Author: claimsbot

What is claimed is:

1. A parenterally deliverable composition comprising an aqueous medium having dispersed therein, in solid particulate form, a steroidal drug in a therapeutically effective amount, wherein:
(a) the aqueous medium comprises one or more wetting andor suspending agents in an amount effective to provide controlled flocculation of the drug, at least one of the wetting andor suspending agents being susceptible to oxidative degradation; and
(b) the composition further comprises, as a component thereof or as an adjunct there to, means for protecting the oxidative degradation susceptible agent from oxidative degradation.
2. The composition of claim 1 wherein the at least one oxidative degradation susceptible agent comprises a polyoxyethylene chain.
3. The composition of claim 1 wherein the at least one oxidative degradation susceptible agent is a polyoxyethylene surfactant.
4. The composition of claim 3 wherein the polyoxyethylene surfactant is a polysorbate.
5. The composition of claim 3 wherein the polyoxyethylene surfactant is polysorbate 80.
6. The composition of claim 5 wherein the polysorbate 80 is present in an amount of about 0.1 to about 10 mgml.
7. The composition of claim 5 wherein the polysorbate 80 is present in an amount of about 1 to about 5 mgml.
8. The composition of claim 1 wherein the steroidal drug is selected from the group consisting of clostebol, estradiol, exemestane, medroxyprogesterone, methylprednisolone, testosterone and pharmaceutically acceptable esters and salts thereof.
9. The composition of claim 1 wherein the steroidal drug is selected from the group consisting of estradiol cypionate, exemestane and medroxyprogesterone acetate.
10. The composition of claim 1 wherein the steroidal drug is medroxyprogesterone acetate.
11. The composition of claim 10 wherein the medroxyprogesterone acetate is present in an amount of about 10 to about 400 mgml.
12. The composition of claim 10 wherein the medroxyprogesterone acetate is present in an amount of about 30 to about 300 mgml.
13. The composition of claim 10 wherein the medroxyprogesterone acetate is present in an amount of about 50 to about 200 mgml.
14. The composition of claim 1 wherein said means for protecting the oxidative degradation susceptible agent from oxidative degradation comprises an antioxidant present as a component of the composition.
15. The composition of claim 1 wherein said means for protecting the oxidative degradation susceptible agent from oxidative degradation comprises a chelating agent present as a component of the composition.
16. The composition of claim 1 wherein said means for protecting the oxidative degradation susceptible agent from oxidative degradation comprises an oxygen-depleted atmosphere in headspace overlying the composition.
17. The composition of claim 16 wherein said atmosphere comprises less than about 5% oxygen.
18. The composition of claim 17 wherein said atmosphere consists essentially of nitrogen.
19. A parenterally deliverable aqueous suspension composition comprising:
(a) medroxyprogesterone acetate, 100-200 mgml;
(b) polyethylene glycol of molecular weight 3000-4000, 20-40 mgml;
(c) polysorbate 80, 2-4 mgml;
(d) sodium chloride, 6-12 mgml; and
(e) optionally at least one parenterally acceptable preservative, 0.1-5 mgml total; said composition having an oxygen-depleted atmosphere in headspace overlying the composition.
20. The composition of claim 19 comprising:
(a) medroxyprogesterone acetate, about 150 mgml;
(b) polyethylene glycol of molecular weight about 3350, about 30 mgml;
(c) polysorbate 80, about 2.5 mgml;
(d) sodium chloride, about 9 mgml;
(e) methylparaben, about 1.5 mgml;
(f) propylparaben, about 0.15 mgml; and
(g) water for injection, q.s.
21. The composition of claim 19 comprising, in a volume of about 0.65 ml:
(a) medroxyprogesterone acetate, about 104 mg;
(b) polyethylene glycol of molecular weight about 3350, about 18.7 mg;
(c) polysorbate 80, about 1.95 mg;
(d) sodium chloride, about 5.2 mg;
(e) methylparaben, about 1.04 mg;
(f) propylparaben, about 0.10 mg;
(g) monobasic sodium phosphate monohydrate, about 0.45 mg;
(h) dibasic sodium phosphate dodecahydrate, about 0.38 mg;
(i) L-methionine, about 0.98 mg;
(j) polyvinylpyrrolidone K17, about 3.25 mg; and
(k) water for injection, q.s.
22. An article of manufacture comprising a sealed vessel having substantially oxygen-impermeable walls and a substantially oxygen-impermeable seal, and having contained therewithin:
(a) a parenterally deliverable aqueous suspension that comprises (i) a steroidal drug in a therapeutically effective amount and (ii) one or more wetting andor suspending agents in an amount effective to provide controlled flocculation of the drug, at least one of the wetting andor suspending agents being susceptible to oxidative degradation; and
(b) an oxygen-depleted atmosphere in headspace overlying the composition.
23. The article of claim 22 wherein the at least one oxidative degradation susceptible agent comprises a polyoxyethylene chain.
24. The article of claim 22 wherein the at least one oxidative degradation susceptible agent is a polyoxyethylene surfactant.
25. The article of claim 24 wherein the polyoxyethylene surfactant is a polysorbate.
26. The article of claim 24 wherein the polyoxyethylene surfactant is polysorbate 80.
27. The article of claim 26 wherein the polysorbate 80 is present in an amount of about 0.1 to about 10 mgml.
28. The article of claim 26 wherein the polysorbate 80 is present in an amount of about 1 to about 5 mgml.
29. The article of claim 22 wherein the steroidal drug is selected from the group consisting of clostebol, estradiol, exemestane, medroxyprogesterone, methylprednisolone, testosterone and pharmaceutically acceptable esters and salts thereof.
30. The article of claim 22 wherein the steroidal drug is selected from the group consisting of estradiol cypionate, exemestane and medroxyprogesterone acetate.
31. The article of claim 22 wherein the steroidal drug is medroxyprogesterone acetate.
32. The article of claim 31 wherein the medroxyprogesterone acetate is present in an amount of about 10 to about 400 mgml.
33. The article of claim 31 wherein the medroxyprogesterone acetate is present in an amount of about 30 to about 300 mgml.
34. The article of claim 31 wherein the medroxyprogesterone acetate is present in an amount of about 50 to about 200 mgml.
35. The article of claim 22 wherein said atmosphere comprises less than about 5% oxygen.
36. The article of claim 22 wherein said atmosphere consists essentially of nitrogen.
37. The article of claim 22 wherein the parenterally deliverable aqueous suspension comprises:
(a) medroxyprogesterone acetate, 100-200 mgml;
(b) polyethylene glycol of molecular weight 3000-4000, 20-40 mgml;
(c) polysorbate 80, 2-4 mgml;
(d) sodium chloride, 6-12 mgml; and
(e) optionally at least one parenterally acceptable preservative, 0.1-5 mgml total.
38. The article of claim 22 wherein the parenterally deliverable aqueous suspension comprises:
(a) medroxyprogesterone acetate, about 150 mgml;
(b) polyethylene glycol of molecular weight about 3350, about 30 mgml;
(c) polysorbate 80, about 2.5 mgml;
(d) sodium chloride, about 9 mgml;
(e) methylparaben, about 1.5 mgml;
(f) propylparaben, about 0.15 mgml; and
(f) water for injection, q.s.
39. The article of claim 22 wherein the parenterally deliverable aqueous suspension comprises, in a volume of about 0.65 ml:
(a) medroxyprogesterone acetate, about 104 mg;
(b) polyethylene glycol of molecular weight about 3350, about 18.7 mg;
(c) polysorbate 80, about 1.95 mg;
(d) sodium chloride, about 5.2 mg;
(e) methylparaben, about 1.04 mg;
(f) propylparaben, about 0.10 mg;
(g) monobasic sodium phosphate monohydrate, about 0.45 mg;
(h) dibasic sodium phosphate dodecahydrate, about 0.38 mg;
(i) L-methionine, about 0.98 mg;
(j) polyvinylpyrrolidone K17, about 3.25 mg; and
(k) water for injection, q.s.
40. An article of manufacture comprising a vial having
(a) a first chamber that is substantially filled with a parenterally deliverable aqueous suspension that comprises (i) a steroidal drug in a therapeutically effective amount and (ii) one or more wetting andor suspending agents in an amount effective to provide controlled flocculation of the drug, at least one of the wetting andor suspending agents being susceptible to oxidative degradation,
(b) a second chamber that is substantially empty but for a gaseous medium;
(c) a septum separating the first and second chambers and impermeable to contents thereof; and
(d) actuating means effective to bring the aqueous suspension and the gaseous medium in to contact by breach of the septum such that the gaseous medium acts as an effective headspace for agitation of the aqueous suspension.
41. The article of claim 40 wherein the at least one oxidative degradation susceptible agent comprises a polyoxyethylene chain.
42. The article of claim 40 wherein the at least one oxidative degradation susceptible agent is a polyoxyethylene surfactant.
43. The article of claim 42 wherein the polyoxyethylene surfactant is a polysorbate.
44. The article of claim 42 wherein the polyoxyethylene surfactant is polysorbate 80.
45. The article of claim 44 wherein the polysorbate 80 is present in an amount of about 0.1 to about 10 mgml.
46. The article of claim 44 wherein the polysorbate 80 is present in an amount of about 1 to about 5 mgml.
47. The article of claim 40 wherein the steroidal drug is selected from the group consisting of clostebol, estradiol, exemestane, medroxyprogesterone, methylprednisolone, testosterone and pharmaceutically acceptable esters and salts thereof.
48. The article of claim 40 wherein the steroidal drug is selected from the group consisting of estradiol cypionate, exemestane and medroxyprogesterone acetate.
49. The article of claim 40 wherein the steroidal drug is medroxyprogesterone acetate.
50. The article of claim 49 wherein the medroxyprogesterone acetate is present in an amount of about 10 to about 400 mgml.
51. The article of claim 49 wherein the medroxyprogesterone acetate is present in an amount of about 30 to about 300 mgml.
52. The article of claim 49 wherein the medroxyprogesterone acetate is present in an amount of about 50 to about 200 mgml.
53. The article of claim 40 wherein the parenterally deliverable aqueous suspension comprises:
(a) medroxyprogesterone acetate, 100-200 mgml;
(b) polyethylene glycol of molecular weight 3000-4000, 20-40 mgml;
(c) polysorbate 80, 2-4 mgml;
(d) sodium chloride, 6-12 mgml; and
(e) optionally at least one parenterally acceptable preservative, 0.1-5 mgml total.
54. The article of claim 40 wherein the parenterally deliverable aqueous suspension comprises:
(a) medroxyprogesterone acetate, about 150 mgml;
(b) polyethylene glycol of molecular weight about 3350, about 30 mgml;
(c) polysorbate 80, about 2.5 mgml;
(d) sodium chloride, about 9 mgml;
(e) methylparaben, about 1.5 mgml;
(f) propylparaben, about 0.15 mgml; and
(g) water for injection, q.s.
55. The article of claim 40 wherein the parenterally deliverable aqueous suspension comprises, in a volume of about 0.65 ml:
(a) medroxyprogesterone acetate, about 104 mg;
(b) polyethylene glycol of molecular weight about 3350, about 18.7 mg;
(c) polysorbate 80, about 1.95 mg;
(d) sodium chloride, about 5.2 mg;
(e) methylparaben, about 1.04 mg;
(f) propylparaben, about 0.10 mg;
(g) monobasic sodium phosphate monohydrate, about 0.45 mg;
(h) dibasic sodium phosphate dodecahydrate, about 0.38 mg;
(i) L-methionine, about 0.98 mg;
(j) polyvinylpyrrolidone K17, about 3.25 mg; and
(k) water for injection, q.s.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for allocating seat space, the method comprising:
identifying a seating space requirement in a passenger cabin to form an identified seating space requirement;
detecting positions of a plurality of armrests located between a first seat and a second seat and connected to at least one of the first seat and the second seat using a sensor; and
deploying, using a data processing system, a number of armrests in the plurality of armrests separating the first seat and the second seat based on the identified seating space requirement and the positions of the plurality of armrests.
2. The method of claim 1, wherein the identifying step comprises:
identifying the seating space requirement for a passenger assigned to the first seat in the passenger cabin to form the identified seating space requirement.
3. The method of claim 1, wherein the identifying step comprises:
identifying the seating space requirement based on a size of a passenger assigned to the first seat in the passenger cabin to form the identified seating space requirement.
4. The method of claim 1, wherein the identifying step comprises:
identifying the seating space requirement based on a class of service for a passenger assigned to the first seat in the passenger cabin to form the identified seating space requirement.
5. The method of claim 1, wherein the deploying step comprises:
unlocking the number of armrests separating the first seat and the second seat based on the identified seating space requirement.
6. The method of claim 1, wherein the deploying step comprises:
moving the number of armrests into an unfolded position.
7. The method of claim 1, wherein the deploying step comprises:
unlocking the number of armrests separating the first seat and the second seat based on the identified seating space requirement; and
moving the number of armrests into an unfolded position.
8. A method for allocating seat space, the method comprising:
identifying a seating space requirement for a passenger assigned to a first seat in a row in a passenger cabin based on one of a size of the passenger and a class of service to form an identified seating space requirement, the row having a plurality of seats including the first seat, the plurality of seats supported by a frame, and the row having a plurality of armrests between the first seat and a second seat in the plurality of seats and connected to at least one of the first seat and the second seat, in which the first seat is adjacent to the second seat; and
deploying, using a data processing system, a number of armrests in the plurality of armrests between the first seat and a second seat based on the identified seating space requirement by unlocking the number of armrests based on the identified seating space requirement and moving the number of armrests into an unfolded position to change a seating space for the first seat.

1. A thermal management system, comprising:
a substrate;
a housing having an interior surface;
wherein said housing is comprised of a unitary structure;
a cap having a first surface and a second surface;
wherein said first surface and said interior surface are substantially planar;
wherein said first surface of said cap is attached to said interior surface of said housing;
wherein said second surface of said cap is in thermal communication with at least one heat producing device;
a thermal interface layer between said cap and said heat producing device;
wherein said housing is attached to said substrate and wherein said housing surrounds said at least one heat producing device; and
a plurality of microchannels within said interior surface of said housing, wherein said plurality of microchannels are between 20 micrometers to 500 micrometers;
wherein said plurality of microchannels are formed into said interior surface of said housing so as to cover a greater surface area adjacent to at least one hot zone upon said at least one heat producing device.
2. The thermal management system of claim 1, including at least one inlet port and at least one outlet port extending through said housing in fluid communication with said microchannels.
3. The thermal management system of claim 2, wherein said at least one inlet port is comprised of a plurality of inlet ports.
4. The thermal management system of claim 2, wherein said at least one outlet port is comprised of a plurality of outlet ports.
5. The thermal management system of claim 4, wherein said wherein said at least one inlet port is comprised of a plurality of inlet ports.
6. The thermal management system of claim 2, wherein said at least one inlet port and said at least one outlet port extend through an inlet opening and an outlet opening within said housing respectively.
7. The thermal management system of claim 1, including an inlet coupler attached to said inlet port and an outlet coupler attached to said outlet port for removably coupling to a coolant management system.
8. The thermal management system of claim 1, wherein at least one of said plurality of microchannels is formed into said first surface of said cap.
9. A thermal management system, comprising:
a substrate;
a housing having an interior surface;
wherein said housing is comprised of a unitary structure;
a cap having a first surface and a second surface;
wherein said first surface and said interior surface are substantially planar;
wherein said first surface of said cap is attached to said interior surface of said housing;
wherein said second surface of said cap is in thermal communication with at least one heat producing device;
a thermal interface layer between said cap and said heat producing device;
wherein said housing is attached to said substrate and wherein said housing surrounds said at least one heat producing device;
a plurality of microchannels within said interior surface of said housing, wherein said plurality of microchannels are between 20 micrometers to 500 micrometers;
wherein said plurality of microchannels are formed into said interior surface of said housing so as to cover a greater surface area adjacent to at least one hot zone upon said at least one heat producing device;
at least one inlet port and at least one outlet port extending through said housing in fluid communication with said microchannels;
wherein said at least one inlet port is comprised of a plurality of inlet ports;
wherein said at least one outlet port is comprised of a plurality of outlet ports;
wherein said at least one inlet port and said at least one outlet port extend through an inlet opening and an outlet opening within said housing respectively; and
an inlet coupler attached to said inlet port and an outlet coupler attached to said outlet port for removably coupling to a coolant management system.
10. The thermal management system of claim 9, wherein at least one of said plurality of microchannels is formed into said first surface of said cap.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method comprising:
defining a tracking area for a first avatar in an online immersive environment, wherein the tracking area encompasses the first avatar and some defined area beyond the first avatar, wherein the first avatar represents a first person who is a guardian of a second person external to the online immersive environment, wherein a second avatar represents the second person in the online immersive environment;
tracking a path through the online immersive environment of the tracking area for the first avatar;
marking a region in the online immersive environment as a safe zone for the second avatar, after the path of the tracking area for the first avatar has traversed the region; and
authorizing access to the region marked as the safe zone for the second avatar in the online immersive environment.
2. The method of claim 1, further comprising:
receiving, from the first avatar, a notification to block access to an object in the region while continuing to authorize access to the region for the second avatar; and
disabling access to the object by the second avatar.
3. The method of claim 1, wherein a size of the tracking area is variable based on a type for the region.
4. The method of claim 3, wherein the defining of the tracking area comprises decreasing a size of the tracking area as the first avatar enters regions having at least one of a greater population density and a greater building density.
5. The method of claim 3, wherein the defining of the tracking area comprises increasing a size of the tracking area as the first avatar enters regions having at least one of a lower population density and a lower building density.
6. The method of claim 1, further comprising:
notifying the first avatar of a permanent change to the region that is authorized for access after access has been authorized for the second avatar; and
disabling access to at least one of the region and an object in the region affected by the permanent change based on request by the first avatar, after the first avatar is notified of the permanent change.
7. The method of claim 6, further comprising notifying the first avatar of at least one other region where the first avatar has authorized access based on the tracking area and where a different permanent change has occurred in the at least one other region since the access was authorized and where the different permanent change was created by a same avatar that created the permanent change in the region.
8. The method of claim 7, further comprising:
responsive to notifying the first avatar of the at least one other region, receiving, from the first avatar, a change to the access to the at least one other region for the second avatar, wherein the change is to deny access to the at least one other region by the second avatar; and
disabling access to the at least one other region for the second avatar.
9. The method of claim 1, wherein a third avatar represents a third person who is a guardian of a fourth person in the real world and external to the online immersive environment, wherein the fourth avatar represents the fourth person in the online immersive environment, wherein the method comprises:
responsive to determining that a number of regions authorized by the first avatar and a number of regions authorized by the third avatar overlap by a defined threshold, authorizing access by the fourth avatar to the number of regions authorized by the first avatar.
10. A computer program product for creating authorized regions in an online immersive environment, the computer program product comprising:
a computer readable storage medium having computer usable program code embodied therewith, the computer usable program code comprising a computer usable program code configured to:
define a tracking sphere for a first avatar in the online immersive environment, wherein the tracking sphere encompasses the first avatar and some defined area beyond the first avatar, wherein the first avatar represents a first person who is a guardian of a second person that is a minor in the real world and external to the online immersive environment, wherein a second avatar represents the second person in the online immersive environment;
track a path through the online immersive environment of the tracking sphere for the first avatar;
mark a region in the online immersive environment as a safe zone for the second avatar, after the path of the tracking sphere for the first avatar has traversed the region;
authorize access to the region marked as the safe zone for the second avatar in the online immersive environment;
determine a rate of change of at least one permanent change of the region that was marked;
determine that the rate of change of the at least one permanent change of the region has been exceeded for a time period; and
responsive to a determination that the rate of change of the at least one permanent change of the region has been exceeded for the time period, notify the first avatar of the at least one permanent change of the region.
11. The computer program product of claim 10, wherein the computer usable program code is configured to responsive to notifying the first avatar of the at least one permanent change for the time period, receive, from the first avatar, a change to the access to the region for the second avatar, the change to deny access to the region by the second avatar.
12. The computer program product of claim 10, wherein the computer usable program code is configured to disable access to at least one of the region and an object in the region affected by the at least one permanent change based on request by the first avatar, after the first avatar is notified of the at least one permanent change.
13. The computer program product of claim 12, wherein the computer usable program code is configured to notify the first avatar of at least one other region where the first avatar has authorized access based on the tracking sphere and where a different permanent change has occurred in the at least one other region since the access was authorized and where the different permanent change was created by a same avatar that created the at least one permanent change in the region.
14. The computer program product of claim 13, wherein the computer usable program code is configured to:
responsive to notification to the first avatar of the at least one other region, receive, from the first avatar, a change to the access to the at least one other region for the second avatar, wherein the change is to deny access to the at least one other region by the second avatar; and
disable access to the at least one other region for the second avatar.
15. A computer program product for creating authorized regions in an online immersive environment, the computer program product comprising:
a computer readable storage medium having computer usable program code embodied therewith, the computer usable program code comprising a computer usable program code configured to:
define a tracking sphere for a first avatar in an online immersive environment, wherein the tracking sphere encompasses the first avatar and some defined area beyond the first avatar, wherein the first avatar represents a first person who is a guardian of a second person in the real world and external to the online immersive environment, wherein a second avatar represents the second person in the online immersive environment;
track a path through the online immersive environment of the tracking sphere for the first avatar;
mark a region in the online immersive environment as a safe zone for the second avatar, after the path of the tracking sphere for the first avatar has traversed the region; and
authorize access to the region marked as the safe zone for the second avatar in the online immersive environment.
16. The computer program product of claim 15, wherein the computer usable program code is configured to:
receiving, from the first avatar, a notification to block access to an object in the region while continuing to authorize access to the region for the second avatar; and
disabling access to the object by the second avatar.
17. The computer program product of claim 15, wherein a size of the tracking sphere is variable based on a type for the region.
18. The computer program product of claim 17, wherein the computer usable program code configured to define the tracking sphere comprises computer usable program code configured to decrease a size of the tracking sphere as the first avatar enters regions having at least one of a greater population density and a greater building density.
19. The computer program product of claim 15, wherein the computer usable program code is configured to:
notify the first avatar of a permanent change to the region that is authorized for access after access has been authorized for the second avatar; and
disable access to at least one of the region and an object in the region affected by the permanent change based on request by the first avatar, after the first avatar is notified of the permanent change.
20. The computer program product of claim 19, further comprising notifying the first avatar of at least one other region where the first avatar has authorized access based on the tracking sphere and where a different permanent change has occurred in the at least one other region since the access was authorized and where the different permanent change was created by a same avatar that created the permanent change in the region.
21. The computer program product of claim 20, further comprising:
responsive to notifying the first avatar of the at least one other region, receiving, from the first avatar, a change to the access to the at least one other region for the second avatar, wherein the change is to deny access to the at least one other region by the second avatar; and
disabling access to the at least one other region for the second avatar.
22. An apparatus comprising:
a processor;
a track module executable on the processor, the track module configure to,
define a tracking sphere for a first avatar in the online immersive environment, wherein the tracking sphere encompasses the first avatar and some defined area beyond the first avatar, wherein the first avatar represents a first person who is a guardian of a second person that is a minor in the real world and external to the online immersive environment, wherein a second avatar represents the second person in the online immersive environment;
track a path through the online immersive environment of the tracking sphere for the first avatar;
mark a region in the online immersive environment as a safe zone for the second avatar, after the path of the tracking sphere for the first avatar has traversed the region;
authorize access to the region marked as the safe zone for the second avatar in the online immersive environment;
determine a rate of change of at least one permanent change of the region that was marked;
determine that the rate of change of the at least one permanent change of the region has been exceeded for a time period; and
responsive to a determination that the rate of change of the at least one permanent change of the region has been exceeded for the time period, notify the first avatar of the at least one permanent change of the region.
23. The apparatus of claim 22, wherein the track module is configured to responsive to notifying the first avatar of the at least one permanent change for the time period, receive, from the first avatar, a change to the access to the region for the second avatar, the change to deny access to the region by the second avatar.
24. The apparatus of claim 22, wherein the track module is configured to notify the first avatar of at least one other region where the first avatar has authorized access based on the tracking sphere and where a different permanent change has occurred in the at least one other region since the access was authorized and where the different permanent change was created by a same avatar that created the at least one permanent change in the region.