All The Claims

1. Bicycle and like, having a rear wheel (22) or flywheel, and provided with a pedal group comprising a central shaft and a gear wheel (5) integrally coupled each other, a left crank (1) and a right crank (1), coupled on the two ends of the central shaft, characterised in that a pedal crank (7) is rotatably coupled with each one of said left and right cranks (1) by mechanical means (6, 8, 10) creating a freewheel like mechanism between the crank (1) and the corresponding pedal crank (7), a pedal (12) being coupled with one end of each one of the two pedal cranks (7).
2. Bicycle and like according to claim 1, characterised in that said rotating coupling mechanical means between the crank,(1) and the corresponding pedal crank (7) comprises a shaped pin (6), provided with a ring gear (10) and rotatably coupled with the crank (1) or with the pedal crank (7), said pin (6) coupling with a corresponding shaped hole (8) provided in the pedal crank (7) or in the crank (1).
3. Bicycle and like, having a rear wheel (22) or flywheel, and provided with a pedal group comprising a central shaft (14) and a gear wheel (5) integrally coupled each other, a left crank (16) and a right crank (16), characterised in that said left crank (16) and right crank (16) are rotatably coupled with the central shaft (14) by mechanical means (15, 16, 19) creating a freewheel like mechanism between each crank (16) and the central shaft (14), a pedal (12) being coupled with one end of each one of the two pedal cranks (16).
4. Bicycle and like according to claim 3, characterised in that said rotating coupling mechanical means between each one of the cranks (16) and the central shaft (14) comprises a gear (18) coupled with the crank (16), or to the end (15) of the central shaft (14), and provided with a shaped hole (19) within which the corresponding end (15) of the central shaft (14), or a corresponding crank (16) pin, is inserted.
5. Bicycle and like according to any one of the preceding claims 1-4, characterised in that the central shaft (14) of the pedal group, which is placed parallel with respect to rear wheel (22) hub (23), is provided externally, above, with respect to the circumference of said rear wheel (22), within an angle () between 30 with respect to the line (h) passing through the contact point between the wheel (22) and the ground and the hub (23).
6. Bicycle and like according to claim 5, characterised in that the rear wheel (23) or flywheel hub is connected with the central shaft (14) of the pedal group by at least a rod (25).
7. Bicycle and like according to claim 6, characterised in that it provides at least a further rod (26) connecting the central shaft (14) of the pedal group with the seat supporting rod (27), said at least a further rod (26) being included within an angle () between 40 with respect to a line parallel to the ground and passing through the central shaft (14) of the pedal group.
8. Bicycle and like according to claim 6 or 7, characterised in that it provides at least a further rod (28) connecting the rear wheel (22) or flywheel hub (23) with the lower end of the seat supporting rod (27), the angle () between said at least a further rod (28) and the line (h) perpendicular to the ground and passing through the rear wheel (22) or flywheel hub (23) being between 60 and 120.
9. Fixed bicycle provided with a pedal group operating a rear wheel (38) or flywheel, and comprising a central shaft and a gear wheel (5) integrally coupled, characterised in that it comprises two tanks (30), suitable to contain liquid (31), within each of them a pedal (12) of the pedal group being submerged, within each of the two tanks (30) a cylinder (32) provided with shaped blades (33) and protected by a protection grid (34) being provided, the two cylinders (32) being integrally coupled each other by a shaft (35) inserted within two sealed through holes (36) provided on the faced walls of the two tanks (30), the shaft (35) centrally providing a bigger diameter disc (37) contacting the rear wheel or flywheel (38).
10. Fixed bicycle according to claim 9, characterised in that each one of the two tanks (30) provides a liquid (31) return chute (39).
11. Fixed bicycle according to claim 9 or 10, characterised in that the pedal group is one of those according to claims 1-5.
12. Bicycle or like, provided with at least one seat coupled with a supporting rod, characterised in that said at least one seat is a swinging seat (40) having a foot (41) pivoted on the head (42) of the supporting rod (27), the foot (41) being shaped in such a way to provide two surfaces (43, 44) interacting with two mating surfaces (45, 46) of a head (42) projection (47) to limit the foot rotation with respect to the supporting rod (27) head (42), elastic means (48, 55) being connected with the seat (40) and the supporting rod (27).
13. Bicycle according to claim 12, characterised in that said at least one swinging seat (40) comprises a front bodice (49) to support the user bust, said bodice (49) being provided with elastically swinging means.
14. Bicycle according to claim 13, characterised in that the front bodice (49) provides a rod (50), pivoted on the head (42) of the supporting rod (27) andor on the foot (41) of the seat (40) by said elastically swinging means.
15. Bicycle according to claim 13 or 14, characterised in that said elastically swinging means are provided with adjustable friction means able to vary the elastic resistance opposed by the front bodice (49) to the weight of the supported bust.
16. Bicycle according to each one of the preceding claims 12-15, characterised in that said at least one swinging seat (40) provides sliding means (52) to adjust the seat (40) along the longitudinal direction of the bicycle andor telescopic means (53) to adjust the height and the longitudinal inclination of the seat (40) andor articulation means (54) to adjust the transverse inclination of the seat (40).
17. Bicycle according to each one of the preceding claims 12-15, characterised in that said at least one swinging seat (40) provides a rear equaliser (56) to support the user bust, said equaliser (56) being provided with elastically swinging means.
18. Bicycle according to claim 17, characterised in that the rear equaliser (56) is connected with the seat (40) andor with the supporting rod (27) by elastically swinging means.
19. Bicycle according to claim 17 or 18, characterised in that said elastically swinging means provide quick release means.
20. Bicycle according to each one of the preceding claims 17-19, characterised in that said elastically swinging means provide adjustable friction means capable to vary the elastic resistance opposed by the equaliser (56) to the user bust.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-15. (canceled)
16. A method for inducing an adaptive immune response in a mammal, bird or fish comprising the steps of:
a. obtaining a vector comprising a first RNA element comprising a VARNAI RNA component, and a second RNA element comprising an RIG-I activating immunostimulatory RNA element of 30-200 basepairs operably linked to a U6 RNA polymerase III promoter, and
at least one gene encoding a protein or peptide antigen; and
b. delivering said vector to said mammal, bird or fish, under conditions such that said antigen is expressed and said first RNA element and said second RNA element are expressed and induce an adaptive immune response to said antigen.
17. The method of claim 16, wherein said vector is chosen from the group consisting of: non-viral vector, viral vector, alphavirus vector, poxvirus vector, lentivirus vector, retrovirus vector, adenovirus vector, adenovirus related virus vector, plasmid vector, midge vector, transcriptionally active PCR fragment vector, minicircle vector, and bacteriophage vector.
18. (canceled)
19. The method of claim 16, wherein said immunostimulatory RNA element of 30-200 basepairs operably linked to a U6 RNA polymerase III promoter is chosen from the group consisting of: U6 RNA Polymerase III promoter expressed single stranded immunostimulatory RNA elements, and U6 RNA Polymerase III promoter expressed hairpin double stranded immunostimulatory RNA elements.
20-32. (canceled)
33. The method of claim 19, wherein said immunostimulatory RNA element of 30-200 base pairs operably linked to a U6 RNA polymerase III promoter further comprises a tRNA RNA polymerase III promoter arranged in opposite orientation to said U6 RNA polymerase III promoter, such that transcription of said RNA element is convergent.
34. The method of claim 16, whereby said adaptive immune response is increased, as compared to a vector lacking the combination of VARNAI and at least one additional immunostimulatory RNA element, without reducing antigen expression.
35. A method for inducing an adaptive immune response in a mammal, bird or fish comprising the steps of:
a. providing first and second vectors, said first vector comprising i) a first RNA element comprising a VARNAI RNA component, and ii) a gene encoding a protein or peptide antigen, said second vector comprising a second RNA element comprising an RIG-I activating immunostimulatory RNA element of 30-200 basepairs operably linked to a U6 RNA polymerase III promoter, and
b. delivering said first and second vectors to said mammal, bird or fish under conditions such that said antigen is expressed, and said first RNA element and said second RNA element are expressed and induce an adaptive immune response to said antigen.
36. The method of claim 35, whereby said adaptive immune response is increased, as compared to vector (s) lacking the combination of VARNAI and at least one additional immunostimulatory RNA element, without reducing antigen expression.
37. A method for inducing type 1 interferon production in a mammal, bird or fish comprising the steps of:
a. obtaining a vector comprising a first RNA element comprising a VARNAI RNA component, and a second RNA element comprising an RIG-I activating immunostimulatory RNA element of 30-200 base pairs operably linked to a U6 RNA polymerase III promoter, and
b. delivering said vector to said mammal, bird or fish under conditions such that type 1 interferon production is induced.
38. The method of claim 37, whereby said type 1 interferon production increases anti-viral, anti-tumor or antibacterial activity in said mammal, bird or fish.
39. The method of claim 37, whereby said type 1 interferon production is increased, as compared to a vector lacking the combination of VARNAI and at least one additional immunostimulatory RNA element.
40. The method of claim 37, wherein said immunostimulatory RNA element of 30-200 basepairs operably linked to a U6 RNA polymerase III promoter is chosen from the group consisting of U6 RNA Polymerase III promoter expressed single stranded immunostimulatory RNA elements and U6 RNA Polymerase III promoter expressed hairpin double stranded immunostimulatory RNA elements.
41. The method of claim 40, wherein said immunostimulatory RNA element of 30-200 base pairs operably linked to a U6 RNA polymerase III promoter further comprises a tRNA RNA polymerase III promoter arranged in opposite orientation to said U6 RNA polymerase III promoter, such that transcription of said RNA element is convergent.

1. A pelvic organ prolapse treatment device comprising:
an implantable support configured to treat a prolapsed area of a patient selected from the group consisting of urethrocele prolapse, cystocele prolapse, vault prolapse, uterine prolapse, enterocele prolapse, and rectocele prolapse, the implantable support comprising:
a body portion and an arm having a first end portion connected to the body portion;
a knot connecting a suture to a second end portion of the arm;
the second end portion of the arm being folded to include a first fold and a second fold that combine to reduce the lateral dimension of the second end portion of the arm; and
a tubular dilator disposed over and connected to the knot.
2. The device of claim 1, wherein the tubular dilator is permanently connected to the knot.
3. The device of claim 1, wherein the tubular dilator is permanently connected to the arm.
4. The device of claim 1, wherein the tubular dilator surrounds a circumference of the knot.
5. The device of claim 1, wherein the tubular dilator has an aspect ratio of greater than 7.
6. The device of claim 5, wherein the aspect ratio of the tubular dilator is provided in a range from 7-20.
7. The device of claim 6, wherein the aspect ratio of the tubular dilator is provided in a range from 10-15.
8. The device of claim 1, wherein the tubular dilator has a durometer of between 50-85 Shore D.
9. A pelvic organ prolapse treatment device comprising:
a body implantable support configured to treat a prolapsed area of a patient, the body implantable support comprising a body portion and an arm having a first end portion connected to the body portion, a knot connecting a suture to a second end portion of the arm, with the second end portion of the arm being folded to include a first fold and a second fold that combine to reduce the lateral dimension of the second end portion of the arm; and
a tubular dilator disposed over and connected to the knot,
wherein the tubular dilator has a distal end that is disposed over the knot and a proximal end opposite of the distal end, and the proximal end has a diameter that is smaller than a diameter of the distal end such that the tubular dilator is tapered to converge to the proximal end.
10. The device of claim 9, wherein the tubular dilator has a flexibility characterized in that the dilator bends through at least 180 degrees such that the proximal end is displaced to contact the distal end.
11. The device of claim 10, wherein the tubular dilator has a flexibility characterized in that the dilator bends through an arc associated with a circle having a radius of about 1 mm.
12. A pelvic organ prolapse treatment device comprising:
a body implantable support configured to treat a prolapsed area of a patient, the implantable support comprising a body portion and an arm having a first end portion connected to the body portion, a knot connecting a suture to a second end portion of the arm, with the second end portion of the arm being folded to include a first fold and a second fold that combine to reduce the lateral dimension of the second end portion of the arm; and
a tubular dilator disposed over and connected to the knot,
wherein the tubular dilator is fabricated from a solvent-swellable plastic that is shrinkable to provide attachment of the dilator over the knot and to the arm.
13. The device of claim 12, wherein the tubular dilator is permanently shrunk in place to the knot.
14. The device of claim 1, wherein the first end of the arm is connected to both the edge and a portion of the first lateral side of the body portion.
15. The device of claim 1, further comprising:
a tab connected to the body portion opposite of the edge of the body portion and separated from the arm.
16. The device of claim 1, wherein the knot is located at a juncture of the arm and the suture.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for intercepting application communications for transmission via a virtual private network connection, the method comprising:
(a) receiving, by an agent of a client, an application routing table identifying one or more applications authorized for access via a virtual private network connection established with an device intermediary to the client and at least one server, each of the one or more applications identified via a name of an executable of the corresponding application;
(b) determining, by the agent, whether a first communication from the client is from a first application with a name of an executable identified by the received application routing table; and
(c) transmitting, by the agent based on the determination, the first communication via the virtual private network connection established with the device.
2. The method of claim 1, comprising transmitting, by the device, the application routing table to the agent.
3. The method of claim 1, comprising establishing, by the agent, the virtual private network connection with the device.
4. The method of claim 1, comprising determining, by the agent, that a second communication is from a second application not identified in the application routing table, and allowing the second communication to pass via the client’s network stack.
5. The method of claim 1, comprising determining, by the agent, that a second communication is from a second application not identified in the application routing table, and not intercepting the network communication.
6. The method of claim 1, comprising determining, by the agent, the name of the executable of the first application via a system level or kernel level call.
7. The method of claim 1, comprising determining, by the agent, the name of the executable of the first application via an application programming interface.
8. The method of claim 1, comprising comparing, by the agent, information from the first communication with information in the application routing table.
9. The method of claim 1, comprising one of granting or denying, by the device, a level of access to the first application based on identification of the first application.
10. The method of claim 1, comprising transmitting, by the agent, to the device an identification of the first application.
11. A system for intercepting application communications for transmission via a virtual private network connection, the system comprising:
an application routing table identifying one or more applications authorized for access via a virtual private network connection established with an device intermediary to a client and at least one server, each of the first one or more applications identified via a name of an executable of the corresponding application; and
an agent of a client, configured for receiving the application routing table, determining, based on the identification, whether a first communication from the client is from an application with a name of an executable identified by the received application routing table, and transmitting, based on the determination, the first communication via the virtual private network connection established with the device.
12. The system of claim 11, wherein the application routing table is transmitted by the device to the agent.
13. The system of claim 11, wherein the agent establishes the virtual private network connection with the device.
14. The system of claim 11, wherein the agent determines that a second communication is from a second application not identified in the application routing table, and allows the second communication to pass via the client’s network stack.
15. The system of claim 11, wherein the agent determines that a second communication is from a second application not identified in the application routing table, and does not intercept the network communication.
16. The system of claim 11, wherein the agent determines the name of the executable of the first application via a system level or kernel level call.
17. The system of claim 11, wherein the agent determines the name of the executable of the first application via an application programming interface.
18. The system of claim 11, wherein the agent compares information from the first communication with information in the application routing table.
19. The system of claim 11, wherein the device grants or denies a level of access to the first application based on identification of the first application.
20. The system of claim 11, wherein the agent transmits to the device an identification of the first application.