1. (canceled)
2. (canceled)
3. (canceled)
4. A process for preparing optically active alcohols by asymmetric reduction of ketone substrates, wherein a ketone substrate is reacted with a hydrogen-donating compound under the presence of an organic metal compound represented by the general formula (2):
wherein R1 and R2 may be mutually identical or different, and are an alkyl group, a phenyl group, a naphthyl group, a cycloalkyl group, or an alicyclic ring formed by binding R1 and R2, which may have a substituent; R3 is a hydrogen atom or an alkyl group; Ar is a cyclopentadienyl group or a benzene ring group, which may have a substituent, bound to M2 via a \u03c0 bond; X2 is a hydrido group or an anionic group; M2 is rhodium or iridium; n is 0 or 1, and X2 is absent when n is 0;
and * denotes asymmetric carbon.
5. The process according to claim 4, wherein R3 is a hydrogen atom and M2 is iridium in the general formula (2).
6. The process according to claim 4, wherein a formate is used as a hydrogen-donating compound, and water or waterorganic solvent is used as a solvent.
7. The process according to claim 4, wherein a phase-transfer catalyst is additionally added.
8. The process according to claim 4, wherein a ketone having a hydroxyl group at the \u03b1-position or the \u03b2-position of the ketone is asymmetrically reduced.
9. The process according to claim 4, wherein a ketone having a halogen at the \u03b1-position or the \u03b2-position of the ketone is asymmetrically reduced.
10. The process according to claim 4, wherein a ketone having a carbon-carbon multiple bond at the \u03b1-position or the \u03b2-position of the ketone is asymmetrically reduced.
11. The process according to claim 4, wherein a ketone having an ester group at the \u03b1-position or the \u03b2-position of the ketone, or a ketone having an ester group at the carbonyl carbon of the ketone is asymmetrically reduced.
12. The process according to claim 4, wherein a ketone having a carboxylic amide group at the \u03b1-position or the \u03b2-position of the ketone, or a ketone having a carboxylic amide group at the carbonyl carbon of the ketone is asymmetrically reduced.
13. The process according to claim 4, wherein a ketone having an amino group at the \u03b1-position or the \u03b2-position of the ketone is asymmetrically reduced.
14. The process according to claim 4, wherein 1,2-diketone or 1,3-diketone is asymmetrically reduced.
15. The process according to of claim 4, wherein a cyclic ketone is asymmetrically reduced.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
We claim:
1. A wireless, multi-purpose functional electrical stimulation (FES) system which includes
a plurality of implantable stimulator units, each unit being implanted, in use, at a particular site in a patient’s body for at least one of stimulating and monitoring that site, each stimulator unit including a power source and a programmable control means for controlling stimulation at its associated site, each stimulator unit further having a plurality of implantable transducer elements connected to and in communication with the programmable control means, at least certain of the transducer elements operating as stimulating electrodes; and
a controller arranged, in use, externally of the patient’s body for supplying programming and control signals transcutaneously to each of the stimulator units independently to effect stimulation of the site associated with the stimulator unit being addressed at that time by the controller.
2. The system of claim 1 in which the number of stimulating electrodes connected to each stimulating unit is governed by the number of stimulation points required to cause effective stimulation at the site.
3. The system of claim 2 in which the stimulating electrodes are in communication with the control means of their associated stimulating unit via a switching arrangement.
4. The system of claim 1 in which certain other transducer elements of each stimulator unit function as measurement sensors so that the stimulator unit is also used for making biomedical measurements and measurements of physical parameters at its associated site.
5. The system of claim 1 in which the stimulator units are addressed by the controller individually by means of an addressing technique.
6. The system of claim 1 in which the power source of each stimulator unit includes a battery.
7. The system of claim 6 in which the battery is a rechargeable battery.
8. The system of claim 7 which includes an indicating means for indicating to the controller which stimulator unit requires charging and a charging device for charging the battery of each stimulator unit.
9. The system of claim 8 in which the charging device is incorporated in the controller of the system.
10. The system of claim 8 in which each stimulator unit includes a power receiving device for receiving a recharging signal from the charging device.
11. The system of claim 10 in which the power receiving device is in the form of a charging antenna which is configured to receive electromagnetic charging power from the charging device.
12. The system of claim 11 in which the charging antenna recharges the battery of the power source via a charging circuit in the stimulator unit, the charging circuit operating under control of the control means of the stimulator unit.
13. The system of claim 1 in which each stimulator unit receives stimulator instructions from the controller via a wireless data link.
14. The system of claim 13 in which each stimulator unit includes a transmitterreceiver (transceiver) device for one of receiving data signals from the controller and transmitting data signals to the controller.
15. The system of claim 1 in which the control means of each stimulator unit includes a memory means which receives and stores a control algorithm containing data relevant to a stimulation regime from the controller.
16. The system of claim 1 in which one of the stimulator units is a master unit and the remaining stimulator units are slave units.
17. The system of claim 16 in which the controller addresses the master unit and the master unit, in turn and where applicable, addresses the relevant slave stimulator unit at the site to be stimulated.
18. An implantable stimulator unit for use in a wireless, multi-purpose functional electrical stimulation (FES) system, the stimulator unit including a power source;
a control means which receives power from the power source and which receives data signals from an external controller of the system; and
a plurality of implantable transducer elements connected to and in communication with the programmable control means, at least certain of the transducer elements operating as stimulating electrodes.
19. The unit of claim 18 in which the number of transducer elements functioning as stimulating electrodes is governed by the number of stimulation points required to cause effective stimulation at the site.
20. The unit of claim 18 in which the transducer elements are in communication with the control means via a switching arrangement.
21. The unit of claim 18 which functions as a measurement unit for making biomedical measurements and measurements of physical parameters at its associated site, at least certain other transducer elements being measurement sensors to provide measurement data to the control means.
22. The unit of claim 18 which functions as a self diagnostic unit capable of determining the status of its various components and for transmitting such status data to the controller.
23. The unit of claim 18 in which the power source includes a battery.
24. The unit of claim 23 in which the battery is a rechargeable battery.
25. The unit of claim 24 which includes a power receiving device for receiving a recharging signal from a charging device of the system.
26. The unit of claim 25 in which the power receiving device is in the form of a charging antenna which is configured to receive electromagnetic charging power from the charging device.
27. The unit of claim 26 in which the charging antenna recharges the battery of the power source via a charging circuit, the charging circuit operating under control of the control means.
28. The unit of claim 18 which receives data from the controller via a wireless data link.
29. The unit of claim 28 which includes a transmitterreceiver (transceiver) device for one of receiving data signals from the controller and transmitting data signals to the controller.
30. The unit of claim 18 in which the control means includes a memory means which receives and stores a control algorithm containing data relevant to a stimulation regime.