zero, 1, 2, 3, 4, andor 5;
each R5 is H; and
each Rg is independently H andor \u2014CH3.
2. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O or S.
3. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is O or S.
4. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is NH or NCH3.
5. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein: X1 is N-G2, X2 is N and X3 is CH.
6. A pharmaceutical composition comprising a compound according to claim 1 or stereoisomers or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier.
7. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein:
X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O;
W is \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, or \u2014CH2CF2\u2014;
Q1 is CH or C(CH3); and
Q2 is CH.
8. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein:
X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is S;
W is \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, or \u2014CH2CF2\u2014;
Q1 is CH or C(CH3); and
Q2 is CH.
9. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G1 is: \u2014OH, \u2014CH2OH, \u2014CH(OH)CH2OH, \u2014(CH2)0-2COOH, \u2014CH(OH)(CH2)0-2COOH, \u2014CH2NH(CH2)1-2OH, \u2014CH2NRg(CH2)1-2COOH, \u2014CH2NRg(CH2)1-2C(O)NH2, \u2014CH2NRg(CH2)1-2OP(O)(OH)2, \u2014OCH2CH(OH)CH2OH, \u2014(CH2)0-2 CNH2)(CH3)CH2OH, \u2014(CH2)0-2CRg(NH2)C(O)OH, \u2014(CH2)0-2C(NH2)(CH3)(CH2)1-2OP(O)(OH)2, \u2014CH2CH2C(NH2)(CH2OH)2, \u2014CH2NHCH(CH2OH)2, \u2014CH2N(CH2CH2OH)2, \u2014CH2NHCH2CH(OH)CH2OH, \u2014CH(OH)C(O)NHCH2CN, \u2014CH(OH)C(O)NHCH2CH2S(O)2CH3, \u2014CRg(OH)C(O)NHCH2CH2OH, \u2014CH2(hydroxy pyrrolidinyl), or \u2014CH2(hydroxymethyl pyrrolidinyl).
10. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G1 is:
11. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G2 is:
(i) phenyl substituted with one or two substituents independently selected from propyl, butyl, \u2014CN, \u2014CF3, cyclohexyl, \u2014OCH2CH3, andor \u2014OCH(CH3)2;
(ii) pyrazolyl, isoxazolyl, isothiazolyl, or pyrimidinyl substituted with one or two substituents independently selected from \u2014CF3, \u2014CN, butyl, methyl cyclopropyl, cyclohexyl, phenyl, chlorophenyl, pyridinyl, andor fluoropyridinyl; or
(iii) cyclohexyl substituted with chlorophenyl.
12. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G2 is:
(i) \u2014NHC(O)\u2014(CH2)0-2-(phenyl) or \u2014NHC(O)(pentyl);
(ii) \u2014C(O)NHCH2C(CH3)3, \u2014C(O)NRg\u2014(CHRg)0-3-A1, \u2014C(O)NRg\u2014CH2C(Rg)(A1)(A1), or \u2014C(O)NHCH2(tetrahydronaphthalenyl), wherein A1 is phenyl substituted with zero to 2 substituents independently selected from Cl, \u2014CH3, \u2014OCH3, \u2014OCH2CH3, \u2014OCH(CH3)2, andor phenoxy; or
(iii)
wherein Re is naphthalenyl or \u2014(CH2)0-2(phenyl) and said phenyl is substituted with zero to 1 substituents selected from F, Cl, or OCH3.
13. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein G2 is: \u2014(CR5R5)aCReReB4, \u2014CH\u2550CH\u2014CReReB4, or \u2014(CR5R5)aO(CR5R5)aCReReB4, wherein B4 is phenyl substituted with zero to 2 substituents independently selected from F, Cl, \u2014OH, andor butyl; and each Re is independently H andor \u2014CH3, or two geminal Re along with the carbon atom to which they are attached form a C4-6spirocycloalkyl ring.
14. The compound according to claim 1 or a stereoisomer or a salt thereof, wherein said compound is selected from:
1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-propylphenyl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(4-propylphenyl)-4H-chromeno3,4-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(5-(1-methylcyclopropyl)-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho-1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-isobutyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(4-propylphenyl)-4H-indeno1,2-cisoxazol-6-ol;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(R)-3-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yloxy)propane-1,2-diol;
(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((3-(4-isopropoxy-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamine) propanoic acid;
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)-2,5,7-triazaspiro3.4octane-6,8-dione;
2-((3R)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)ethyl)piperidin-3-yl)acetic acid;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanoic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methanol;
1-((3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(3,5-dichlorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-chlorophenyl)-3-methylbutyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(((1-(4-fluorophenyl)cyclohexyl)methoxy)methyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
1-((3-(3-(1-(4-fluorophenyl)cyclohexyl)propyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
3-(5-phenylisoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(5-(2-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(6-phenylpyrimidin-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(4-hydroxyphenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(2-chloro-4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(3,5-difluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(3,5-dichlorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(2-(1-(3-fluorophenyl)cyclopentyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
(E)-3-(2-(1-(4-chlorophenyl)cyclohexyl)vinyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
3-(4-isobutylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-ol;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho1,2-doxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(S)-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yloxy) propane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt;
1-((3-(2,2-diphenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA salt;
1-((3-(2-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(neopentylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butan-1-ol;
(2S)-2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-2,3-dihydrobenzoboxepino-4,5-disoxazol-8-yl)methyl)-azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-(Pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-Methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-Hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphthol1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-fluoro-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
3-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)piperidine-3-carboxylic acid;
2-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)acetic acid;
3-hydroxy-2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propanoic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanamide;
4-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)morpholino-3-yl)methanol;
1-((3-(5-cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(5-Cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazole-7-carboxylic acid;
1-((5-methyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydroisoxazolo4,3-cquinolin-7-yl)methyl)azetidine-3-carboxylic acid;
1-((1-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-1H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((2-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-(3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)-2-hydroxyethyl) piperidine-3-carboxylic acid, HCl;
(3S)-1-(2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)ethyl)piperidine-3-carboxylic acid, HCl;
(\xb1)1-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl) ethane-1,2-diol;
2-hydroxy-N-(2-hydroxyethyl)-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
1-((2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-indeno1,2-cisoxazol-6-yl)methyl) azetidine-3-carboxylic acid;
2-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)acetic acid;
(\xb1)2-(hydroxy(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-(amino(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-amino-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-(2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)propane-1,3-diol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
(\xb1)2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethyl dihydrogen phosphate;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethyl dihydrogen phosphate;
1-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) ethane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isothiazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-cyano-3-phenylisothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethanol;
(\xb1)4-hydroxy-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2,2\u2032-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylazanediyl)diethanol;
(2R)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propane-1,2-diol;
(2S)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,2-diol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,3-diol;
(3R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-3-ol;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-3-ol;
((2R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
((2S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
1-((3-(4-cyclohexyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methanol;
1-((3-(1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethanol;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
N-(methylsulfonyl)-1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxamide;
(\xb1)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetic acid;
(\xb1)-N-(cyanomethyl)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) acetamide;
(\xb1)-2-Hydroxy-N-(2-hydroxyethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
(\xb1)-2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
1-((3-(4-propylphenyl)-4,5-dihydro-3H-benzoeindazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)benzamide;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)-2-phenylacetamide;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)-3-phenylpropanamide;
N-(7-hydroxy-4,5-dihydronaphtho1,2-dthiazol-2-yl)hexanamide;
1-((3-(2-methoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-ethoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2,2-diphenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1((3-(phenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(benzyl(methyl)carbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-benzylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenethylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-(4-methoxyphenyl)-2-phenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(naphthalen-1-yl)piperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenylpiperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-((1,2,3,4-tetrahydronaphthalen-1-yl)methylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-fluorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(2-chlorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(3-methoxyphenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-isopropoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1S,3S)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1S,3S)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1R,3R)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid; and
(1R,3R)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid.
15. A compound of Formula (I):
or a stereoisomer or a salt thereof, wherein:
(i) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is O or S;
(ii) X2 is C-G2, one of X1 and X3 is N, and the other of X1 and X3 is O or S;
(iii) X1 is C-G2, one of X2 and X3 is N, and the other of X2 and X3 is NH or NCH3; or
(iv) X1 is N-G2, X2 is N, and X3 is CH;
wherein the broken circle represents two non-adjacent double bonds within Ring A;
Q1 is CH, C(CH3), or CF;
Q2 is CH;
W is \u2014CH2\u2014, \u2014CH2CH2\u2014, \u2014CH2C(CH3)2\u2014, \u2014CH2CF2\u2014, \u2014CH\u2550CH\u2014, \u2014CH2N(CH3)\u2014, \u2014CH2O\u2014, or \u2014CH2CH2O\u2014;
G1 is \u2014CH2OH, \u2014CH(OH)CH2OH, \u2014(CH2)0-2COOH, \u2014CH(OH)(CH2)0-2COOH, \u2014CH2NH(CH2)1-2OH, \u2014CH2NRg(CH2)1-2COOH, \u2014CH2NRg(CH2)1-2C(O)NH2, \u2014CH2NRg(CH2)1-2OP(O)(OH)2, \u2014OCH2CH(OH)CH2OH, \u2014(CH2)0-2C(NH2)(CH3)CH2OH, \u2014(CH2)0-2CRg(NH2)C(O)OH, \u2014(CH2)0-2C(NH2)(CH3)(CH2)1-2OP(O)(OH)2, \u2014CH2CH2C(NH2)(CH2OH)2, \u2014CH2NHCH(CH2OH)2, \u2014CH2N(CH2CH2OH)2, \u2014CH2NHCH2CH(OH)CH2OH, \u2014CH(OH)C(O)NHCH2CN, \u2014CH(OH)C(O)NHCH2CH2S(O)2CH3, \u2014CRg(OH)C(O)NHCH2CH2OH, \u2014CH2(hydroxy pyrrolidinyl), \u2014CH2(hydroxymethyl pyrrolidinyl),
G2 1 S:
(i) pentyl or \u2014NH2;

(ii) phenyl substituted with one or two substituents independently selected from propyl, butyl, \u2014CN, \u2014CF3, cyclohexyl, \u2014OCH2CH3, andor \u2014OCH(CH3)2;
(iii) pyrazolyl, isoxazolyl, isothiazolyl, or pyrimidinyl substituted with one or two substituents independently selected from \u2014CF3, \u2014CN, butyl, methyl cyclopropyl, cyclohexyl, phenyl, chlorophenyl, pyridinyl, andor fluoropyridinyl;
(iv) cyclohexyl substituted with chlorophenyl;
(v) \u2014NHC(O)\u2014(CH2)0-2-(phenyl) or \u2014NHC(O)(pentyl);
(vi) \u2014C(O)NHCH2C(CH3)3, \u2014C(O)NRg\u2014(CHRg)0-3-A1, \u2014C(O)NRg\u2014CH2C(Rg)(A1)(A1), or \u2014C(O)NHCH2(tetrahydronaphthalenyl), wherein A1 is phenyl substituted with zero to 2 substituents independently selected from Cl, \u2014CH3, \u2014OCH3, \u2014OCH2CH3, \u2014OCH(CH3)2, andor phenoxy;
(vii)
\u2003wherein Re is naphthalenyl or \u2014(CH2)0-2(phenyl) and said phenyl is substituted with zero to 1 substituents selected from F, Cl, or OCH3; or
(viii) \u2014(CR5R5)aCReReB4, \u2014CH\u2550CH\u2014CReReB4, or \u2014(CR5R5)a0 (CR5R5)aCReReB4, wherein B4 is phenyl substituted with zero to 2 substituents independently selected from F, Cl, \u2014OH, andor butyl; and each Re is independently H andor \u2014CH3, or two geminal Re along with the carbon atom to which they are attached form a C4-6spirocycloalkyl ring;

each a is independently zero, 1, 2, 3, 4, andor 5;
each R5 is H; and
each Rg is independently H andor \u2014CH3.
16. The compound according to claim 15 or a stereoisomer or a salt thereof, wherein said compound is selected from:
1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-propylphenyl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(4-propylphenyl)-4H-chromeno3,4-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, trifluoroacetic acid salt;
1-((3-(5-(1-methylcyclopropyl)-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho-1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-isobutyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(R)-3-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yloxy)propane-1,2-diol;
(3S)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((3-(4-isopropoxy-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-((3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamine) propanoic acid;
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)-2,5,7-triazaspiro3.4octane-6,8-dione;
2-((3R)-1-(2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)ethyl)piperidin-3-yl)acetic acid;
1-((3-(4-propylphenyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(3-(3-cyano-4-isopropoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanoic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-isobutyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
(3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methanol;
1-((3-(3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-(1-(3,5-dichlorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-chlorophenyl)-3-methylbutyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(((1-(4-fluorophenyl)cyclohexyl)methoxy)methyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
1-((3-(3-(1-(4-fluorophenyl)cyclohexyl)propyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho1,2-doxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(S)-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yloxy) propane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt;
1-((3-(2,2-diphenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA salt;
1-((3-(2-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(neopentylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-doxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butan-1-ol;
(2S)-2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazole-3-yl)-2,3-dihydrobenzoboxepino-4,5-disoxazol-8-yl)methyl)-azetidine-3-carboxylic acid;
1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid, TFA;
1-((2-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno3,4-disoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-chromeno4,3-cisoxazol-7-yl)methyl)-azetidine-3-carboxylic acid;
1-((3-(3-(Pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-Methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-Hydroxy-2-(8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphthol1,2-cisoxazol-7-yl)ethyl)piperidine-3-carboxylic acid;
1-((5,5-difluoro-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((8-fluoro-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)azetidine-3-carboxylic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
3-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanoic acid;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)piperidine-3-carboxylic acid;
2-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)acetic acid;
3-hydroxy-2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propanoic acid;
3-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)propanamide;
4-((3-(5-Phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)morpholino-3-yl)methanol;
1-((3-(5-cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
3-(5-Cyclohexyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazole-7-carboxylic acid;
1-((5-methyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydroisoxazolo4,3-cquinolin-7-yl)methyl)azetidine-3-carboxylic acid;
1-((l-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-1H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((2-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydro-2H-benzogindazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(3S)-1-(2-(3-(3,4-diethoxyphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)-2-hydroxyethyl) piperidine-3-carboxylic acid, HCl;
(3S)-1-(2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)ethyl)piperidine-3-carboxylic acid, HCl;
(\xb1)1-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl) ethane-1,2-diol;
2-hydroxy-N-(2-hydroxyethyl)-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)acetamide;
1-((2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA;
1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4H-indeno1,2-cisoxazol-6-yl)methyl) azetidine-3-carboxylic acid;
2-(methyl((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)amino)acetic acid;
(\xb1)2-(hydroxy(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-(amino(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)furan-3-carboxylic acid;
(\xb1)2-amino-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-(2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethyl)propane-1,3-diol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2-amino-2-methyl-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
(\xb1)2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethyl dihydrogen phosphate;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethyl dihydrogen phosphate;
1-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) ethane-1,2-diol;
1-((3-(3-phenyl-4-(trifluoromethyl)isothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho 1,2-cisoxazol-7-yl)butyl dihydrogen phosphate;
1-((3-(5-phenyl-4-(trifluoromethyl)isothiazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-cyano-3-phenylisothiazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
2-amino-2-methyl-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)ethanol;
(\xb1)4-hydroxy-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)butanoic acid;
2,2\u2032-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylazanediyl)diethanol;
(2R)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)propane-1,2-diol;
(2S)-3-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,2-diol;
2-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)ethylamino)propane-1,3-diol;
(3R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-3-ol;
(3S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) methyl)pyrrolidin-3-ol;
((2R)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
((2S)-1-((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)pyrrolidin-2-yl)methanol;
1-((3-(4-cyclohexyl-3-(trifluoromethyl)phenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butan-1-ol;
2-amino-2-methyl-4-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)butyl dihydrogen phosphate;
(1-amino-3-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)cyclopentyl)methanol;
1-((3-(1-(5-fluoropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
2-(1-amino-3-(2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)ethanol;
2-amino-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propan-1-ol;
N-(methylsulfonyl)-1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methyl)azetidine-3-carboxamide;
(\xb1)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetic acid;
(\xb1)-N-(cyanomethyl)-2-hydroxy-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl) acetamide;
(\xb1)-2-Hydroxy-N-(2-hydroxyethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
(\xb1)-2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(4-propylphenyl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
N-(1-cyanocyclopropyl)-2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)acetamide;
2-hydroxy-N-(2-hydroxyethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
2-hydroxy-N-(2-(methylsulfonyl)ethyl)-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)propanamide;
1-((3-(4-propylphenyl)-4,5-dihydro-3H-benzoeindazol-7-yl)methyl)azetidine-3-carboxylic acid;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methanol;
(1-amino-3-(2-pentyl-4,5-dihydronaphtho2,1-dthiazol-7-yl)cyclopentyl)methyl dihydrogen phosphate;
(R)-3-(2-amino-4,5-dihydronaphthol1,2-dthiazol-7-yloxy)propane-1,2-diol;
1-((3-(2-methoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-ethoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(4-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2,2-diphenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(phenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpropylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(benzyl(methyl)carbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorobenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-chlorophenethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-benzylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-phenethylpyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-(4-methoxyphenyl)-2-phenylethylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(naphthalen-1-yl)piperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-phenylpiperidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-((1,2,3,4-tetrahydronaphthalen-1-yl)methylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(4-fluorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(2-chlorophenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(3-(3-methoxyphenyl)pyrrolidine-1-carbonyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1-((3-(2-isopropoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(2-phenoxybenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl) azetidine-3-carboxylic acid;
1-((3-(3-methylbenzylcarbamoyl)-4,5-dihydronaphtho2,1-disoxazol-7-yl)methyl)azetidine-3-carboxylic acid;
1S,3S)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1S,3S)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid;
(1R,3R)-3-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid; and
(1R,3R)-3-(cyano(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho1,2-cisoxazol-7-yl)methylamino)cyclobutanecarboxylic acid.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for processing circuitry, comprising:
acquiring a single carrier signal based on a determined time slot boundary, the single carrier signal comprising primary carrier data;
receiving a dual carrier radio frequency signal based on the determined time slot boundary, the dual carrier radio frequency signal comprising the primary carrier data and secondary carrier data;
generating a baseband dual carrier signal by demodulating the dual carrier radio frequency signal;
separating the primary carrier data from the baseband dual carrier signal by filtering the baseband dual carrier signal; and
separating the secondary carrier data from the baseband dual carrier signal by filtering the baseband dual carrier signal.
2. The method of claim 1, wherein the determined time slot boundary is determined from a primary synchronization signal;
3. The method of claim 2, wherein the time slot boundary is a frame boundary.
4. The method of claim 1, wherein the dual carrier radio frequency signal is received from a base station.
5. The method of claim 1, wherein the dual carrier radio signal is received in response to a request for additional bandwidth.
6. The method of claim 5, wherein the request is sent from a wireless device configured to receive the dual carrier signal.
7. The method of claim 1, wherein separating the primary carrier data from the baseband dual carrier signal comprises identifying a center frequency of the baseband dual carrier signal.
8. The method of claim 7, wherein separating the primary carrier data from the baseband dual carrier signal further comprises translating the identified center frequency.
9. The method of claim 8, wherein separating the primary carrier data from the baseband dual carrier signal further comprises applying a filter to filter out a secondary carrier baseband frequency range, the secondary carrier data being encoded within the secondary carrier baseband frequency range, wherein the filter comprises hardcoded coefficients.
10. The method of claim 1, further comprising transmitting the primary carrier data and the secondary carrier data to baseband processing circuitry according to a predetermined latency.
11. The method of claim 10, wherein the predetermined latency is based on a latency caused by separating the primary carrier data from the baseband dual carrier signal and separating the secondary carrier data from the baseband dual carrier signal.
12. A system for signal processing, comprising:
circuitry that receives a dual carrier radio frequency signal comprising primary carrier data transmitted from a base station and secondary carrier data transmitted by the base station;
a demodulator that generates a baseband dual carrier signal based on the dual carrier radio frequency signal;
a first filter that suppresses adjacent carrier frequencies to separate the primary carrier data from the baseband dual carrier signal; and
a second filter that suppresses adjacent carrier frequencies to separate the secondary carrier data from the baseband dual carrier signal.
13. The system of claim 12, further comprising circuitry that acquires a single carrier signal based on a determined time slot boundary, the single carrier signal comprising the primary carrier data.
14. The system of claim 13, wherein the circuitry that receives the dual carrier radio frequency signal further comprises circuitry that receives the dual carrier radio frequency signal based on the determined time slot boundary.
15. The system of claim 12, wherein the dual carrier radio signal is received in response to a request for additional bandwidth.
16. The system of claim 12, further comprising a digital mixer for performing a frequency translation, the digital mixer preparing the baseband dual carrier signal for filtering by the first filter
17. The system of claim 12, further comprising a delay line for transmitting the primary carrier data and the secondary carrier data to baseband processing circuitry according to a predetermined latency.
18. A carrier separation circuit comprising:
circuitry that receives a dual carrier radio frequency signal comprising primary carrier data and secondary carrier data, the primary carrier data and the secondary carrier data being transmitted by a base station;
circuitry that generates a secondary carrier baseband signal by extracting the secondary carrier data from the dual carrier radio frequency signal; and
circuitry that delays a transmission of the secondary carrier baseband signal to baseband processing circuitry according to a predetermined dual carrier latency.
19. The carrier separation circuit of claim 18, further comprising:
circuitry that receives a single carrier radio frequency signal comprising the primary carrier data transmitted from the base station; and
circuitry that generates a single carrier frequency baseband signal based on single carrier radio frequency signal, the circuitry that generates the single carrier frequency baseband signal causing an intrinsic single carrier latency, the predetermined dual carrier latency being determined based on the intrinsic single carrier latency.
20. The carrier separation circuit of claim 18, wherein the circuitry that delays a transmission comprises circuitry that selects one of a plurality of predetermined dual carrier latency values, each predetermined dual carrier latency value corresponding to a respective operating condition.