1. A device comprising:
a resorbable porous scaffold comprising a plurality of particles, the plurality of particles comprising at least one resorbable polymer,
wherein at least a portion of the plurality of particles are fused together, the fused particles having a consolidated polymer structure.
2. The device of claim 1, wherein the at least one resorbable polymer is selected from the group consisting of poly(lactic acid), poly(glycolic acid), poly(lactide-co-glycolide), and combinations thereof.
3. The device of claim 1, wherein the porous scaffold includes at least two different resorption profiles, thereby providing a step-wise resorption.
4. The device of claim 1, wherein the porous scaffold comprises two or more polymers having at least two different resorption profiles including a first polymer and a second polymer.
5. The device of claim 4, wherein the first polymer has an inherent viscosity of about 0.5-1.5 and the second polymer has an inherent viscosity of about 4-7.
6. The device of claim 4, wherein the first polymer comprises 82:18 poly (L-lactide co-glycolide) and the second polymer comprises 85:15 poly (D, L lactide-co-glycolide).
7. The device of claim 4, wherein the first polymer comprises 70:30 poly (LD,L lactide) and the second polymer comprises 82:18 poly(lactide-co-glycolide).
8. The device of claim 1, wherein the porous scaffold comprises a first polymer having a degradation time of about 6-9 months and a second polymer having a degradation time of about 2-3 months.
9. The device of claim 1, wherein the porous scaffold is a multi-phase composite.
10. The device of claim 1, wherein the porous scaffold is at least partially filled with a calcium-containing material selected from the group consisting of hydroxyapatite, tricalcium phosphate, calcium carbonate, calcium sulfate, and combinations thereof.
11. The device of claim 1, wherein the porous scaffold comprises macropores.
12. The device of claim 1, wherein the porous scaffold has substantially no microporosity.
13. The device of claim 1 further comprising a coating on a surface of the resorbable porous scaffold.
14. The device of claim 1, wherein the porous scaffold is in the shape of a plurality of granules, a sheet, a rod, or a block.
15. The device of claim 1, wherein the device is selected from the group consisting of an interbody spacer, a fusion device, a bone graft, fusion cages, bone graft struts, structural augments, rods, screws, tacks, suture anchors, interference screws, a cartilage repair device, a tissue augmentation device, and a disc repair device.
16. An implant comprising:
a resorbable porous scaffold comprising a plurality of particles, the plurality of particles comprising at least one resorbable polymer,
wherein at least a portion of the plurality of particles are fused together, the fused particles having a consolidated polymer structure.
17. A method of treating a patient comprising inserting into a patient the implant of claim 16.
18. The method of claim 17 further comprising applying at least one biologically active agent to the implant before inserting the implant into the patient.
19. The method of claim 17, wherein the at least one biologically active agent includes growth factors, cells, blood factors, antibiotic substances, demineralized bone matrix powder, and combinations thereof.
20. A kit comprising:
the implant of claim 16, and
at least one device for placement, application of a biologically active agent, or shaping of the implant.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A cyclonic separator for separating a single phase fluid into a gas phase and a liquid phase, said single phase fluid comprising either a liquid containing dissolved gas or a mixture of liquids with different vapor pressures, the cyclonic separator comprising an inlet chamber, a cyclonic separation chamber and an outlet chamber, all arranged sequentially to allow fluids to flow substantially uniaxially through the separator, wherein the inlet chamber comprises a curved inlet duct of decreasing radius that induces fluids flowing through the chamber to swirl around an axis, wherein the cyclonic separation chamber receives fluids from the inlet chamber, increases a rotational speed of the fluids and separates the fluids by cyclonic action into a gas portion and a liquid portion, wherein the outlet chamber is connected to receive the gas and liquid portions from the cyclonic separation chamber and comprises a curved outlet duct of increasing radius, a first outlet for liquids and a second outlet for gases, wherein the separation chamber is elongate and has a length L and an inlet diameter D, wherein LD is in the range of 1 to 10, and includes a throat portion with a diameter DT , wherein DT <D, and includes a convergent portion upstream of the throat portion and a divergent portion downstream of the throat portion.
2. A cyclonic separator according to claim 1, wherein the throat diameter DTD is in the range of 0.3 to <1.0.
3. A cyclonic separator according to claim 1, wherein the throat portion has a length LT, wherein LTDT is in the range of 0 to 3.5.
4. A cyclonic separator according to claim 1, wherein the convergent portion is enclosed by a wall which is inclined at an included angle \u03b8c that is less than 45\xb0.
5. A cyclonic separator according to claim 1, wherein the elongate separation chamber includes a cylindrical inlet portion upstream of the convergent portion.
6. A cyclonic separator according to claim 5, wherein the inlet portion has a length L1, wherein L1 D is less than 2.
7. A cyclonic separator to claim 1, wherein the divergent portion is enclosed by a wall which is inclined at an included angle \u03b8D that is less than 30.
8. A cyclonic separator according to claim 1, wherein the elongate separation chamber includes a cylindrical outlet portion downstream of the divergent portion.
9. A cyclonic separator according to claim 8, wherein the outlet portion has a length LO, where LOD is less than 2.
10. A cyclonic separator according to claim 1, wherein the curved inlet duct has a decreasing cross-sectional area.
11. A cyclonic separator according to claim 1, wherein the curved inlet duct has an involute shape.
12. A cyclonic separator according to claim 1, wherein the curved inlet duct extends around approximately 360\xb0.
13. A cyclonic separator according claim 1, wherein the inlet chamber has a substantially tangential inlet and an axial outlet.
14. A cyclonic separator according to claim 1, wherein the curved outlet duct has an increasing cross-sectional area.
15. A cyclonic separator according to claim 1, wherein the curved outlet duct has an involute shape.
16. A cyclonic separator according to claim 1, wherein the curved outlet duct extends around approximately 360\xb0.
17. A cyclonic separator according claim 1, wherein the outlet chamber has an axial inlet, a substantially tangential outlet for liquids and an axial outlet for gases.
18. A cyclonic separator according claim 1, wherein the inlet chamber, the separation chamber and the outlet chamber are substantially coaxial.
19. A method of separating a single phase fluid into a gas phase and a liquid phase, said single phase fluid comprising either a liquid containing dissolved gas or a mixture of liquids with different vapour pressures, the method comprising passing the fluids through a cyclonic separator comprising an inlet chamber with a curved inlet duct of decreasing radius, a cyclonic separation chamber with a throat portion, a convergent portion upstream of the throat portion and a divergent portion downstream of the throat portion, and an outlet chamber with a curved outlet duct of increasing radius, separating the fluids by cyclonic action into a gas portion and a liquid portion, and capturing through separate outlets any gases and liquids exiting the separator.
20. A method according to claim 19, comprising passing fluids including liquids and dissolved gases through a cyclonic separator to separate at least some of the dissolved gases from the liquids, and capturing the gases and liquids separately as they flow through the respective outlets.
21. A method according to claim 19, comprising passing fluids including at least two liquids having different vapour pressures through a cyclonic separator to convert at least one of the liquids to a gas, separating at least some of the evolved gases from the liquids, and capturing the gases and liquids separately as they flow through the respective outlets.
22. A method according to claim 19, wherein the pressure of the fluids is reduced while passing them through the cyclonic separator to a value of less than 0.9 bar absolute, when the inlet pressure is 3 bar absolute or lower.
23. A method according to claim 19, comprising passing the fluids through a cyclonic separator according claim 1.
24. The cyclonic separator according to claim 2, wherein the throat diameter DTD is in the range of 0.5 to 0.9.
25. The cyclonic separator according to claim 3, wherein LTDT is in the range of 0.1 to 3.
26. The cyclonic separator according to claim 4, wherein the wall is inclined at an included angle \u03b8c that is in the range of 5\xb0 to 45\xb0.
27. The cyclonic separator according to claim 26, wherein the wall is inclined at an included angle \u03b8c that is in the range of 5\xb0 to 30\xb0.
28. The cyclonic separator according to claim 6, wherein L1D is in the range of 0.1 to 1.
29. The cyclonic separator according to claim 7, wherein the wall is inclined at an included angle \u03b8D that is in the range of 2\xb0 to 20\xb0.
30. The cyclonic separator according to claim 9, wherein LOD is in the range of 0.1 to 1.
31. The method of claim 22, wherein the pressure of the fluids is reduced while passing them through the cyclonic separator to a value of less than about 0.4 bar absolute.