All The Claims

1. A compound of formula (I)
or a salt thereof, wherein:
each R is independently selected from fluoro, chloro, cyano, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, trifluoromethoxy and difluoromethoxy; and
n is 1, 2 or 3.
2. The compound of formula (I) as claimed in claim 1, or a salt thereof, which is a compound of formula (IA)
3. The compound of formula (I) as claimed in claim 1, or a salt thereof, which is a compound of formula (IB)
4. The compound as claimed in claim 1 which is selected from
cis-4-(3-Fluoro-4-{5-(2,4,5-trifluoro-phenylamino)-1,3,4oxadiazole-2-carbonyl-amino}-phenoxy)-cyclohexanecarboxylic acid;
cis-4-(3-Fluoro-4-{5-(3,4,5-trifluoro-phenylamino)-1,3,4oxadiazole-2-carbonyl-amino}-phenoxy)-cyclohexanecarboxylic acid;
cis-4-3-Fluoro-4-5-(4-fluorophenyl)amino1,3,4-oxadiazole-2-carbonylaminophenoxycyclohexane-1-carboxylic acid;
trans-4-3-Fluoro-4-5-(2,4,5-trifluorophenyl)amino1,3,4-oxadiazole-2-carbonylaminophenoxycyclohexane-1-carboxylic acid;
trans-4-3-fluoro-4-5-(4-fluorophenyl)amino1,3,4-oxadiazole-2-carbonylaminophenoxycyclohexane-1-carboxylic acid; and
or a pharmaceutically-acceptable salt of any of these.
5. A method for producing an inhibition of DGAT1 activity in a warm-blooded animal in need of such treatment comprising administering to said animal an effective amount of a compound of formula (I) as claimed in claim 1 or a pharmaceutically-acceptable salt thereof.
6. A method of treating diabetes mellitus andor obesity in a warm-blooded animal in need of such treatment comprising administering to said animal an effective amount of a compound of formula (I) as claimed in claim 1 or a pharmaceutically-acceptable salt thereof.
7. A pharmaceutical composition comprising a compound of formula (I) as claimed in claim 1 or a pharmaceutically-acceptable salt thereof, in association with a pharmaceutically-acceptable excipient or carrier.
8. A process for preparing a compound according to claim 1 comprising one of the following steps (wherein all variables are as hereinbefore defined for a compound of formula (I) unless otherwise stated):
a) reacting an amine of formula (2) with a carboxylate salt of formula (3), wherein RP is (1-4C)alkyl group followed by hydrolysis of the RP group
b) cyclising a compound of formula (4) wherein X is S or O and wherein R is (1-4C)alkyl group followed by hydrolysis of the RP group
and optionally thereafter:
1) removing any protecting groups; andor
2) forming a (pharmaceutically-acceptable) salt.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A device for testing a subject for detecting a state of a vascular pathology of the subject, the device comprising:
a sensor signal unit for receiving a sensor signal representative of a blood volume in a body part of the subject;
a comparator for comparing the sensor signal with a reference signal; and
a user interface for conveying a result based on the comparison to a user of the device.
2. The device of claim 1, wherein the sensor signal unit acquires and processes the sensor signal provided by a photoplethysmogram sensor.
3. The device of claim 1, wherein the reference signal is at least one of a sensor signal previously acquired from a test on the subject and a sensor signal acquired from at least one healthy subject.
4. The device of claim 1, further including:
an electrocardiogram signal unit for acquiring an electrocardiogram signal of the subject; and
a synchronizer for synchronizing an acquisition of the sensor signal with the electrocardiogram signal.
5. The device of claim 4, further including:
an electrocardiogram signal processing unit for processing the electrocardiogram signal of the subject; and
a sensor signal processing unit for processing the sensor signal based on the electrocardiogram signal.
6. A method of testing a subject for detecting a state of a vascular pathology of a subject, the method comprising:
sensing a blood volume in a body part of the subject and obtaining a sensor signal representative of the blood volume;
comparing the sensor signal with a reference signal; and
conveying a result based on the comparison to a user of the device.
7. The method of claim 6, further including:
acquiring an electrocardiogram signal of the subject;
synchronizing an acquisition of the sensor signal with the electrocardiogram signal; and
comparing the sensor signal with the reference signal, based on the electrocardiogram signal.

1. A process for extending the cyclic service life of a thermal barrier coating made of chemical thermal barrier coating composition, which has been applied to a substrate with an oxidizing bond coat in between, the thermal barrier coating includes microcracks, which are bridged by punctiform contact locations, the process comprising:
improving a strain tolerance of the thermal barrier coating by weakening the punctiform contact locations in the thermal barrier coating.
2-9. (canceled)
10. The process as recited in claim 1, wherein the weakening of the microcontacts includes performing a shot-peening process.
11. The process as recited in claim 1, wherein the weakening of the microcontacts includes performing a Trowal process.
12. The process as recited in claim 1, wherein the weakening of the microcontacts includes an infiltration process using an infiltration medium, followed by a heat treatment, wherein the infiltration medium undergoes a volumetric expansion during a liquid-solid phase change.
13. The process as recited in claim 12, wherein the infiltration medium is water, further comprising introducing the water introduced into pores in the thermal barrier coating by at least one of immersion, spraying and via the is phase and briefly freezing the water using liquid nitrogen or dry ice, and subsequently removing the infiltration agent by one of standard drying and vacuum drying.
14. The process as claimed in claim 12, further comprising restricting a penetration depth of the infiltration medium to an outer region of the thermal barrier coating using suitable process parameters so as to avoid having a negative effect on the adhesion of the thermal barrier coating.
15. The process as recited in claim 13, wherein a spatial propagation of the brief freezing step is controlled by targeted dissipation of heat into the component interior, so that a solidification front, starting from an interface of the thermal barrier coating, is guided in a direction of the surface of the thermal barrier coating instead of prematurely closing off the porosity from the outside before the solidification has ended so as to avoid having a negative effect on the adhesion of the thermal barrier coating.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system, the gas delivery conduit comprising:
a first connector adapted for connecting to the respiratory gases delivery system;
a second connector adapted for connecting to a fitting of a patient interface; and
tubing fluidly connecting the first connector to the second connector;
wherein the first connector has a gas inlet adapted to receive the supplied respiratory gas.
2. The gas delivery conduit of claim 1, further comprising one of electrical contacts and temperature contacts integrated into the first connector.
3. The gas delivery conduit of claim 1, further comprising a sensing conduit integrated into the gas delivery conduit.
4. The gas delivery conduit of claim 3, wherein the sensing conduit is adapted to facilitate monitoring one of pressure, pulse oximetry, carbon dioxide and oxygen.
5. The gas delivery conduit of claim 1, wherein the first connector is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.
6. The gas delivery conduit of claim 1, wherein the first connector is adapted to allow the user to couple the first connector with the respiratory gases delivery system by moving the connector in a direction along an axis of the gas inlet.
7. The gas delivery conduit of claim 1, wherein the first connector is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a predetermined orientation.
8. The gas delivery conduit of claim 1, further comprising an orientation feature adapted to allow the connector to couple with the respiratory gases delivery system in a predetermined orientation.
9. The gas delivery conduit of claim 8, wherein the orientation feature is a flange portion of the first connector.
10. The gas delivery conduit of claim 1, further comprising at least one temperature sensor.
11. The gas delivery conduit of claim 1, further comprising a heating element.
12. The gas delivery conduit of claim 3, wherein the sensing conduit is configured to couple with a port of the respiratory gases delivery system.
13. The gas delivery conduit of claim 2, wherein the electrical contacts are adapted to couple with system electrical contacts of the respiratory gases delivery system.
14. The gas delivery conduit of claim 2, wherein the electrical contacts are adapted to facilitate providing power to the connector.
15. The gas delivery conduit of claim 1, wherein the connector is adapted to allow the user to couple the connector with the respiratory gases delivery system by moving the connector in a single direction.
16. The gas delivery conduit of claim 1, wherein the first connector is adapted to couple with a gas outlet of the respiratory gases delivery system and a receptacle of the respiratory gases delivery system.
17. A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system, the gas delivery conduit comprising:
a first connector adapted for connecting to the respiratory gases delivery system;
a second connector adapted for connecting to a fitting of a patient interface; and
tubing fluidly connecting the first connector to the second connector;
wherein the first connector has a gas inlet adapted to receive the supplied respiratory gas from a humidity chamber.
18. The gas delivery conduit of claim 17, wherein the first connector is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a predetermined orientation.
19. The gas delivery conduit of claim 17, wherein the connector is adapted to allow the user to couple the connector with the respiratory gases delivery system by moving the connector in a single direction
20. A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system, the gas delivery conduit comprising:
a first connector adapted for connecting to the respiratory gases delivery system;
a sensing conduit with a sensing conduit outlet port;
wherein the first connector has a gas inlet adapted to receive the supplied respiratory gas from a humidity chamber;
wherein the gas inlet conduit has a first axis;
wherein the sensing conduit outlet port has a second axis; and
wherein the first axis and the second axis are not parallel.