Author: claimsbot

1. A method for treating pulmonary disease comprising delivering directly to a patient’s lungs a therapeutically effective amount of oxybutynin in combination with one or more pharmaceutically effective agents.
2. The method according to claim 1, wherein oxybutynin is delivered in dry powder form.
3. The method according to claim 1, wherein pharmaceutically effective agent is delivered in dry powder form.
4. The method according to claim 1, wherein the dry powder oxybutynin is selected from the group consisting of a xinafoate salt, a palmitate salt, a pamoic salt, a resonate salt and a laurate salt.
5. The method according to claim 1, wherein oxybutynin comprises oxybutynin xinafoate.
6. The method of claim 1, wherein the pharmaceutically effective agents comprise bronchodilators, antiinflammatories, corticosteroids, inhaled corticosteroid, corticosteroid reversal agents, alveolar growth agents, proteinase inhibitors, or protease inhibitors.
7. The method of claim 6, wherein the bronchodilators comprise long-acting beta agonists and short-acting beta agonists and derivatives or pharmaceutically acceptable salts thereof.
8. The method of claim 6, wherein the antiinflammatories comprise inhaled corticosteroids, phosphodiesterase inhibitors or leukotriene receptor antagonists.
9. The method of claim 8, wherein the corticosteroids comprise budesonide, fluticasone, beclomethasone, flunisolide, triamcinolone, ciclesonide, loteprednol, fluorometholone, and derivatives or pharmaceutically acceptable salts thereof.
10. The method of claim 6, wherein the corticosteroid reversal agent comprises vitamin D, synthetic vitamin D, vitamin D analogs, vitamin D receptor agonists, vitamin D receptor partial agonists, calcitriol, antioxidants, iNOS inhibitors, Phosphoinositide-3-kinase-.delta. inhibitors, p38 MAP kinase inhibitors, JNK inhibitors, MIF inhibitors, low-dose theophylline, p-glycoprotein inhibitors, macrolides, calcineurin inhibitors, statins and equivalents thereof.
11. The method of claim 6, wherein the alveolar growth agent comprises vitamin A, All Trans Retinoic Acid (ATRA), retinoic acid receptor (RAR) agonists and RAR selective alveolar growth agents, RAR selective agonists, palovarotene and equivalents thereof.
12. The method of claim 7, wherein the oxybutynin comprises oxybutynin xinofoate, and the long-acting beta agonist comprises formoterol, salmeterol, odalaterol, carmoterol or vilanterol.
13. The method of claim 12, further comprising an inhaled corticosteroid wherein the inhaled corticosteroid comprises budesonide, fluticasone, or mometasone.
14. The method of claim 13, further comprising a selective agent selected from a soft steroid class, wherein the soft steroid class comprises ciclesonide or loteprednol.
15. The method of claim 12, further comprising a CR reversal agent, wherein the CR reversal agent is selected from the group consisting of vitamin D, vitamin D analogs, synthetic vitamin D, vitamin D receptor agonists and antagonists, calcitol and equivalents thereof.
16. The method of claim 14, further comprising a CR reversal agent wherein the CR reversal agent is selected from the group consisting of vitamin D, vitamin D analogs, synthetic vitamin D, vitamin D receptor agonists and antagonists, calcitol and equivalents thereof.
17. The method of claim 1,
wherein the oxybutynin comprises oxybutynin xinofoate, the pharmaceutically effective agents comprise
a long-acting beta agonist comprising formoterol,
and an alveolar growth agent selected from the group consisting ATRA, cis-retionoic acid and palovarotene.
18. The method of claim 1, wherein the pulmonary disease comprises asthma, atelectasis, bronchitis, chronic obstructive pulmonary disease, emphysema, lung cancer, pneumonia or pulmonary edema.
19. The method of claim 1, wherein the pulmonary disease comprises chronic obstructive pulmonary disease,
wherein the oxybutynin comprises oxybutynin xinofoate,
and wherein the pharmaceutically effective agents comprise long acting muscarinic antagonists.
20. The method according to claim 1, wherein oxybutynin and the pharmaceutically effective agent is delivered using a dry powder inhaler (DPI) or a metered dose inhaler (MDI) or liquid nebulizer.
21. The method according to claim 19, wherein the dry powder inhaler includes a piezo vibrator.
22. The method according to claim 1, wherein oxybutynin is delivered in dry powder form having a mass median aerodynamic particle size selected from the group consisting of 0.5-20 microns, 0.5-15 microns, 0.5-10 microns, or 0.5-5 microns.
23. The method according to claim 1, wherein the dosage of the therapeutically effective amount of oxybutynin in combination with one or more pharmaceutically effective agents is within the range of 0.001 to 20 mg per day, 0.02 to 15 mg per day, or 0.05 to 10 mg per day administered as needed.
24. A method for treating chronic obstructive pulmonary disease comprising delivering directly to a patient’s lungs a therapeutically effective amount of oxybutynin in combination with one or more pharmaceutically effective agents.
25. The method of claim 24 wherein oxybutynin is selected from the group consisting of a xinafoate salt, a palmitate salt, a pamoic salt, a resonate salt and a laurate salt.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A six-piece optical lens system comprising, in order from an object side to an image side:
a first lens element with a negative refractive power having a concave image-side surface, at least one of an object-side and the image-side surfaces of the first lens element being aspheric;
a second lens element with a positive refractive power having a convex image-side surface, at least one of an object-side and the image-side surfaces of the second lens element being aspheric;
a third lens element with a positive refractive power having a convex object-side surface;
a fourth lens element with a negative refractive power having a concave image-side surface, at least one of an object-side and the image-side surfaces of the fourth lens element being aspheric;
a fifth lens element with a positive refractive power having a convex object-side surface;
a sixth lens element with a negative refractive power having a concave image-side surface, at least one of an object-side and the image-side surfaces of the sixth lens element being aspheric; and
one of the third lens element and the fifth lens element being made of glass;
wherein a focal length of the first lens element is f1, a focal length of the second lens element and the third lens element combined is f23, and they satisfy the relation:
1.4<|f1||f23|<2.1.
2. The six-piece optical lens system as claimed in claim 1 further comprising a stop which is located between the first lens element and the second lens element.
3. The six-piece optical lens system as claimed in claim 1 further comprising a stop which is located between the second lens element and the third lens element.
4. The six-piece optical lens system as claimed in claim 1, wherein the focal length of the first lens element is f1, a focal length of the third lens element is f3, and they satisfy the relation:
0.6<|f1||f3|<2.0.
5. The six-piece optical lens system as claimed in claim 1, wherein a focal length of the third lens element is f3, a focal length of the fourth lens element is f4, and they satisfy the relation:
0.5<|f3||f4|<1.8.
6. The six-piece optical lens system as claimed in claim 1, wherein a focal length of the fourth lens element is f4, a focal length of the fifth lens element is f5, and they satisfy the relation:
0.4<|f4||f5|<1.2.
7. The six-piece optical lens system as claimed in claim 1, wherein a focal length of the first lens element, the second lens element and the third lens element combined is f123, a focal length of the six-piece optical lens system is f, and they satisfy the relation:
0.5<|f123||f|<1.0.
8. The six-piece optical lens system as claimed in claim 1, wherein a focal length of the fourth lens element, the fifth lens element and the sixth lens element combined is f456, a focal length of the six-piece optical lens system is f, and they satisfy the relation:
2.5<|f456||f|<4.8.
9. The six-piece optical lens system as claimed in claim 1, wherein the focal length of the second lens element and the third lens element combined is f23, a focal length of the fourth lens element and the fifth lens element combined is f45, and they satisfy the relation:
|f23||f45|<0.3.
10. The six-piece optical lens system as claimed in claim 1, wherein the focal length of the second lens element and the third lens element combined is f23, a focal length of the fifth lens element and the sixth lens element combined is f56, and they satisfy the relation:
0.3<|f23||f56|<0.8.
11. The six-piece optical lens system as claimed in claim 1, wherein a focal length of the six-piece optical lens system is f, a distance from the object-side surface of the first lens element to an image plane along an optical axis is TL, and they satisfy the relation:
|fTL|<0.5.
12. The six-piece optical lens system as claimed in claim 1, wherein the first, second, third, fourth, and sixth lens elements are made of plastic, the fifth lens element is made of glass, the object-side surface of the first lens element is convex, the object-side surface and the image-side surface of the first lens element are aspheric, the object-side surface of the second lens element is convex, the object-side surface and the image-side surface of the second lens element are aspheric, the image-side surface of the third lens element is convex, the object-side surface and the image-side surface of the third lens element are aspheric, the object-side surface of the fourth lens element is concave, the object-side surface and the image-side surface of the fourth lens element are aspheric, the image-side surface of the fifth lens element is convex, the object-side surface and the image-side surface of the fifth lens element are aspheric, the object-side surface of the sixth lens element is convex, and the object-side surface and the image-side surface of the sixth lens element are aspheric.
13. The six-piece optical lens system as claimed in claim 1, wherein the first, second, fourth, fifth and sixth lens elements are made of plastic, the third lens element is made of glass, the object-side surface of the first lens element is convex, the object-side surface and the image-side surface of the first lens element are aspheric, the object-side surface of the second lens element is convex, the object-side surface and the image-side surface of the second lens element are aspheric, the image-side surface of the third lens element is convex, the object-side surface and the image-side surface of the third lens element are aspheric, the object-side surface of the fourth lens element is concave, the object-side surface and the image-side surface of the fourth lens element are aspheric, the image-side surface of the fifth lens element is convex, the object-side surface and the image-side surface of the fifth lens element are aspheric, the object-side surface of the sixth lens element is convex, and the object-side surface and the image-side surface of the sixth lens element are aspheric.

1. A design support system for aiding design of a semiconductor integrated circuit, the design support system comprising:
a rough wiring unit configured to:
receive cell arrangement information indicating an arrangement of a plurality of cells;
define a plurality of rough grid areas on a wiring region having a plurality of layers;
roughly allocate wiring paths into each rough grid area, wherein the wiring paths are configured to connect the plurality of cells, and wherein the wiring paths are allocated based on occupying areas of the wiring paths when a multi-cut via is used; and
output rough wiring path information indicating the roughly allocated wiring paths;

a detailed wiring unit configured to:
receive the rough wiring path information;
arrange the wiring paths in each rough grid area by use of a single-cut via; and
output detailed wiring path information indicating the arranged wiring paths; and

multi-cut via replacing unit configured to:
receive the detailed wiring path information; and
replace the single-cut via with the multi-cut via; and
output layout information indicating the wiring paths that have been arranged with the multi-cut via replacing the single-cut via.
2. The design support system according to claim 1, wherein the multi-cut via has a plurality of holes for a connection between the plurality of layers.
3. The design support system according to claim 1, wherein rough wiring unit is further configured to calculate wiring resource consuming information that indicates the number of adjacent wiring paths which can be consumed when the multi-cut via is to be used.
4. The design support system according to claim 1, wherein the rough wiring unit is further configured to calculate a wiring congestion degree by calculating a ratio of the number of rough wiring paths actually allocated to a total number of preset rough wiring paths.
5. The design support system according to claim 1, wherein the detailed wiring unit is further configured to:
dispose a plurality of virtual terminals in the wiring region; and
connect the plurality of virtual terminals using one of a labyrinth method or a segment searching method.
6. The design support system according to claim 5, wherein the detailed wiring unit uses the labyrinth method and is further configured to:
set one of the plurality of virtual terminals to be a source and another one to be a target; and
label a distance from the source in such a manner that a wave spreads from the source, so that the shortest wiring path can be determined between the source and the target.
7. The design support system according to claim 5, wherein the detailed wiring unit uses the segment searching method and is further configured to obtain a path by:
generating a segment to be a candidate of the wiring path between the plurality of virtual terminals; and
searching for the wiring path between the plurality of terminals to minimize the number of segments.
8. The design support system according to claim 1, wherein the rough wiring unit is further configured to calculate, for each rough grid area, a wiring congestion degree based on:
the number of the multi-cut vias to be used; and
a wiring resource required to dispose the multi-cut vias.
9. The design support system according to claim 8, wherein the rough wiring unit is further configured to make the wiring congestions degree substantially uniform among the rough grid areas thereby correcting the rough wiring path.
10. The design support system according to claim 1, wherein the rough wiring unit is further configured to estimate the number of the multi-cut vias to be used based on an intersecting point information of a Steiner Tree of the roughly-allocated wiring paths.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-21. (canceled)
22. A system comprising:
a ventilation device; and
a vital signs tracking device; and
an airway opening device,
wherein the system is configured to facilitate an opening of an airway of a subject in a supine position using the airway opening device, by alerting or instructing a user upon an attempt to open an airway, and
wherein the alerting or instructing is based on real time measurements of the vital signs of the subject tracked by the vital signs tracking device during the attempt to open an airway.
23. The system according to claim 22, wherein the ventilation device is further configured, upon a successful opening of an airway, to supply oxygen to the subject such that oxygen supply is sufficient, based on real time measurements of the vital signs of the subject tracked during oxygen supply.
24. The system according to claim 22, further configured, upon a successful opening of an airway, to supply oxygen to the subject and to alert the user whenever the oxygen supply is non-satisfactory, based on real time measurements of the vital signs of the subject tracked during oxygen supply.
25. The system according to claim 22, further comprising a housing enclosing the ventilation device and further shaped as a neck support.
26. The system according to claim 1, further comprising a communications unit configured to: (i) transmit data collected via said vital signs tracking device to a remote location and (ii) receive data andor instructions from the remote location.
27. The system according to claim 26, wherein the transmission of collected data from the system, and the receipt of the data andor instructions from the remote location are carried out automatically.
28. The system according to claim 22, wherein the system is further configured to record over time the tracked vital signs of the subject and treatment carried out by the user, for later analysis.
29. The system according to claim 22, further comprising a location tracking unit for determining a geographic location of the system.
30. The system according to claim 22, further comprising a mechanism for modifying a head angle of said subject when in said supine position.
31. The system according to claim 30, wherein said mechanism is operated manually by the user in accordance with instructions presented by the system which are further based on the tracked vital signs.
32. The system according to claim 30, wherein said mechanism is operated automatically based on the tracked vital signs.
33. The system according to claim 30, wherein said mechanism includes a motor, a servo or an inflatable bladder.
34. The system according to claim 22, wherein said ventilation device includes a pressurized oxygen source and a face mask.
35. The system according to claim 22, wherein the vital signs tracking device is configured to track at least one of: a respiration rate, a heart rate, blood pressure, pulse rate, and blood oxygenation.
36. The system according to claim 22, wherein the housing includes a recess at a top surface thereof, said recess being designed for accommodating a neck of said subject in a manner which extends said neck to open an airway of said subject.
37. The system according to claim 22, wherein said vital signs tracking device is configured as a wrist cuff.
38. The system according to claim 35, wherein said ventilation device includes a respiration sensor.
39. The system according to claim 38, wherein said respiration sensor is positioned in a reservoir of said face mask.
40. The system according to claim 38, wherein data from said respiration sensor is useable for determining a respiration parameter that is at least one of: inspirationexpiration ratio, respiration rate, and respiratory volume.