Author: claimsbot

1. A method of modulating the level of high-density-lipoprotein cholesterol in a mammal, which comprises administering to said mammal a therapeutically effective amount of an ester derivative of fluphenazine having the formula (I)
or a pharmaceutical acceptable salt thereof, wherein \u201cR\u201d is a 2 to 18 carbon atom-containing substituent with an acyclic carbonyl-terminated linker covalently bound to the fluphenazine moiety via the carbonyl terminus.
2. The method of claim 1, wherein R is a substituent including five to fourteen carbons atoms projecting a substantially planar face.
3. The method of claim 2, wherein R is a substituent having a substantially planar geometry except for the acyclic carbonyl linker.
4. The method of 3, wherein R is a cyclic ring structure being independently selected from the group consisting of a substituted or unsubstituted aromatic ring structure, a substituted or unsubstituted non-aromatic cyclic ring structure, a substituted or unsubstituted heterocyclic ring structure, and combinations thereof.
5. The method of claim 4, wherein said cyclic ring structure is independently selected from the group consisting of a monocyclic structure, a fused bicyclic structure and a fused tricyclic ring structure and combinations thereof.
6. The method of claim 1, wherein R is selected from the group consisting of
wherein R1 and R2 are independently hydrogen, methyl or ethyl, \u201cZ\u201d is methylene, oxygen, nitrogen or sulfur; \u201cX\u201d is independently a C1-4 alkyl group, a halogen atom, a nitro group or C1-4 alkyl ether groups, and \u201cn\u201d is 0 to 5 for formula (IIa) and 0 to 7 for formula (IIb), with the proviso that if \u201cn\u201d is greater than 1, \u201cX\u201d attached to the aromatic ring is same or different.
7. The method of claim 1, wherein R is selected from the group consisting of
wherein R1 and R2 are independently hydrogen, methyl or ethyl, \u201cZ\u201d is methylene, oxygen, nitrogen or sulfur; \u201cX\u201d is independently a C1-4 alkyl group, a halogen atom, a nitro group or C1-4 alkyl ether groups, and \u201cn\u201d is 0 to 5 for formula (IIIa), 0 to 4 for formula (IIIb), and 0 to 7 for formula (IIIc), with the proviso that if \u201cn\u201d is greater than 1, \u201cX\u201d attached to the ring is the same or different.
8. The method of claim 1, wherein R is formula (IIa), R1 and R2 are methyl, Z is oxygen, X is chlorine and n is 1.
9. The method of claim 1, wherein said ester derivative of fluphenazine is fluphenazine 4-chlorophenoxyisobutyric acid ester.
10. The method of claim 1, wherein said mammal is in need of treatment.
11. The method of claim 1, wherein said mammal is a human.
12. The method of claim 1, wherein said ester derivative is administered in the amount of at least 0.1 mgkg.
13. The method of claim 12, wherein said ester derivative is administered in an amount from 0.3 mgkg.
14. The method of claim 1, wherein said ester derivative is administered in an amount that does not provide said mammal with a neuroleptic effect.
15. The method of claim 1, where said mammal exhibits at least a 10 percent increase in HDL-C levels.
16. The method of claim 1, where said mammal exhibits at least a 20 percent increase in HDL-C levels.
17. A pharmaceutical formulation for modulating the level of high-density-lipoprotein cholesterol in a mammal, which comprises:
a therapeutically effective amount of an ester derivative of fluphenazine having the formula (I)
or a pharmaceutical acceptable salt thereof, wherein \u201cR\u201d is a 2 to 18 carbon atom-containing substituent with an acyclic carbonyl-terminated linker covalently bound to the fluphenazine moiety via the carbonyl terminus; and
a pharmaceutically acceptable carrier.
18. The formulation according to claim 17, wherein said ester derivative of fluphenazine is fluphenazine 4-chlorophenoxyisobutyric acid ester.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

What is claimed is:

1. A mortise and tenon joint adapter system for making mortises and tenons in work pieces in combination with a jig base having a base top surface, an abutting base front surface, a top hold down bar and a front hold down bar and a router having a bit and a guide bushing, said system comprising:
a template support adapted to mount on said base top surface, and including a top face having a horizontal rear portion and an upwardly spaced, horizontal front portion, said rear portion being secured by said top hold down bar, a mortise shelf including a vertical support portion and a horizontal shelf portion extending forwardly from said support portion, said support portion being adapted to mount on said base front surface with vertical adjustability and secured by said front hold down bar under said shelf portion, said mortise shelf including means for clamping a laterally extending mortise workpiece, and at least one template mountable on said front portion of said top face of said template support, and including a mortising slot and a tenoning slot with each said mortising and tenoning slot being sized to provide two sided guidance of said guide bushing.
2. The system as set forth in claim 1 wherein each said template is adjustable forwardly and rearwardly relative to said template support.
3. The system as set forth in claim 2 wherein said front portion of said top face of said template support includes two laterally spaced, upwardly projecting template guides that extend perpendicular to said base front surface, and two laterally spaced threaded template support apertures between said template guides, and
each said template is sized to fit between said template guides, and includes a pair of spaced template support slots parallel to said template guides that are located one each over a said template support aperture and a pair of threaded fasteners that each extend through a said template support slot and into a said template support aperture.
4. The system as set forth in claim 1 wherein said at least one template includes a plurality of mortising slots and a plurality of tenoning slots.
5. The system as set forth in claim 4 wherein said at least one template includes a mortise template having said mortising slots and a tenoning template having said tenoning slots.
6. The system as set forth in claim 1 wherein said template includes a plurality of first mortising slots parallel to said base front surface and a plurality of second mortising slots perpendicular to said first mortising slots.
7. The system as set forth in claim 1
wherein each said mortising slot and tenoning slot has an upwardly opening upper channel, a downwardly opening lower channel and an intermediate passage connecting said upper and lower channels, and
said template includes at least one slidably adjustable movable stop having an upper piece sized and shaped to fit into a said upper channel, a lower piece sized and shaped to fit into a said lower channel, and a screw connecting said upper and lower pieces.
8. The system as set forth in claim 1 wherein said tenoning slot includes a laterally extending lateral section and a pair of spaced end sections that extend rearwardly from opposite ends of said lateral section.
9. The system as set forth in claim 1 wherein said shelf portion of said mortise shelf includes a pair of spaced, opposed end sections that extend laterally beyond jig base, said support portion includes a raised section that extends above said shelf portion, and said means for clamping includes a shelf hold down bar on each said end section and a sliding clamp opposite said raised section, said sliding clamp being forwardly and rearwardly adjustable, and having a raised portion that, in combination with said raised section of said support portion, clamps said mortise workpiece.
10. The system as set forth in claim 1 including a layout guide having a front edge and a plurality of spaced guide lines at selected precise distances from and parallel to said front edge, with said distances being selected as the radius of said guide bushing and the difference between the radius of said guide bushing and the radius of said bit, for different said guide bushing and bit sizes.
11. A mortise and tenon joint adapter system for making mortises and tenons in work pieces in combination with a jig base having a base top surface, an abutting base front surface, a top hold down bar and a front hold down bar and a router having a bit and a guide bushing, said system comprising:
a template support adapted to mount on said base top surface, and including a top face having a horizontal rear portion and an upwardly spaced, horizontal front portion, with said rear portion being secured by said top hold down bar, said front portion including two laterally spaced, upwardly projecting template guides that extend perpendicular to said base front surface and two laterally spaced threaded template support apertures between said template guides,
a mortise shelf including a vertical support portion and a horizontal shelf portion extending forwardly from said support portion, said support portion being adapted to mount on said base front surface with vertical adjustability and to be secured by said front hold down bar under said shelf portion, said support portion including a raised section that extends above said shelf portion, said shelf portion including a pair of spaced, opposed end sections that extend laterally beyond jig base with each said end section having a shelf hold down bar, said shelf portion including a sliding clamp opposite said raised section, said sliding clamp being forwardly and rearwardly adjustable, and having a raised portion that, in combination with said raised section of said support portion and further in conjunction with one of said shelf hold down bars, clamps a mortise workpiece,
a mortise template sized and shaped to mount on said front portion of said top face of said template support between said template guides, and having a pair of spaced elongated mortise template support slots extending parallel to said template guides and located one each over a said template support aperture, and a machine screw extending through each said mortise template support slot into a said template support aperture, said mortise template including a plurality of spaced first mortising slots perpendicular to said mortise template support slots sized to provide two sided guidance of said guide bushing and a plurality of spaced second mortising slots parallel to said mortise template support slots sized to provide two sided guidance of said guide bushing, said first and second mortising slots each having an upwardly opening upper,channel, a downwardly opening lower channel and an intermediate passage connecting said upper and lower channels, and said first and second mortising slots having slidably adjustable movable stops each having an upper piece sized and shaped to fit into a said upper channel, a lower piece sized and shaped to fit into a said lower channel, and a screw connecting said upper and lower pieces,
a tenon template sized and shaped to mount on said front portion of said top face of said template support between said template guides, and having a pair of spaced elongated tenon template support slots extending parallel to said template guides and located one each over a said template support aperture, and a machine screw extending through each said tenon template support slot into a said template support aperture, said tenon template including a plurality of spaced tenoning slots sized to provide two sided guidance of said guide bushing, each said tenoning slot having a laterally extending lateral section and a pair of spaced end sections that extend rearwardly from opposite ends of said lateral section, each said tenoning slot having an upwardly opening upper channel, a downwardly opening lower channel and an intermediate passage connecting said upper and lower channels, said tenoning slots having slidably adjustable movable stops each having an upper piece sized and shaped to fit into a said upper channel, a lower piece sized and shaped to fit into a said lower channel, and a screw connecting said upper and lower pieces, and
a layout guide having a front edge and a plurality of spaced guide lines at selected precise distances from and parallel to said front edge, with said distances being selected as the radius of said guide bushing and the difference between the radius of said guide bushing and the radius of said bit, for different said guide bushing and bit sizes.

We claim:

1. An apparatus, comprising:
a stent; and
means for enhancing microwave radiation that is scattered from said stent, wherein said means produces a larger scattered microwave radiation field over that which would occur from said stent absent said means.
2. The apparatus of claim 1, wherein said means comprises a cylindrical symmetry variation in said stent.
3. The apparatus of claim 1, wherein said stent comprises a cylindrical axis, wherein said means comprises a gap along said cylindrical axis.
4. The apparatus of claim 1, further comprising a microwave transmitter for transmitting microwave radiation to said stent, wherein said stent produces scattered or reflected microwave radiation.
5. The apparatus of claim 4, further comprising a microwave receiver for receiving data comprising said scattered or reflected microwave radiation.
6. The apparatus of claim 5, further comprising computer hardware with software comprising an algorithm for analyzing said data to determine whether in-stent restenosis has occurred.
7. The apparatus of claim 6, wherein said software further comprises an algorithm for analyzing said data to quantify the amount of in-stent restenosis that has occurred.
8. The apparatus of claim 3, further comprising dielectric material within said gap.
9. The apparatus of claim 3, wherein said stent comprises a stent cavity, said apparatus further comprising an electric shield to block electronic field penetration into said stent cavity.
10. The apparatus of claim 1, wherein said means comprises a dimension that is tuned to maximize the detection of in-stent restenosis.
11. The apparatus of claim 1, wherein said means comprises a dimension that is tuned for at least one microwave frequency.
12. The apparatus of claim 3, wherein said gap comprises a dimension that is tuned for at least one desired frequency.
13. The apparatus of claim 1, wherein said stent comprises a compact state with a first cross-sectional area and an expanded state with a second cross-sectional area that is greater than said first cross-sectional area.
14. The apparatus of claim 1, wherein said stent is selected from the group consisting of a cardiovascular stent, a neurovascular stent and a urological stent.
15. The apparatus of claim 6, further comprising an alarm, wherein said algorithm triggers said alarm if in-stent restenosis is present.
16. The apparatus of claim 7, further comprising an alarm, wherein said algorithm triggers said alarm if in-stent restenosis exceeds a pre-set level.
17. The apparatus of claim 7, further comprising an alarm, said apparatus further comprising a wireless transmitter operatively connected to said computer hardware, wherein said algorithm notifies a selected contact if in-stent restenosis exceeds a pre-set level.
18. An apparatus, comprising:
a stent; and
a microwave transmitter or microwave receiver operatively connected to said stent, wherein said microwave transmitter is configured for transmitting microwave radiation to said stent to produce scattered microwave radiation, and wherein said microwave receiver is configured for receiving data comprising microwave radiation scattered from said stent.
19. The apparatus of claim 18, further comprising computer hardware with software comprising an algorithm programmed to perform a task selected from the group consisting of (i) analyzing said data to determine whether in-stent restenosis has occurred and (ii) analyzing said data to quantify the amount of in-stent restenosis that has occurred.
20. The apparatus of claim 18, further comprising means for enhancing microwave radiation that is scattered or reflected from said stent, wherein said means produces a larger scattered or reflected microwave radiation field over that which would occur from said stent absent said means.
21. The apparatus of claim 20, wherein said means comprises a cylindrical symmetry variation in said stent.
22. The apparatus of claim 18, wherein said stent comprises a cylindrical axis, wherein said means comprises a gap along said cylindrical axis.
23. The apparatus of claim 22, further comprising dielectric material within said gap.
24. The apparatus of claim 20, wherein said stent comprises a stent cavity, said apparatus further comprising an electric shield to block electronic field penetration into said stent cavity.
25. The apparatus of claim 20, wherein said means comprises a dimension that is tuned to maximize the detection of in-stent restenosis.
26. The apparatus of claim 20, wherein said means comprises a dimension that is tuned for at least one microwave frequency.
27. The apparatus of claim 22, wherein said gap comprises a dimension that is tuned for at least one desired frequency.
28. The apparatus of claim 18, wherein said stent comprises a compact state with a first cross-sectional area and an expanded state with a second cross-sectional area that is greater than said first cross-sectional area.
29. The apparatus of claim 18, wherein said stent is selected from the group consisting of a cardiovascular stent, a neurovascular stent and a urological stent.
30. The apparatus of claim 19, further comprising an alarm, wherein said algorithm triggers said alarm if in-stent restenosis is present.
31. The apparatus of claim 19, further comprising an alarm, wherein said algorithm triggers said alarm if in-stent restenosis exceeds a pre-set level.
32. The apparatus of claim 19, further comprising an alarm, said apparatus further comprising a wireless transmitter operatively connected to said computer hardware, wherein said algorithm notifies a selected contact if in-stent. restenosis exceeds a pre-set level.
33. An apparatus, comprising:
a computer readable medium; and
computer software programmed onto said computer readable medium, wherein said software comprises an algorithm programmed to perform a task selected from the group consisting of (i) analyzing data to determine whether in-stent restenosis has occurred and (ii) analyzing data to quantify the amount of in-stent restenosis that has occurred.
34. The apparatus of claim 33, wherein said algorithm is programmed to perform the task of analyzing data to determine whether in-stent restenosis has occurred, said algorithm comprises the steps of:
analyzing measurement of scattered signal as a function of microwave frequency to identify peaks; and
comparing peaks to previously measured baseline when no restenosis had occurred, wherein if the shifts in the peak locations exceed a predefined maximum then in-stent restenosis has occurred.
35. The apparatus of claim 33, wherein when said algorithm is programmed to perform the task of analyzing data to quantify the amount of in-stent restenosis that has occurred.
36. A method for detecting in-stent restenosis in a patient that has an implanted stent, comprising:
probing said stent with microwave radiation to produce reflected or scattered microwave radiation;
detecting and collecting said reflected or scattered microwave radiation to produce data; and
analyzing said data to determine whether in-stent restenosis has occurred.
37. A method for quantifying the amount of in-stent restenosis that has occurred in a stent implanted in a patient, comprising:
probing said stent with microwave radiation to produce reflected or scattered microwave radiation;
detecting and collecting said reflected or scattered microwave radiation to produce data; and
analyzing said data to quantify the amount of in-stent restenosis that has occurred in said stent.
38. The method of claim 37, wherein the microwave transmitter and receiver have a fixed relative position.
39. The method of claim 37, further comprising optimizing the signal levels of said reflected or scattered microwave radiation by moving at least one of a microwave transmitter or a receiver.
40. The method of claim 37, wherein said microwave radiation comprises less than 200 MHz to excite acoustic oscillations in said stent, wherein the step of detecting is carried out with an ultrasound transducer placed in contact with the skin to detect acoustic oscillations.
41. The method of claim 40, further comprising pulsing said radiation and wherein said step of detecting includes time gated ultrasound detection to increase signal to noise.
42. A method for preparing a patient for detection of in-stent restenosis, comprising implanting a stent within a patient, wherein said stent comprises means for enhancing microwave radiation that is scattered reflected from said stent, wherein said means produces a larger scattered or reflected microwave radiation field over that which would occur from said stent absent said means.
43. The apparatus of claim 3, further comprising a microwave diode within said gap.
44. The apparatus of claim 5, wherein said microwave transmitter and said microwave receiver operate over a frequency range of 0.1 to 50 GHz.
45. The apparatus of claim 5, wherein said microwave transmitter and said microwave receiver are polarization sensitive.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A flame-retardant polyamide molding material for sheathing optical waveguides and optical cables, characterized in that this polyamide molding material is composed of:
(A) 40 to 71 wt.-% copolyamide MACMI12;
(B) 20 to 51 wt.-% of at least one aliphatic polyamide;
(C) 6 to 20 wt.-% melamine cyanurate;
(D) 3 to 10 wt.-% aryl phosphate; and
(E) 0 to 6 wt.-% further additives;
wherein the components (A) to (E) add up to 100 wt.-% of the polyamide molding material,
wherein the copolyamide MACMI12 has a laurin lactam content of 23 to 45 mol-% in relation to the molar sum of the monomers MACM, isophthalic acid, and laurin lactam of this copolyamide, and
wherein the isophthalic acid in the copolyamide MACMI12 can be entirely or partially replaced by terephthalic acid.
2. The flame-retardant polyamide molding material according to claim 1, characterized in that a test specimen produced from this polyamide molding material has a Shore hardness D of at least 77, and a buckling test using a PA 12 extrudate coated with this molding material is passed upon winding around a metal rod having 12 mm diameter, wherein the PA 12 extrudate for this buckling test has a diameter of 1.5 mm and is coated 0.7 mm thick.
3. The flame-retardant polyamide molding material according to claim 1, characterized in that this polyamide molding material is composed of:
(A) 45 to 66 wt.-% copolyamide MACMI12;
(B) 20 to 46 wt.-% of at least one aliphatic polyamide;
(C) 8 to 15 wt.-% melamine cyanurate;
(D) 3 to 8 wt.-% aryl phosphate; and
(E) 0 to 4 wt.-% further additives;
wherein the components (A) to (E) add up to 100 wt.-% of the polyamide molding material.
4. The flame-retardant polyamide molding material according to claim 1, characterized in that a test specimen produced from this polyamide molding material at least has the classification V2 in the vertical fire test 50 W (20 mm) according to UL-94 of Underwriters Laboratories both at a thickness of 1.6 mm and also at a thickness of 0.8 mm.
5. The flame-retardant polyamide molding material according to claim 1, characterized in that the copolyamide MACMI12 has a laurin lactam content of 25-40 mol-%, preferably of 30-40 mol-%, in relation to the molar sum of the monomers MACM, isophthalic acid, and laurin lactam of this copolyamide.
6. The flame-retardant polyamide molding material according to claim 1, characterized in that the copolyamide MACMI12 has a glass transition temperature of 140-185\xb0 C., preferably of 150-170\xb0 C., particularly preferably of 155-165\xb0 C.
7. The flame-retardant polyamide molding material according to claim 1, characterized in that the at least one aliphatic polyamide of the component (B) is synthesized from linear-aliphatic monomers.
8. The flame-retardant polyamide molding material according to claim 7, characterized in that the at least one linear-aliphatic polyamide is selected from the group consisting of PA 6, PA 11, PA 12, PA 66, PA 69, PA 610, PA 612, PA 614, PA 618, PA 1010, PA 1012, PA 1212, PA 666, PA 612, PA 66612, polyether amides, polyether ester amides, polyester amides, copolyamides thereof and mixtures thereof.
9. The flame-retardant polyamide molding material according to claim 7, characterized in that the at least one linear-aliphatic polyamide is selected from the group consisting of PA 1010 and mixtures of PA 1010 with at least one other linear-aliphatic polyamide.
10. The flame-retardant polyamide molding material according to claim 1, characterized in that the aryl phosphate is selected from the group consisting of tricresyl phosphate, triphenyl phosphate, diphenyl cresyl phosphate, bis(methylphenyl)-phenyl phosphate and mixtures thereof.
11. The flame-retardant polyamide molding material according to claim 1, characterized in that the further additives are selected from the group consisting of inorganic stabilizers, organic stabilizers, lubricants, polytetrafluoroethylene, colorants, marking materials, inorganic pigments, organic pigments, IR absorbers, antistatic agents, antiblocking agents, nucleating agents, crystallization accelerators, crystallization delayers, conductivity additives, carbon black, graphite, carbon nanotubes, demolding agents, separating agents, optical lighteners, photochromic additives, softeners, adhesion promoters, anti-dripping agents, metallic pigments, metal glitters, metal-coated particles, and mixtures thereof.
12. The flame-retardant polyamide molding material according to claim 2, characterized in that a test specimen produced from this polyamide molding material has a Shore hardness in the range of 80-98, preferably in the range of 80-95.
13. The flame-retardant polyamide molding material according to claim 2, characterized in that a buckling test using a PA 12 extrudate coated with this molding material is passed in the case of winding around a metal rod having 10 mm diameter, preferably having 8 mm diameter.
14. A use of a flame-retardant polyamide molding material, in particular according to claim 1, which is composed of:
(A) 40 to 71 wt.-% copolyamide MACMI12;
(B) 20 to 51 wt.-% of at least one aliphatic polyamide;
(C) 6 to 20 wt.-% melamine cyanurate;
(D) 3 to 10 wt.-% aryl phosphate; and
(E) 0 to 6 wt.-% further additives;
wherein the components (A) to (E) add up to 100 wt.-% of the polyamide molding material,
wherein the copolyamide MACMI12 has a laurin lactam content of 23 to 45 mol-% in relation to the molar sum of the monomers MACM, isophthalic acid, and laurin lactam of this copolyamide, and
wherein the isophthalic acid in the copolyamide MACMI12 can be entirely or partially replaced by terephthalic acid, and
wherein a test specimen produced from this polyamide molding material has a Shore hardness D of at least 77, and a buckling test using a PA 12 extrudate coated with this molding material is passed upon winding around a metal rod having 12 mm diameter, wherein the PA 12 extrudate for this buckling test has a diameter of 1.5 mm and is coated 0.7 mm thick,
for producing an optical waveguide sheath or a sheath of an optical cable by means of a tubing sheath tool.
15. A use of a sheathed optical waveguide andor sheathed optical cable according to claim 14 for interior applications andor exterior applications, wherein sheaths made of such a polyamide molding material have a bite-inhibiting effect in relation to rodents.