Author: claimsbot

1. A basketball system comprising:
a basketball goal including a backboard and a rim;
a support structure that is sized and configured to support the basketball goal at a plurality of heights, the support structure comprising:
a support pole; and
one or more connecting members connecting the support pole and the basketball goal; and

a height adjustment assembly that is sized and configured to adjust the height of the basketball goal, the height adjustment assembly comprising:
an arm connected to at least one of the connecting members, the arm including a plurality of receiving portions formed in an inner surface of the arm that is disposed towards the support pole, the arm including a generally planar outer surface that is disposed away from the support pole;
an engaging member extending outwardly from the support pole, the engaging member being sized and configured to engage a first receiving portion of the plurality of receiving portions to secure the basketball goal at a first height and to engage a second receiving portion of the plurality of receiving portions to secure the basketball goal at a second height;
a bracket connected to the support pole; and
a stop pivotally connected to the bracket, the stop movable between an unlocked position in which the stop does not engage the generally planar outer surface of the arm and a locked position in which the stop engages the generally planar outer surface of the arm, the stop comprising:
a first end that engages the arm when the stop is in the locked position, the first end being disengaged from the arm when the stop is in the unlocked position to allow the arm to move;
a second end that extends outwardly and away from the arm, the second end including an engagement surface that facilitates movement of the stop between the locked and unlocked positions; and
an engagement portion that slides along a surface of the bracket when the stop moves between the locked and unlocked positions.
2. The basketball as in claim 1, wherein when the stop is in the locked position and the stop engages the generally planar outer surface of the arm, the engaging member engages one of the plurality of receiving portions in the inner surface of the arm to secure the basketball goal at a desired height; and
wherein when the stop is in the unlocked position, the engaging member can be disengaged from the receiving portions in the inner surface of the arm to allow the height of the basketball goal to be adjusted.
3. The basketball system as in claim 1, wherein the engaging member includes a first portion that connects the bracket to the support pole and a second portion that extends outwardly and away from the support pole, the second portion selectively engaging the plurality of receiving portions in the inner surface of the arm.
4. The basketball as in claim 1, wherein a portion of the stop pivots upwardly as the stop is moved from the locked position to the unlocked position.
5. The basketball as in claim 1, wherein the stop includes a guide pin and the bracket includes a guide track;
wherein movement of the stop between the locked and unlocked positions is controlled and limited by the movement of the guide pin relative to the guide track.
6. The basketball system as in claim 5, wherein the guide pin extends outwardly and away from the stop and the guide track is formed by an outer surface of the bracket.
7. The basketball system as in claim 1, wherein the adjustment assembly further comprises a biasing member that is sized and configured to bias the stop towards the locked position.
8. The basketball system as in claim 1, wherein the stop comprises a cam that helps maintains the arm in the fixed position when the stop is in the locked position.
9. The basketball system as in claim 1, wherein the first end of the stop includes an engagement surface that engages the generally planar outer surface of the arm when the stop is in the locked position, the engagement surface of the stop pivoting outwardly and away from the generally planar outer surface of the arm when the stop is moved from the locked position to the unlocked position.
10. A basketball system comprising:
a basketball goal including a backboard and a rim;
a support structure that is sized and configured to support the basketball goal above a playing surface;
a connecting structure connecting the support structure and the basketball goal; and
a height adjustment assembly that is sized and configured to adjust the height of the basketball goal relative to the playing surface, the height adjustment assembly comprising:
an arm including a first end connected to the connecting structure and a second end including a plurality of coupling portions; and
a locking mechanism that is sized and configured to secure the basketball goal at a desired height relative to the playing surface, the locking mechanism comprising:
a coupling member that is sized and configured to be selectively coupled to one of the plurality of coupling portions of the arm to secure the arm in a fixed position relative to the support structure;
a bracket connected to the support structure; and
a stop pivotally connected to the bracket, the stop movable between an unlocked position in which the arm may be moved to allow the height of the basketball goal to be adjusted and a locked position in which the stop engages the arm and the coupling member of the locking mechanism is coupled to one of the coupling portions of the arm to secure the basketball goal at a height above the playing surface, the stop comprising:
a first end that engages the arm when the stop is in the locked position, the first end being disengaged from the arm when the stop is in the unlocked position to allow the arm to move;
a second end that extends outwardly and away from the arm, the second end including an engagement surface that facilitates movement of the stop between the locked and unlocked positions; and
an engagement portion that slides along a surface of the bracket when the stop moves between the locked and unlocked positions.
11. The basketball system as in claim 10, wherein the coupling member includes a first portion that attaches the bracket to the support structure and a second portion that extends outwardly and away from the support structure, the second portion of the coupling member being selectively coupled to the coupling portions of the arm.
12. The basketball system as in claim 10, wherein the bracket of the locking mechanism includes a pair of flanges that extend outwardly and away from the support structure;
wherein the stop is pivotally connected to the flanges of the bracket; and
wherein the arm is disposed between the support structure, the flanges and the stop.
13. The basketball system as in claim 10, wherein the stop includes a guide member and the bracket includes a guide;
wherein the guide guides the guide member when the stop is moved between the locked and unlocked positions.
14. The basketball system as in claim 13, wherein the guide member comprises an outwardly extending projection and the guide comprises a curved outer surface of a flange of the bracket.
15. The basketball system as in claim 10, wherein the stop allows the arm to be moved away from the support structure and the coupling member to be disconnected from the coupling portion of the arm when the stop is in the unlocked position; and
wherein the second end of the arm is disposed towards the support structure and the coupling member is connected to one of the coupling portions of the arm when the stop is in the locked position.
16. The basketball system as in claim 10, wherein the plurality of coupling portions are disposed in an inner surface of the arm facing the support pole; and
wherein the arm includes a generally planar outer surface that is disposed away from the support pole.
17. The basketball system as in claim 16, wherein when the stop is in the locked position, an engagement surface of the stop engages the generally planar outer surface of the arm; and
wherein when the stop is in the unlocked position, the coupling member can be disengaged from the coupling portion in the inner surface of the arm to allow the height of the basketball goal to be adjusted.
18. The basketball system as in claim 17, wherein an end of the stop pivots upwardly and towards the arm as the stop is moved from the locked position to the unlocked position; and
wherein the engagement surface of the stop pivots downwardly and away from the arm as the stop is moved from the locked position to the unlocked position.
19. The basketball system as in claim 10, wherein the height adjustment assembly further comprises a biasing member that is sized and configured to bias the stop towards the locked position.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1) Reading is taught through unique movements that associate soundsphonemes with their letters.
2) The American Sign Language letter is made with the handsfine motor while the movement is made with the large motor.
3) Letters are taught in alphabetical order.
4) All movements for the sounds of the letter are taught order of most frequent use. For example, letter Aa has four sounds taught in frequency of use: a (apple), A (apron), o (ball), u (villa). A different movement is made for each with the hands still in the ASL sign for Aa. Some letter sounds are taught after all basic sounds are taught. (see ***Age is a consideration, p. 1, Detailed Description)
5) Digraphs, trigraphs, diphthongs, and blends have movements unique to this reading method (p 5-6, Detailed Description).
6) The technique used in Reverse Phonics (p. 5, Detailed Description) is exclusive to this reading method because it uses the sound to produce the unique movement in order to remember, produce, and write the sound during the writing process, specifically journaling.

1. An image sensor comprising:
an array of photo-detectors formed in a semiconductor substrate;
a plurality of conductive line regions formed in the semiconductor substrate, each conductive line region formed under a respective line of photo-detectors along a first direction; and
a conductive junction region formed between the array of photo-detectors and the plurality of conductive line regions within the semiconductor substrate.
2. The image sensor of claim 1, wherein the conductive line regions are doped with a first dopant, and wherein the conductive junction region is doped with a second dopant that is of opposite conductivity from the first dopant.
3. The image sensor of claim 2, wherein each photo-detector has a respective junction region doped with a third dopant of the same conductivity type as the first dopant.
4. The image sensor of claim 3, wherein the semiconductor substrate is doped with a fourth dopant of the same conductivity type as the second dopant.
5. The image sensor of claim 4, wherein the semiconductor substrate is P type doped, wherein the conductive line regions are N+ type doped, wherein the conductive junction region is P+ type doped, and wherein the respective junction regions of the photo-detectors are N type doped.
6. The image sensor of claim 3, wherein each photo-detector has a respective top junction region doped with a fifth dopant of the opposite conductivity type as the third dopant.
7. The image sensor of claim 6, wherein the semiconductor substrate is P type doped, wherein the conductive line regions are N+ type doped, wherein the conductive junction region is P+ type doped, wherein the respective junction regions of the photo-detectors are N type doped, and wherein the respective top junction regions of the photo-detectors are P type doped.
8. The image sensor of claim 3, further comprising:
a surrounding junction that surrounds the array of photo-detectors.
9. The image sensor of claim 8, wherein the semiconductor substrate is P type doped, wherein the conductive line regions are N+ type doped, wherein the conductive junction region is P+ type doped, wherein the respective junction regions of the photo-detectors are N type doped, and wherein the surrounding junction is P+ type doped.
10. The image sensor of claim 1, wherein the conductive junction region is separated from the conductive line regions by a material of the semiconductor substrate.
11. The image sensor of claim 10, wherein the conductive junction region surrounds a portion of the conductive line regions.
12. The image sensor of claim 11, wherein the conductive junction region surrounds a respective top surface, and surrounds respective side portions of each conductive line region with inclined surfaces of the conductive junction region.
13. The image sensor of claim 1, wherein the array of photo-detectors includes:
a respective transmission transistor coupled to the respective junction region of each of the photo-detectors.
14. The image sensor of claim 13, wherein the respective transmission transistor is a respective field effect transistor.
15. The image sensor of claim 1, further comprising:
at least one respective conductive plug formed onto each of the conductive line regions for making contact to the respective conductive line region.
16. The image sensor of claim 15, further comprising:
two respective conductive plugs formed onto two ends of each conductive line region.
17. The image sensor of claim 15, further comprising:
a respective impurity diffusion layer surrounding each conductive plug.
18. The image sensor of claim 15, wherein a conductive plug is formed onto a plurality of conductive line regions.
19. The image sensor of claim 15, further comprising:
an overlying conductive line coupled to a line of conductive plugs disposed along a second direction that is perpendicular to the first direction.
20. The image sensor of claim 19, further comprising:
a surrounding junction that surrounds the array of photo-detectors, wherein the conductive plugs and the overlying conductive line are formed outside of the surrounding junction.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound having the formula:
wherein:
R1 is selected from the group consisting of hydrogen, F, Cl, Br, I, NO2, OR9, NR10R11, S(O)nR9, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, S(O)nR9, NR10R11, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R3 and R4 each independently is selected from the group consisting of hydrogen, OR9, S(O)nR9, NR10R11, C(Y)OR11, C(Y)NR10R11, optionally substituted C1\u2013C8alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R5 and R6 each independently is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R7 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R8 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R10 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, CO2R12, C(O)R12, SO2R12 and S(O)R12;
R11 and R12 each independently is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R13 is selected from the group consisting of optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C2\u2013C8 alkenyl, optionally substituted C2\u2013C8 alkynyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl;
m is selected from the group consisting of 0, 1 and 2;
n is selected from the group consisting of 0, 1 and 2;
W is selected from the group consisting of NH, N{R13}, N{C(Y)R11} and N{SO2R11};
X is O;
Z is selected from the group consisting of NH, N{R11}, N{C(Y)R11}, N{SO2R12} and N{S(O)R12}; and
Y is O;

and pharmaceutically acceptable salts thereof; wherein:
the substituents of an optionally substituted group comprise one or more substituents independently selected from among alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, haloalkenyl, haloalkynyl, cycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, aryloxy, haloalkoxy, amino, alkylamino, dialkylamino, alkylthio, arylthio, heteroarylthio, oxo, carboxyester, carboxamido, acyloxy, hydrogen, F, Cl, Br, I, CN, NO2, NH2, N3, NHCH3, N(CH3)2, SH, SCH3, OH, OCH3, OCF3, CH3, CF3, C(O)CH3, CO2CH3, CO2H, C(O)NH2, OR9, SR9, NR10R11, CF2CF3, CH2CH2F and CH2CF3.
2. A compound according to claim 1, wherein R1 is selected from the group consisting of hydrogen, F, Cl, OR9, NR10R11, S(O)nR9, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4heteroalkyl.
3. A compound according to claim 2, wherein R1 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
4. A compound according to claim 3, wherein R1 is selected from the group consisting of hydrogen, F and optionally substituted C1\u2013C4 alkyl.
5. A compound according to claim 1, wherein R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
6. A compound according to claim 5, wherein R2 is selected from the group consisting of hydrogen, F, Cl, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
7. A compound according to claim 6, wherein R2 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C2 alkyl, optionally substituted C1\u2013C2 haloalkyl and optionally substituted C1\u2013C2 heteroalkyl.
8. A compound according to claim 7, wherein R2 is CF3.
9. A compound according to claim 1, wherein
R3 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, C(Y)OR11 and C(Y)NR10R11.
10. The compound of claim 1, wherein:
R1 is selected from the group consisting of hydrogen, F, Cl, Br, I, NO2, OR9, NR10R11, S(O)nR9, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, C3\u2013C8 cycloalkyl, aryl, arylalkyl, heteroaryl, C2\u2013C8 alkynyl and C2\u2013C8 alkenyl;
R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, NR10R11, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, C3\u2013C8 cycloalkyl, aryl, arylalkyl, heteroaryl, C2\u2013C8 alkynyl and C2\u2013C8 alkenyl;
R3 and R4 each independently is selected from the group consisting of hydrogen, OR9, S(O)nR9, NR10R11, C(Y)OR11, C(Y)NR10R11, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, C3\u2013C8 cycloalkyl, aryl, arylalkyl, heteroaryl, C2\u2013C8 alkynyl and C2\u2013C8 alkenyl;
R5 and R6 each independently is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, C3\u2013C8 aryl, arylalkyl, heteroaryl, C2\u2013C8 alkynyl and C2\u2013C8 alkenyl;
R7 is selected from the group consisting of hydrogen, F, Cl, Br, I, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, aryl, heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R8 is selected from the group consisting of hydrogen, F, Cl, Br, I, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, aryl, heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R9 is selected from the group consisting of hydrogen, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, aryl, heteroaryl and arylalkyl;
R10 is selected from the group consisting of hydrogen, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, aryl, heteroaryl, arylalkyl, CO2R12, C(O)R12, SO2R12 and S(O)R12;
R11 and R12 each independently is selected from the group consisting of hydrogen, C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, aryl, heteroaryl and arylalkyl;
R13 is selected from the group consisting of C1\u2013C8 alkyl, C1\u2013C8 haloalkyl, C1\u2013C8 heteroalkyl, C2\u2013C8 alkenyl, C2\u2013C8 alkynyl, C3\u2013C8 cycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl;
m is selected from the group consisting of 0, 1 and 2;
n is selected from the group consisting of 0, 1 and 2;
W is selected from the group consisting of NH, N{R13}, N{C(Y)R11} and N{SO2R11};
X is O;
Z is selected from the group consisting of NH, N{R11}, N{C(Y)R11}, N{SO2R12} and N{S(O)R12}; and
Y is O;

and pharmaceutically acceptable salts thereof.
11. A compound according to claim 9, wherein R3 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
12. A compound according to claim 1, wherein R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
13. A compound according to claim 12, wherein R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl, optionally substituted C1\u2013C4 heteroalkyl, optionally substituted C2\u2013C4 alkynyl and optionally substituted C2\u2013C4 alkenyl.
14. A compound according to claim 13, wherein R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
15. A compound according to claim 12, wherein R6 is selected from the group consisting of optionally substituted aryl, optionally substituted arylalkyl and optionally substituted heteroaryl.
16. A compound according to claim 1, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6haloalkyl, optionally substituted C1\u2013C6heteroalkyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted C2\u2013C6 alkenyl.
17. A compound according to claim 16, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
18. A compound according to claim 17, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
19. A compound according to claim 18, wherein R5 is hydrogen or CF3.
20. A compound according to claim 1, wherein R7 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
21. A compound according to claim 1, wherein R8 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
22. A compound according to claim 21, wherein R7 and R8 are each hydrogen or optionally substituted C1\u2013C2 alkyl.
23. A compound according to claim 1, wherein R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
24. A compound according to claim 23, wherein R9 is selected from the group consisting of hydrogen and optionally substituted C3\u2013C4 alkyl.
25. A compound according to claim 1, wherein R10 is selected from the group consisting of hydrogen, S(O)R12, SO2R12, C(O)R12, CO2R12, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
26. A compound according to claim 25, wherein R10 is selected from the group consisting of hydrogen, S(O)R12, SO2R12, C(O)R12 and CO2R12.
27. A compound according to claim 1, wherein R4 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
28. A compound according to claim 27, wherein R4 is selected from the group consisting of hydrogen and optionally substituted C1\u2013C2 alkyl.
29. A compound according to claim 1, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C6 alkyl, optionally substituted C3\u2013C6 cycloalkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkenyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl.
30. A compound according to claim 29, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl, optionally substituted C1\u2013C4 heteroalkyl, optionally substituted C2\u2013C4 alkenyl and optionally substituted aryl.
31. A compound according to claim 30, wherein R13 is selected from the group consisting of CF3,CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, methyl, ethyl, propyl, isopropyl, isobutyl, cyclopropylmethyl, allyl.
32. A compound according to claim 1, wherein m is 0 or 1.
33. A compound according to claim 32, wherein m is 1.
34. A compound according to claim 1, wherein W is selected from the group consisting of NH, N{R13} and N{C(Y)R11}.
35. A compound according to claim 34, wherein W is NH or N{R13}.
36. A compound according to claim 1, wherein Z is NH or N{R11}.
37. A compound according to claim 1, wherein:
R1 is selected from the group consisting of hydrogen, F, Cl, OR9, S(O)nR9, NR10R11, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl;
R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl;
R3 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, C(Y)OR11 and C(Y)NR10R11;
R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl; and
R6 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
38. A compound according to claim 37, wherein:
R7 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl;
R8 is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl; and
R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C3\u2013C6 cycloalkyl, optionally substituted C2\u2013C6 alkenyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl.
39. A compound according to claim 38, wherein:
m is 0 or 1;
W is selected from the group consisting of NH, N{R13}, N{C(Y)R11} and N{SO2R11};
X is O;
Z is NH or N{R11}.
40. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula:
wherein:
R1 is selected from the group consisting of hydrogen, F, Cl, Br, I, NO2, OR9, NR10R11, S(O)nR9, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, NR10R11, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R3 and R4 each independently is selected from the group consisting of hydrogen, OR9, S(O)nR9, NR10R11, C(Y)OR11, C(Y)NR10R11, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R5 and R6 each independently are selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2,optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C8 alkynyl and optionally substituted C2\u2013C8 alkenyl;
R7 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 optionally substituted heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9, S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R8 is selected from the group consisting of hydrogen, F, Cl, Br, I, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, OR9,S(O)nR9, NR10R11, C(Y)OR11 and C(Y)NR10R11;
R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R10 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, CO2R12, C(O)R12, SO2R12 and S(O)R12;
R11 and R12 each independently is selected from the group consisting of hydrogen, optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted arylalkyl;
R13 is selected from the group consisting of optionally substituted C1\u2013C8 alkyl, optionally substituted C1\u2013C8 haloalkyl, optionally substituted C1\u2013C8 heteroalkyl, optionally substituted C2\u2013C8 alkenyl, optionally substituted C2\u2013C8 alkynyl, optionally substituted C3\u2013C8 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl;
m is 1;
n is selected from the group consisting of 0, 1 and 2;
W is selected from the group consisting of NH, N{R13}, N{C(Y)R11} and N{SO2R11};
X is O;
Z is selected from the group consisting of NH, N{R11}, N{C(Y)R11}, N{SO2R12} and N{S(O)R12}; and
Y is O;

and pharmaceutically acceptable salts thereof; wherein:
the substituents of an optionally substituted group comprise one or more substituents independently selected from among alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, haloalkenyl,. haloalkynyl. cycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, aryloxy, haloalkoxy, amino, alkylamino, dialkylamino, alkylthio, arylthio, heteroarylthio, oxo, carboxyester, carboxamido, acyloxy, hydrogen, F, Cl, Br, I, CN, NO2, NH2, N3, NHCH3, N(CH3)2, SH, SCH3, OH, OCH3, OCF3, CH3, CF3, C(O)CH3, CO2CH3, CO2H, C(O)NH2, OR9, SR9, NR10R11, CF2CF3, CH2CH2F and CH2CF3.
41. A pharmaceutical composition according to claim 40, wherein said composition is suitable for enteral, parenteral, suppository or topical administration.
42. A pharmaceutical composition according to claim 40, wherein R1 is selected from the group consisting of hydrogen, F, Cl, OR9, NR10R11, S(O)nR9, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
43. A pharmaceutical composition according to claim 41, wherein:
R1 is selected from the group consisting of hydrogen, F and optionally substituted C1\u2013C4 alkyl; and
R2 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C2 alkyl, optionally substituted C1\u2013C2 haloalkyl and optionally substituted C1\u2013C2 heteroalkyl.
44. A pharmaceutical composition according to claim 40, wherein R3 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, C(Y)OR11 and C(Y)NR10R11.
45. A pharmaceutical composition according to claim 40, wherein R6 selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
46. A pharmaceutical composition according to claim 45, wherein R6 selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl, optionally substituted C1\u2013C4 heteroalkyl, optionally substituted C2\u2013C4 alkynyl and optionally substituted C2\u2013C4 alkenyl.
47. A pharmaceutical composition according to claim 40, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
48. A pharmaceutical composition according to claim 47, wherein R5 is selected from the group consisting of hydrogen, CF3, CF2Cl, CF2H, CFH2, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
49. A pharmaceutical composition according to claim 40, wherein R7 and R8 each independently is selected from the group consisting of hydrogen, F, Cl, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
50. A pharmaceutical composition according to claim 40, wherein:
R9 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, and optionally substituted C1\u2013C6 heteroalkyl; and
R10 is selected from the group consisting of hydrogen, S(O)R12, SO2R12, C(O)R12, CO2R12, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl and optionally substituted C1\u2013C6 heteroalkyl.
51. A pharmaceutical composition according to claim 40, wherein R4 is selected from the group consisting of hydrogen, optionally substituted C1\u2013C4 alkyl, optionally substituted C1\u2013C4 haloalkyl and optionally substituted C1\u2013C4 heteroalkyl.
52. A pharmaceutical composition according to claim 40, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6 haloalkyl, optionally substituted C1\u2013C6 heteroalkyl, optionally substituted C2\u2013C6 alkenyl, optionally substituted C2\u2013C6 alkynyl, optionally substituted C3\u2013C6 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl and optionally substituted heteroarylalkyl.
53. A pharmaceutical composition according to claim 52, wherein R13 is selected from the group consisting of CF3, CF2Cl, CF2H, CFH2, CH2CF3, CH2CF2Cl, CH2CCl2F, methyl, ethyl, propyl, isopropyl, isobutyl, cyclopropylmethyl, and allyl.
54. A pharmaceutical composition according to claim 40, wherein:
W is selected from the group consisting of NH, N{R13} and N{C(Y)R11}; and
X is O.
55. A pharmaceutical composition according to claim 40, wherein Z is N{R11}.
56. A pharmaceutical composition comprising a compound according to claim 1, wherein R2 is selected from the group consisting of hydrogen, F, Cl, Br, I, CF3, CF2Cl, CF2H, CFH2, CF2OR9, CH2OR9, OR9, S(O)nR9, optionally substituted C1\u2013C6 alkyl, optionally substituted C1\u2013C6haloalkyl, optionally substituted C1\u2013C6heteroalkyl, optionally substituted C2\u2013C6 alkynyl and optionally substituted C2\u2013C6 alkenyl.
57. A compound selected from the group consisting of:
(3R)-2,3,4,7-Tetrahydro-3-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3,4-dimethyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-4-Ethyl-2,3,4,7-tetrahydro-3-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3 4,7-Tetrahydro-3-methyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-methyl-4-propyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-4-Allyl-2,3,4,7-tetrahydro-3-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-methyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3,4-Diethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-propyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-4-Allyl-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-isobutyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3RS)-2,3,4,7-Tetrahydro-3-propyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3RS)-2,3,4,7-Tetrahydro-4-methyl-3-propyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3RS)-4-Ethyl-2,3,4,7-tetrahydro-3-propyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3RS)-2,3,4,7-Tetrahydro-3-propyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-4-methyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3R)-4-Ethyl-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-Allyl-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino-2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-phenyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-phenyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-Cyclopropylmethyl-2,3,4,7-tetrahydro-3-phenyl-10-(trifluoromethyl)-8H-1,4oxazinol2,3-fquinolin-8-one;
(3R)-3-Benzyl-2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
2,3,4,7-Tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(7aR,10aS)-7,7a,8,9,10,10a-Hexahydro-1-(trifluoromethyl)-7-(2,2,2-trifluoroethyl)-4H-cyclopenta5,61,4oxazino2,3-fquinolin-3-one;
(7aR,10aS)-7-Ethyl-7,7a,8,9,10,10a-hexahydro-1-(trifluoromethyl)-4H-cyclopenta-5,61,4oxazino2,3-fquinolin-3-one;
(7aR,10aS)-7,7a,8,9,10,10a-Hexahydro-3-isopropoxy-1-(trifluoromethyl)-7-(2,2,2-trifluoroethyl)-4H-cyclopental5,61,4oxazino2,3-fquinolin-3-one;
(\xb1)-(2S,3R)-2,3,4,7-Tetrahydro-2,3-dimethyl-4-(2,2,2-trifluoroethyl)-10 -(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(6aR)-6a,7,8,9-Tetrahydro-4-(trifluoromethyl)-1H,6H-pyrrolo1\u2032,2\u2032:4,51,4-oxazino2,3-fquinolin-2-one;
2,3,4,7-Tetrahydro-2,2,4-trimethyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-f-quinolin-8-one;
(3R)-8-Chloro-3-ethyl-3,4-dihydro-8-isopropoxy-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-2H-1,4oxazino2,3-fquinoline;
(3R)-3-Ethyl-3,4-dihydro-8-isopropoxy-8-methoxy-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-2H-1,4oxazino2,3-fquinoline;
(\xb1)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\u2212)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(+)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-4-methyl-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-4-Ethyl-2,3,4,7-tetrahydro-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-3,4-bis(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\u2212)-2,3,4,7-Tetrahydro-3,4-bis(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(+)-2,3,4,7-Tetrahydro-3,4-bis(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-4-Cyclopropylmethyl-2,3,4,7-tetrahydro-3-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-Cyclopropylmethyl-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-2-methyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-4-(2-hydroxy-2-methylpropyl)-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isobutyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one; and
pharmaceutically acceptable salt thereof.
58. A compound selected from the group consisting of:
(3R)-2,3,4,7-Tetrahydro-3-methyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-3-Ethyl-2,3,4,7-tetrahydro-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-3-ethyl-2,3,4,7-tetrahydro-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-2,3,4,7-Tetrahydro-3-isopropyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2-Chloro-2,2-difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(3R)-4-(2,2-Difluoroethyl)-2,3,4,7-tetrahydro-3-isopropyl-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(7aR,10aS)-7-Ethyl-7,7a,8,9,10,10a-hexahydro-1-(trifluoromethyl)-4H-cyclopenta5,61,4oxazino2,3-fquinolin-3-one;
(7aR,10aS)-7,7a,8,9,10,10a-Hexahydro-1-(trifluoromethyl)-7-(2,2,2-trifluoroethyl)-4H-cyclopenta5,61,4oxazino2,3-fquinolin-3-one;
(\xb1)-(2S,3R)-2,3,4,7-Tetrahydro-2,3-dimethyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\xb1)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(\u2212)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one;
(+)-2,3,4,7-Tetrahydro-4-(2,2,2-trifluoroethyl)-3,10-bis(trifluoromethyl)-8H-1,4oxazino2,3-fquinolin-8-one; and
a pharmaceutically acceptable salts thereof.