All The Claims

We claim:

1. A process for the preservation of coconut sap, the said process comprising steps of:
a) collecting coconut sap from the spathe of coconut palm, which is tapped earlier for more than 10 days using a mud pot,
b) filtering the sap of step (a),
c) chilling the filtered sap solution of step (b),
d) adding an acidulant to the step (c) solution,
e) adding preservative to step (d) solution,
f) bottling the step (e) solution and croning the glass bottles, and
g) pasteurizing the bottles of step (f) for a time period of 3 to 7 minutes.
2. A process of claim 1, wherein in step (c) the temperature for chilling is in the range of 2 to 8 C.
3. A process of claim 1, wherein in step (d) the acidulant used, is citric acid.
4. A process of claim 3, wherein the concentration of acidulant is in the range of 0.04 to 0.2%.
5. A process of claim 1, wherein in step (e) the preservative used, is nisin.
6. A process of claim 5, wherein the concentration of nisin used is in the range of 5 to 15 ppm.
7. A process of claim 1, wherein the coconut sap retain its natural constituents.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-7. (canceled)
8. A computer implemented system for providing a signal at a point-of-sale depending upon a customer’s shopping history, comprising:
a terminal for entering, during a transaction, a unique customer identification;
a database storing transaction data from prior transactions for a plurality of customers, such that data regarding a customer’s prior transactions are stored in association with an identification of that customer;
circuitry responsive to the entry of said unique customer identification at said terminal during said transaction for transmitting to said point-of-sale during said transaction a customer information response signal; and
wherein said customer information response signal depends upon data stored in said database indicating dollar amount of at least one prior purchase associated with said unique customer identification.
9. The system of claim 8 wherein said customer information response signal depends upon dollar amount of a plurality of prior purchases associated with said unique customer identification.
10. The system of claim 8 wherein said customer information response signal also depends upon a frequency of prior purchases associated with said unique customer identification.
11. The system of claim 8 wherein said terminal can also receive customer transaction data.
12. The system of claim 8 wherein said data regarding said individual customer’s prior transactions stored in association with said individual customer’s identification in said database includes transaction frequency and dollar amount.
13. A computer implemented method for providing a signal at a point-of-sale depending upon a customer’s shopping history, comprising the steps of:
entering in a terminal, during a transaction, a unique customer identification;
storing, in a database, transaction data from prior shopping transactions for a plurality of customers, such that data regarding a customer’s prior transactions are stored in association with said an identification of that customer;
transmitting to a point-of-sale during said transaction a customer information response signal in response to the entry of said unique customer identification at said terminal during said transaction; and
wherein said customer information response signal depends upon data stored in said database indicating dollar amount of at least one prior purchase associated with said unique customer identification.
14. The method of claim 13 wherein said customer information response signal depends upon dollar amount of a plurality of prior purchases associated with said unique customer identification.
15. The method of claim 13 wherein said customer information response signal also depends upon a frequency of prior purchases associated with said unique customer identification.
16. The method of claim 13 further comprising the step of receiving in said terminal customer transaction data.
17. The method of claim 13 wherein said data regarding said individual customer’s prior transactions stored in association with said individual customer’s identification in said database includes transaction frequency and dollar amount.
18. A computer implemented system for updating data in a customer database, comprising:
a terminal for entering, during a transaction, a unique customer identification and transaction data for said transaction;
a database storing transaction data for a plurality of customers from prior shopping transactions, such that transaction data regarding prior transactions of a customer are stored in association with identification of that customer; and
circuitry responsive to the entry of said unique customer identification and said transaction data at said terminal for updating transaction data and a dollar amount of purchases associated with said unique customer identification in said customer database, and for storing in said customer database the date that transaction data association with said unique customer identification was updated.
19. The system of claim 18 wherein said circuitry updates said transaction data associated with said unique customer identification during said transaction.
20. The system of claim 18 wherein said database also stores a time of day that said transaction data was updated in association with said unique customer identification.
21. A computer implemented method for updating data in a customer database, comprising the steps of:
entering in a terminal, during a transaction, a unique customer identification and transaction data for said transaction;
storing, transaction data for a plurality of customers from prior shopping transactions, such that data regarding a prior transactions of a customer are stored in association with identification of that customer; and
updating transaction data and a dollar amount of purchases associated with said unique customer identification in said customer database in response to entry of said unique customer identification and said transaction data at said terminal; and
storing in said customer database the date that transaction data association with said unique customer identification was updated.
22. The method of claim 21 wherein said circuitry updates said transaction data associated with said unique customer identification during said transaction.
23. The method of claim 21 further comprising the step of storing in said database a time of day that said transaction data stored in association with said unique identification was updated.
24. A computer implemented customer database comprising stored transaction data from prior point-of-sale transactions for a plurality of customers, such that data regarding a customer’s prior transactions are stored in association with an identification of that customer said transaction data stored in association with an identification of that customer including:
dollar amount of purchases and time period.
25. A computer implemented customer database comprising stored transaction data from prior transactions for a plurality of customers, such that data regarding a customer’s prior transactions are stored in association with an identification of that customer, said transaction data stored in association with said identification of that customer including:
total dollar amount of purchases purchased during a period of time.
26. The database of claim 25 wherein said period of time is one of a day and a week.
27. The database of claim 25 wherein said transaction data stored in association with said identification of that customer further comprises a number of transactions associated with an identification of a customer.
28. The database of claim 25 wherein said transaction data stored in association with said identification of that customer further comprises a frequency of transactions.
29. The database of claim 25 wherein said transaction data stored in association with said identification of that customer further comprises a frequency of transactions for a specified period of time associated with an identification of a customer.
30. The database of claim 29 wherein said specified period of time is one of a day and a week.
31. The system of any one of claims 8, 13, 18, 21, 24, and 25, wherein said database is local to the point-of-sale, said database stores transaction data from prior transactions for a plurality of customers such that data regarding a customer’s prior transactions are stored in association with an identification of that customer, and said database is updatable from a global database concatenated from multiple store databases including said transaction data from the prior transactions of the customers at multiple stores.
32. The system of claim 8 wherein said database stores the date that transaction data association with said unique customer identification was updated.
33. The system of claim 8 wherein said terminal is in a first retail store, said database is a first store database, and said first store database is located at said first retail store.
34. The system of claim 33 further comprising:
a second store database local at a second retail store, said second store database storing transaction data from prior transactions at said second store for a plurality of customers, such that data regarding a customer’s prior transactions are stored in said second store database in association with a unique identification of that customer; and
a global database storing transaction data from prior transactions in both said first retail store and said second retail store.
35. The system of claim 34 further comprising at least one data connection, said at least one data connection enabling transmission of data stored in said first store database and said second store database to said global database, and enabling transmission of data from said global database to each one of said first store database and said second store database.
36. The system of claim 35 configured to update customer records in said first store database based upon data stored in said global database.
37. The system of claim 35 configured to update customer records in said first store database based upon data stored in said global database for transactions that occurred in said second retail store.
38. The system of claim 37 configured to update customer records in said first store database based upon data transmitted to said global database from said second store database for transactions that occurred in said second retail store.
39. The system of claim 37 configured to update customer records in said second store database based upon data stored in said global database for transactions that occurred in said first retail store.
40. The database of claim 24, wherein said database is structured to store in association with said identification of that customer transaction data including a first frequency of transactions by that customer during a first period of time.
41. The database of claim 40, wherein said database is structured to store in association with said identification of that customer transaction data including a second frequency of transactions by that customer during a second period of time.
42. The database of claim 41, wherein said database is structured to store in association with said identification of that customer transaction data including a third frequency of transactions by that customer during a third period of time.
43. The database of claim 24, wherein said database is structured to store in association with said identification of that customer transaction data including a first dollar amount for one or more transactions by that customer during a first time period.
44. The database of claim 43, wherein said database is structured to store in association with said identification of that customer transaction data including a second dollar amount for one or more transactions by that customer during a second time period.
45. The database of claim 44, wherein said database is structured to store in association with said identification of that customer transaction data including a third dollar amount for one or more transactions by that customer during a third time period.
46. The database of claim 24, wherein said database is structured to store in association with said identification of that customer a customer status.
47. The database of claim 46, wherein said database is structured to store in association with said identification of that customer a datetime that said customer status changed.
48. The database of claim 47, wherein said database is structured to store in association with said identification of that customer a previous status of said customer.
49. The database of claim 24, wherein said database is structured to store in association with said identification of that customer a user flag.
50. The database of claim 24, wherein said database is structured to store in association with said identification of that customer a transfer datetime indicating when the customer’s record was last written to disk.
51. The database of claim 24, wherein said database is structured to store in association with said identification of that customer an access datetime indicating when the customer’s record was last accessed and updated.
52. The database of claim 24, wherein said database is structured to store in association with said identification of that customer a total number of transactions since a last global update, said global update updating data stored in association with said identification of that customer based upon data stored in association with said identification of that customer in a second database.
53. The database of claim 52, wherein said database is structured to store in association with said identification of that customer a total dollar volume since said last global update.
54. The database of claim 24, wherein said database is structured so that it is indexed at least by customer identification.
55. The database of claim 24, wherein said database is structured so that it is indexed at least by status.
56. The database of claim 24, wherein said database is structured so that it is indexed at least by transfer date.
57. A computer implemented system comprising:
computer implemented customer database comprising stored transaction data from prior point-of-sale transactions, said stored transaction data comprising:
(1) data for a first customer such that data regarding said first customer’s prior transactions are stored in a first customer record associating a first customer identification of said first customer with at least a first customer first dollar amount; and
(2) data for a second customer such that data regarding said second customer’s prior transactions are stored in a second customer record associating a second customer identification of said second customer with at least a second customer first dollar amount;
a point of sale terminal;
a digital data processor;
and wherein said system is programmed to respond to transaction information received from the point of sale terminal including said first customer identification by identifying said first customer record in said database, and returning to said point of sale terminal a first customer information response signal;
wherein a value of said first customer information response signal depends at least in part upon data stored in said first customer record, including at least said first customer first dollar amount.
58. The system of claim 57 wherein a value of said first customer information response signal also depends at least in part upon data stored in said first customer record, including at least a first customer second dollar amount.
59. The system of claim 58 wherein a value of said first customer information response signal also depends at least in part upon data stored in said first customer record, including at least a first customer third dollar amount.
60. The system of claim 57 wherein a value of said first customer information response signal also depends at least in part upon data stored in said first customer record, including at least a first customer first frequency value.
61. The system of claim 60 wherein a value of said first customer information response signal also depends at least in part upon data stored in said first customer record, including at least a first customer second frequency value.
62. The system of claim 61 wherein a value of said first customer information response signal also depends at least in part upon data stored in said first customer record, including at least a first customer third frequency value.
63. The system of claim 58 wherein a value of said first customer information response signal also depends at least in part upon data stored in said first customer record, including at least a first customer first frequency value.
64. The system of claim 63 wherein said signal also depends at least in part upon data stored in said first customer record, including at least a first customer second frequency value.
65. The system of claim 57 wherein said signal also depends at least in part upon data stored in said first customer record, including at least a first customer first status value.
66. The system of claim 65 wherein said signal also depends at least in part upon data stored in said first customer record, including at least a first customer first flag value.
67. The system of claim 57 wherein said signal also depends at least in part upon data stored in said first customer record, including at least a first customer first time value.

1. A computer-implemented method comprising:
receiving, in a clustered storage system, a request to migrate a storage object from a source node servicing the storage object to a destination node;
verifying the destination node is configured to service the storage object, wherein the verifying further comprises attempting to access the storage object and determining the storage object is accessible if the attempted access is successful;
verifying the source node is configured to migrate the storage object, wherein verifying the source node comprises performing a veto check that determines whether active operations on they source node include one or more of fault tolerance, maintenance, and servicing of access requests;
offlining the storage object at the source node to prevent servicing of storage requests on the storage object;
updating ownership information of the storage object to indicate the destination node instead of the source node;
onlining the storage object at the destination node to resume servicing of storage requests on the storage object; and
routing storage requests for the storage object to the destination node instead of the source node as a result of updating the ownership information.
2. A computer-implemented method of claim 1, the step of verifying the destination node comprising determining that the destination node is configured according to predetermined configuration.
3. A computer-implemented method of claim 2, wherein the predetermined configuration is stored as a configuration table at the destination node, the configuration table including an operating characteristic of the destination node for servicing the storage object.
4. A computer-implemented method of claim 2, wherein the predetermined configuration comprises the destination node operating in a cluster quorum.
5. A computer-implemented method of claim 1, wherein performing the veto check comprises determining that a proper operating condition exists at the source node.
6. A computer-implemented method of claim 1, wherein performing the veto check comprises determining migration of the storage object is permitted based on a state of the storage object.
7. A computer-implemented method of claim 1, wherein the ownership information is stored in a metadata location of the storage object and updating ownership information comprises accessing the metadata location of the storage object.
8. A computer-implemented method of claim 1, wherein the step of onlining comprises:
receiving, by the destination node, a notification for new ownership information of the storage object;
reading the new ownership information in a metadata location within the storage object;
updating a list of storage objects serviced by the destination node; and
providing the updated list to nodes in the clustered storage system.
9. A computer-implemented method of claim 1, wherein the step of onlining comprises:
receiving, by the destination node, cached storage requests stored at the source node during the offlining; and
processing, by the destination node, the cached storage requests on the storage object.
10. A computer-implemented method of claim 1, wherein the clustered storage system comprises a plurality of nodes, the plurality of nodes each comprising a D-module, an N-module, and an M-host.
11. A computer-implemented method of claim 10, wherein the step of routing comprises:
receiving a new storage request for the storage object at the N-module of one of the plurality of nodes;
determining, by the N-module, the destination node owns the storage object using the updated ownership information; and
forwarding the new storage request to the D\u2014module of the destination node for processing by the ID-module of the destination node.
12. A computer-implemented method comprising:
determining, by a source node servicing a storage object in a clustered storage system, a destination node is configured to service the storage object in response to a request to migrate the storage object to the destination node, wherein the verifying further comprises attempting to access the storage object and determining the storage object is accessible if the attempted access is successful;
performing a veto check that determines whether active operations on the source node include one or more of fault tolerance, maintenance, and servicing of access requests;
preventing, by the source node, servicing of storage requests on the storage object while ownership information of the storage object is updated to indicated the destination node in accordance with the request;
synchronizing, by the source and destination nodes, updated ownership information to indicate ownership of the storage object by the destination node instead of the source node; and
resuming, by the destination node, servicing of storage requests on the storage object at a second node based on the synchronizing.
13. A computer-implemented method of claim 12, the step of determining comprising the destination node confirming that the destination node is configured according to a predetermined configuration.
14. A computer-implemented method of claim 13, wherein the predetermined configuration is stored as a configuration table at the destination node, the configuration table including an operating characteristic of the destination node for participating in a migration operation.
15. A computer-implemented method of claim 12, wherein the ownership information is stored in a metadata location of the storage object and updating ownership information comprises accessing the metadata location of the storage object.
16. A computer-implemented method of claim 12, further comprising:
storing, by the source node, the storage requests in memory during the preventing;
sending, by the source node, the stored storage requests to the destination after synchronizing the updated ownership information; and
processing, by the destination node, the stored storage requests on the storage object.
17. A computer-implemented method of claim 12, wherein the step of synchronizing comprises:
receiving, by the destination node, a notification from the source node indicating an update to the ownership information;
reading the ownership information in a metadata location of the storage object;
updating a list of storage objects serviced by the destination node; and
providing the updated list to nodes in the clustered storage system.
18. A data processing device comprising:
a processor coupled to a bus;
a memory coupled to the processor through the bus; and
instructions executed by the processor from the memory to cause the processor to:
receive, at a cluster manager, a request to migrate a storage object of a first node to a second node in a clustered storage system;
forward, to the first node, the request to migrate the storage object;
determine, by the cluster manager, the first node is configured to migrate the storage object and the second node is configured to service the storage object, and attempt to access the storage object and determine the storage object is accessible if the attempted access is successful;
perform a veto check that determine; whether active operations on the first node include one or more of fault tolerance, maintenance, and servicing of access requests;
update ownership information of the storage object to indicate the second node instead of the first node; and
prevent servicing of storage request; on the storage object at the first node when the second node is configured to service the storage object and for resuming servicing of storage requests on the storage object at the second node upon updating ownership information of the storage object.
19. A data processing device of claim 18, further configured to update a first data structure of the first node and a second data structure of the second node, the first and second data structures accessed by respective first and second nodes for routing storage requests to the storage object.
20. A data processing device of claim 18, further configured to update a centralized data structure for synchronizing routing information of the storage object at the first and second nodes.
21. A data processing device of claim 18, wherein the determining on the second node by confirming the second node is configured according to a predetermined configuration.
22. A data processing device of claim 21, wherein the predetermined configuration is stored as a configuration table at the second node, the configuration table including an operating characteristic of the second node for participating in a migration operation.
23. A system data processing devise of claim 18, further configured to perform the determining of the first node by performing a veto check on the first node.
24. A data processing device of claim 18, further configured to:
store, at the first node, the storage requests in memory during the preventing;
send the stored storage requests to the second node upon resuming servicing of storage requests at the second node; and
processing the stored storage requests on the storage object at the second node.
25. A data processing device of claim 18, further configured to:
notify the second node of an update to the ownership information of the storage object;
reading the ownership information in a metadata location of the storage object;
updating a list of storage objects serviced by the second node; and
providing the updated list to nodes in the clustered storage system for use in routing a new storage request of the storage object to the second node.
26. A data processing device of claim 18, further configured to:
generate, automatically by the cluster manager, the request to migrate a storage object based on monitoring events in the clustered storage system.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-20. (canceled)
21. A method of treating a disorder of reduced motility of the gastrointestinal tract in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I):
wherein:
R1 is hydrogen, halo, or C1-4alkyl;
R2 is C3-4alkyl or C3-6cycloalkyl;
a is 0 or 1;
Z is a moiety of formula (c):
wherein:
X is carbon and Q is -A-;
or X is nitrogen and Q is selected from \u2014OC(O)\u2014, \u2014S(O)2\u2014, \u2014S(O)2(CH2)2\u2014, and -A(CH2)2\u2014;
b is 1, X is carbon, and W is \u2014S(O)2\u2014;
or b is 2, X is carbon or nitrogen, and W is selected from \u2014S(O)2\u2014, \u2014N{C(O)R9}\u2014, \u2014N{S(O)2R10}\u2014, \u2014N{C(O)NR13R14}\u2014, and \u2014N{R16}\u2014; or
Z is a moiety of formula (d):
wherein:
Q is selected from \u2014OC(O)\u2014, \u2014S(O)2\u2014, \u2014S(O)2(CH2)2\u2014, and -A(CH2)2\u2014;
W\u2032 is selected from \u2014N(R8)C(O)R9, \u2014N(R8)S(O)2R10, \u2014S(R11)(O)2, \u2014N(R8)C(O)NR13R14, \u2014OR15, and \u2014N(R8)R16; provided that when W\u2032 is attached to a carbon atom bonded to the nitrogen atom of the ring, that W\u2032 is \u2014C(O)NR13R14; and
b is 1 or 2;
A is selected from \u2014S(O)2CH2C(O)N(R3)\u2014, \u2014N{C(O)R5}\u2014, \u2014N{C(O)NR6aR6b}\u2014, \u2014N{S(O)2C1-3alkyl}-, \u2014N{S(O)2NR6aR6b}\u2014, \u2014S(O)2N(R7a)\u2014, and \u2014OC(O)N(R7b)\u2014;
R3 is C1-4alkyl;
R5 is hydrogen, C1-3alkyl, or C1-3alkoxy;
R6a and R6b are independently hydrogen or C1-4alkyl;
R7a and R7b are independently hydrogen or C1-4alkyl;
R8 is hydrogen, methyl, or ethyl;
R9 is tetrahydrofuranyl, methyl, or ethyl;
R10 is methyl or ethyl;
R11 is methyl or ethyl;
R13 and R14 are independently hydrogen, methyl or ethyl;
R15 is hydrogen or methyl;
R16 is \u2014(CH2)n\u2014R17, wherein r is 0, 1, or 2; and R17 is selected from hydroxy, cyano, C1-3alkyl, and C1-3alkoxy; provided that when r is O, R17 is C1-3alkyl; and when r is 1, R17 is cyano or C1-3alkyl;
or a pharmaceutically-acceptable salt or stereoisomer thereof.
22. The method of claim 21, wherein Z is a moiety of formula (c), wherein X is nitrogen and Q is selected from \u2014OC(O)\u2014, \u2014S(O)2\u2014, \u2014S(O)2(CH2)2\u2014, \u2014S(O)2N(R7a)(CH2)2\u2014, \u2014N{C(O)C1-3alkoxy}(CH2)2\u2014, and \u2014N{S(O)2C1-3alkyl}(CH2)2\u2014.
23. The method of claim 21, wherein Z is a moiety of formula (c), wherein X is carbon and Q is selected from \u2014N{C(O)C1-3alkoxy}-, N{C(O)NR6aR6b}\u2014, \u2014N{S(O)2C1-3alkyl}, and \u2014S(O)2N(R7a)\u2014.
24. The method of claim 21, wherein Z is a moiety of formula (d), wherein Q is selected from \u2014OC(O)\u2014 and \u2014S(O)2\u2014.
25. The method of claim 21, wherein the compound of formula (I) is selected from:
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-3-(4-methanesulfonylpiperazine-1-sulfonyl)propyl-8-azabicyclo3.2.1oct-3-yl}amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-3-(3-dimethylaminopyrrolidine-1-sulfonyl)propyl-8-azabicyclo3.2.1oct-3-yl}amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{3-4-(2-hydroxyethyl)piperazine-1-sulfonylpropyl}-8-azabicyclo3.2.1oct-3-yl)amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-3-(4-methylpiperazine-1-sulfonyl)propyl-8-azabicyclo3.2.1oct-3-yl}amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{2-methanesulfonyl-(1-propylpiperidin-4-yl)aminoethyl}-8-azabicyclo3.2.1oct-3-yl)-amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (1S,3R,5R)-8-(3-{1-(2-methoxyethyl)piperidin-4-ylmethylsulfamoyl}propyl)-8-azabicyclo3.2.1oct-3-ylamide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{3-(1-methanesulfonylpiperidin-4-yl)methylsulfamoylpropyl}-8-azabicyclo3.2.1oct-3-yl)amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (1S,3R,5R)-8-(3-{1-(2-cyanoethyl)piperidin-4-ylmethylsulfamoyl}propyl)-8-azabicyclo3.2.1oct-3-ylamide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{2-(1,1-dioxotetrahydro-1\u03bb6-thiophen-3-yl)methanesulfonylaminoethyl}-8-azabicyclo3.2.1oct-3-yl)amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{2-1-(1,1-dioxotetrahydro-1\u03bb6-thiophen-3-yl)-3,3-dimethylureidoethyl}-8-azabicyclo3.2.1-oct-3-yl)amide;
(1,1-dioxo-tetrahydro-1\u03bb6-thiophen-3-yl)-(2-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}ethyl)-carbamic acid methyl ester;

1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (1S,3R,5R)-8-(2-{2-(4-dimethylcarbamoylpiperazin-1-yl)ethylmethanesulfonylamino}ethyl)-8-azabicyclo-3.2.1oct-3-ylamide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{2-2-(4-methanesulfonylpiperazin-1-yl)ethanesulfonylethyl}-8-azabicyclo3.2.1oct-3-yl)amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (1S,3R,5R)-8-(2-{2-4-(tetrahydrofuran-2-carbonyl)piperazin-1-ylethanesulfonyl}ethyl)-8-azabicyclo3.2.1oct-3-ylamide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{2-2-(4-ethanesulfonylpiperazin-1-yl)ethanesulfonylethyl}-8-azabicyclo3.2.1oct-3-yl)amide;
(1,1-dioxo-hexahydro-1\u03bb6-thiopyran-4-yl)-(2-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}ethyl)-carbamic acid methyl ester;

1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{2-1-(1,1-dioxotetrahydro-1\u03bb6-thiophen-3-yl)-3-methylureidoethyl}-8-azabicyclo3.2.1oct-3-yl)amide;
(2-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)-amino-8-azabicyclo3.2.1oct-8-yl}ethyl)-2-(4-methanesulfonylpiperazin-1-ylethyl-carbamic acid methyl ester;
2-(4-dimethylcarbamoylpiperazin-1-yl)ethyl-(2-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}-ethyl)-carbamic acid methyl ester;
2-(4-acetyl-piperazin-1-yl)ethyl-(2-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}ethyl)-carbamic acid methyl ester;
2-(1,1-dioxo-1\u03bb6-thiomorpholin-4-yl)ethyl-(2-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}ethyl)-carbamic acid methyl ester;
(1,1-dioxo-tetrahydro-1\u03bb6-thiophen-3-yl)-(3-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}propyl)-carbamic acid methyl ester;
((S)-1,1-dioxo-tetrahydro-1\u03bb6-thiophen-3-yl)-(2-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}ethyl)-carbamic acid methyl ester;
1-isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid {(1S,3R,5R)-8-3-(methyl-{2-4-(tetrahydrofuran-2-carbonyl)piperazin-1-ylethyl}sulfamoyl)propyl-8-azabicyclo3.2.1oct-3-yl}amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ((1S,3R,5R)-8-{3-4-(tetrahydrofuran-2-carbonyl)piperazine-1-sulfonylpropyl}-8-azabicyclo-3.2.1oct-3-yl)amide;
1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-3-(4-acetylpiperazine-1-sulfonyl)propyl-8-azabicyclo3.2.1oct-3-yl}amide;
4-methanesulfonyl-piperazine-1-carboxylic acid 3-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}propyl ester;
4-(tetrahydrofuran-2-carbonyl)piperazine-1-carboxylic acid 3-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}propyl ester;
4-acetyl-piperazine-1-carboxylic acid 3-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}propyl ester; and
4-hydroxypiperidine-1-carboxylic acid 3-{(1S,3R,5R)-3-(1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino-8-azabicyclo3.2.1oct-8-yl}-propyl ester;
and pharmaceutically-acceptable salts thereof.
26. The method of claim 21, wherein the disorder of reduced motility is chronic constipation, irritable bowel syndrome, gastroparesis, post-operative ileus, intestinal pseudo-obstruction, drug-induced delayed transit, or functional dyspepsia.
27. The method of claim 26, wherein the disorder of reduced motility is chronic constipation, constipation-predominant irritable bowel syndrome, diabetic and idiopathic gastroparesis, or functional dyspepsia.
28. The method of claim 25, wherein the disorder of reduced motility is chronic constipation, irritable bowel syndrome, gastroparesis, post-operative ileus, intestinal pseudo-obstruction, drug-induced delayed transit, or functional dyspepsia.
29. The method of claim 28, wherein the disorder of reduced motility is chronic constipation, constipation-predominant irritable bowel syndrome, diabetic and idiopathic gastroparesis, or functional dyspepsia.
30. A method of treating a mammal having a medical condition ameliorated by treatment with a 5-HT4 receptor agonist, the method comprising administering to the mammal, a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I) as defined in claim 21 or a pharmaceutically-acceptable salt or stereoisomer thereof.
31. The method of claim 30 wherein the medical condition is irritable bowel syndrome, chronic constipation, functional dyspepsia, delayed gastric emptying, gastroesophageal reflux disease, gastroparesis, post-operative ileus, intestinal pseudo-obstruction, or drug-induced delayed transit.