1460729672-582b5ad0-36fc-42cd-bb5f-34e0a96c5633

1. An assay method for detecting scrub typhus comprising:
a. obtaining a sample from a subject;
b. exposing said sample to a combination of a truncated r47 protein plus a truncated r56 protein or a laboratory produced antibodies to said combination in assay equipment; and
c. detecting antibodies to said protein combination in said sample or detecting an antigen to said laboratory antibodies in said sample in said assay equipment.
2. The assay method of claim 1, wherein said sample comprises blood, urine, or oral fluids.
3. The assay method of claim 1, wherein said assay equipment is selected from the group consisting of ELISA plates, dot-blot matrices, and hand held chromatographic and flow through assay devices

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

What is claimed is:

1. An electrochemical cell, which comprises:
a) a casing;
b) a negative electrode of an anode material which intercalates and deintercalates with an alkali metal;
c) a positive electrode comprising a cathode active material which intercalates and deintercalates with the alkali metal; and
d) an electrolyte solution activating the negative and positive electrodes, wherein the cell has an electrode surface area to volume ratio greater than 25.
2. The electrochemical cell of claim 1 wherein the casing has an external volume of about 5 cm3, or less.
3. The electrochemical cell of claim 1 wherein the anode material is contacted to at least one side of an anode current collector to provide the negative electrode of a first thickness less than about 0.15 mm.
4. The electrochemical cell of claim 3 wherein the anode material is contacted to both sides of the anode current collector.
5. The electrochemical cell of claim 1 wherein the cathode active material is contacted to at least one side of a cathode current collector to provide the positive electrode of a second thickness less than about 0.15 mm.
6. The electrochemical cell of claim 5 wherein the cathode material is contacted to both sides of the cathode current collector.
7. The electrochemical cell of claim 3 wherein the first thickness of the negative electrode is less than about 0.11 mm.
8. The electrochemical cell of claim 5 wherein the second thickness of the positive electrode is less than about 0.11 mm.
9. The electrochemical cell of claim 3 wherein a first area of the anode current collector contacted with anode material is at least about 95 cm2.
10. The electrochemical cell of claim 5 wherein a second area of the cathode current collector contacted with cathode active material is at least about 80 cm2.
11. The electrochemical cell of claim 1 wherein the electrode surface area to volume ratio is greater than 35.
12. The electrochemical cell of claim 1 wherein the anode material of the negative electrode active material is selected from the group consisting of hairy carbon, coke, carbon black, graphite, acetylene black, carbon fibers, glassy carbon, and mixtures thereof.
13. The electrochemical cell of claim 1 wherein the cathode active material is selected from the group consisting of lithiated oxides, lithiated sulfides, lithiated selenides and lithiated tellurides of the group selected from vanadium, titanium, chromium, copper, molybdenum, niobium, iron, nickel, cobalt, manganese, and mixtures thereof.
14. The electrochemical cell of claim 1 wherein the anode material is mixed with a fluoro-resin binder.
15. The electrochemical cell of claim 1 wherein the cathode active material is mixed with a fluoro-resin binder.
16. The electrochemical cell of claim 1 wherein the cathode active material is mixed with a conductive addition selected from the group consisting of acetylene black, carbon black, graphite, nickel powder, aluminum powder, titanium powder, stainless steel powder, and mixtures thereof.
17. The electrochemical cell of claim 1 wherein the electrolyte comprises ethylene carbonate, dimethyl carbonate, ethylmethyl carbonate and diethyl carbonate.
18. The electrochemical cell of claim 17 wherein the electrolyte includes an alkali metal salt selected from the group consisting of LiPF6, LiBF4, LiAsF6, LiSbF6, LiClO4, LiAlCl4, LiGaCl4, LiNO3, LiC(SO2CF3)3, LiN(SO2CF3)2, LiSCN, LiO3SCF2CF3, LiC6F5SO3, LiO2CCF3, LiSO3F, LiB(C6H5)4, LiCF3SO3, and mixtures thereof.
19. An electrochemical cell, which comprises:
a) a negative electrode of a carbonaceous material which intercalates and deintercalates with lithium, wherein the carbonaceous material is contacted to at least one side of an anode current collector to provide the negative electrode of a first thickness less than about 0.15 mm.;
b) a positive electrode comprising lithium cobalt oxide which intercalates and deintercalates with lithium, wherein the lithium cobalt oxide is contacted to at least one side of a cathode current collector to provide the positive electrode of a second thickness less than about 0.15 mm.;
c) an electrolyte solution activating the negative electrode and the positive electrode; and
d) a casing of an external volume of about 5 cm3, or less, wherein the cell has an electrode surface area to volume ratio greater than 25.
20. The electrochemical cell of claim 19 wherein the anode material is contacted to both sides of the anode current collector.
21. The electrochemical cell of claim 20 wherein the anode current collector is of copper.
22. The electrochemical cell of claim 19 wherein the cathode material is contacted to both sides of the cathode current collector.
23. The electrochemical cell of claim 22 wherein the cathode current collector is of aluminum.
24. The electrochemical cell of claim 19 wherein the first thickness of the negative electrode is less than about 0.11 mm.
25. The electrochemical cell of claim 19 wherein the second thickness of the positive electrode is less than about 0.11 mm.
26. The electrochemical cell of claim 19 wherein the electrode surface area to volume ratio is greater than 35.
27. In combination with an implantable medical device requiring at least one current pulse for a medical device operating function, a first electrochemical cell which is dischargeable to deliver the current pulse electrically coupled to a second electrochemical cell, the first cell comprising:
a) a casing;
b) a negative electrode of an anode material which intercalates and deintercalates with an alkali metal;
c) a positive electrode comprising a cathode active material which intercalates and deintercalates with the alkali metal;
d) an electrolyte solution activating the negative and positive electrodes, wherein the cell has an electrode surface area to volume ratio greater than 25, and wherein the first cell is rechargeable by the second cell.
28. The combination of claim 27 wherein the casing has an external volume of about 5 cm3, or less.
29. The combination of claim 27 wherein the anode material is contacted to at least one side of an anode current collector to provide the negative electrode of a first thickness less than about 0.15 mm.
30. The combination of claim 27 wherein the cathode active material is contacted to at least one side of a cathode current collector to provide the positive electrode of a second thickness less than about 0.15 mm.
31. The combination of claim 27 wherein a first area of the anode current collector contacted with anode material is at least about 95 cm2.
32. The combination of claim 27 wherein a second area of the cathode current collector contacted with cathode active material is at least about 80 cm2.
33. The combination of claim 27 wherein the second electrochemical cell is of a LiCFx couple.
34. The combination of claim 27 wherein the first cell and the second cell are in separate casings.
35. The combination of claim 27 wherein the first cell and the second cell are in the same casing.
36. A method for providing an electrochemical cell, comprising the steps of:
a) providing a casing;
b) providing a negative electrode comprising an anode material which intercalates and deintercalates with an alkali metal;
c) providing a positive electrode comprising a cathode active material which intercalates and deintercalates with the alkali metal; and
d) activating the negative electrode and the positive electrode housed inside the casing with an electrolyte, wherein the cell has an electrode surface area to volume ratio greater than 25.
37. The method of claim 36 including providing the casing having an external volume of about 5 cm3, or less.
38. The method of claim 36 including the anode material being contacted to at least one side of an anode current collector to provide the negative electrode of a first thickness less than about 0.15 mm.
39. The method of claim 38 wherein the anode current collection is of copper.
40. The method of claim 36 including the cathode active material being contacted to at least one side of a cathode current collector to provide the positive electrode of a second thickness less than about 0.15 mm.
41. The method of claim 40 wherein the cathode current collector is of aluminum.
42. The method of claim 36 including the first thickness of the negative electrode being less than about 0.11 mm.
43. The method of claim 36 including the second thickness of the positive electrode being less than about 0.11 mm.
44. The method of claim 36 including the electrode surface area to volume ratio being greater than 35.
45. The method of claim 36 including providing the electrolyte having an alkali metal salt dissolved in a quaternary nonaqueous carbonate solvent mixture comprising ethylene carbonate, dimethyl carbonate, ethylmethyl carbonate and diethyl carbonate.
46. The method of claim 45 wherein the ethylene carbonate is in the range of about 20% to about 50%, the dimethyl carbonate is in the range of about 12% to about 75%, the ethylmethyl carbonate is in the range of about 5% to about 45%, and the diethyl carbonate is in the range of about 3% to about 45%, by volume.
47. The method of claim 36 including selecting the anode material from the group consisting of hairy carbon, coke, carbon black, graphite, acetylene black, carbon fibers, glassy carbon, and mixtures thereof.
48. The method of claim 36 including selecting the cathode active material from the group consisting of lithiated oxides, lithiated sulfides, lithiated selenides and lithiated tellurides of the group selected from vanadium, titanium, chromium, copper, molybdenum, niobium, iron, nickel, cobalt, manganese, and mixtures thereof.

1460729664-5c267647-a9b7-482f-a2f8-f267a1f05045

1. A computer implemented method for processing information on a nucleotide sequence comprising the steps of:
(a) receiving, via a communication network, request information of an object or service, wherein the object or service is provided for an individual based on one or more genetic differences between individuals, and wherein the request information does not include genetic information;
(b) searching a first memory area for positional information, and wherein the positional information corresponds to information on classification of the object or service, and wherein the positional information represents a position in a nucleotide sequence, and retrieving the positional information, and wherein the first memory area is permitted to be accessed by a first processor;
(c) transmitting, via the communication network, the positional information retrieved in step (b) above to a second processor which is permitted to access a second memory area storing polymorphism information regarding the individual;
(d) receiving, via the communication network, polymorphism information based on the positional information transmitted in step (c) above;
(e) searching a third memory area for semantic information or information corresponding to the semantic information based on the polymorphism information received in step (d) above, and retrieving said semantic information or information corresponding to the semantic information, and wherein the third memory area is permitted to be accessed by the first processor; and
(f) outputting the semantic information or information corresponding to the semantic information retrieved in step (e) above to a user; and
wherein steps (a)-(f) are conducted under the control of the first processor.
2. The method for processing information on a nucleotide sequence according to claim 1, wherein the user includes the second processor or a device that utilizes the semantic information or information corresponding to the semantic information.
3. The method for processing information on a nucleotide sequence according to claim 1, wherein in step (c) above, secondary positional information corresponding to the positional information retrieved in step (b) above is set and the positional information retrieved in step (b) above is transmitted along with the secondary positional information, and in step (d) above, the polymorphism information is received along with the secondary positional information, and in step (e) above, semantic information or information corresponding to the semantic information is retrieved based on the received polymorphism information and the received secondary positional information.
4. The method for processing information on a nucleotide sequence according to claim 1, wherein the third memory area further stores a level of disclosure corresponding to the semantic information, said level of disclosure determining whether output of the semantic information or the information corresponding to the semantic information is approved or not.
5. The method for processing information on a nucleotide sequence according to claim 1, wherein in step (b) above, a plurality of pieces of positional information corresponding to the information on classification of the object or service of the request information are retrieved, and in step (d) above, polymorphism information corresponding to each of the plurality of pieces of positional information retrieved in step (b) above is received, and in step (e) above, semantic information or information corresponding to the semantic information is retrieved based on the plurality of pieces of the polymorphism information received in step (d) above.
6. The method for processing information on a nucleotide sequence according to claim 1, further comprising the steps of: in advance of step (f) above, receiving, via the communication network, consent information regarding the provision of polymorphism information from a provider of the request information; or in advance of step (f) above, receiving, via the communication network, consent information regarding the content of semantic information or information corresponding to the semantic information from the provider of the request information.
7. The method for processing information on a nucleotide sequence according to claim 1, wherein the semantic information comprises at least one piece of information selected from the group consisting of information on medical examination items, information on a morbidity rate of a disease, information on the production of objects, information on the selection of types of objects, and information on compatibility with other individual organisms.
8. The method for processing information on a nucleotide sequence according to claim 1, wherein in step (e) above, additional information is retrieved from a memory or is received via a communication network, and wherein in step (f) above, the semantic information or the information corresponding to the semantic information retrieved in step (e) above is outputted along with the additional information.
9. A computer-readable medium encoded with a program for processing information on a nucleotide sequence which allows a computer to execute processes including:
(a) receiving, via a communication network, request information of an object or service, wherein the object or service is provided for an individual based on one or more genetic differences between individuals, and wherein the request information does not include genetic information;
(b) searching a first memory area for positional information, and wherein the positional information corresponds to information on classification of the object or service, and wherein the positional information represents a position in a nucleotide sequence, and retrieving the positional information, and wherein the first memory area is permitted to be accessed by a first processor;
(c) transmitting, via the communication network, the positional information retrieved in process (b) above to a second information processor which is permitted to access a second memory area storing polymorphism information regarding the individual;
(d) receiving, via the communication network, polymorphism information based on the positional information transmitted in process (c) above;
(e) searching a third memory area for semantic information or information corresponding to the semantic information based on the polymorphism information received in process (d) above, and retrieving the semantic information or information corresponding to the semantic information, and wherein the third memory area is permitted to be accessed by the first processor; and
(f) outputting the semantic information or information corresponding to the semantic information retrieved in process (e) above to a user,
wherein processes (a)-(f) are conducted under the control of the first processor.
10. The computer-readable medium according to claim 9, wherein in process (c) above, secondary positional information corresponding to the positional information retrieved in process (b) above is set and the positional information retrieved in process (b) above is transmitted along with the secondary positional information, and in process (d) above, the polymorphism information is received along with the secondary positional information, and in process (e) above, semantic information or information corresponding to the semantic information is retrieved based on the received polymorphism information and the received secondary positional information.
11. The computer-readable medium according to claim 9, wherein the third memory area further stores a level of disclosure corresponding to the semantic information, said level of disclosure determining whether output of the semantic information or the information corresponding to the semantic information is approved or not.
12. The computer-readable medium according to claim 9, wherein in process (b) above, a plurality of pieces of positional information corresponding to the information on classification of the object or service of the request information are received, and in process (d) above, polymorphism information corresponding to each of the plurality of pieces of positional information retrieved in process (b) above is retrieved, and in process (e) above, semantic information or information corresponding to the semantic information is retrieved based on the plurality of pieces of polymorphism information received in process (d) above.
13. The computer-readable medium according to claim 9, wherein the processes further comprise: in advance of step (f) above, receiving, via the communication network, consent information regarding the provision of polymorphism information from a provider of the request information; or in advance of step (f) above, receiving, via the communication network, consent information regarding the content of semantic information or information corresponding to the semantic information from the provider of the request information.
14. The computer-readable medium according to claim 9, wherein the semantic information comprises at least one piece of information selected from the group consisting of information on medical examination items, information on a morbidity rate of a disease, information on the production of objects, information on the selection of types of objects, and information on compatibility with other individual organisms.
15. The computer-readable medium according to claim 9, wherein in step (e) above, additional information is retrieved from a memory or is received via a communication network, and wherein in step (f) above, the semantic information or the information corresponding to the semantic information retrieved in step (e) above is outputted along with the additional information.
16. The computer-readable medium according to claim 9, wherein the user includes the second processor or a device that utilizes the semantic information or information corresponding to the semantic information.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An ophthalmologic imaging apparatus comprising:
a light source section for emitting illumination light to illuminate a retina;
an illumination optical system for illuminating the retina of an eye under measurement by a first passage for passing a part of an illumination light flux from the light source section through a first aperture diaphragm having an opening formed at a center portion at a conjugate position with a pupil, and a second passage for passing a part of the illumination light flux from the light source section through a second aperture diaphragm having an opening formed on a periphery portion at a conjugate position with the pupil;
an aberration compensation section for applying compensation to a reflection light flux from the retina on the basis of measured aberrations so as to offset the aberrations;
an aberration measuring section for illuminating the eye under measurement, receiving a reflection light flux under the illumination from the eye under measurement through the aberration compensation section and, measuring the aberrations of the reflection light flux;
an image pickup optical system including a reflection section that has an opening at a center portion at a conjugate position with the pupil, passes a light flux at the center portion and reflects the light flux at a peripheral portion, for achieving images of first and second magnifications of the retina of the eye under measurement by a third passage for achieving a retinal image of a first magnification by the reflection light flux which is from the retina and is compensated in aberrations in the aberration compensation section and is passed through the opening of the reflection section, and a fourth passage for achieving a retinal image of a second magnification by the reflection light flux which is from the retina and is compensated in aberrations in the aberration compensation section and is reflected from the peripheral portion around the opening of the reflection section;
a first light-receiving section for receiving the light flux passing through the third passage; and
a second light-receiving section for receiving the light flux passing through the fourth passage, and
images of different magnifications being achieved by the first light-receiving section and the second light receiving section.
2. The ophthalmologic imaging apparatus according to claim 1, wherein
the size of the opening of the reflection section is changeable in accordance with the difference of a desired observation target on the retina.
3. The ophthalmologic imaging apparatus according to claim 1, further comprising
a dividing section for dividing the illumination light flux from the light source section into a light flux of first polarization light and a light flux of second polarization light, leading the light flux of first polarization light to the first passage and leading the light flux of second polarization light to the second passage,
wherein the image pickup optical system
has, on the third passage, a first polarizer for passing the light flux of second polarization light out of the light fluxes which are passed through the reflection section and include the light flux of first polarization light reflected from a cornea and the light flux of second polarization light reflected from the retina, to lead the reflection light flux reflected from the retina to the first light-receiving section, and
has, on the fourth passage, a second polarizer for passing the light flux of first polarization light out of the light fluxes which are reflected from the reflection section and include the light flux of second polarization light reflected from the cornea and the light flux of first polarization light reflected from the retina, to lead the reflection light flux reflected from the retina to the second light-receiving section.
4. The ophthalmologic imaging apparatus according to claim 3, wherein
the first polarization light and the second polarization light are P-polarization light and S-polarization light, respectively.
5. The ophthalmologic imaging apparatus according to claim 1, wherein
the image pickup optical system has
an optical system having first magnifying power on the third passage, and
an optical system having second magnifying power on the fourth passage,
the second magnifying power is higher than the first magnifying power.
6. The ophthalmologic imaging apparatus according to claim 1, further comprising
a display section for displaying the retinal image of the first magnification based on the first light-receiving section and the retinal image of the second magnification based on the second light-receiving section.