Author: claimsbot

What is claimed is:

1. A multimedia cooperative work system, comprising:
generating a model of a multimedia electronic tag in which display of a comment and attribute data thereofcomment input in tree-shape structure is possible for each scene of multimedia data, the registration of which is requested by an arbitrary client in a server and which are obtained by dividing multimedia data in terms of time; and
exchanging comments on each scene among a plurality of clients, including the requesting client, using the multimedia electronic tag, thereby realizing multimedia cooperative work.
2. The multimedia cooperative work system according to claim 1, wherein
each said client further comprises an electronic tag editing unit displaying a comment displayinput screen, using a multimedia electronic tag obtained from the server or another client.
3. The multimedia cooperative work system according to claim 1, wherein
each said client further comprises a format conversion unit converting a format of the multimedia electronic tag into a format in which the multimedia data and a comment aggregate of each scene of the multimedia data can be synchronizedreproduced.
4. The multimedia cooperative work system according to claim 1, wherein
the attribute data include at least one of a comment writer name, a comment generation date and a comment adding destination.
5. The multimedia cooperative work system according to claim 2, wherein
a publication destination of the comment can be selected and designated in the comment displayinput screen,
the multimedia electronic tag is updated by adding description on the publication destination, and
the multimedia electronic tag after the update is stored in the server,
the server further comprises an electronic tag communication unit transmitting a multimedia electronic tag without comment, the publication destinations of which are designated, to the requesting client if the client requesting the transmission of the multimedia electronic tag is not included in the publication destinations.
6. The multimedia cooperative work system according to claim 1, wherein
the multimedia electronic tag is described in XML.
7. A multimedia cooperative work system exchanging a comment on arbitrary multimedia data among a plurality of clients through a server, wherein
the server, comprising:
a multimedia communication unit assigning an identifier to multimedia data requested by an arbitrary client and returning the identifier to the requesting client;
a multimedia storage unit storing the multimedia data;
a management unit obtaining electronic mail, by which the registration requesting client notifies other clients of the identifier of the multimedia data, obtaining member data from a destination address of the electronic mail and storingmanaging the member data in relation to the identifier of the multimedia data;
an electronic tag model generation unit generating a model of a multimedia electronic tag in which a comment can be inputted to each scene obtained by dividing the multimedia data in terms of time, in tree-shape structure, based on the multimedia data and data storedmanaged by the management unit, assigning an identifier to the multimedia electronic tag and enabling the management unit to storemanage the identifier in relation to the multimedia data identifier; and
an electronic tag storage unit storing the electronic tag model and also storing the multimedia electronic tag if an arbitrary comment is added based on the electronic tag model, and

a client of each member, including the registration requester, comprising:
an electronic tag communication unit obtaining a multimedia electronic tag from the server using the multimedia data identifier;
an electronic tag editing unit generating and displaying a comment editing screen by which a comment on an arbitrary scene of multimedia data or a comment on a comment can be inputted using the multimedia electronic tag;
a format conversion unit converting a format of the multimedia electronic tag into a multimedia synchronous reproduction format; and
a synchronous reproduction unit synchronizingreproducing the multimedia data and comment using the conversion result of the format conversion unit.
8. A server, comprising:
a communication unit transmittingreceiving data tofrom each client through a network; and
a multimedia electronic tag model generation unit generating a model of a multimedia electronic tag in which display of a comment and attribute data thereofcomment input in tree-shape structure is possible for each scene obtained by dividing multimedia data that is requested by an arbitrary client in a server, in terms of time.
9. The server according to claim 8, further comprising
a member management unit obtaining member data, which are data on a user engaging in the multimedia data cooperative work, from electronic mail by which the registration requesting client notifies other clients of the identifier of the multimedia data, and managing the member data in relation to the multimedia data and multimedia electronic tag, wherein
said multimedia electronic tag model generation unit generates the multimedia electronic tag model using the data managed by the management unit.
10. The server according to claim 8 or 9, wherein,
a publication destination and expiration date of a comment are described as attribution data of the comment in the multimedia electronic tag, and further comprising a multimedia electronic tag modificationcommunication unit deleting an overdue comment from a multimedia electronic tag, or when receiving a multimedia electronic tag request from a client of an arbitrary member, transmitting the multimedia electronic tag without comment, the publication destination of which are not designated the requesting client, to the requesting client.
11. A client, comprising:
a communication unit transmittingreceiving data tofrom a sever or each client through a network; and
a multimedia electronic tag editing unit displaying a comment with attribute data attached to each scene of multimedia data corresponding to the multimedia electronic tag, using a multimedia electronic tag obtained from a server or another client, and simultaneously enabling a comment to be inputted to an arbitrary scene or a comment and updating the content of the multimedia electronic tag, based on the input.
12. The client according to claim 11, further comprising:
a format conversion unit converting a format of the multimedia electronic tag into a format for synchronizingreproducing the multimedia data and comment thereof; and
a multimedia synchronous reproduction unit synchronizing and displaying multimedia data and comments corresponding to each scene of the multimedia data.
13. A multimedia cooperative work method, comprising
generating a model of a multimedia electronic tag in which display of a comment and attribute data thereofcomment input in tree-shape structure is possible for each scene of multimedia data, the registration of which is requested by an arbitrary client in a server, obtained by dividing multimedia data in terms of time; and
exchanging comments on each scene among a plurality of clients, including the requesting client, using the multimedia electronic tag, thereby realizing multimedia cooperative work.
14. A computer-readable storage medium that records a program enabling a computer to execute a process, the process comprising:
displaying a comment with a variety of attributes of a writer user attached to each scene of multimedia data corresponding to the multimedia electronic tag, using a multimedia electronic tag obtained from a server or another client, and simultaneously enabling a comment to be inputted to an arbitrary scene or a comment and updating a content of the multimedia electronic tag, based on the input.
15. A computer-readable storage medium that records a program enabling a computer to execute a process, the process comprising:
converting the format of a multimedia electronic tag obtained from a server or another client or a multimedia electronic tag after update into a format for synchronizingreproducing multimedia data corresponding to the multimedia electronic tag and a comment on each scene of the multimedia data described in the multimedia electronic tag.
16. A program as a multimedia electronic tag in which display of a comment and attribute data thereofcomment input in tree-shape structure is possible for each scene obtained by dividing multimedia data that is requested by an arbitrary client in a server, in terms of time, when the program is executed.
17. A program enabling a computer to display a comment with a variety of attributes of a writer user attached to each scene of multimedia data corresponding to the multimedia electronic tag, using a multimedia electronic tag obtained from a server or another client, and simultaneously enabling a comment on an arbitrary scene or comment to be inputted and updating the content of the multimedia electronic tag, based on the input.
18. A program enabling a computer to convert a format of a multimedia electronic tag obtained from a server or another client or a multimedia electronic tag after update into a format for synchronizingreproducing multimedia data corresponding to the multimedia electronic tag and a comment on each scene of the multimedia data described in the multimedia electronic tag.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A machine for making double chain stitches in a material, the double chain stitches being made using at least one upper thread and at least one lower thread, the machine comprising:
at least one needle bar
a plurality of needles,
wherein the needle bar has attached thereto the plurality of needles and
wherein each needle brings the at least one upper thread from above the material to below the material; and

at least one arm
wherein the arm having a first end and a second end, the first end of the arm being connected to a drive train and the second end of the arm having attached thereto the needle bar;
wherein the arm is sufficiently designed such that the second end of the arm moves along a path forming an arc; and
wherein each of the plurality of needles is elongated along a long axis and
wherein each of the plurality of needles is curved along the long axis.
2. The machine of claim 1, wherein each needle oscillate as each needle brings the upper thread from above the material to below the material.
3. The machine of claim 1 further comprising:
a plurality of loopers disposed below the material sufficiently designed to manipulate the lower thread to form double chain stitches in combination with the upper thread;
wherein each looper sufficiently designed to cut the lower thread with at least one cutting element associated with each looper; and
wherein each looper oscillates as the looper manipulates the lower thread to form double chain stitches in combination with the upper thread.
4. The machine of claim 1, wherein the cutting element comprises a knife edge.
5. The machine of claim 1, wherein the looper comprises a leading end extending from a neck portion, and wherein the cutting element of the looper is disposed in a direction extending from the neck away from the leading end.
6. The machine of claim 5, wherein the cutting element of the looper is disposed in a direction extending approximately 180 degrees away from the leading end.
7. The machine of claim 1, wherein the cutting element is attached to the looper.
8. The machine of claim 1, wherein the cutting element is integral with the looper.
9. The machine of claim 1 further including at least a first and second needle bar, wherein each needle bar is independently moved.
10. A method for making double chain stitches in a material, the double chain stitches being made using a plurality of upper threads and a plurality of lower threads, the method comprising:
providing the material to receive the double chain stitches;
utilizing a plurality of needles, each needle bringing one of the upper threads from above the material to below the material;
utilizing a plurality of loopers disposed below the material, wherein each looper is used to manipulate one of the lower threads to form double chain stitches in combination with a respective one of the upper threads; and
utilizing the plurality of loopers to cut each respective lower thread with at least one cutting element associated with each of the loopers.

1. A compound of formula (I):
wherein
R1 is (CRcRd)m\u2014X \u2014Ra or (CRcRd)n\u2014X \u2014Rb, in which m is 3-5; n is 2-5; X is N(Re),O, or S, or X and Ra or X and Rb, taken together, is heteroaryl; Ra is H, C1-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, heteroaryl, or aryl optionally substituted with OH, halogen, C3-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, C1-C6 alkoxy, aryloxy, heteroaryloxy, heteroaryl, aryl, NO2, CN, COORf, or C(O)Rf, or Ra and X, taken together, is heteroaryl; Rb is H, C1-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, heteroaryl, or aryl optionally substituted with OH, halogen, C3-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, aryloxy, heteroaryloxy, heteroaryl, aryl, NO2, CN, COORf, or C(O)Rf, or Rb and X, taken together, is heteroaryl; each Rc, independently, is H, C1-C6 alkyl, aryl, or heteroaryl; and each Rd, independently, is H, C1-C6 alkyl, aryl, or heteroaryl; each of Re and Rf, independently, being H, C1-C6 alkyl, aryl, or heteroaryl; each of R2 and R3 is H; and
one of R4, R5,R6, and R7 is OH, C1-C6 alkyl, C3-C15 cycloalkyl, C3\u2014C15 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, NO2, CN, SO3H, SO2N(RgRh), SO2Rg, COORg, or C(O)Rg; and each of the others, independently, is H, C1-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NH2, C1-C6 alkylamino, C1- C12 dialkylamino, arylamino, diarylamino, NO2, CN, SO3H, SO2N(RgRh), SO2Rg, COORg, or C(O)Rg; each Rg, independently, is H, C1-C6 alkyl, aryl, or heteroaryl; and each Rh, independently, is H or C1-C6 alkyl.
2. The compound of claim 1, wherein Ra is heteroaryl or aryl substituted with C3-C6 alkyl, C1-C6 alkoxy, heteroaryl, C(O)Rf, or NO2, or Ra and X, taken together, is heteroaryl; Rb is heteroaryl; n is 2; each of R2 and R3 is H; and one of R4, R5, R6, and R7 is OH, C1-C6 alkyl, C1-C6 alkoxy, or COORe; and each of the others, independently, is H, C1-C6 alkyl, C1-C6 alkoxy, or C(O)Re.
3. The compound of claim 2, wherein Ra is heteroaryl or aryl substituted with C3-C6 alkyl or C(O)Rf.
4. The compound of claim 3, wherein each Ra, independently, is
5. The compound of claim 3, wherein each of R2 and R3 is H; and one of R4, R5,R6, and R7 is OH, OCH2COOR, OC(CH3)2COOR,
OCH(CH3)COOR, O(CH2)2COOR, O(CH2)3COOR, CH2COOR,COOR,
in which R is H, C1-C6 alkyl, aryl, or heteroaryl
6. The compound of claim 4, wherein each of R2 and R3 are H; and
one of R4, R5,R6, and R7 is OH, OCH2COOR, OC(CH3)2COOR,

OCH(CH3)COOR, O(CH2)2COOR, O(CH2)3COOR, CH2COOR,COOR,
in which R is H, C1-C6 alkyl, aryl, or heteroaryl.
7. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
8. A pharmaceutical composition comprising a compound of claim 1 and tetraethylthiuram disulfide.
9. A compound of formula (I):
wherein
R1 is H, C1-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, aryl, heteroaryl, C(O)Ra, or SO2Ra, in which Ra is C1-C6 alkyl, heteroaryl, or aryl optionally substituted with CF3, OH, halogen, C1-C6 alkoxy, aryloxy, heteroaryloxy, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, aryl, heteroaryl, NO2, CN, COORb, or C(O)Rb; Rb being H, C1-C6 alkyl, aryl, or heteroaryl;
each of R2 and R3 is H; and
one of R4, R5,R6, R7 is O\u2014(CReRf)m\u2014X\u2014Rc, or O \u2014C(ReRf)Rd; and
each of the others, independently, is H, OH, halogen, C1-C6 alkyl, C3-C15 cycloalkyl, C3\u2014C15 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, NO2, CN, SO3H, SO2N(RgRh), SO2Rg, COORg,or C(O)Rg; or one R4, R5, R6, and R7 is, O \u2014(CReRf)n\u2014X \u2014Rc, or O \u2014C(ReRf)Rd; and each of the others, independently, is H, OH, halogen, C3-C6 alkyl, C3-C15 cycloalkyl, C3\u2014C15 heterocycloalkyl, aryl, heteroaryl, C3-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, NO2, CN, SO3H, SO2N(RgRh), SO2Rg, COORg, or C(O)Rg; in which m is 3-5; n is 2-5; X is O; each Rc, independently, is C1-C6 alkyl, COORj, heteroaryl containing at least two aromatic rings fused together, or aryl optionally substituted with OH, halogen, C3-C6 alkyl, C3-C15 cycloalkyl, C3\u2014C15 heterocycloalkyl, C1-C6 alkoxy, aryloxy, heteroaryloxy, heteroaryl, aryl, NO2, CN, COORj, or C(O)Rj; each Rd, independently, is H, OH, halogen, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, C1-C6 alkyl COORj ; each Re, independently, is H, C1-C6 alkyl, aryl, or heteroaryl; each Rf, independently, is H, or C1-C6 alkyl; and each of Rg and Rh, independently, is H, C1-C6 alkyl, aryl, or heteroaryl; each of Ri and Rj, independently, is H, C1-C6 alkyl, aryl, or heteroaryl.
10. The compound of claim 9, wherein R1 is H, C1-C6 alkyl, or SO2Ra; each R2 and R3 is H; one of R4, R5,R6,and R7 is O \u2014(CReCRf)m\u2014X \u2014Rc, or O \u2014C(ReRf)Rd, and each of the others, independently, is H, C1-C6 alkyl, C1-C6 alkoxy, or COORg; or each of R2 and R3 is H and one of R4, R5, R6, and R7 is O \u2014(CReRf)n\u2014X \u2014Rc, and each of the others, independently, is H; n is 2; Rc is heteroaryl containing at least two aromatic rings fused together or aryl substituted with C3-C6 alkyl, heteroaryl, or C(O)Rj; and Rd is COORj.
11. The compound of claim 10, wherein Rc is heteroaryl containing at least two aromatic rings fused together or aryl substituted with C3-C6 alkyl or C(O)Rj.
12. The compound of claim 11, wherein Rc is
13. The compound of claim 11, wherein R1 is H, CH2COOR, CH(CH3)COOR, CH(CH2CH3)COOR, CH2CH2COOR, CH2(CH2)2COOR, or
,in which R is H, C1C6 alkyl, aryl, or heteroaryl.
14. The compound of claim 12,wherein R1 is H, CH2COOR, CH(CH3)COOR, CH(CH2CH3)COOR, CH2CH2COOR, CH2(CH2)2COOR, or
,in which R is H, C1-C6 alkyl, aryl, or heteroaryl.
15. The compound of claim 9, wherein the compound is one of compounds 2, 17, 26-29, 32, 35, 42, 53-55, 57, 58, 60, 69-73, 80-83, 88, 90, 93, 100, 112, 113, 115, 117, 119, 125-129, 131-133, 137-140, 144, 145, 152, 166, 167, and 170-174, or a salt thereof.
16. A pharmaceutical composition comprising a compound of claim 9 and a pharmaceutically acceptable carrier.
17. A pharmaceutical composition comprising a compound of claim 9 and tetraethylthiuram disulfide.
18. A compound of formula (I):
wherein
R1 is C1-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, heteroaryl, C(O)Ra, SO2Ra, or aryl optionally substituted with OH, C1-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, C1-C6 alkoxy, aryloxy, heteroaryloxy, heteroaryl, aryl, NO2, CN, COORa, or C(O)Ra; in which Ra is C1-C6 alkyl, heteroaryl, or aryl optionally substituted with CF3, OH, halogen, C1-C6 alkoxy, aryloxy, heteroaryloxy, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, aryl, heteroaryl, NO2, CN, COORb, or C(O)Rb; Rb being H, C1-C6 alkyl, aryl, or heteroaryl;
Each of R2 and R3 is H; and
one of R4, R5,R6, R7 is O \u2014(CReCRf)m\u2014X \u2014Rc, or O \u2014C(ReRf)Rd; and each of the others, independently, is H, OH, halogen, C1-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, aryl, heteroaryl, C1-C6 alkoxy, aryloxy, heteroaryloxy, C1-C6 alkylthio, arylthio, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, NO2, CN, SO3H, SO2N(RgRh), SO2Rg, COORg, or C(O)Rg; or one R4, R5, R6, and R7 is O \u2014(CReRf)n\u2014X \u2014Rc, or O \u2014C(ReRf)Rd; and each of the others, independently, is H, OH, halogen, C3-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, aryl, heteroaryl, C3-C6 alkoxy, aryloxy, heteroaryloxy, C1, -C6 alkylthio, arylthio, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, NO2, CN, SO3H, SO2N(RgRh), SO2Rg, COORg, or C(O)Rg; in which m is 3-5; n is 2-5; X is O; Rc is C1-C6 alkyl, COORj, heteroaryl, or aryl optionally substituted with OH, halogen, C3-C6 alkyl, C3-C15 cycloalkyl, C3-C15 heterocycloalkyl, C1-C6 alkoxy, aryloxy, heteroaryloxy, heteroaryl, aryl, NO2, CN, COORj, or C(O)Rj; Rd is H, OH, halogen, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, C1-C6 alkyl, COORi; each Re, independently, is H, C1-C6 alkyl, aryl, or heteroaryl; each Rf, independently, is H, C1-C6 alkyl, and each Rg is H, C1-C6 alkyl, aryl, or heteroaryl; and each Rh is H, C1C6 alkyl, each Ri is C1-C6 alkyl, aryl, or heteroaryl; each Rj is H, C1-C6 alkyl, aryl, or heteroaryl.
19. The compound of claim 18, wherein R1 is C1-C6 alkyl or SO2Ra; each of R2, and R3 is H; and one of R4, R5, R6, R7 is (CReRf)n\u2014X \u2014Rc or O \u2014(CReRf)n\u2014X \u2014Rc, and each of the others, independently, is H, C1-C6 alkyl, C1-C6 alkoxy, or COORf; and Rc is heteroaryl or aryl substituted with heteroaryl or C(O)Ri.
20. The compound of claim 19, wherein Rc is heteroaryl.
21. The compound of claim 20, wherein Rc is pyridinyl.
22. A pharmaceutical composition comprising a compound of claim 18 and a pharmaceutically acceptable carrier.
23. A pharmaceutical composition comprising a compound of claim 18 and tetraethylthiuram disulfide.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound represented by formula (I):
wherein R1 is a hydrogen atom(s) or a substituent(s),
t is 0 or an integer of 1 to 8, when t is 2 or more, R1s are same or different, two R1s may together form a cyclic group which may have a substituent(s);
R2, R3, R4, R5, R6 and R7 are each independently a hydrogen atom(s) or a substituent(s), R4 and R5 andor R6 and R7 may form a cyclic group which may have a substituent(s) together with their binding carbon atom;
ring A1 is a monocyclic carbocyclic ring or a monocyclic heterocyclic ring;
ring A2 is a cyclic group which may have a substituent(s);
B is a hydrogen atom, a hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s);
X and Z are each independently a bond, C1-3 alkylene which may have a substituent(s), C2-3 alkenylene which may have a substituent(s) or C2-3 alkynylene which may have a substituent(s);
Y is a bond, \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, \u2014C(\u2550O)NR8\u2014, \u2014C(\u2550S)NR8\u2014, \u2014SO2\u2014, \u2014C(\u2550O)O\u2014 or \u2014SO2NR8\u2014 group wherein X binds to a left side of each group,
R8 is a hydrogen atom or a substituent;
m is 0 or 1;
is a single bond or a double bond wherein 1) a and b are not a double bond at the same time, 2) when m is 0, b is a double bond, 3) when m is 1, b is a single bond,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
2. The compound according to claim 1, wherein R4 and R5 form a cyclic group which may have a substituent(s) together with their binding carbon atom, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
3. The compound according to claim 1, wherein ring A1 is a monocyclic heterocyclic ring, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
4. The compound according to claim 1, wherein ring A1 is a monocyclic carbocyclic ring, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
5. The compound according to claim 1, wherein X is a bond, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
6. The compound according to claim 1, wherein Y is \u2014C(\u2550O)\u2014 or \u2014C(\u2550O)NR8\u2014 wherein X binds to a left side of each group, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
7. The compound according to claim 1, wherein Z is a bond or C1-3 alkylene which may have a substituent(s), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
8. The compound according to claim 1, wherein B is C1-8 alkyl which may have a substituent(s), C3-10 monocyclic or bicyclic aromatic carbocyclic which may have a substituent(s), a carbocyclic ring which is partially or fully saturated, or 3-10 membered monocyclic or bicyclic aromatic heterocyclic ring which may be partially or fully saturated, and which contains 1 to 4 hetero atom(s) selected from an oxygen atom, a nitrogen atom andor a sulfur atom, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
9. The compound according to claim 1, which is a compound represented by formula (I-A):
wherein all the symbols have the same meanings as described in claim 1, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
10. The compound according to claim 9, which is a compound represented by formula (I-A-1):
wherein R1A has the same meaning as R1;
tB is 0 or an integer of 1 to 3, when tB is 2 or more, R1s are same or different;
other symbols have the same meanings as described in claim 1,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
11. The compound according to claim 1, which is a compound represented by formula (I-B-1):
wherein tA is 0 or an integer of 1 to 4, when tA is 2 or more, R1s are same or different;
R4 and R5 form cyclic group which may have a substituent(s) together with their binding carbon atom;
other symbols have the same meanings as described in claim 1,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
12. The compound according to claim 1, which is a compound represented by formula (I-B-2):
wherein all symbols have the same meaning as described in claim 1 or 10,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
13. The compound according to claim 11, which is a compound represented by formula (I-B-1-1):
wherein B2 is C1-8 alkyl which may have a substituent(s);
D is an atom which constitutes ring A and is a carbon atom or a nitrogen atom,
\u2003is a cyclic group which has at least two same or different substituents;
other symbols have the same meanings as described in claim 1 or 11, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
14. The compound according to claim 13, wherein
is a cyclic group which has two same or different substituents, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
15. The compound according to claim 14,
wherein one substituent on ring A2 is (1) C1-8 alkoxy which may have a substituent(s), or (2) C3-7 cycloalkyloxy which may have a substituent(s);
the other substituent is selected from (1) a halogen atom, (2) cyano, (3) C1-8 alkyl which may have a substituent(s) and (4) C1-8 alkoxy which may have a substituent(s),
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
16. The compound according to claim 15,
wherein one substituent on ring A2 is selected from (1) methoxy which may have a fluorine atom(s), (2) isopropoxy which may have a fluorine atom(s), (3) cyclopentyloxy which may have a fluorine atom(s);
the other substituent is selected from (1) a fluorine atom, (2) a chlorine atom, (3) cyano, (4) methyl, and (5) methoxy which may have a fluorine atom(s),
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
17. The compound according to claim 14, wherein the cyclic group represented by
is a benzene ring, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
18. The compound according to claim 13, wherein one substituent is substituted to an atom neighboring D, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
19. The compound according to claim 13, which is a compound represented by formula (I-B-1-1-a):
wherein is \u03b2-configuration and other symbols have the same meanings as described in claim 13,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
20. The compound according to claim 14, which is a compound represented by formula (I-B-1-2):
wherein R20 is C1-8 alkoxy which may have a substituent(s) or C3-7 cycloalkyl which may have a substituent(s);
R202 is a halogen atom, cyano, C1-8 alkyl which may have a substituent(s) or C1-8 alkoxy which may have a substituent(s);
other symbols have the same meanings as described in claim 11,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
21. The compound according to claim 20, which is a compound represented by formula (I-B-1-2-a):
wherein all symbols have the same meanings as described in claim 11, 19 or 20,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
22. The compound according to claim 20 or 21,
wherein R201 is selected from (1) methoxy which may have a fluorine atom(s), (2) isopropoxy which may have a fluorine atom(s), and (3) cyclopentyloxy which may have a fluorine atom(s);
R202 is selected from (1) a fluorine atom, (2) a chlorine atom, (3) cyano, (4) methyl, and (5) methoxy which may have a fluorine atom(s),
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
23. The compound according to claim 1, which is
(1) 1-(1,3-benzodioxol-5-yl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(2) 2-acetyl-1-(2,4-difluorophenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(3) 2-acetyl-1-(3,4-difluorophenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(4) 2-acetyl-1-(3-fluorophenyl)-6-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(5) 2-acetyl-6-fluoro-1-(3-fluorophenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(6) 2-acetyl-1-(2,4-difluorophenyl)-6-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(7) 2-acetyl-1-(3,4-difluorophenyl)-6-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(8) 2-acetyl-1-(3-fluorophenyl)-7-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(9) 2-acetyl-7-fluoro-1-(3-fluorophenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(10) 2-acetyl-1-(3-fluorophenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(11) 1-(2,6-difluorophenyl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(12) 1-(3,5-difluorophenyl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(13) 1-(2,4-difluorophenyl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(14) 1-(2,3-difluorophenyl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(15) 1-(2,5-difluorophenyl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(16) 1-(3,4-difluorophenyl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(17) 6-chloro-N-(3,5-dimethylphenyl)-1-(3-fluorophenyl)-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(18) N-(3,5-dimethylphenyl)-1-(3-fluorophenyl)-6-methoxy-1,9-dihydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-2(3H)-carboxamide,
(19) 2-acetyl-1-(3-fluorophenyl)-6,7-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(20) 2-acetyl-1-(2,4-difluorophenyl)-6,7-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(21) 2-acetyl-1-(2,4-difluorophenyl)-7-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(22) 2-acetyl-1-(3,4-difluorophenyl)-7-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(23) 2-acetyl-5-fluoro-1-(3-fluorophenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(24) 2-acetyl-1-(2,4-difluorophenyl)-5-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(25) 2-acetyl-1-(3,4-difluorophenyl)-5-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(26) 2-acetyl-1-(3-fluorophenyl)-8-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(27) 2-acetyl-1-(2,4-difluorophenyl)-8-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(28) 2-acetyl-1-(3,4-difluorophenyl)-8-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(29) 2-acetyl-1-(3-fluorophenyl)-6,8-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(30) 2-acetyl-1-(3,4-difluorophenyl)-6,8-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(31) 8-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-(3,5-dimethylphenyl)-5,6,8,9-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine-7-carboxamide,
(32) N-(3,5-dimethylphenyl)-8\u2032-(3-fluorophenyl)-1\u2032,8\u2032-dihydrospirocyclopropane-1,5\u2032-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine-7\u2032(6\u2032H)-carboxamide,
(33) N-(3,5-dimethylphenyl)-8-(3-fluorophenyl)-9-methyl-5,6,8,9-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine-7-carboxamide,
(34) N-(3,5-dimethylphenyl)-8-(3-fluorophenyl)-1-methyl-1,5,6,8-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine-7-carboxamide,
(35) N-(3,5-dimethylphenyl)-6-(3-fluorophenyl)-5,6,8,9-tetrahydro-7H-pyrido3\u2032,4\u2032:4,5pyrrolo2,3-cpyridine-7-carboxamide,
(36) 7-acetyl-6-(3-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrido3\u2032,4\u2032:4,5pyrrolo2,3-cpyridine,
(37) N-(3,5-dimethylphenyl)-8\u2032-(3-fluorophenyl)-1\u2032-methyl-1\u2032,8\u2032-dihydrospirocyclopropane-1,5\u2032-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine-7\u2032(6\u2032H)-carboxamide,
(38) 7\u2032-acetyl-8\u2032-(3-fluorophenyl)-1\u2032-methyl-1\u2032,6\u2032,7\u2032,8\u2032-tetrahydrospirocyclopropane-1,5\u2032-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine,
(39) N-(3,5-dimethylphenyl)-8-(3-methoxyphenyl)-1-methyl-1,5,6,8-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine-7-carboxamide,
(40) 8-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-(3,5-dimethylphenyl)-1-methyl-1,5,6,8-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo2,3-bpyridine-7-carboxamide,
(41) N-(3,5-dimethylphenyl)-6-(3-fluorophenyl)-2-methoxy-5,6,8,9-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo3,2-bpyridine-7-carboxamide,
(42) 2-chloro-N-(3,5-dimethylphenyl)-6-(3-fluorophenyl)-5,6,8,9-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo3,2-bpyridine-7-carboxamide,
(43) N-(3,5-dimethylphenyl)-6-(3-fluorophenyl)-5,6,8,9-tetrahydro-7H-pyrido4\u2032,3\u2032:4,5pyrrolo3,2-bpyridine-7-carboxamide,
(44) 7-acetyl-2-chloro-6-(3-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrido4\u2032,3\u2032:4,5pyrrolo3,2-bpyridine,
(45) 7-acetyl-6-(3-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrido4\u2032,3\u2032:4,5pyrrolo3,2-bpyridine,
(46) 2-ethyl-1-(3-fluorophenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(47) 2-acetyl-5-fluoro-1-(2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(48) 2-acetyl-5-methoxy-1-(2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane, or
(49) 4-(2-acetyl-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-1-yl)benzonitrile,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
24. The compound according to claim 13, which is
(1) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(2) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(3) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-5,6-difluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(4) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-6-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(5) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(6) 2-acetyl-5-chloro-1-(4-chloro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(7) 2-acetyl-5-chloro-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(8) 2-acetyl-5-fluoro-1-(2-fluoro-6-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(9) 2-acetyl-6-fluoro-1-(4-fluoro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(10) 2-acetyl-5-fluoro-1-(4-fluoro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(11) 2-acetyl-1-(5-fluoro-2-methoxyphenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(12) 2-acetyl-1-(4-fluoro-2-methoxyphenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(13) 2-acetyl-1-(2,4-dimethoxyphenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane
(14) 2-acetyl-1-(2-fluoro-6-methoxyphenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(15) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-6,7-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(16) 2-acetyl-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(17) 2-acetyl-5-fluoro-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(18) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-6-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(19) 2-acetyl-1-(4-fluoro-2-methoxyphenyl)-6-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(20) 2-acetyl-6-methoxy-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(21) 2-acetyl-1-(2-fluoro-6-methoxyphenyl)-6-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(22) 2-acetyl-6,7-dimethoxy-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(23) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-methyl-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(24) 2-acetyl-1-(2-methoxy-4-methylphenyl)-5-methyl-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(25) 2-acetyl-1-(2,3-dihydro-1-benzofuran-7-yl)-6-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(26) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-6-methoxy-5-methyl-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(27) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-5,6-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(28) (1S)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(29) (\u2212)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5,6-difluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(30) (+)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5,6-difluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(31) (+)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(32) (+)-2-acetyl-1-(2-fluoro-6-methoxyphenyl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(33) (+)-2-acetyl-5-fluoro-1-(2-fluoro-6-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(34) (+)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-6,7-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(35) 2-acetyl-5-chloro-1-(4-fluoro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(36) 2-acetyl-5,6-difluoro-1-(4-fluoro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(37) 2-acetyl-5,6-difluoro-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(38) 2-acetyl-5-chloro-1-(2-fluoro-6-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(39) 2-acetyl-1-(4-chloro-2-isopropoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(40) 2-acetyl-1-4-chloro-2-(cyclopentyloxy)phenyl-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(41) 4-(2-acetyl-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-1-yl)-3-methoxybenzonitrile,
(42) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-5,7-difluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(43) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-8-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(44) 4-(2-acetyl-5-fluoro-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane-1-yl)-3-methoxybenzonitrile,
(45) 2-acetyl-5,6-dimethoxy-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(46) 2-acetyl-1-(2,3-dihydro-1-benzofuran-7-yl)-5-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(47) 2-acetyl-5-methoxy-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(48) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-6,8-dimethoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(49) 2-acetyl-6-chloro-1-(4-chloro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(50) 2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-8-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(51) 2-acetyl-5-fluoro-1-(4-fluoro-2-methoxyphenyl)-8-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(52) (+)-2-acetyl-1-(2-fluoro-6-methoxyphenyl)-6-methoxy-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(53) (+)-2-acetyl-1-(2-methoxy-4-methylphenyl)-5-methyl-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(54) (+)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-6-methoxy-5-methyl-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(55) (+)-2-acetyl-5-fluoro-1-(4-fluoro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
(56) (+)-2-acetyl-5,6-difluoro-1-(2-methoxy-4-methylphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane, or
(57) (+)-2-acetyl-5-chloro-1-(4-chloro-2-methoxyphenyl)-1,2,3,9-tetrahydrospiro\u03b2-carboline-4,1\u2032-cyclopropane,
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
25. A pharmaceutical composition comprising the compound represented by formula (I) described in claim 1, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.
26. The pharmaceutical composition according to claim 25, which is an agent for preventing andor treating a disease caused by stress.
27. The pharmaceutical composition according to claim 26, wherein the disease caused by stress is a digestive system disease caused by stress.
28. The pharmaceutical composition according to claim 27, wherein the digestive system disease caused by stress is irritable bowel syndrome, ulcerative colitis, or Crohn’s disease.
29. A pharmaceutical composition comprising the compound represented by formula (I) described in claim 1, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof and one or more kind of agents selected from an antianxiety, an antidepressant, an anticholinergic, a gastrointestinal tract function regulator, a gastrointestinal tract prokinetic drug, an antidiarrheal, an evacuant, a calcium antagonist, a phosphodiesterase inhibitor and a serotonin antagonist in combination.
30. A method for preventing andor treating a disease caused by stress in a mammal comprising administering an effective amount of the compound represented by formula (I) described in claim 1, a salt thereof, an N-oxide, a solvate or a prodrug thereof to the mammal.