Author: claimsbot

1. A frequency multiplying circuit for multiplying a first frequency, the circuit comprising: a transadmittance portion having a first transfer characteristic, the transadmittance portion having two input terminals for a signal of said first frequency; and a transimpedance portion having a second transfer characteristic, the transimpedance portion having two output terminals for a signal of a second frequency higher than the first frequency as an output of said multiplying circuit, wherein a transfer characteristic of the transimpedance portion is steeper than a transfer characteristic of the transadmittance portion, and wherein a modulation range of the transadmittance portion is greater than a modulation range of the transimpedance portion.
2. The circuit according to claim 1, wherein the transadmittance portion has a first symmetrical DC amplifier with a first transistor circuit, a second transistor circuit, and a first constant-current source that is connected to a common emitter terminal of the first transistor circuit and the second transistor circuit.
3. The circuit according to claim 2, wherein the transimpedance portion has a second symmetrical DC amplifier that has a third transistor circuit and a fourth transistor circuit, wherein the third transistor circuit and the fourth transistor circuit each include at least one transistor, and a resistor connected between the collector and the base of the transistor and said transimpedance portion further including a second constant current source, and wherein the second constant current source is connected to a common emitter terminal of the third and fourth transistor circuits.
4. The circuit according to claim 3, wherein at least one of the first, second, third or fourth transistor circuits has at least one bipolar transistor.
5. The circuit according to claim 3, wherein at least one of the first, second, third or fourth transistor circuits has at least one field-effect transistor.
6. The circuit according to claim 3, wherein first partial currents of the two constant-current sources are collected at a first node that is connected to an operating voltage of the circuit through a first load resistor, second partial currents of the two constant-current sources are collected at a second node that is connected to the operating voltage through a second load resistor, and wherein a first terminal of the transimpedance portion is connected to the first node and a second terminal of the transimpedance portion is connected to a second node.
7. The circuit according to claim 1, wherein the transadmittance portion and the transimpedance portion are integrated on a chip with a transmit path and a receive path.
8. The circuit according to claim 7, wherein an electrical connection is formed between the terminals of the transimpedance portion and a transmit path or a receive path.
9. The circuit according to claim 8, wherein an electrical connection is formed between the terminals of the transadmittance portion and a voltage-controlled oscillator.
10. The circuit according to claim 9, wherein an output frequency of the voltage-controlled oscillator is two thirds of a transmit frequency, halved for internal signal processing and tripled by the circuit.
11. The circuit according to claim 1, wherein the transadmittance portion is in series with the transimpedance portion.
12. A frequency multiplying circuit for multiplying a first frequency, the circuit comprising: a transadmittance portion having a voltage-current transfer characteristic, the transadmittance portion having two input terminals for a signal of said first frequency; and a transimpedance portion having a current-voltage transfer characteristic, the transimpedance portion having two output terminals for a signal of a second frequency, which is higher than said first frequency, and which is output from said multiplying circuit, wherein a modulation range of the transadmittance portion is greater than a modulation range of the transimpedance portion.
13. The circuit according to claim 12, wherein the current-voltage transfer characteristic of the transimpedance portion is steeper than voltage-current transfer characteristic of the transadmittance portion.
14. The circuit according to claim 1, wherein said transadmittance portion includes two transadmittance output terminals and said transimpedance portion includes two transimpedance input terminals and wherein said two transadmittance output terminals are directly connected to said two transimpedance input terminals.
15. The circuit according to claim 12 wherein said transadmittance portion includes two transadmittance output terminals and said transimpedance portion includes two transimpedance input terminals and wherein said two transadmittance output terminals are directly connected to said two transimpedance input terminals.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An electric bending endoscope comprising:
an inserting portion having a bending portion which is inserted in a subject;
an operation wire which is inserted in the inserting portion for bending the bending portion;
a motor for supplying a driving force to the operation wire for bending the bending portion;
a first unit for holding the motor;
a driving force transmitting member which transmits the driving force supplied from the motor to the operation wire in order to bend the bending portion, the driving force transmitting member being connected to the operation wire via a connecting portion;
a second unit for holding the driving force transmitting member;
a first connecting member for connecting the first unit and the second unit so that the driving force of the motor maybe transmitted to the driving force transmitting member; and
a second connecting member for connecting the second unit and the inserting portion so that the bending portion many be bent by the driving force transmitted from the driving force transmitting member.
2. An electric bending endoscope according to claim 1, wherein the driving force transmitting member is rotatably supported by the second unit in order to operate a bending operation member passed through the inserting portion in accordance with the driving of the motor, the first unit has an attaching hole which accommodates a rotating shaft of the driving force transmitting member and at least three positioning holes arranged near the attaching hole, and the first connecting member has a hole through which the rotating shaft is passed, a projecting and positioning piece which is accommodated in the attaching hole, and at least three projecting and positioning pins which are fit into the positioning holes.
3. An electric bending endoscope according to claim 2, wherein the first unit is further provided with an opening which connectably accommodates the second unit to the motor and the driving force transmitting member, and a guide hole which guides and accommodates the rotating shaft upon mounting the second unit via the opening.
4. An electric bending endoscope according to claim 1, wherein the second connecting member holds a universal cord for connecting the electric bending endoscope to a peripheral device, wherein the first unit comprises an outer frame and an inner frame for holding the motor, and the second connecting member is connected to the inner frame and the inner frame is accommodated in the outer frame so as to be at least partially exposed to form an exposed portion, and the second connecting member is fixed to the exposed portion.
5. An electric bending endoscope according to claim 4, wherein the second connecting member has a ring-shaped holding portion for holding the universal cord and a fixing portion for fixing the holding portion to the inner frame at at least three positions.
6. An electric bending endoscope according to claim 5, wherein the holding portion has a plurality of screw holes on a peripheral surface and the universal cord is fit by screw operation of a screw via a screw hole arranged to a connector at an edge portion of the universal cord and the screw holes of the holding portion.
7. An electric bending endoscope according to claim 4, further comprising:
a fixing member which fixes the inner frame to a main frame in the second unit.
8. An electric bending endoscope according to claim 7, wherein the main frame is positioned to the inner frame by using a positioning tool for positioning the main frame in the second unit in three-axis directions to the inner frame, and the inner frame and the main frame in the second unit are fixed by using a fixing member for fixing them.
9. An electric bending endoscope according to claim 8, wherein a positioning and fixing member for positioning and fixing the main frame in the second unit in three-axis directions to the inner frame is arranged to a connecting portion of the inner frame and the main frame.
10. An electric bending endoscope according to claim 7, wherein the bending operation member is constituted such as to slide with respect to the second unit in accordance with the driving of the motor when bending the bending portion, and the main frame in the second unit is arranged so that a signal cable which is passed through the endoscope for transmitting an endoscope image pick-up signal, a light guide for transmitting illumination light, and the bending operation member are detached.
11. An electric bending endoscope according to claim 1, wherein the first unit comprises an inner frame for holding the motor and an outer frame for accommodating the inner frame, the inner frame having a holding member for holding a universal cord for connecting the electric bending endoscope to a peripheral device.
12. An electric bending endoscope comprising:
an inserting portion which is inserted in a subject;
bending means for bending the inserting portion;
driving force supplying means for supplying a driving force for bending the inserting portion;
driving force transmitting means which transmits the driving force supplied from the driving force supplying means to the inserting portion in order to bend the inserting portion;
first connecting means for connecting the driving force supplying means and the driving force transmitting means in order to transmit the driving force supplied from the driving force supplying means to the driving force transmitting means; and
second connecting means for connecting the driving force transmitting means and the inserting portion in order to transmit the driving force transmitted to the driving force transmitting means to the bending portion.

We claim:

1. A compound of formula (I) wherein R1 represents a hydrogen atom or a 3-halogen atom, and R2 represents a straight-chain alkyl group containing up to 6 carbon atoms, a straight-chain alkyl group containing up to 3 carbon atoms with unsubstituted or substituted aromatic ring, or alkoxycarbonyl substituent at the end position, or aryloxyalkoxyalkyl group.
2. A compound according to claim 1 wherein R1 is hydrogen and R2 is n-hexyl, 3-phenylpropyl or 3-methoxycarbonylpropyl. The compounds of claim 2, which are 2,4-diamino-6-(n-hexyl)-5-phenylpyrimidine 2,4-diamino-5-phenyl-6-(3-phenylpropyl)pyrimidine 2,4-diamino-6-(3-methoxycarbonylpropyl)-5-phenylpyrimidine
3. A compound according to claim 1 wherein R1 is 3-chloro and R2 is 3-phenylpropyl, 3-(4-methoxyphenyl)propyl, 3-methoxycarbonylpropyl or 2-(3-phenoxypropyloxy)ethyl. The compounds of claim 3, which are 2,4-diamino-5-(3-chlorophenyl)-6-(3-phenylpropyl)pyrimidine 2,4-diamino-5-(3-chlorophenyl)-6-3-(4-methoxyphenyl)propylpyrimidine 2,4-diamino-5-(3-chlorophenyl)-6-(3-methoxycarbonylpropyl)pyrimidine 2,4-diamino-5-(3-chlorophenyl)-6-2-(3-phenoxypropyloxy)ethylpyrimidine
4. Pharmaceutically acceptable salts of a compound of formula (I) wherein R1 represents a hydrogen atom or a 3-halogen atom, and R2 represents a straight-chain alkyl group containing up to 6 carbon atoms, a straight-chain alkyl group containing up to 3 carbon atoms with unsubstituted or substituted aromatic ring, or alkoxycarbonyl substituent at the end position, or aryloxyalkoxyalkyl group.
5. A process for the production of a compound of formula (I) as in claims 1 and 2, comprising: a) acylation of arylacetonitrile (II) with acid chloride (Ill) employing lithium diisopropylamide in tetrahydrofuran at 78 C. affords the desired keto nitrile (IV); b) reaction of keto nitrile (IV) with diazomethane in dioxane at room temperature affords the corresponding methoxyacrylonitrile (V); c) condensation reaction of the methoxyacrylonitrile (V) with guanidine in dimethyl sulfoxide at 80 C. provides the desired pyrimethamine derivative compound (I).
6. A pharmaceutical composition which comprises a compound of formula (I) wherein R1 represents a hydrogen atom or a 3-halogen atom, and R2 represents a straight-chain alkyl group containing up to 6 carbon atoms, a straight-chain alkyl group containing up to 3 carbon atoms with unsubstituted or substituted aromatic ring, or alkoxycarbonyl substituent at the end position, or aryloxyalkoxyalkyl group. This compound can be used by itself or in synergistic combination with sulfonamides andor other agents.
7. Use of a compound as defined in claim 6 for the treatment or prophylaxis of malaria.
8. Use of a compound as defined in claim 6 for the treatment or prophylaxis of drug-resistant malaria.
9. Use of a compound as defined in claim 6 for the treatment or prophylaxis of malaria resistant to antifolate compounds in use, including pyrimethamine.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A wireless sensor that comprises a wireless sensor location controller that determines a location of the wireless sensor.
2. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller determines a location of the wireless sensor in response to a request from a wireless sensor base station.
3. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller associates identity information of the wireless sensor with location information of the wireless sensor.
4. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller determines a location of the wireless sensor whenever the wireless sensor changes its location.
5. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller provides location information of the wireless sensor to an external wireless device.
6. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller determines a location of the wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
7. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller generates a beacon signal that uniquely identifies the wireless sensor.
8. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller generates an alert signal that signifies that an event of interest has occurred with respect to the wireless sensor.
9. A wireless sensor network comprising:
at least one wireless sensor that comprises a wireless sensor location controller that determines a location of the wireless sensor; and
a wireless sensor base station that communicates with the at least one wireless sensor.
10. The wireless sensor network as set forth in claim 9 wherein the wireless sensor location controller of the wireless sensor determines a location of the wireless sensor in response to a request from the wireless sensor base station.
11. The wireless sensor network as set forth in claim 9 wherein the wireless sensor location controller of the wireless sensor determines a location of the wireless sensor whenever the wireless sensor changes its location.
12. The wireless sensor network as set forth in claim 9 wherein the wireless sensor location controller of the wireless sensor determines a location of the wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
13. The wireless sensor network as set forth in claim 9 wherein the wireless sensor base station comprises a wireless sensor location controller of the base station that comprises a database that contains location information for each wireless sensor in the wireless sensor network.
14. The wireless sensor network as set forth in claim 9 wherein the wireless sensor base station comprises a wireless sensor location controller of the base station that provides for display on a display unit of the base station location information for each wireless sensor in the wireless sensor network.
15. A wireless sensor network that comprises:
at least one wireless sensor; and
a wireless sensor location controller that determines a location of the wireless sensor.
16. The wireless sensor network as set forth in claim 15 wherein the wireless sensor location controller determines a location of the wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
17. The wireless sensor network as set forth in claim 16 wherein the wireless sensor network is a multi tier wireless sensor network that comprises a plurality of multi tier wireless network elements.
18. A method for operating a wireless sensor network comprising the steps of:
providing at least one wireless sensor that comprises a wireless sensor location controller that determines a location of the wireless sensor; and
providing a wireless sensor base station that communicates with the at least one wireless sensor.
19. The method as set forth in claim 18 further comprising the steps of:
sending a request from the wireless sensor base station to the at least one wireless sensor to obtain location information of the wireless sensor;
in response to the request from the wireless sensor base station, determining a location of the at least one wireless sensor; and
sending the wireless sensor location information of the at least one wireless sensor to the wireless sensor base station.
20. The method as set forth in claim 18 wherein the step of determining a location of the at least one wireless sensor comprises determining the location of the at least one wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
21. The method as set forth in claim 18 further comprising the steps of:
in response to a change of location of the at least one wireless sensor, determining new location information of the at least one wireless sensor; and
sending the new location information of the at least one wireless sensor to the wireless sensor base station.
22. The method as set forth in claim 18 further comprising the steps of:
in response to an occurrence of an event of interest with respect to the at least one wireless sensor, generating an alert signal in the wireless sensor location controller of the at least one wireless sensor; and
sending the alert signal to the wireless sensor base station.
23. The method as set forth in claim 18 further comprising the steps of:
sending location information for the at least one wireless sensor to the wireless sensor base station;
recording the location information of the at least one wireless sensor in a database in the wireless sensor base station; and
displaying the location information of the at least one wireless sensor on a display unit of the wireless sensor base station.