Author: claimsbot

1. A storage system, comprising:
a first mounting plate operatively coupled to a wheel;
a second mounting plate spaced from said first mounting plate and operatively coupled to a plurality of wheels;
at least one of said first and second mounting plates comprising a plurality arched channels, each channel configured to receive a fastener;
a first wheel assembly spaced from said first mounting plate;
a second wheel assembly spaced from said second mounting plate;
a cable operatively engaging each of said wheels operatively coupled to said first mounting plate or said second mounting plate;
a coupler extending from said first wheel assembly and a second coupler extending from said second wheel assembly; and
a self-locking mechanism coupled to said second mounting plate, said self-locking mechanism comprising a first bracket rotationally coupled to said second mounting plate and a second bracket directly coupled to said first bracket;
wherein said second bracket pivots at a point of said direct coupling;
wherein each of said mounting plates comprises a base portion configured to be mounted substantially parallel to a mounting surface.
2. A storage system according to claim 1, wherein each of said mounting plates comprises a plurality of sides extending downward from said base.
3. A storage system according to claim 2, wherein said base and said plurality of sides are a unitary structure.
4. A storage system according to claim 3, wherein said base and said plurality of sides are stamped sheet metal.
5. A storage system according to claim 1, wherein said coupler and said second coupler each comprise a strap operatively coupled to a carabineer.
6. A storage system, comprising:
a first plate and a second plate, each plate having a top with a base portion, a plurality of downwardly extending portions, and a plurality of fastener-receiving arched channels,
at least one pulley rotatably coupled to said plurality of downwardly extending portions for each of said plates;
a plurality of pulleys extending downward from said plates; and
a cable operatively engaging said pulleys coupled to said plates and said pulleys extending downward from said plates;
wherein said second plate has a second pulley rotatably coupled to said plurality of downwardly extending portions;
said storage system further comprising a self-locking mechanism coupled to said second plate, said self-locking mechanism comprising a first bracket coupled to said downwardly extending portions and a second bracket mounted to said first bracket at an open end of said second bracket;
wherein said second bracket pivots at a point or said mounting.
7. A storage system according to claim 6, wherein said downwardly extending portions are generally parallel.
8. A storage system according to claim 6, wherein each of said downwardly extending pulleys is coupled to a pulley frame, and each pulley frame engages a coupling mechanism.
9. A storage system, comprising:
two plates, each plate having a top with a base portion and a plurality of extensions extending away from said base portion and generally coplanar with said base portion;
said base portions comprising a plurality of fastener-receiving arched channels;
said plates further comprising a plurality of downwardly extending portions,
wherein each downwardly extending portion has top edges adjacent to at least two of said extensions;

at least one pulley rotatably coupled to said plurality of downwardly extending portions for each of said plates;
a plurality of pulleys extending downward from said plates; and
a cable operatively engaging said pulleys coupled to said plates and said pulleys extending downward from said plates

wherein a second plate has a second pulley rotatably coupled to said plurality of downwardly extending portions
said storage system further comprising a self-locking mechanism coupled to said second plate,
wherein said self-locking mechanism comprises a first bracket coupled to said downwardly extending portions and a second bracket coupled to said first bracket.
10. A storage system according to claim 9, wherein said edges of said downwardly extending portions are integral with edges of said extensions.
11. A storage system according to claim 9, wherein said downwardly extending portions are generally parallel.
12. A storage system according to claim 9, wherein each of said downwardly extending pulleys is coupled to a pulley frame, and each pulley frame engages a coupling mechanism.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A memory system comprising:
a primary memory controller;
a point-to-point memory data bus, having an effective bit-width m, coupled to the primary memory controller;
at least one memory module directly connected to the primary controller via a segment of the memory data bus, the memory module having a module data bus with an effective bit-width N=R\xd7m, where R is an integer value greater than one, the memory module comprising an interface circuit coupled between the memory data bus and the module data bus, the interface circuit capable of performing m-bit-wide data transfers on the memory data bus, the interface circuit capable of performing N-bit-wide data transfers on the module data bus, said interface circuit comprising:
R m-bit-wide data registers, each register capable of exchanging point-to-point data signaling with a corresponding rank of memory devices; and
a multiplexer, having a multiplexing ratio R, coupled between the R data registers and the memory data bus; and

one additional segment of the memory data bus for each additional memory module, the additional segment directly connecting the additional memory module to the module immediately preceding it.
2. The memory system of claim 1, wherein the memory data bus further comprising a ring data bus segment connecting the last of the memory modules in the memory system back to the primary memory controller.
3. The memory system of claim 1, wherein the memory data bus and the module data bus each having a clock rate, the memory data bus clocking at a rate R times the clock rate of the module data bus.
4. A memory module comprising:
R ranks of memory devices, where R is at least two, each rank having an m-bit-wide data port;
a module data port capable of exchanging data signaling over a memory data bus having an effective bit-width m;
an interface circuit coupled between the module data port and the R memory-device-rank data ports, the interface circuit capable of performing m-bit-wide data transfers at the module data port, the interface circuit capable of performing R\xd7m-bit-wide data transfers with the R ranks of memory devices, said interface circuit comprising:
R m-bit-wide data registers, each register capable of exchanging point-to-point data signaling with a corresponding rank of memory devices through the data port of that rank; and
a multiplexer, having a multiplexing ratio R, coupled between the R data registers and the external data port; and

a controller capable of synchronizing the operation of the interface circuit and the memory device ranks such that a data transfer comprising R serial data transfers on the memory data bus can be completed internal to the memory module with one R\xd7m-bit-wide data transfer with the memory device ranks.
5. The memory module of claim 4, wherein the controller supplies rank selection signals to the multiplexer and register latching signals to each of the data registers.
6. The memory module of claim 4, wherein data signaling between a data register and its rank of memory devices further comprises a bit mask received from the memory data bus along with a corresponding m bits, the multiplexer transferring the bit mask to the data register along with the corresponding m bits.
7. The memory module of claim 4, wherein the controller is capable of synchronizing the operation of the data registers, the module data port, and the multiplexerdemultiplexer in order to serialize data from a subset of the data registers onto the memory data bus.
8. The memory module of claim 4, wherein data transfers between one of the data registers and the corresponding rank of memory devices occurs at a clock rate related to the clock rate of the memory data bus by a factor 1R.
9. The memory module of claim 4, where the module is a dual-inline memory module comprising a printed circuit board capable of connection to the memory data bus via insertion of the circuit board into a card edge connector connected to the memory data bus.
10. The memory module of claim 9, wherein R equals two, one of the two ranks of memory devices arranged on each side of the circuit board and connected to the corresponding data register via a set of module data signaling lines routed on the circuit board.
11. The memory module of claim 9, where the interface circuit comprises two interface circuits each serving half of the module data port and half of each rank of memory devices.
12. The memory module of claim 4, wherein the module data port comprises a dual-port buffer, each port of the dual-port buffer capable of connection to another memory module in a point-to-point configuration of memory data bus segments.
13. The memory module of claim 12, wherein each port is capable of connection to an m-bit-wide memory data bus segment, wherein one port comprises a transfer port and the other port comprises a forwarding port, the module capable of using the transfer port to transfer data signals between the interface circuit and a higher-level controller connected to the memory data bus, the module capable of using the forwarding port to connect to a second memory module in order to transfer data signals between the transfer port on the first memory module and the transfer port on the second memory module.
14. The memory module of claim 12, wherein each module data port is capable of connection to an m2-bit-wide memory data bus segment, wherein the dual module data ports comprise first and second transferforwarding ports, the module capable of retransmitting data signals received at one of the transferforwarding ports, but not destined for that memory module, on the other transferforwarding port, the module also capable of transferring m2 data signals between each of the transferforwarding ports and the interface circuit.
15. The memory module of claim 4, wherein data exchanges over the memory data bus comprise a data strobe signal, the module further comprising a data strobe circuit to generate data strobe signaling when transmitting data over the memory data bus.
16. The memory module of claim 15, wherein the controller begins an internal sequence of interface circuit write operations in response to an externally-supplied data strobe signal.
17. The memory module of claim 4, wherein data exchanges between the interface circuit and the ranks of memory devices comprise a data strobe signal, the module further comprising a data strobe circuit to generate data strobe signaling when transmitting data from the interface circuit to the ranks of memory devices, the interface circuit comprising a register circuit to latch data from the ranks of memory devices based on data strobe signaling received from those devices.
18. A method of hostmemory communication comprising:
initiating a data access transaction, involving N data bits, between a memory controller and a memory module;
at the memory module, initiating a corresponding data access transaction between an interface circuit and R ranks of memory devices, each rank capable of m-bit-wide data transfers, R>1;
transferring the N data bits between the memory controller and the memory module in m-bit-wide data segments;
transferring the N data bits between the interface circuit and the R ranks of memory devices in M R\xd7m-bit-wide segments, where
M
=

N

R
\xd7
m
is an integer value; and
initiating a valid data access transaction when N is an integer multiple of m, but less than R\xd7m.
19. The method of claim 18, wherein N=R\xd7m, such that for R data segments transferred between the memory controller and the memory module, one transfer occurs between the interface circuit and the memory devices.
20. The method of claim 18, further comprising clocking transfers between the memory controller and the memory module at R times the rate that transfers are clocked between the interface circuit and the memory devices.
21. The method of claim 18, wherein when the data access transaction is a write transaction, transferring the N data bits between the interface circuit and Nm of the ranks of memory devices, while signaling the remainder of the ranks to ignore the write transaction.
22. The method of claim 18, wherein when the data access transaction is a read transaction, transferring R\xd7m data bits, including the N data bits requested for the read transaction, from the R ranks of memory devices to the interface circuit, and transferring the N data bits requested for the read transaction from the memory module to the memory controller.
23. A memory module comprising:
R ranks of memory devices, where R is at least two, each rank having an m-bit-wide data port;
a module data port capable of exchanging data signaling over a memory data bus having an effective bit-width m, the module data port comprising a dual-port buffer, each port of the dual-port buffer capable of connection to another memory module in a point-to-point configuration of memory data bus segments, each port capable of connection to an m-bit-wide memory data bus segment, wherein one port comprises a transfer port and the other port comprises a forwarding port, the module capable of using the transfer port to transfer data signals between the interface circuit and a higher-level controller connected to the memory data bus, the module also capable of using the forwarding port to connect to a second memory module in order to transfer data signals between the transfer port on the first memory module and the transfer port on the second memory module;
an interface circuit coupled between the module data port and the R memory-device-rank data ports, the interface circuit capable of performing m-bit-wide data transfers at the module data port, the interface circuit capable of performing R\xd7m-bit-wide data transfers with die R ranks of memory devices; and
a controller capable of synchronizing the operation of the interface circuit and the memory device ranks such that a data transfer comprising R serial data transfers on the memory data bus can be completed internal to the memory module with one R\xd7m-bit-wide data transfer with the memory device ranks.
24. A memory module comprising:
R ranks of memory devices, where R is at least two, each rank having an m-bit-wide data port;
a module data port capable of exchanging data signaling over a memory data bus having an effective bit-width m, the module data port comprising a dual-port buffer, each port of the dual-port buffer capable of connection to another memory module in a point-to-point configuration of memory data bus segments, each module data port capable of connection to an m2-bit-wide memory data bus segment, wherein the dual module data ports comprise first and second transferforwarding ports, the module capable of retransmitting data signals received at one of the transferforwarding ports, but not destined for that memory module, on the other transferforwarding port, the module also capable of transferring m2 data signals between each, of the transferforwarding ports and the interface circuit;
an interface circuit coupled between the module data port and the R memory-device-rank data ports, the interface circuit capable of performing m-bit-wide data transfers at the module data port, the interface circuit capable of performing R\xd7m-bit-wide data transfers with the R ranks of memory devices; and
a controller capable of synchronizing the operation of the interface circuit and the memory device ranks such that a data transfer comprising R serial data transfers on the memory data bus can be completed internal to the memory module with one R\xd7m-bit-wide data transfer with the memory device ranks.

1. A heterocyclic compound of the formula (I)
the stereoisomers, N-oxides, prodrugs, tautomers andor physiologically tolerated acid addition salts thereof, and the compounds of the general formula I, wherein at least one of the atoms has been replaced by its stable, non-radioactive isotope, wherein
A is selected from the group consisting of CRA1RA2 and NRB; where
RA1 and RA2 are independently of each other selected from the group consisting of hydrogen, C1-C2-alkyl, C1-C2-haloalkyl, NH2 and OH; and
RB is selected from hydrogen, C1-C4-alkyl and C1-C4-haloalkyl;

X1 and X2 are independently of each other selected from the group consisting of CR2 and N;
X3, X4, X5 and X6 are independently of each other selected from the group consisting of CR3, CR4 and N;
with the proviso that no more than two of X3, X4, X5 and X6 are CR4;

Y1, Y2, Y3 and Y4 are independently of each other selected from the group consisting of CR4, CR5 and N;
with the proviso that at most one of Y1, Y2, Y3 and Y4 is N and with the proviso that at most one of Y1, Y2, Y3 and Y4 is CR4; and
with the proviso that one of Y1, Y2, Y3 and Y4 is CR4 or C\u2014CF3 if none of X3, X4, X5 and X6 is CR4;

R1 is selected from hydrogen, C1-C4-alkyl and C1-C4-haloalkyl;
each R2 is independently selected from the group consisting of hydrogen, OH, halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy and NRaRb;
or two radicals R2 bonded at the carbon atoms of groups X1 and X2, together with the carbon atoms to which they are bonded, form a 5- or 6-membered saturated or unsaturated ring which may contain 1 or 2 heteroatoms as ring members selected from the group consisting of N, O and S and which optionally carries 1, 2 or 3 substituents R6;

each R3 is independently selected from the group consisting of hydrogen, CN, NRaRb, OH, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, C1-C6-alkyl-NRaRb and an aromatic radical Ar, which is selected from the group consisting of phenyl and a 5- or 6-membered N- or C-bound heteroaromatic radical comprising one nitrogen atom and optionally 1, 2 or 3 further heteroatoms independently selected from O, S and N as ring members, wherein Ar is unsubstituted or carries one or two radicals R7 and wherein Ar may also be bonded via a CH2 group;
R4 is a C-bound saturated or partially unsaturated monocyclic 3-, 4-, 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 heteroatoms or heteroatom-containing groups selected from O, N, S, NO, SO and SO2 as ring members, where the heterocyclic ring optionally carries 1, 2 or 3 C- or N-bound substituents R8;
R5 is selected from the group consisting of hydrogen, CN, NRaRb, OH, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, C1-C6-alkyl-NRaRb and an aromatic radical Ar, which is selected from the group consisting of phenyl and a 5- or 6-membered N- or C-bound heteroaromatic radical comprising one nitrogen atom and optionally 1, 2 or 3 further heteroatoms independently selected from O, S and N as ring members, wherein Ar is unsubstituted or carries one or two radicals R7 and wherein Ar may also be bonded via a CH2 group;
R6 and R8, independently of each other and independently of each occurrence, are selected from the group consisting of CN, NRaRb, OH, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, C1-C6-alkyl-NRaRb and an aromatic radical Ar, which is selected from the group consisting of phenyl and a 5- or 6-membered N- or C-bound heteroaromatic radical comprising one nitrogen atom and optionally 1, 2 or 3 further heteroatoms independently selected from O, S and N as ring members, wherein Ar is unsubstituted or carries one or two radicals R7 and wherein Ar may also be bonded via a CH2 group;
each R7 is independently selected from the group consisting of halogen, CN, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, NRaRb, a phenyl group and a 5- or 6-membered heteroaromatic radical comprising one nitrogen atom and optionally 1, 2 or 3 further heteroatoms independently selected from O, S and N as ring members, wherein phenyl and the heteroaromatic radical are, independently of each other, unsubstituted or substituted by 1, 2, 3 or 4 radicals selected from halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; and
Ra and Rb are independently of each other selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylcarbonyl and C1-C4-haloalkylcarbonyl;
or Ra and Rb form, together with the nitrogen atom to which they are bonded, a 3-, 4-, 5-, 6- or 7-membered saturated or unsaturated aromatic or non-aromatic N-heterocyclic ring, which may contain 1 further heteroatom or heteroatom containing group selected from the group consisting of O, S, SO, SO2 and N as a ring member.
2. The heterocyclic compound of claim 1, wherein either one of X3, X4, X5 and X6 is CR4 and none of Y1, Y2, Y3 and Y4 is CR4, or one of Y1, Y2, Y3 and Y4 is CR4 and none of X3, X4, X5 and X6 is CR4.
3. The heterocyclic compound of claim 1, wherein one of Y1, Y2, Y3 and Y4 is CR4 if none of X3, X4, X5 and X6 is CR4.
4. The heterocyclic compound of claim 1, wherein one of Y1, Y2, Y3 and Y4 is C\u2014CF3 if none of X3, X4, X5 and X6 is CR4.
5. The heterocyclic compound of claim 1, wherein R4 is selected from a C-bound saturated or partially unsaturated monocyclic 4-, 5- or 6-membered heterocyclic ring containing 1 or 2 or 3 heteroatoms selected from O, N, S and SO, as ring members, where the heterocyclic ring optionally carries 1, 2 or 3 substituents R8.
6. The heterocyclic compound of claim 5, wherein R4 is selected from C-bound oxetanyl, thietanyl, azetidinyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydrothienyl-1-oxide, pyrrolidinyl, pyrrolinyl, pyrazolidinyl, pyrazolinyl, imidazolidinyl, imidazolinyl, tetrahydropyranyl, dihydropyranyl, piperidinyl, tetrahydropyridinyl, dihydropyridinyl, piperazinyl and morpholinyl, where the heterocyclic ring optionally carries 1, 2 or 3 substituents R8.
7. The heterocyclic compound of claim 6, wherein R4 is selected from C-bound oxetanyl, azetidinyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydrothienyl-1-oxide, pyrrolidinyl, pyrrolinyl, tetrahydropyranyl, dihydropyranyl, piperidinyl, tetrahydropyridinyl, dihydropyridinyl, piperazinyl and morpholinyl, where the heterocyclic ring optionally carries 1, 2 or 3 substituents R8.
8. The heterocyclic compound of claim 7, wherein R4 is selected from azetidin-3-yl, tetrahydrofuran-3-yl, pyrrolidin-3-yl, pyrrolin-3-yl, tetrahydropyran-4-yl, tetrahydropyran-3-yl, dihydropyran-4-yl, dihydropyran-3-yl, piperidin-4-yl, 1,2,5,6-tetrahydropyridin-4-yl and 1,2-dihydropyridin-4-yl, where the heterocyclic ring optionally carries 1, 2 or 3 substituents R8.
9. The heterocyclic compound of claim 1, wherein R8 is selected from C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl and benzyl and is preferably C1-C6-alkyl, C1-C6-haloalkyl or C1-C6-alkoxycarbonyl.
10. The heterocyclic compound of claim 1, wherein R8 is N-bound.
11. The heterocyclic compound of claim 1, wherein R4 is selected from following structures:
where
R8a is hydrogen or has one of the meanings given in claim 1 for R8; and
# is the attachment point to the remainder of the molecule.
12. The heterocyclic compound of claim 1, wherein at most one of X1, X2, X3, X4, X5 and X6 is N.
13. The heterocyclic compound of claim 12, wherein X1 and X2 are CR2 and X3, X4, X5 and X6 are CR3 or CR4, or where X1 and X2 are CR2, X3 is N and X4, X5 and X6 are CR3 or CR4.
14. The heterocyclic compound of claim 1, wherein Y1, Y2, Y3 and Y4 are CR4 or CR5 or Y2 is N and Y3 and Y4 are CR4 or CR5.
15. The heterocyclic compound of claim 1, wherein A is NRB, preferably NH.
16. The heterocyclic compound of claim 1, wherein R1 is hydrogen or methyl, preferably hydrogen.
17. The heterocyclic compound of claim 1, wherein R2 is hydrogen.
18. The heterocyclic compound of claim 1, wherein R3 is selected from hydrogen, CN, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl and C1-C6-haloalkoxycarbonyl and is preferably selected from hydrogen, CN, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy.
19. The heterocyclic compound of claim 1, wherein 0, 1 or 2 of the radicals R3 are different from hydrogen.
20. The heterocyclic compound of claim 1, wherein R5 is selected from hydrogen, CN, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C7-cycloalkyl, C3-C7-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, formyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl and C1-C6-haloalkoxycarbonyl and is preferably selected from hydrogen, halogen, C1-C4-haloalkyl, C3-C7-cycloalkyl and C3-C7-halocycloalkyl and in particular from hydrogen, fluorinated C1-C2-alkyl and C3-C6-cycloalkyl.
21. The heterocyclic compound of claim 1, wherein at most one of the radicals R5 is different from hydrogen.
22. The heterocyclic compound of claim 1, of formula I-1
where
X3 is N or CH;
Y2 is N or CH;
R31 has one of the meanings given in claim 1, for R3 except for hydrogen, and is preferably halogen, C1-C4-alkyl or C1-C4-alkoxY;
R4 has one of the meanings given in claim 1;
R51 has one of the meanings given in claim 1, for R5 except for hydrogen;
a is 0, 1 or 2; and
b, c and d are independently of each other 0 or 1, with the proviso that one of b and c is 1.
23. The heterocyclic compound of claim 1, of formula I-2
where
Y2 is N or preferably CH;
R31 has one of the meanings given in claim 1 for R3 except for hydrogen, and is preferably selected from the group consisting of halogen, trifluoromethyl, cyano or methoxy;
R4 has one of the meanings given in claim 1;
a is 0, 1 or 2;
b is 0 or 1.
24. The heterocyclic compound of claim 23, where Y2 is CH, b is 0 and a is 0, 1 or 2 and where R31, if present, is selected from the group consisting of halogen, trifluoromethyl, cyano and methoxy.
25. A heterocyclic compound selected from the group consisting of
1-(6-(3,6-dihydro-2H-pyran-4-yl)pyridin-2-yl)-3-(8-fluoroquinolin-4-yl)urea,
1-(8-fluoroquinolin-4-yl)-3-(6-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)urea,
1-(6-(3,4-dihydro-2H-pyran-5-yl)pyridin-2-yl)-3-(8-fluoroquinolin-4-yl)urea,
1-(6-(3,6-dihydro-2H-pyran-4-yl)pyridin-2-yl)-3-(7-methoxyquinolin-4-yl)urea,
1-(6-(3,4-dihydro-2H-pyran-5-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)-urea,
1-(7-(3,6-dihydro-2H-pyran-4-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)-urea,
1-(6-(tetrahydro-2H-pyran-4-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)-urea,
1-(7-methoxyquinolin-4-yl)-3-(6-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)urea,
1-(7-(tetrahydro-2H-pyran-4-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)-urea,
1-(6-(tetrahydro-2H-pyran-3-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)-urea,
1-(7-(3,6-dihydro-2H-pyran-4-yl)quinolin-4-yl)-3-(pyrazin-2-yl)urea,
1-(6-(3,4-dihydro-2H-pyran-5-yl)pyridin-2-yl)-3-(7-methoxyquinolin-4-yl)urea,
1-(7-methoxyquinolin-4-yl)-3-(6-(tetrahydro-2H-pyran-3-yl)pyridin-2-yl)urea,
1-(pyrazin-2-yl)-3-(7-(tetrahydro-2H-pyran-4-yl)quinolin-4-yl)urea,
1-(7-(3,4-dihydro-2H-pyran-5-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)-urea,
1-(6-bromo-quinolin-4-yl)-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-(6-(trifluoromethyl)pyridin-2-yl)-3-quinolin-4-yl-urea,
1-(6,8-difluoroquinolin-4-yl)-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-(7-bromoquinolin-4-yl)-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-(7-trifluoromethylquinolin-4-yl)-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-(7-methoxyquinolin-4-yl)-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-(8-trifluoromethylquinolin-4-yl)-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-(8-cyanoquinolin-4-yl)-3-(6-trifluoromethyl)pyridin-2-yl)-urea,
1-(8-iodoquinolin-4-yl)-3-(6-trifluoromethyl)pyridin-2-yl)-urea,
1-(8-cyanoquinolin-4-yl)-3-pyrazin-2-yl-urea,
1-(7-methoxyquinolin-4-yl)-3-pyrazin-2-yl-urea,
tert-butyl 4-{4-3-(6-trifluoromethyl-pyridin-2-yl)-ureido-quinolin-6-yl}-3,6-dihydro-2H-pyridine-1-carboxylate,
1-6-(1,2,3,6-tetrahydro-pyridin-4-yl)-quinolin-4-yl-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-(6-(piperidin-4-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)urea,
1-6-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-quinolin-4-yl-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-6-(1-methyl-piperidin-4-yl)-quinolin-4-yl-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-{6-1-(2-fluoro-ethyl)-piperidin-4-yl-quinolin-4-yl}-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-{6-1-(2,2-difluoro-ethyl)-piperidin-4-yl-quinolin-4-yl}-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-6-(3,6-dihydro-2H-pyran-4-yl)-quinolin-4-yl-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-6-(3,6-dihydro-2H-pyran-4-yl)-quinolin-4-yl-3-pyrazin-2-yl-urea,
tert-butyl 4-4-(3-pyrazin-2-ylureido)quinolin-6-yl-5,6-dihydropyridine-1(2H)-carboxylate,
1-pyrazin-2-yl-3-6-(1,2,3,6-tetrahydro-pyridin-4-yl)-quinolin-4-yl-urea,
1-(6-piperidin-4-yl-quinolin-4-yl)-3-pyrazin-2-yl-urea,
1-{6-1-(2-fluoro-ethyl)-piperidin-4-yl-quinolin-4-yl}-3-pyrazin-2-yl-urea,
1-6-(1-methyl-piperidin-4-yl)-quinolin-4-yl-3-pyrazin-2-yl-urea,
tert-butyl 4-{4-3-(6-cyclopropyl-pyrazin-2-yl)-ureido-quinolin-6-yl}-3,6-dihydro-2H-pyridine-1-carboxylate,
tert-butyl 4-{4-3-(6-cyclopropyl-pyrazin-2-yl)-ureido-quinolin-6-yl}-piperidine-1-carboxylate,
1-(6-cyclopropyl-pyrazin-2-yl)-3-(6-piperidin-4-yl-quinolin-4-yl)-urea,
1-(6-cyclopropyl-pyrazin-2-yl)-3-6-(1-methyl-piperidin-4-yl)-quinolin-4-yl-urea,
tert-butyl 3-{4-3-(6-Trifluoromethyl-pyridin-2-yl)-ureido-quinolin-6-yl}-2,5-dihydropyrrole-1-carboxylate,
1-6-(2,5-dihydro-1H-pyrrol-3-yl)-quinolin-4-yl-3-(6-trifluoromethyl-pyridin-2-yl)-urea,
1-6-(3,6-dihydro-2H-pyran-4-yl)-pyridin-2-yl-3-(8-fluoro-quinolin-4-yl)-urea,
1-(8-fluoro-quinolin-4-yl)-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-(8-chloro-6-methyl-quinolin-4-yl)-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-(6,8-dichloro-quinolin-4-yl)-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-(6,8-difluoro-quinolin-4-yl)-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-(8-chloro-quinolin-4-yl)-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-1,5naphthyridin-4-yl-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-(5,8-difluoro-quinolin-4-yl)-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-(8-fluoro-6-methoxy-quinolin-4-yl)-3-6-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
1-6-(5,6-dihydro-4H-pyran-3-yl)-pyridin-2-yl-3-(8-fluoro-quinolin-4-yl)-urea,
1-(8-fluoro-quinolin-4-yl)-3-6-(tetrahydro-pyran-3-yl)-pyridin-2-yl-urea,
1-6-(3,6-dihydro-2H-pyran-4-yl)-pyridin-2-yl-3-1,5naphthyridin-4-yl-urea,
tert-butyl-6-3-(8-fluoro-quinolin-4-yl)-ureido-3\u2032,6\u2032-dihydro-2\u2032H-2,4\u2032bipyridinyl-1\u2032-carboxylate,
1-(8-fluoro-quinolin-4-yl)-3-(1\u2032,2\u2032,3\u2032,6\u2032-tetrahydro-2,4\u2032bipyridinyl-6-yl)-urea,
tert-butyl-6-3-(8-fluoro-quinolin-4-yl)-ureido-3\u2032,4\u2032,5\u2032,6\u2032-tetrahydro-2\u2032H-2,4\u2032bipyridinyl-1\u2032-carboxylate,
1-(8-fluoro-quinolin-4-yl)-3-(1\u2032,2\u2032,3\u2032,4\u2032,5\u2032,6\u2032-hexahydro-2,4\u2032bipyridinyl-6-yl)-urea,
1-(8-fluoro-quinolin-4-yl)-3-(1\u2032-methyl-1\u2032,2\u2032,3\u2032,4\u2032,5\u2032,6\u2032-hexahydro-2,4\u2032bipyridinyl-6-yl)-urea,
1-1\u2032-(2-fluoro-ethyl)-1\u2032,2\u2032,3\u2032,4\u2032,5\u2032,6\u2032-hexahydro-2,4\u2032bipyridinyl-6-yl-3-(8-fluoroquinolin-4-yl)-urea,
1-1\u2032-(2,2-difluoro-ethyl)-1\u2032,2\u2032,3\u2032,4\u2032,5\u2032,6\u2032-hexahydro-2,4\u2032bipyridinyl-6-yl-3-(8-fluoroquinolin-4-yl)-urea,
1-(8-fluoro-quinolin-4-yl)-3-(1\u2032-isopropyl-1\u2032,2\u2032,3\u2032,4\u2032,5\u2032,6\u2032-hexahydro-2,4\u2032bipyridinyl-6-yl)-urea,
1-(8-fluoro-quinolin-4-yl)-3-5-(tetrahydro-pyran-4-yl)-pyridin-2-yl-urea,
tert-butyl-3-4-(3-pyrazin-2-yl-ureido)-quinolin-6-yl-2,5-dihydro-pyrrole-1-carboxylate,
tert-butyl-3-4-(3-pyrazin-2-yl-ureido)-quinolin-6-yl-pyrrolidine-1-carboxylate,
1-pyrazin-2-yl-3-(6-pyrrolidin-3-yl-quinolin-4-yl)-urea,
the stereoisomers, N-oxides, prodrugs, tautomers or physiologically tolerated acid addition salts thereof.
26. The heterocyclic compound of claim 1, wherein at least one of the atoms has been replaced by its stable, non-radioactive isotope, and preferably wherein at least one hydrogen atom has been replaced by a deuterium atom.
27. A pharmaceutical composition comprising at least one heterocyclic compound of claim 1, a stereoisomer, N-oxide, prodrug, tautomer andor physiologically tolerated acid addition salt thereof or comprising at least one heterocyclic compound as defined in any of the preceding claims wherein at least one of the atoms has been replaced by its stable, non-radioactive isotope, preferably wherein at least one hydrogen atom has been replaced by a deuterium atom, and at least one physiologically acceptable carrier andor auxiliary substance.
28. The heterocyclic compounds of claim 1 or the stereoisomers, N-oxides, prodrugs, tautomers or physiologically tolerated acid addition salts thereof for use as a medicament.
29. The heterocyclic compounds of claim 1 or the stereoisomers, N-oxides, prodrugs, tautomers or physiologically tolerated acid addition salts thereof for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3\u03b2.
30. The use of the heterocyclic compound of claim 1 or of a stereoisomer, N-oxide, prodrug, tautomer or physiologically tolerated acid addition salt thereof for the preparation of a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3\u03b2.
31. A method for treating a medical disorder susceptible to treatment with a compound that modulates, preferably inhibits, glycogen synthase kinase 3\u03b2 activity, said method comprising administering an effective amount of at least one heterocyclic compound of claim 1 or of a stereoisomer, prodrug, N-oxide, tautomer or physiologically tolerated acid addition salt thereof or of a pharmaceutical composition of claim 1 to a subject in need thereof.
32. The heterocyclic compounds of claim 29, wherein the medical disorder is a neurodegenerative disorder or an inflammatory disorder.
33. The heterocyclic compounds or the use or the method of claim 32, wherein the medical disorder is selected from schizophrenia, Alzheimer’s disease, behavioural and psychiatric symptoms of dementia, Parkinson’s disease, tauopathies, vascular dementia, acute stroke and other traumatic injuries, cerebrovascular accidents, brain and spinal cord trauma, peripheral neuropathies, bipolar disorders, retinopathies, glaucoma, pain, rheumatoid arthritis and osteoarthritis.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A radiation imaging apparatus comprising:
an area sensor arranged with pixels in a matrix, each pixel having a conversion element for converting incident radiation into an electric signal;
a driving circuit unit for applying a driving signal to a driving line and driving a plurality of the pixels connected in common to the driving line;
a read out circuit unit reading out the electric signal from the pixel driven by the driving circuit unit and outputting the electric signal as image data;
a processing unit for executing a process for producing image data for correction based on partial image data for correction, wherein the partial image data for correction is read out by the read out circuit unit as an electric signal from one or more of the plurality of pixels in the area sensor without the incident radiation while the one or more of the pixels are driven by the driving circuit unit and the other pixels are not driven by the driving circuit unit, and then outputted from the read out circuit unit; and
an arithmetic operation unit for subjecting radiation image data to an arithmetic operation processing using the image data for correction, wherein the radiation image data is read out by the read out circuit unit as an electric signal from the pixels driven by the driving circuit unit based on the incident radiation, and then outputted from the read out circuit unit.
2. The radiation imaging apparatus according to claim 1, wherein the processing unit synthesizes first partial image data for correction output from the read out circuit unit after the processing unit reads out the electric signal in a state in which the radiation is not incident from the pixel included in a first pixel group partially driven by the driving circuit unit, after the radiation image data is output, and second partial image data for correction output from the read out circuit after the processing unit reads out the electric signal in a state in which the radiation is not incident from the pixel included in a second pixel group different from the first pixel group partially driven by the driving circuit unit, before the radiation image data is output, thereby to generate the image data for correction.
3. The radiation imaging apparatus according to claim 2, wherein the first pixel group comprises a plurality of pixels connected to the odd-numbered driving lines among the plurality of the pixels inside the area sensor, and the second pixel group comprises the plurality of pixels connected to the even-numbered driving lines among the plurality of the pixels inside the area sensor.
4. The radiation imaging apparatus according to claim 3, wherein the first pixel group comprises the plurality of pixels connected to the odd-numbered driving lines given an interlace scanning by the driving circuit unit and the second pixel group comprises the plurality of pixels connected to the even-numbered driving lines given the interlace scanning by the driving circuit unit.
5. The radiation imaging apparatus according to claim 4, further comprising radiographing condition setting means for performing the setting of radiographing conditions, wherein, according to the radiographing conditions set by the radiographing condition setting means, the number of lines of the driving lines performing the interlace scanning is controlled.
6. The radiation imaging apparatus according to claim 5, wherein, according to the radiographing conditions set by the radiographing condition setting means, a pulse period, an energy, and an intensity of the radiation can be changed.
7. The radiation imaging apparatus according to claim 2, wherein the processing unit, when synthesizing the first partial image data for correction and the second partial image data for correction, performs the synthesis by applying a specific coefficient to both or either of them.
8. The radiation imaging apparatus according to claim 1, wherein the arithmetic operation means performs a subtraction as the arithmetic operation processing.
9. The radiation imaging apparatus according to claim 1, wherein, every time the radiation image data is output, the partial image data for correction is output from the read out circuit unit.
10. The radiation imaging apparatus according to claim 1, wherein the pixel comprises the conversion element and a switch element for transferring the electric signal of the conversion element on an insulating substrate, and control electrodes of the switch elements of a plurality of pixels arranged in a row direction are connected in common to the driving lines, and one electrode among main electrodes of the switch elements of the plurality of pixels arranged in a column direction is connected in common to the signal line, and another electrode among main electrodes of the switch elements is connected to the conversion element, and the signal line is connected to the read out circuit unit, and the conversion element includes a photoelectric conversion element comprising amorphous silicon as a main material and a wavelength converter for converting the radiation into a light perceptible by the photoelectric conversion element.
11. The radiation imaging apparatus according to claim 1, wherein the driving circuit unit comprises a shift resistor input with a start pulse, a shift clock and an output enable signal.
12. A radiation imaging system, comprising:
a radiation generator for generating radiation; and
a radiation imaging apparatus according to claim 1,
wherein the radiation generated by the radiation generator is incident upon the area sensor.
13. A driving method of a radiation imaging apparatus, which comprises an area sensor arranged with pixels in a matrix, each pixel having a conversion element for converting incident radiation into an electric signal, a driving circuit unit for applying a driving signal to a driving line and driving a plurality of the pixels connected in common to the driving line, and a read out circuit unit reading out the electric signal from the pixel driven by the driving circuit unit and outputting the electric signal as image data, comprising:
a step of outputting radiation image data from the read out circuit unit, wherein the radiation image data is read out by the read out circuit unit as an electric signal from pixels driven by a driving circuit unit based on the incident radiation, and then outputted from the read out circuit unit;
a step of outputting partial image data for correction from the read out circuit unit, wherein the partial image data for correction is read out by the read out circuit unit as an electric signal from one or more of the plurality of pixels in the area sensor without the incident radiation while the one or more of the pixels are driven by the driving circuit unit and the other pixels are not driven by the driving circuit unit, and then outputted from the read out circuit unit;
a step of generating image data for correction by using the partial image data for correction; and
a step of performing an arithmetic operation processing on the radiation image data by using the image data for correction.