Author: claimsbot

1. A composite support comprising:
an ordered mesoporous carbon comprising mesopores having an average diameter of about 2 nanometers to about 8 nanometers; and
a silicon carbide dispersed in the ordered mesoporous carbon,
wherein the ordered mesoporous carbon is in the form of a framework including walls which define the mesopores, and
wherein the silicon carbide is in the form of a particle and is disposed on an inner surface of the walls of the framework of the ordered mesoporous carbon.
2. The composite support of claim 1, wherein the silicon carbide is disposed on an inner surface and on an outer surface of the walls of the framework of the ordered mesoporous carbon.
3. The composite support of claim 1, wherein the silicon carbide is bound to the ordered mesoporous carbon.
4. The composite support of claim 1, wherein the silicon carbide has a shape of least one selected from a spherical, platelet, amorphous, and an acicular shape.
5. The composite support of claim 1, wherein the ordered mesoporous carbon and the silicon carbide are in a weight ratio of about 1:99 to about 30:70.
6. The composite support of claim 1, wherein the composite support has a specific surface area of about 300 square meters per gram to about 600 square meters per gram.
7. A method of preparing a composite support, the method comprising:
contacting an ordered mesoporous silica template and a carbonaceous precursor-containing mixture to prepare a first mixture;
thermally treating the first mixture at a temperature of about 1300\xb0 C. to about 1500\xb0 C. to form a pre-composite comprising an ordered mesoporous carbon comprising mesopores having an average diameter of about 2 nanometers to about 8 nanometers, a silicon carbide dispersed in the ordered mesoporous carbon, and the ordered mesoporous silica template; and
removing the ordered mesoporous silica template from the pre-composite to prepare the composite support, wherein the composite support comprises the ordered mesoporous carbon comprising mesopores having an average diameter of about 2 nanometers to about 8 nanometers and the silicon carbide dispersed in the ordered mesoporous carbon,
wherein the ordered mesoporous carbon is in the form of a framework including walls which define the mesopores,
wherein the silicon carbide is in the form of a particle and is disposed on an inner surface of the walls of the framework of the ordered mesoporous carbon, and
wherein the silicon carbide in the pre-composite is derived from the ordered mesoporous silica template and the carbonaceous precursor of the first mixture.
8. The method of claim 7, wherein the ordered mesoporous silica template comprises at least one selected from MCM-48, SBA-1, SBA-15, KIT-1, and MSU-1.
9. The method of claim 7, wherein a carbonaceous precursor of the carbonaceous precursor-containing mixture comprises at least one selected from glucose, sucrose, fructose, benzene, naphthalene, anthracene, phenanthrene, pyrene, phenol-formaldehyde (PF) resin, urea-formaldehyde (UF) resin, quinoxaline, propylenediamine, 4,4\u2032-dipyridyl, phenanthroline, p-toluenesulfonic acid, and furfuryl mercaptan.
10. The method of claim 7, wherein the carbonaceous precursor-containing mixture further comprises a metal precursor and a solvent.
11. The method of claim 7, wherein the thermally treating of the first mixture is performed at a temperature of about 1350\xb0 C. to about 1450\xb0 C.
12. The method of claim 7, wherein the thermal treating of the first mixture is performed in an inert atmosphere.
13. The method of claim 7, wherein the removing of the ordered mesoporous silica template from the pre-composite comprises contacting the pre-composite with an acid or an alkali solution capable of dissolving silica.
14. An electrode catalyst for a fuel cell, comprising: the composite support of claim 1; and a catalyst particle disposed on the composite support.
15. A membrane-electrode assembly for a fuel cell, the membrane-electrode assembly comprising:
a cathode;
an anode disposed opposite to the cathode; and
an electrolyte membrane disposed between the cathode and the anode,
wherein at least one of the cathode and the anode comprises the electrode catalyst of claim 14.
16. A fuel cell comprising the membrane-electrode assembly of claim 15.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An interface card for interfacing a drive to a LAN without modifying a main control card of the drive, the interface card comprising:
a dual port memory interface to the main control card of the drive for receiving feedbacks and transmitting setpoints;
an ASIC for generating an interrupt signal;
an interrupt line that transmits the interrupt signal and informs a communication processor connected on the main control card to update the feedbacks in the dual port memory and read the setpoints from the dual port memory; and
control registers for interfacing the communication processor to the LAN.
2. The interface card of claim 1, wherein the ASIC is a controller for interfacing with firmware in the communication processor in order to pass data between a main processor and the interface card.
3. The interface card of claim 1, further comprising a stab terminal for a ground connection.
4. The interface card of claim 1, further comprising a LNPL connector for connecting the interface card with the main control card of the drive.
5. The interface card of claim 1, further comprising a 2PL connector for transmitting power to the interface card.
6. The interface card of claim 1, wherein the LAN is an ISBus LAN.
7. A method for interfacing a drive to a LAN without modifying a main control card of the drive, the main control card including a communications processor and a main processor, the method comprising the steps of:
triggering an interrupt to notify the communications processor on the main control card to update feedbacks in a dual port memory and read setpoints from the dual port memory;
transmitting setpoints from the dual port memory interface to the main processor on the main control card;
transmitting feedback from the main processor on the main control card to the dual port memory interface; and
interfacing the communications processor with the LAN with control registers.
8. The method of claim 7, further comprising performing a page swap in the dual port memory after updating the feedbacks in the dual port memory.
9. The method of claim 8, further comprising storing the transmitted set points in a communication processor external RAM inactive page.
10. The method of claim 9, further comprising performing an external RAM page swap.
11. A method for interfacing a drive to a LAN, the drive having a main control card including a communication processor and a main processor, the method comprising the steps of:
providing an interface card having an ASIC, a dual port memory and an interrupt line for transmitting an interrupt signal generated by the ASIC over the interrupt line to the communications processor;
updating feedbacks in an inactive page of the dual port memory;
swapping the inactive page with an active page;
reading setpoints from the inactive page after swapping;
loading setpoints into an external RAM of the communication processor;
performing a page swap on the external RAM of the communication processor; and
transmitting setpoints from the active page of the communication processor external RAM to the main processor.

1. A holding plate for automatic transmission mounted in an automatic transmission of an automotive vehicle and configured to hold wires, characterized in that:
the holding plate is formed with a support surface for holding the wires, a pair of through holes, through which a tie band for tying the wires is inserted, is formed on the support surface, the through holes are formed to be able to hold the wires in a tied state by allowing a free end side of a band portion of the tie band to be successively inserted therethrough and locked to a lock portion formed on an opposite end part of the band portion, and the pair of through holes are formed to have mutually different shapes; and
out of the pair of through holes, the one through which the free end side of the band portion is first inserted includes a general part through which the free end side of the band portion is insertable and an extended part communicating with the general part and formed by extending the general part.
2. The holding plate for automatic transmission of claim 1, wherein, out of the pair of through holes, the other through which the free end part of the band portion is not first inserted is formed to be open sideways by cutting a side edge of the support surface.
3. (canceled)
4. The holding plate for automatic transmission of claim 2, wherein the extended part is arranged at a side of the general part opposite to a side toward which the wires are pulled as being tied by the tie band.
5. The holding plate for automatic transmission of claim 4, wherein the extended part is formed to have a curved hole edge.
6. A wiring unit mounted in an automatic transmission of an automotive vehicle and configured to execute a control relating to a speed changing operation, comprising the holding plate for automatic transmission of claim 5.
7. The holding plate for automatic transmission of claim 1, wherein the extended part is arranged at a side of the general part opposite to a side toward which the wires are pulled as being tied by the tie band.
8. The holding plate for automatic transmission of claim 7, wherein the extended part is formed to have a curved hole edge.
9. A wiring unit mounted in an automatic transmission of an automotive vehicle and configured to execute a control relating to a speed changing operation, comprising the holding plate for automatic transmission of claim 8.
10. The holding plate for automatic transmission of claim 2, wherein the extended part is formed to have a curved hole edge.
11. A wiring unit mounted in an automatic transmission of an automotive vehicle and configured to execute a control relating to a speed changing operation, comprising the holding plate for automatic transmission claim 10.
12. The holding plate for automatic transmission of claim 1, wherein the extended part is formed to have a curved hole edge.
13. A wiring unit mounted in an automatic transmission of an automotive vehicle and configured to execute a control relating to a speed changing operation, comprising the holding plate for automatic transmission of claim 12.
14. A wiring unit mounted in an automatic transmission of an automotive vehicle and configured to execute a control relating to a speed changing operation, comprising the holding plate for automatic transmission of claim 1.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

What is claimed is:

1. A compound of formula (Ia)

33
wherein R1, R2, R3, and R4 independently of each other represent hydrogen, halogen, perhalomethyl, hydroxy, nitro, cyano, formyl, or C1-12alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, C1-12alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyC1-12alkyl, amino, acylamino, C1-12alkyl-amino, arylamino, aralkylamino, aminoC1-12alkyl, C1-12alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C1-12alkoxyC1-12alkyl, aryloxyC1-12alkyl, aralkoxyC1-12alkyl, C1-12alkylthio, thioC1-12alkyl, C1-12alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, COR11, or SO2R12, wherein R11 and R12 independently of each other are selected from hydroxy, halogen, perhalomethyl, C1-6alkoxy or amino optionally substituted with one or more C1-6alkyl, perhalomethyl or aryl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
or R1 and R2, R2 and R3 andor R3 and R4 may form a cyclic ring containing from 5 to 7 carbon atoms optionally substituted with one or more C1-6alkyl;
ring A represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro, cyano, formyl, or C1-12alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, C1-12alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyC1-12alkyl, amino, acylamino, C1-12alkyl-amino, arylamino, aralkylamino, aminoC1-12alkyl, C1-12alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C1-12alkoxyC1-12alkyl, aryloxyC1-12alkyl, aralkoxyC1-12alkyl, C1-12alkylthio, thioC1-12alkyl, C1-12alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, COR11, or SO2R12, wherein R11 and R12 independently of each other are selected from hydroxy, halogen, perhalomethyl, C1-12alkoxy or amino optionally substituted with one or more C1-6alkyl, perhalomethyl or aryl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
X is a valence bond, (CHR9), (CHR9)CH2, CHCH, O, O(CHR9), S(CHR9), (NR9)CH2, (CHR9)CHCH, (CHR9)CH2CH2, (CO), OCH2O, (NR9), (NR9)S(O2), CH(CR9), (CO)(CHR9), CH2(SO), S, (SO), (SO2), CH2(SO2), CH2OCH2, wherein R9 is hydrogen, halogen, hydroxy, nitro, cyano, formyl, C1-12alkyl, C1-12alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, C1-12alkyl-amino, arylamino, aralkylamino, aminoC1-12alkyl, C1-12alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C1-12alkoxyC1-12alkyl, aryloxyC1-12alkyl, aralkoxyC1-12alkyl, C1-12alkylthio, thioC1-12alkyl, C1-12alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, COR13, or SO2R14, wherein R13 and R14 independently of each other are selected from hydroxy, halogen, C1-6alkoxy, amino optionally substituted with one or more C1-6alkyl, perhalomethyl or aryl;
T is >N, >CH, >C<, CH2N<;
Z is CH2, CH, >N, O, S, >CO, >SO, >SO2, >NR15, wherein R15 is hydrogen, halogen, hydroxy, nitro, cyano, formyl, C1-12alkyl, C1-12alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, C1-12alkyl-amino, arylamino, aralkylamino, aminoC1-12alkyl, C1-12alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C1-12alkoxyC1-12alkyl, aryloxyC1-12alkyl, aralkoxyC1-12alkyl, C1-12alkylthio, thioC1-12alkyl, C1-12alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, COR16, or SO2R17, wherein R16 and R17 independently of each other are selected from hydroxy, halogen, C1-6alkoxy, amino optionally substituted with one or more C1-6alkyl, perhalomethyl or aryl;
Q is O, S, >NR18, wherein R18 is hydrogen, halogen, hydroxy, nitro, cyano, formyl, C1-12alkyl, C1-12alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryi, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, C1-12alkyl-amino, arylamino, aralkylamino, aminoC1-12alkyl, C1-12alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C1-12alkoxyC1-12alkyl, aryloxyC1-12alkyl, aralkoxyC1-12alkyl, C1-12alkylthio, thioC1-12alkyl, C1-12alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, COR19, or SO2R20, wherein R19 and R20 independently of each other are selected from hydroxy, halogen, C1-6alkoxy, amino optionally substituted with one or more C1-6alkyl, perhalomethyl or aryl;
U is O, S, >SO2, >NR21, wherein R21 is hydrogen or C1-6alkyl;
T(Z)p represents a single bond or a double bond;
Ar represents arylene, heteroarylene, or a divalent heterocyclic group optionally substituted with one or more C1-6alkyl or aryl;
R5 represents hydrogen, hydroxy, halogen, C1-12alkoxy, C1-12alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl or aralkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R5 forms a bond together with R6;
R6 represents hydrogen, hydroxy, halogen, C1-12alkoxy, C1-12alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, acyl or aralkyl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano; or R8 forms a bond together with R5;
R7 represents hydrogen, C1-12alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, aralkyl, C1-12alkoxyC1-12alkyl, C1-12alkoxycarbonyl, aryloxycarbonyl, C1-12alkylaminocarbonyl, arylaminocarbonyl, acyl, heterocyclyl, heteroaryl or heteroaralkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
R8 represents hydrogen, C1-12alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, aralkyl, heterocyclyl, heteroaryl or heteroaralkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
Y represents oxygen, sulphur or NR10, where R10 represents hydrogen, C1-12alkyl, aryl, hydroxyC1-12alkyl or aralkyl groups or when Y is NR10, R8 and R10 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C1-6alkyl;
n is an integer ranging from 1 to 4;
p is an integer ranging from 0 to 1;
or a pharmaceutically acceptable salt thereof.
2. A compound of claim 1 wherein R1, R2, R3, and R4 independently of each other represent hydrogen, halogen, perhalomethyl, hydroxy, cyano, or C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, C1-7alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyC1-7alkyl, amino, acylamino, C1-7alkyl-amino, arylamino, aralkylamino, aminoC1-7alkyl, C1-7alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl, aralkoxyC1-7alkyl, C1-7alkylthio, thioC1-7alkyl, C1-7alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, COR11, or SO2R12, wherein R11 and R12 independently of each other are selected from hydroxy, perhalomethyl, C1-6alkoxy or amino optionally substituted with one or more C1-6alkyl, perhalomethyl or aryl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
or R1 and R2, R2 and R3 andor R3 and R4 may form a cyclic ring containing from 5 to 7 carbon atoms optionally substituted with one or more C1-6alkyl.
3. A compound of claim 1 wherein R1, R2, R3, and R4 independently of each other represent hydrogen, halogen, perhalomethyl, hydroxy, cyano, or C1-7alkyl, C4-7-alkenynyl, C27-alkenyl, C2-7-alkynyl, C1-7alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, hydroxyC1-7alkyl, amino, acylamino, C1-7alkyl-amino, arylamino, aralkylamino, aminoC1-7alkyl, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl, aralkoxyC1-7alkyl, C1-7alkylthio, thioC1-7alkyl, C1-7alkoxycarbonylamino, aryloxycarbonylamino or aralkoxycarbonylamino.
4. A compound of claim 1 wherein R1, R2, R3, and R4 independently of each other represent hydrogen, halogen, perhalomethyl, hydroxy, cyano, or C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, C1-7alkoxy, aryl, aryloxy, aralkyl, aralkoxy, acyl, hydroxyC1-7alkyl, amino, C1-7alkyl-amino, arylamino, aralkylamino, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl, aralkoxyC1-7alky or C1-7alkylthio.
5. A compound of claim 1 wherein R1, R2, R3, and R4 independently of each other represent hydrogen, halogen, perhalomethyl, or C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, aryl, aralkyl, hydroxyC1-7alkyl, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl or aralkoxyC1-7alkyl.
6. A compound of claim 1 wherein R1, R2, R3, and R4 independently of each other represent hydrogen, halogen or C1-7alkyl.
7. A compound of claim 1 wherein R1, R2, R3, and R4 represent hydrogen.
8. A compound of claim 1 wherein ring A represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, cyano, or C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, C1-7alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxyC1-7alkyl, amino, acylamino, C1-7alkyl-amino, arylamino, aralkylamino, aminoC1-7alkyl, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl, aralkoxyC1-7alkyl, C1-7alkylthio, thioC1-7alkyl, C1-7alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonylamino, COR11, or SO2R12, wherein R11 and R12 independently of each other are selected from hydroxy, perhalomethyl, C1-6alkoxy or amino optionally substituted with one or more C1-6alkyl, perhalomethyl or aryl; optionally substituted with one or more halogen, perhafomethyl, hydroxy or cyano.
9. A compound of claim 1 wherein ring A represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, cyano, or C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, C1-7alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, hydroxyC1-7alkyl, amino, acylamino, C1-7alkyl-amino, arylamino, aralkylamino, aminoC1-7alkyl, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl, aralkoxyC1-7alkyl, C1-7alkylthio, thioC1-7alkyl, C1-7alkoxycarbonylamino, aryloxycarbonylamino or aralkoxycarbonylamino.
10. A compound of claim 1 wherein ring A represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, cyano, or C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, C1-7alkoxy, aryl, aryloxy, aralkyl, aralkoxy, acyl, hydroxyC1-7alkyl, amino, C1-7alkyl-amino, arylamino, aralkylamino, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl, aralkoxyC1-7alkyl or C1-7alkylthio.
11. A compound of claim 1 wherein ring A represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl or C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, C1-7alkoxy, aryl, aralkyl, hydroxyC1-7alkyl, C1-7alkoxyC1-7alkyl, aryloxyC1-7alkyl or aralkoxyC1-7alkyl.
12. A compound of claim 1 wherein ring A represents a 6 membered cyclic ring, optionally substituted with one or rriore chlorine or methyl groups.
13. A compound of claim 1 wherein ring A represent a phenyl ring.
14. A compound of claim 1 wherein X is a valence bond, (CHR9), (CHR9)CH2, CHCH, O, O(CHR9), S(CHR9), (NR9)CH2, (CHR9)CHCH, (CHR9)CH2CH2, (CO), OCH2O, (NR9)S(O2), (NR9), CH(CR9), (CO)(CHR9), CH2(SO), S, (SO), (SO2), CH2(SO2) or CH2OCH2, wherein R9 is hydrogen, halogen, hydroxy, C1-7alkyl, C1-7alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, hydroxyalkyl, amino, acylamino, C1-7alkyl-amino, arylamino, aralkylamino, aminoC1-7alkyl, C1-7alkoxyC1-12alkyl, aryloxyC1-7alkyl, aralkoxyC1-7alkyl, C1-12alkylthio, thioC1-7alkyl, C1-7alkoxycarbonylamino, aryloxycarbonylamino or aralkoxycarbonylamino.
15. A compound of claim 1 wherein X is a valence bond, (CHR9), (CHR9)CH2, CHCH, O, O(CHR9), S(CHR9), (NR9)CH2, (CHR9)CHCH, (CHR9)CH2CH2, (CO), OCH2O, (NR9)S(O2), (NR9), CH(CR9), (CO)(CHR9), CH2(SO), S, (SO), (SO2), CH2(SO2) or CH2OCH2, wherein R9 is hydrogen, halogen, hydroxy, C1-7alkyl, aryl, aralkyl, C1-7alkoxyC1-12alkyl, aryloxyC1l7alkyl or aralkoxyC1-7alkyl.
16. A compound of claim 1 wherein X is a valence bond, (CHR9), (CHR9)CH2, CHCH, O, O(CHR9), S(CHR9), (NR9)CH2, (CHR9)CHCH, (CHR9)CH2CH2, (CO), OCH2O, (NR9)S(O2), (NR9), CH(CR9), (CO)(CHR9), CH2(SO), S, (SO), (SO2), CH2(SO2) or CH2OCH2, wherein R9 is hydrogen.
17. A compound of claim 1 wherein X is a valence bond, (CHR9), (CHR9)CH2, CHCH, O, O(CHR9), S(CHR9), (NR9)CH2, OCH2O, (NR9), S, (SO) or CH2OCH2, wherein R9 is hydrogen.
18. A compound of claim 1 wherein X is a valence bond, (CHR9), (CHR9)CH2, CHCH, O, O(CHR9), S(CHR9), (NR9)CH2, CCH2O, (NR9), S or CH2OCH2, wherein R9 is hydrogen.
19. A compound of claim 1 wherein X is a valence bond, (CHR9), (CHR9)CH2, CHCH, O, O(CHR9), S(CHR9), OCH2O or S, wherein R9 is hydrogen.
20. A compound of claim 1 wherein X is S.
21. A compound of claim 1 wherein T is >C<.
22. A compound of claim 1 wherein Z is CH2, CH, >N, O, S, >CO, >SO, >SO2.
23. A compound of claim 1 wherein Z is >N.
24. A compound of claim 1 wherein Q is O, S, >NR18, wherein R18 is hydrogen or C1-7alkyl.
25. A compound of claim 1 wherein Q is >NR18, wherein R18 is hydrogen.
26. A compound of claim 1 wherein U is O.
27. A compound of claim 1 wherein T(Z)p represents a double bond.
28. A compound of claim 1 wherein Ar represents arylene optionally substituted with one or more C1-6alkyl or aryl.
29. A compound of claim 1 wherein Ar is phenyl.
30. A compound of claim 1 wherein R5 represents hydrogen, hydroxy, halogen, C1-7alkoxy, C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl or aralkyl, or R5 forms a bond together with R6.
31. A compound of claim 1 wherein R5 represents hydrogen or R5 forms a bond together with R6.
32. A compound of claim 1 wherein R5 represents hydrogen, hydroxy, halogen, C1-7alkoxy, C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl or aralkyl, or R5 forms a bond together with R6.
33. A compound of claim 1 wherein R5 represents hydrogen or R5 forms a bond together with R6.
34. A compound of claim 1 wherein R7 represents hydrogen, C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, aryl, aralkyl, C1-7alkoxyC1-7alkyl, C1-7alkoxycarbonyl, aryloxycarbonyl, C1-7alkylaminocarbonyl, arylaminocarbonyl, acyl, heterocyclyl, heteroaryl or heteroaralkyl.
35. A compound of claim 1 wherein R7 represents hydrogen, C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl or C2-7-alkynyl.
36. A compound of claim 1 wherein R7 is C1-12alkyl.
37. A compound of claim 1 wherein R8 represents hydrogen, C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, aryl, aralkyl, heterocyclyl, heteroaryl or heteroaralkyl groups; optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano.
38. A compound of claim 1 wherein R8 represents hydrogen, C1-7alkyl, C4-7-alkenynyl, C2-7-alkenyl, C2-7-alkynyl, aryl or aralkyl.
39. A compound of claim 1 wherein R8 is hydrogen or C1-12alkyl.
40. A compound of claim 1 wherein Y represents oxygen, sulphur or NR10, where R10 represents hydrogen, C1-7alkyl, aryl, hydroxyC1-7alkyl or aralkyl groups.
41. A compound of claim 1 wherein Y is oxygen.
42. A compound of claim 1 wherein n is an integer ranging from 2 to 3.
43. A compound of claim 1 wherein p is 1.
44. A compound of claim 1 wherein A is benzo.
45. A compound of claim 1 wherein X is O.
46. A compound of claim 1 wherein X is S.
47. A compound of claim 1 wherein Z is S and p is 1.
48. A compound of claim 1 wherein Z is CH2 and p is 1.
49. A compound of claim 1 wherein X is CH and p is 1.
50. A compound of claim 1 wherein T(Z)p represents a single bond or a double bond.
51. A compound of claim 1 wherein T is >CH.
52. A compound of claim 1 wherein T is >C<.
53. A compound of claim 1 wherein Q is O.
54. A compound of claim 1 wherein Q is S.
55. A compound of claim 1 wherein Q is >NR18, wherein R18 is H.
56. A compound of claim 1 wherein n is 2.
57. A compound of claim 1 wherein U is O.
58. A compound of claim 1 wherein Ar is phenylene.
59. A compound of claim 1 wherein R5 is H.
60. A compound of claim 1 wherein R6 is H.
61. A compound of claim 1 wherein R7 is ethyl.
62. A compound of claim 1 wherein R8 is H.
63. A compound of claim 1 wherein p is 0.
64. A compound of claim 1 A is a five membered ring containing S.
65. A compound of claim 1 wherein X is (CHR9)CH2, wherein R9 is H.
66. A compound of claim 1 wherein X is O(CHR9), wherein R9 is H.
67. A compound of claim 1 wherein X is S(CHR9), wherein R9 is H.
68. A compound of claim 1 wherein X is OCH2O.
69. A compound of claim 1 which is:
2-Ethoxy-3-4-2-(11H-5-oxa-10-thia-dibenzoa,dcyclohepten-11-yloxy)-ethoxy-phenyl-propionic acid,
3-(4-2-(Dibenzob,f-1,4-thiazepin-11-ylamino)-ethoxy-phenyl)-2-ethoxy-propionic acid ethyl ester,
3-4-2-(Dibenzob,f1,4thiazepin-11-ylamino)-ethoxy-phenyl-2-ethoxy-propionic acid,
3-4-2-(10,11-Dihydro-dibenzob,fthiepin-10-ylsulfanyl)-ethoxy-phenyl-2-ethoxy-propionic acid,
3-(4-2-5H-Dibenzoa,dcyclohepten-5-yloxy)-ethoxy-phenyl)-2-ethoxy-propionic acid ethyl ester,
3-(4-2-(6,11-Dihydrodibenzob,ethiepin-11-yloxy)-ethoxy-phenyl)-2-ethoxy-propionic acid ethyl ester,
3-(4-2-(6,11-Dihydrodibenzob,ethiepin-11-yloxy)-ethoxy-phenyl)-2-ethoxy-propionic acid,
3-(4-2-(6,11-Dihydrodibenzob,eoxepin-11-yloxy)-ethoxy-phenyl)-2-ethoxy-propionic acid ethyl ester,
3-(4-2-(2,10-Dichloro-12H-5,7-dioxa-dibenzoa,dcycloocten-12-yloxy)-ethoxy-phenyl)-2-ethoxy-propionic acid ethyl ester,
3-(4-2-(2,10-Dichloro-12H-5,7-dioxa-dibenzoa,dcycloocten-12-yloxy)-ethoxy-phenyl)-2-ethoxy-propionic acid,
2-Ethoxy-3-(4-2-(2-methyl-9,1 0-dihydro-4H-1-oxa-3-aza-benzofazulen-4-yloxy)-ethoxy-phenyl)-propionic acid ethyl ester,
3-(4-2-(10,11-Dihydro-5H-dibenzoa,dcyclohepten-5-yloxy)-ethoxy-phenyl)-2-ethoxy-propanoic acid ethyl ester,
3-(4-2-(10,11-Dihydro-5H-dibenzoa,dcyclohepten-5-yloxy)-ethoxy-phenyl)-2-ethoxy-propanoic acid,
3-(4-2-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-yl-methyl-amino)-ethoxy-phenyl)-2-ethoxypropanoic acid ethyl ester, or
3-(4-2-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-yl-methyl-amino)-ethoxy-phenyl)-2-ethoxypropanoic acid;
or a pharmaceutically acceptable salt thereof.
70. A compound of claim 1 which is:
2-Ethoxy-3-4-2-(11H-5-oxa-10-thia-dibenzoa,dcyclohepten-11-yloxy)-ethoxy-phenyl-propionic acid,
3-4-2-(Dibenzob,f1,4thiazepin-11-ylamino)-ethoxy-phenyl-2-ethoxy-propionic acid, or
3-4-2-(10,11-Dihydro-dibenzob,fthiepin-10-ylsulfanyl)-ethoxy-phenyl-2-ethoxy-propionic acid;
or a pharmaceutically acceptable salt thereof.
71. A pharmaceutical composition comprising, as an active ingredient, an effective amount of a compound of claim 1 together with a pharmaceutically acceptable carrier or diluent.
72. The composition of claim 71 in unit dosage form, comprising from about 0.05 to about 100 mg of the compound.
73. The pharmaceutical composition of claim 71 wherein the route of administration is oral, nasal, transdermal, pulmonal, or parenteral.
74. A method of treating or preventing conditions mediated by nuclear receptors, the method comprising administering to a subject in need thereof an effective amount of a compound of claim 1.
75. The method of claim 74 wherein the nuclear receptors are the Peroxisome Proliferator-Activated Receptors (PPAR).
76. A method of treating or preventing diabetes or obesity, the method comprising administering to a subject in need thereof an effective amount of a compound of claim 1.
77. The method of claim 74, wherein the effective amount of the compound is in the range of from about 0.05 to about 100 mg per day.