All The Claims

1-22. (canceled)
23. A solid pharmaceutical composition for oral administration comprising
a 5-HT4 partial agonist in base or salt form in an amount of up to 10% by weight,
a diluent in an amount of 70 to 90% by weight,
a disintegrant in an amount of less than 15% by weight, and
wherein the amounts by weight are based on the total weight of the composition.
24. A pharmaceutical composition as claimed in claim 23 optionally, further comprising a glidant.
25. A pharmaceutical composition as claimed in claim 24 wherein the glidant is colloidal silica dioxide.
26. A pharmaceutical composition as claimed in claim 24 optionally, further comprising a lubricant.
27. A pharmaceutical composition as claimed in claim 26 wherein the lubricant is present in an amount of 3 to 7% based on the total weight of the composition.
28. A pharmaceutical composition as claimed in claim 26 wherein the lubricant is glycerol monostearate or glycerol behenate.
29. A pharmaceutical composition as claimed in claim 26 optionally, further comprising a binder.
30. A pharmaceutical composition as claimed in claim 29 wherein the binder is hydroxy propylmethyl cellulose.
31. A pharmaceutical composition as claimed in claim 29 wherein the 5-HT4 partial agonist is tegaserod.
32. A pharmaceutical composition as claimed in claim 31 wherein tegaserod is in the form of the maleate salt.
33. A pharmaceutical composition as claimed in claim 29 wherein the diluent is selected from the group consisting of lactose, mannitol, sucrose, calcium phosphate or microcrystalline cellulose.
34. A pharmaceutical composition as claimed in claim 33 wherein the diluent is lactose.
35. A pharmaceutical composition as claimed in claim 29 wherein the disintegrant is present in an amount of 12% or less by weight based on the total weight of the composition.
36. A composition as claimed in claim 29 wherein the disintegrant is crospovidone.
37. A process for the production of a composition as claimed in claim 29 which process is carried out under substantially dry conditions using granulation.
38. A process for the production of a composition as claimed in claim 29 which process comprises:
(i) preparing a mixture of 5-HT4 partial agonist, e.g. tegaserod, diluent and lubricant,
(ii) sieving the mixture,
(iii) adding the disintegrant, glidant and optionally binder and blending the sieved mixture of step (ii), and
(iv) forming tablets by direct compression.
39. A process for the production of a composition as claimed in claim 38 wherein the components are mixed with tegaserod, sieved and mixed again before tabletting.
40. A process for the production of a composition as claimed in claim 29 which process comprises:
(i) preparing a mixture of 5-HT4 partial agonist, e.g. tegaserod, and diluent
(ii) sieving the mixture
(iii) adding the disintegrant, glidant and optionally binder and blending the sieved mixture of step (ii)
(iv) adding the lubricant by spray lubrication when forming tablets by direct compression.
41. A process for the production of a composition as claimed in claim 40 wherein all the components are mixed with tegaserod, sieved through and mixed again before tabletting.
42. A process for the production of a composition as claimed in claim 29 which process comprises:
(i) preparing a mixture of 5-HT 4 partial agonist e.g. tegaserod, diluent, disintegrant, glidant and optionally binder
(ii) compacting the premix of step (i) by roller compaction
(iii) milling the mixture of step (ii) and
(iv) forming tablets by compression.
43. A solid pharmaceutical composition for oral administration consisting of or consisting essentially of
tegaserod in base or salt form in an amount of up to 10% by weight,
a diluent in an amount of 70 to 90% by weight,
a disintegrant in an amount of less than 15% by weight,
a glidant and a lubricant,
wherein the amounts are by weight based on the total weight of the composition.
44. A solid pharmaceutical composition for oral administration consisting of or consisting essentially of
tegaserod in base or salt form in an amount of up to 10% by weight,
a diluent in an amount of 70 to 90% by weight,
a disintegrant in an amount of less than 15% by weight,
a binder, glidant and a lubricant,
wherein the amounts are by weight based on the total weight of the composition.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A copolymer, comprising:
a predominantly alternating monomer structure, comprising:
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-donor properties; and
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-acceptor properties;
a terminal functional group selected from a radically transferable atom or group, a halogen, Cl, Br, I, OR10, SR14, SeR14, OC(\u2550O)R14, OP(\u2550O)R14, OP(\u2550O)(OR14)2, O\u2014N(R14)2, S\u2014C(\u2550S)N(R14)2, CN, NC, SCN, CNS, OCN, CNO, N3, OH, C1-C6-alkoxy, (SO4), PO4, HPO4, H2PO4, triflate, hexafluorophosphate, methanesulfonate, arylsulfonate, carboxylic acid halide, R15CO2, NH2, COOH, or CONH2, where R14 is aryl or a straight or branched C1-C20 alkyl group or where an N(R14)2 group is present, the two R14 groups may be joined to form a 5-, 6- or 7-member heterocyclic ring, R15 is H or a straight or branched C1-C6 alkyl group, aryl or aryl substituted 1 to 5 times with a halogen, and R10 is an alkyl of from 1 to 20 carbon atoms or an alkyl of from 1 to 20 carbon atoms in which each of the hydrogen atoms may be replaced by a halide, alkenyl of from 2 to 20 carbon atoms, alkynyl of from 2 to 10 carbon atoms, phenyl, phenyl substituted with from 1 to 5 halogen atoms or alkyl groups with from 1 to 4 carbon atoms, aralkyl, aryl substituted alkyl, in which the aryl group is phenyl or substituted phenyl and the alkyl group is from 1 to 6 carbon atoms;
a residue of initiator, wherein the residue is of the formula:
R11R12R13C;
R11C(\u2550O);
R11R12R13Si;
R11R12N;
R11N;
(R11)nP(O)m; or
(R11)(R12O)P(O)m
where:
R11, R12 and R13 are each independently selected from the group consisting of H, halogen, C1-C20 alkyl, C3-C8 cycloalkyl, R83Si, C(\u2550Y)R5, C(\u2550Y)NR6R7, COCl, OH, CN, C2-C20 alkenyl or alkynyl, oxiranyl, glycidyl, C2-C6 alkylene or alkenylene substituted with oxiranyl or glycidyl, aryl, heterocyclyl, aralkyl, aralkenyl, aryl-substituted alkenyl, and alkenyl is vinyl which may be substituted with one or two C1-C6 alkyl groups andor halogen atoms, C1-C6 alkyl in which from 1 to all of the hydrogen atoms are replaced with halogen and C1-C6 alkyl substituted with from 1 to 3 substituents selected from the group consisting of C1-C4 alkoxy, aryl, heterocyclyl, C(\u2550Y)R5, C(\u2550Y)NR6R7, oxiranyl and glycidyl, with the provisio that no more than 2 of R11, R12 and R13 are H;
R5 is C1-20 alkyl, C1-20 alkylthio, OR24, C1-20 alkoxy, aryloxy or heterocyclyloxy, where R24 is H or an alkali metal;
Y is NR8, S, or O; and
R6 and R7 are independently H or C1-20 alkyl, or R6 and R7 may be joined together to form a C2-7 alkylene group, thus forming a 3- to 8-membered ring, and R8 is H, straight or branched C1-C20 alkyl or aryl;
m is 0 or 1; and n is 0, 1 or 2;
at least one of an average degree of polymerization of at least 3 and a number average molecular weight of at least 250 gmol; and
a molecular weight distribution less than 2, wherein the copolymer is an alternating copolymer or the predominantly alternating monomer structure is a block in a block copolymer, star copolymer, graft copolymer, comb copolymer or hyperbranched copolymer.
2. The copolymer of claim 1, wherein the radically (co)polymerizable monomer having electron-donor properties is selected from unsaturated hydrocarbons, vinyl ethers, C2-C20 unsaturated hydrocarbons, C2-C20 unsaturated hydrocarbons having one or more alky, alkenyl, alkynyl, alkoxy, alkylthio, dialkylamino, aryl or trialkyl silyl, or tri aryl silyl, isobutene, or vinyl C3-C10 ethers and the monomer having electron-acceptor properties is at least one of acrylates, methacrylates, unsaturated nitrites, unstaturated ketones, (meth)acrylic acid, methacrylic acid salts, C1-C20(meth)acrylate, esters, C3-C20 unsaturated nitrites, C3-C20 \u03b1-\u03b2 unsaturated aldehydes, ketones, sulfones, phosphates, or sulfonates.
3. The copolymer of claim 1, wherein the radically (co)polymerizable monomer having electron-acceptor properties is methyl acrylate and the radically polymerizable monomer having electron-donor properties is isobutylene.
4. The copolymer of claim 1, wherein the radically (co)polymerizable monomer having electron-acceptor properties is an acrylate and the radically polymerizable monomer having electron-donor properties is a vinyl ether.
5. The copolymer of claim 1, wherein the radically (co)polymerizable monomer having electron-acceptor properties is an methyl acrylate and the radically polymerizable monomer having electron-donor properties is isobutyl vinyl ether.
6. The copolymer of claim 1, wherein the radically (co)polymerizable monomer having electron-acceptor properties is an acrylate and the radically polymerizable monomer having electron-donor properties is an alkene.
7. The copolymer of claim 1, comprising:
at least one monomer unit derived from a monomer having bulky substituents selected from 1,1-diarylethylene, didehydromalonate C1-C20 diesters, C1-C20 diesters of maleic or fumaric acid, maleic anhydride, maleic diimides, C1-C8 alkyl maleimides, or 1,1-diphenylethylene; and
at least one monomer unit derived from a monomer selected from styrene, acrylonitrile, or C1-C8 esters of (meth)acrylic acid.
8. A copolymer, comprising:
a predominantly alternating monomer structure, comprising:
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-donor properties; and
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-acceptor properties;

a terminal functional group selected from a radically transferable atom or group, a halogen, Cl, Br, I, OR10, SR14, SeR14, OC(\u2550O)R14, OP(\u2550O)R14, OP(\u2550O)(OR14)2, O\u2014N(R14)2, S\u2014C(\u2550S)N(R14)2, CN, NC, SCN, CNS, OCN, CNO, N3, OH, C1-C6-alkoxy, (SO4), PO4, HPO4, H2PO4, triflate, hexafluorophosphate, methanesulfonate, arylsulfonate, carboxylic acid halide, R15CO2, NH2, COOH, or CONH2, where R14 is aryl or a straight or branched C1-C20 alkyl group or where an N(R14)2 group is present, the two R14 groups may be joined to form a 5-, 6- or 7-member heterocyclic ring, R15 is H or a straight or branched C1-C6 alkyl group, aryl or aryl substituted 1 to 5 times with a halogen, and R10 is an alkyl of from 1 to 20 carbon atoms or an alkyl of from 1 to 20 carbon atoms in which each of the hydrogen atoms may be replaced by a halide, alkenyl of from 2 to 20 carbon atoms, alkynyl of from 2 to 10 carbon atoms, phenyl, phenyl substituted with from 1 to 5 halogen atoms or alkyl groups with from 1 to 4 carbon atoms, aralkyl, aryl substituted alkyl, in which the aryl group is phenyl or substituted phenyl and the alkyl group is from 1 to 6 carbon atoms;
a residue of initiator, wherein the residue is of the formula:
R11R12R13C;
R11C(\u2550O);
R11R12R13Si;
R11R12N;
R11N;
(R11)nP(O)m; or
(R11)(R12O)P(O)m
where:
R11, R12 and R13 are each independently selected from the group consisting of H, halogen C1-C20 alkyl, C3-C8 cycloalkyl, R83Si, C(\u2550Y)R5, C(\u2550Y)NR6R7, COCl, OH, CN, C2-C20 alkenyl or alkynyl, oxiranyl, glycidyl, C2-C6 alkylene or alkenylene substituted with oxiranyl or glycidyl, aryl, heterocyclyl, aralkyl, aralkenyl, aryl-substituted alkenyl, and alkenyl is vinyl which may be substituted with one or two C1-C6 alkyl groups andor halogen atoms, C1-C6 alkyl in which from 1 to all of the hydrogen atoms are replaced with halogen and C1-C6 alkyl substituted with from 1 to 3 substituents selected from the group consisting of C1-C4 alkoxy, aryl, heterocyclyl, C(\u2550Y)R5, C(\u2550Y)NR6R7, oxiranyl and glycidyl, with the provisio that no more than 2 of R11, R12 and R13 are H;
R5 is C1-20 alkyl, C1-20 alkylthio, OR24, C1-20 alkoxy, aryloxy or heterocyclyloxy, where R24 is H or an alkali metal;
Y is NR8, S, or O; and
R6 and R7 are independently H or C1-20 alkyl, or R6 and R7 may be joined together to form a C2-7, alkylene group, thus forming a 3- to 8-membered ring, and R8 is H straight or branched C1-C20 alkyl or aryl;
m is 0 or 1; and n is 0, 1 or 2;
at least one of an average degree of polymerization of at least 3 and a number average molecular weight of at least 250 gmol; and
a molecular weight distribution less than 2.
9. The copolymer of claim 8, wherein the radically (co)polymerizable monomer having electron-donor properties is selected from unsaturated hydrocarbons, vinyl ethers, C2-C20 unsaturated hydrocarbons, C2-C20 unsaturated hydrocarbons having one or more alkyl, alkenyl, alkynyl, alkoxy, alkylthio, dialkylamino, aryl or trialkyl silyl, or tri aryl silyl, isobutene, or vinyl C3-C10 ethers and the monomer having electron-acceptor properties is at least one of acrylates, methacrylates, unsaturated nitriles, unstaturated ketones, (meth)acrylic acid, methacrylic acid salts, C1-C20(meth)acrylate esters, C3-C20 unsaturated nitriles, C3-C20 \u03b1-\u03b2unsaturated aldehydes, ketones, sulfones, phosphates, or sulfonates.
10. The copolymer of claim 8, wherein the radically (co)polymerizable monomer having electron-acceptor properties is methyl acrylate and the radically polymerizable monomer having electron-donor properties is isobutylene.
11. The copolymer of claim 8, wherein the radically (co)polymerizable monomer having electron-acceptor properties is an acrylate and the radically polymerizable monomer having electron-donor properties is a vinyl ether.
12. The copolymer of claim 8, wherein the radically (co)polymerizable monomer having electron-acceptor properties is a methyl acrylate and the radically polymerizable monomer having electron-donor properties is isobutyl vinyl ether.
13. The copolymer of claim 8, wherein the radically (co)polymerizable monomer having electron-acceptor properties is an acrylate and the radically polymerizable monomer having electron-donor properties is an alkene.
14. A copolymer, comprising:
a predominantly alternating monomer structure, comprising:
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-donor properties; and
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-acceptor properties;

a residue of initiator, wherein the residue is of the formula:
R11R12R13C;
R11C(\u2550O);
R11R12R13Si;
R11R12N;
R11N;
(R11)nP(O)m; or
(R11)(R12O)P(O)m
where:
R11, R12 and R13 are each independently selected from the group consisting of H, halogen, C1-C20 alkyl, C3-C8 cycloalkyl, R83Si, C(\u2550Y)R5, C(\u2550Y)NR6N7, COCl, OH, CN, C2-C20 alkenyl or alkynyl, oxiranyl, glycidyl, C2-C6 alkylene or alkenylene substituted with oxiranyl or glycidyl, aryl, heterocyclyl, aralkyl, aralkenyl, aryl-substituted alkenyl, and alkenyl is vinyl which may be substituted with one or two C1-C6 alkyl groups andor halogen atoms, C1-C6 alkyl in which from 1 to all of the hydrogen atoms are replaced with halogen and C1-C6 alkyl substituted with from 1 to 3 substituents selected from the group consisting of C1-C4 alkoxy, aryl, heterocyclyl, C(\u2550Y)R5, C(\u2550Y)NR6R7, oxiranyl and glycidyl, with the provisio that no more than 2 of R11, R12 and R13 are H;
R5 is C1-20 alkyl, C1-20 alkylthio, OR24, C1-20 alkoxy, aryloxy or heterocyclyloxy, where R24 is H or an alkali metal;
Y is NR8, S , or O; and
R6 and R7 are independently H or C1-20 alkyl, or R6 and R7 may be joined together to form a C2-7 alkylene group, thus forming a 3- to 8-membered ring, and R8 is H, straight or branched C1-C20 alkyl or aryl;
m is 0 or 1; and
n is 0, 1 or 2;
at least one of an average degree of polymerization of at least 3 and a number average molecular weight of at least 250 gmol; and
a molecular weight distribution less than 2.
15. A copolymer, comprising:
a predominantly alternating monomer structure, comprising:
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-donor properties; and
at least one monomer unit derived from a radically (co)polymerizable monomer having electron-acceptor properties;

a residue of initiator, wherein the residue is of the formula:
R11R12R13C;
R11C(\u2550O);
R11R12R13Si;
R11R12N;
R11N;
(R11)nP(O)m; or
(R11)(R12O)P(O)m
where:
R11, R12 and R13 are each independently selected from the group consisting of H, halogen, C1-C20 alkyl, C3-C8 cycloalkyl, R83Si, C(\u2550Y)R5, C(\u2550Y)NR6R7, COCl, OH, CN, C2-C20 alkenyl or alkynyl, oxiranyl, glycidyl, C2-C6 alkylene or alkenylene substituted with oxiranyl or glycidyl, aryl, heterocyclyl, aralkyl, aralkenyl, aryl-substituted alkenyl, and alkenyl is vinyl which may be substituted with one or two C1-C6 alkyl groups andor halogen atoms, C1-C6 alkyl in which from 1 to all of the hydrogen atoms are replaced with halogen and C1-C6 alkyl substituted with from 1 to 3 substituents selected from the group consisting of C1-C4 alkoxy, aryl, heterocyclyl, C(\u2550Y)R5, C(\u2550Y)NR6R7, oxiranyl and glycidyl, with the provisio that no more than 2 of R11, R12 and R13 are H;
R5 is C1-20 alkyl, C1-20 alkylthio, OR24, C1-20 alkoxy, aryloxy or heterocyclyloxy, where R24 is H or an alkali metal;
Y is NR8, S, or O; and
R6 and R7 are independently H or C1-20 alkyl, or R6 and R7 may be joined together to form a C2-7 alkylene group, thus forming a 3- to 8-membered ring, and R8 is H, straight or branched C1-C20 alkyl or aryl;
m is 0 or 1; and n is 0, 1 or 2;
at least one of an average degree of polymerization of at least 3 and a number average molecular weight of at least 250 gmol; and
a molecular weight distribution less than 2,
wherein the radically (co)polymerizable monomer having electron-donor properties is selected from unsaturated hydrocarbons, vinyl ethers, C2-C20 unsaturated hydrocarbons, C2-C20 unsaturated hydrocarbons having one or more alkyl, alkenyl, alkynyl, alkoxy, alkylthio, dialkylamino, aryl or trialkyl silyl, or tri aryl silyl, isobutene, or vinyl C3-C10 ethers and the monomer having electron-acceptor properties is at least one of acrylates, methacrylates, unsaturated nitriles, unstaturated ketones, (meth)acrylic acid, methacrylic acid salts, C1-C20(meth)acrylate esters, C3-C20 unsaturated nitriles, C3-C20 \u03b1-\u03b2 unsaturated aldehydes, ketones, sulfones, phosphates, or sulfonates.

What is claimed is:

1. A method of exposing and producing at least one path on one of a curved surface and an irregular surface, the method comprising:
aiming a beam of light to the surface;
providing relative movement between the beam of light and the surface, wherein the act of providing relative movement includes providing a robotic device in communication with a computer, and providing a laser on the robotic device for providing the beam of light; and
using the computer to control the robotic device to aim and move the beam of light at the surface to create and expose the path on the surface, wherein actuation of the robotic device allows the beam of light to strike any point on the surface.
2. The method of claim 1, further comprising laying conductive material on the path to form a conductive path after the step of using the beam of light to expose the path.
3. The method of claim 1 wherein the step of providing relative movement includes controlling the robotic device to move the beam of light in three degrees of motion.
4. The method of claim 1 wherein the step of providing relative movement comprises moving the surface.
5. The method of claim 1 wherein the step of exposing the path comprises using the beam of light for accomplishing one or more of the following along the path: cutting the surface, etching the surface, or burning the surface.
6. The method of claim 1, further including altering the strength of the beam of light.
7. The method of claim 1, further including applying a seed chemical to the surface before exposing the path.
8. A method of exposing and producing at least one path on one of a curved surface and an irregular surface, the method comprising:
aiming a beam of light to the surface;
providing relative movement between the beam of light and the surface, wherein the act of providing relative movement includes providing a triaxial light beam source in communication with a computer, the triaxial light beam source being capable of focusing a beam of light in three dimensions; and
using the computer to control the triaxial light beam source to move the beam of light at the surface to create and expose the path on the surface, wherein the control of the triaxial light beam source allows the beam of light to strike any point on the surface.
9. The method of claim 8, further comprising laying conductive material on the path to form a conductive path after the step of using the beam of light to expose the path.
10. The method of claim 8 wherein the step of providing relative movement comprises moving the surface.
11. The method of claim 8 wherein the step of exposing the path comprises using the beam of light for accomplishing one or more of the following along the path: cutting the surface, etching the surface, or burning the surface.
12. The method of claim 8, further including altering the strength of the beam of light.
13. The method of claim 8 wherein the step of providing the triaxial light beam source includes using a multiplanar photonic crystal slab.
14. An apparatus for exposing and producing at least one path on one of a curved surface and an irregular surface, comprising:
a robotic device;
a laser, attached to the robotic device, for generating a beam of light; and
a computer in communication with the robotic device, wherein the computer operates to control the robotic device to aim and move the beam of light at the surface to create and expose the path on the surface, wherein actuation of the robotic device allows the beam of light to strike any point on the surface.
15. The apparatus of claim 14, further including a motor for moving the surface.
16. The apparatus of claim 14 wherein the computer further operates to alter a strength of the beam of light.
17. An apparatus for exposing and producing at least one path on one of a curved surface and an irregular surface, comprising:
a triaxial light beam source capable of focusing a beam of light in three dimensions; and
a computer in communication with the triaxial light beam source, wherein the computer operates to control the triaxial light beam source to aim and move the beam of light at the surface to create and expose the path on the surface, wherein actuation of the triaxial light beam source allows the beam of light to strike any point on the surface.
18. The apparatus of claim 17, further including a motor for moving the surface.
19. The apparatus of claim 17 wherein the computer further operates to alter a strength of the beam of light.
20. The apparatus of claim 17 wherein the triaxial light beam source comprises a multiplanar photonic crystal slab.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of identifying and locating debt settlement candidates, the method comprising:
receiving a request for a debt score for a consumer;
accessing, from an electronic data store, credit data of the consumer;
calculating, with one or more hardware computer processors, a debt score based on at least the accessed credit data of the consumer, wherein the debt score is within a debt score range including at least two sub-ranges associated with corresponding debt services, wherein the debt score is usable to determine a likelihood of the consumer being eligible for each of multiple debt services; and
providing a requesting entity with the debt score andor the debt service associated with the sub-range of the calculated debt score.
2. The method of claim 1, wherein the debt services include a debt help service.
3. The method of claim 1, wherein the debt score services include bankruptcy approval.
4. The method of claim 1, wherein the debt score is calculated based on one or more attributes of the credit data that have been pre-selected by the requesting entity.
5. The method of claim 1, wherein the debt score is calculated based on two or more of:
a credit score rank,
a credit score,
a ratio of revolving credit to debt,
an amount of credit available,
a quantity of delinquent accounts,
a quantity of negative accounts,
an average age of tradelines in the credit data, or
a quantity of negative information in the credit data.
6. The method of claim 1, wherein the debt score is further calculated based on one or more of:
public record, debit, demographic, or psychographic information associated with the consumer.
7. The method of claim 5, wherein the credit score rank is a percentage based on a comparison of the consumer’s credit score with an average of a plurality of consumer credit scores.
8. The method of claim 1, wherein the debt score is usable to estimate an outcome of the debt service associated with the sub-range of the calculated debt.
9. The method of claim 1, wherein the calculated debt score is based on at least the accessed credit data of the consumer and a credit score ranking of the consumer, wherein the credit score ranking indicates a relationship between the credit score of the consumer and credit scores of a plurality of other consumers.