Author: claimsbot

1. A composition of matter comprising: an electroluminescent material; a fluorescent quencher for the electroluminescent material; and a free radical generating compound that, when thermally degraded, generates free radicals that react with the quencher to bleach the quencher.
2. The composition of matter of claim 1, wherein the electroluminescent material comprises poly(p-phenyl vinylene).
3. The composition of matter of claim 2, wherein the quencher comprises a compound selected from the group consisting of 3,3\u2032-diethyloxadiccarbocya- nine iodide, 4-dicyanomethylene -2-methyl-6-(p-dimethylaminostyryl)-4H-pyra- n and 1,1\u2032-diethel-2,2\u2032-carbocyanine iodide.
4. The composition of matter of claim 3, wherein the free radical generating compound comprises azodiizobutyronitryle.
5. The composition of matter of claim 1, wherein the electroluminescent material is a polymer selected from the group of electroluminescent polymers consisting of polypyridines, polypyridyvinylenes, polyphenylenes, polyphenylenevinylenes, polythiophenes, polyvinylcarbazoles, polyfluorenes, polynaphthalenevinylenes, polyphenyleneacetylenes, polyphenylenediacetylenes, polycyanoterephthalylidenes, polyphenylenebenzobisthiazoles, polybenzimidazobenzophenanthrolines, polypyridine copolymers, polypyridylvinylene copolymers, polyphenylene copolymers, polyphenylenevinylene copolymers, polythiophene copolymers, polyvinylcarbazole copolymers, polyfluorene copolymers, polynaphthalenevinylene copolymers, polyphenyleneacetylene copolymers, polyphenylenediacetylene copolymers, polycyanotherephthalylidene copolymers, polyphenylenebenzobisthiazole copolymers, polybenzimidazobenzophenanthroline copolymers, and mixtures thereof.
6. The composition of matter of claim 1, which further comprises a compound that promotes photothermic bleaching.
7. The composition of matter of claim 1, which further comprises a compound that suppresses photothermic bleaching.
8. The composition of matter of claim 1, which further comprises an organic reducer present in an amount to prevent free radical deactivation by oxygen.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-8, or 17-37, a mature protein coding portion of SEQ ID NO: 1-8, or 17-37, an active domain coding portion of SEQ ID NO: 1-8, or 17-37, and complementary sequences thereof.
2. An isolated polynucleotide encoding a polypeptide with biological activity, wherein said polynucleotide hybridizes to the polynucleotide of claim 1 under stringent hybridization conditions.
3. An isolated polynucleotide encoding a polypeptide with biological activity, wherein said polynucleotide has greater than about 90% sequence identity with the polynucleotide of claim 1.
4. The polynucleotide of claim 1 wherein said polynucleotide is DNA.
5. An isolated polynucleotide of claim 1 wherein said polynucleotide comprises the complementary sequences.
6. A vector comprising the polynucleotide of claim 1.
7. An expression vector comprising the polynucleotide of claim 1.
8. A host cell genetically engineered to comprise the polynucleotide of claim 1.
9. A host cell genetically engineered to comprise the polynucleotide of claim 1 operatively associated with a regulatory sequence that modulates expression of the polynucleotide in the host cell.
10. An isolated polypeptide, wherein the polypeptide is selected from the group consisting of:
a polypeptide encoded by any one of the polynucleotides of claim 1; and
a polypeptide encoded by a polynucleotide hybridizing under stringent conditions with any one of SEQ ID NO: 1-8, or 17-37.
11. A composition comprising the polypeptide of claim 10 and a carrier.
12. An antibody directed against the polypeptide of claim 10.
13. A method for detecting the polynucleotide of claim 1 in a sample, comprising:
a) contacting the sample with a compound that binds to and forms a complex with the polynucleotide of claim 1 for a period sufficient to form the complex; and
b) detecting the complex, so that if a complex is detected, the polynucleotide of claim 1 is detected.
14. A method for detecting the polynucleotide of claim 1 in a sample, comprising:
a) contacting the sample under stringent hybridization conditions with nucleic acid primers that anneal to the polynucleotide of claim 1 under such conditions;
b) amplifying a product comprising at least a portion of the polynucleotide of claim 1; and
c) detecting said product and thereby the polynucleotide of claim 1 in the sample.
15. The method of claim 14, wherein the polynucleotide is an RNA molecule and the method further comprises reverse transcribing an annealed RNA molecule into a cDNA polynucleotide.
16. A method for detecting the polypeptide of claim 10 in a sample, comprising:
a) contacting the sample with a compound that binds to and forms a complex with the polypeptide under conditions and for a period sufficient to form the complex; and
b) detecting formation of the complex, so that if a complex formation is detected, the polypeptide of claim 10 is detected.
17. A method for identifying a compound that binds to the polypeptide of claim 10, comprising:
a) contacting the compound with the polypeptide of claim 10 under conditions sufficient to form a polypeptidecompound complex; and
b) detecting the complex, so that if the polypeptidecompound complex is detected, a compound that binds to the polypeptide of claim 10 is identified.
18. A method for identifying a compound that binds to the polypeptide of claim 10, comprising:
a) contacting the compound with the polypeptide of claim 10, in a cell, under conditions sufficient to form a polypeptidecompound complex, wherein the complex drives expression of a reporter gene sequence in the cell; and
b) detecting the complex by detecting reporter gene sequence expression, so that if the polypeptidecompound complex is detected, a compound that binds to the polypeptide of claim 10 is identified.
19. A method of producing the polypeptide of claim 10, comprising,
a) culturing a host cell comprising a polynucleotide sequence selected 1-8, or 17-37, a mature protein coding portion of SEQ ID NO: 1-8, or 17-37, an active domain coding portion of SEQ ID NO: 1-8, or 17-37, complementary sequences thereof and a polynucleotide sequence hybridizing under stringent conditions to SEQ ID NO: 1-8, or 17-37, under conditions sufficient to express the polyp eptide in said cell; and
b) isolating the polypeptide from the cell culture or cells of step (a).
20. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of any one of the polypeptides SEQ ID NO: 9-16 or 38-58, the mature protein portion thereof, or the active domain thereof.
21. The polypeptide of claim 20 wherein the polypeptide is provided on a polypeptide array.
22. A collection of polynucleotides, wherein the collection comprising the sequence information of at least one of SEQ ID NO: 1-8, or 17-37.
23. The collection of claim 22, wherein the collection is provided on a nucleic acid array.
24. The collection of claim 23, wherein the array detects full-matches to any one of the polynucleotides in the collection.
25. The collection of claim 23, wherein the array detects mismatches to any one of the polynucleotides in the collection.
26. The collection of claim 22, wherein the collection is provided in a computer-readable format.
27. A method of treatment comprising administering to a mammalian subject in need thereof a therapeutic amount of a composition comprising a polypeptide of claim 10 or 20 and a pharmaceutically acceptable carrier.
28. A method of treatment comprising administering to a mammalian subject in need thereof a therapeutic amount of a composition comprising an antibody that specifically binds to a polypeptide of claim 10 or 20 and a pharmaceutically acceptable carrier.

What is claimed is:

1. A system, comprising:
an exertion level sensor;
an activity level sensor; and
a processor coupled to the exertion level sensor and the activity level sensor, the processor programmed to estimate a maximum exercise capacity by determining a maximum exertion level from exertion levels measured by the exertion level sensor and cross-checking the maximum exertion level with an activity level measured by the activity level sensor, the activity level associated with the maximum exertion level.
2. The system of claim 1, further comprising a pulse generator, coupled to the processor, to deliver pacing pulses, and wherein the processor is programmed to adjust a rate at which the pacing pulses are delivered based on the maximum exercise capacity.
3. The system of claim 2, further comprising:
an atrial sensing and pacing channel communicatively coupled to the processor; and
a ventricular sensing and pacing channel communicatively coupled to the processor.
4. The system of claim 3, further comprising at least one moving average filter, coupled to the exertion level sensor, to remove spurious peaks in signals sensed by the exertion level sensor.
5. The system of claim 3, further comprises at least one moving average filter, coupled to the activity level sensor, to remove spurious peaks in signals sensed by the activity level sensor.
6. The system of claim 3, wherein the exertion level sensor comprises a minute ventilation sensor.
7. The system of claim 3, wherein the activity level sensor comprises an accelerometer.
8. A method, comprising:
measuring exertion levels;
measuring activity levels;
determining a resting exertion level from the measured exertion levels;
determining a maximum exertion level from the measured exertion levels;
associating the maximum exertion level with a corresponding activity level;
estimating a maximum exercise capacity by cross-checking the maximum exertion level with the corresponding activity level; and
adjusting a response factor based on the estimated maximum exercise capacity and the resting exertion level, the response factor being a slope of a rate-response curve in a rate-adaptive cardiac pacing mode.
9. The method of claim 8, further comprising defining a minimum value for the response factor.
10. The method of claim 8, further comprising determining a maximum target heart rate and a minimum target heart rate, and wherein adjusting the response factor comprises adjusting the response factor based on the maximum target heart rate, the minimum target heart rate, the maximum exercise capacity, and the resting exertion level.
11. The method of claim 10, wherein adjusting the response factor comprises determining the response factor using an equation:
RF(MaxHRMinHR)(MECREL),
where RF is the response factor, MaxHR is the maximum target heart rate, MinHR is the minimum target heart rate, MEC is the maximum exercise capacity, and REL is the resting exertion level.
12. The method of claim 11, further comprising determining the minimum target heart rate and the resting exertion level after an implantation of a rate-adaptive pacemaker.
13. The method of claim 12, further comprising determining an initial value of the maximum target heart rate based on population data and age.
14. The method of claim 8, wherein determining the maximum exertion level comprises determining a periodic maximum exertion level.
15. The method of claim 14, wherein determining the periodic maximum exertion level comprises:
collecting a plurality of first maximum exertion levels each determined from exertion levels measured over a predetermined first period; and
selecting a highest exertion level among the plurality of first maximum exertion levels collected over a predetermined second period.
16. The method of claim 15, wherein determining the periodic maximum exertion level comprises:
collecting a plurality of daily maximum exertion levels over a predetermined period; and
selecting the highest exertion level among the plurality of daily exertion levels.
17. The method of claim 15, wherein estimating the maximum exercise capacity comprises:
estimating a plurality of first periodic maximum exercise capacities by cross-checking each of the plurality of first maximum exertion levels with its corresponding activity level; and
selecting the maximum exercise capacity from the plurality of first periodic maximum exercise capacities.
18. The method of claim 8, further comprising removing spurious peaks in at least one of the measured exertion levels and the measured activity levels.
19. The method of claim 18, wherein removing spurious peaks in at least one of the measured exertion levels and the measured activity levels comprises using a moving average filter to remove the spurious peaks.
20. The method of claim 8, further comprising mapping the corresponding activity level to a percentage of a reserve exercise capacity being the difference between the maximum exercise capacity and the rest exertion level, and wherein the cross-checking comprises dividing the maximum exertion level by the percentage of the reserve exercise capacity represented by the corresponding activity level.
21. The method of claim 20, furthering comprising defining a minimum value for the percentage of the reserve exercise capacity represented by the corresponding activity level.
22. A system comprising:
means for measuring exertion levels and determining a periodic maximum exertion level;
means for measuring activity levels and associating the periodic maximum exertion level with a corresponding activity level measurement; and
means for estimating a maximum exercise capacity by cross-checking the periodic maximum exertion level with the corresponding activity level measurement.
23. The system of claim 22, further comprising:
means for delivering pacing pulses at an adjustable pacing rate; and
means for adjusting the pacing rate based on the estimated maximum exercise capacity.
24. The system of claim 23, wherein the means for adjusting the pacing rate comprises:
means for mapping the measured exertion levels to target pacing rates with a rate response curve defined with respect to the estimated maximum exercise capacity; and
means for adjusting a slope of the rate response curve by mapping the exertion level corresponding to the estimated maximum exercise capacity to a predetermined maximum allowable pacing rate.
25. The system of claim 22, further comprising means for mapping activity levels to percentages of reserve exercise capacity, and wherein the means for estimating the maximum exercise capacity comprises means for cross-checking the periodic maximum exertion level with the corresponding activity level measurement by dividing the periodic maximum exertion level by the percentage of reserve exercise capacity mapped to by the corresponding activity level measurement.
26. The system of claim 25, wherein the means for mapping activity levels to percentages of reserve exercise capacity comprises means for mapping the activity levels to the percentages of reserve exercise capacity by a linear relationship.
27. The system of claim 25, wherein the means for mapping activity levels to percentages .of a reserve exercise capacity comprises means for mapping the activity levels to discrete percentages of reserve exercise capacity according to predetermined activity level thresholds.
28. The system of claim 22, further comprising:
means for determining a plurality of periodic maximum exertion levels;
means for cross-checking the plurality of periodic maximum exertion levels; and
means for estimating the maximum exercise capacity as a maximum among the plurality of cross-checked periodic maximum exertion levels.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A system for automatic folder ownership assignment in an enterprise computer network, the system comprising:
sensitive content scrutinizing functionality operative for ascertaining which first folders, among a first multiplicity of folders in an enterprise computer network, comprise at least sensitive content, and adding said first folders to a list of base-folder candidates for ownership assignment;
first pruning functionality operative for defining a second multiplicity of folders, said second multiplicity of folders being a subset of said first multiplicity of folders which does not include said first folders, all descendents of said first folders and all ancestors of said first folders;
topmost folder scrutinizing functionality operative for ascertaining which second folders among said second multiplicity of folders are topmost folders and adding said second folders to said list of base-folder candidates for ownership assignment; and
possible ownership assignment recommendation functionality operative for recommending possible assignment of ownership of at least one of said list of base- folder candidates.
2. A system for automatic folder ownership assignment in an enterprise computer network according to claim 1 and wherein said possible ownership assignment recommendation functionality comprises:
functionality operative for recommending possible assignment of ownership of at least one of said list of base-folder candidates to an entity which has been most active with regard to said at least one of said list of base-folder candidates.
3. A method for automatic folder ownership assignment in an enterprise computer network, the method comprising:
maintaining a list of base-folder candidates for ownership assignment;
ascertaining which first folders, among a first multiplicity of folders in an enterprise computer network, comprise at least sensitive content, and adding said first folders to said list of base-folder candidates for ownership assignment;
defining a second multiplicity of folders, said second multiplicity of folders being a subset of said first multiplicity of folders which does not include said first folders, all descendents of said first folders and all ancestors of said first folders;
ascertaining which second folders among said second multiplicity of folders are topmost folders and adding said second folders to said list of base-folder candidates for ownership assignment; and
recommending possible assignment of ownership of at least one of said list of base-folder candidates.
4. A method for automatic folder ownership assignment in an enterprise computer network according to claim 3 and wherein said recommending comprises:
recommending possible assignment of ownership of at least one of said list of base-folder candidates to an entity which has been most active with regard to said at least one of said list of base-folder candidates.