All The Claims

1. A computer-implemented system for administering a drug registry database, comprising:
an electronic database containing at least a plurality of healthcare claims of a plurality of patients and a plurality of new drugcomparator drug pairings;
an electronic user interface configured to
display the plurality of new drugcomparator drug pairings, wherein each new drug is added to the database when a threshold number of healthcare claims for the new drug have been received and wherein each comparator drug paired with a new drug that has substantially similar medical indications as the new drug; and
receive a selection of the new drugcomparator drug pairing, and filter parameters input by a user; and
a computer-implemented analysis engine configured to
search the healthcare claims stored in the database to identify a first and second group of patients satisfying the filter parameters input by the user, wherein the first group includes patients with claim data indicating use of the new drug and the second group includes patients with claim data indicating use of the comparator drug;
identify a comparative occurrence of one or more existing medical conditions or new medical conditions in the first and second groups of patients; and
calculate a probability value indicating a relative likelihood that a patient taking the new drug will have each of the one or more new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have each of the one or more new or existing medical conditions;
wherein the electronic user interface displays each new or existing medical condition and the probability value for the new drug and the comparator drug in accordance with one or more report parameters entered by the user.
2. The system according to claim 1, wherein the display generated by the electronic user interface includes demographic characteristics, prevalence of diagnosis, prevalence of procedures, prevalence of drug class, or healthcare utilization.
3. The system according to claim 1, wherein the filter parameters include one or more diagnosis codes, procedure codes, drug categories, or demographic characteristics.
4. A computer-implemented method for administering a drug registry database, comprising:
storing a plurality of healthcare claims for a plurality of patients on a computing device and a plurality of new drugcomparator drug pairings;
displaying on an electronic user interface a plurality of new drugcomparator drug pairings, wherein each new drug is added to the database when a threshold number of healthcare claims for the new drug have been received and wherein each comparator drug paired with a new drug that has substantially similar medical indications as the new drug;
receiving a selection of the new drugcomparator drug pairing, and filter parameters input by a user;
searching by a computer-implemented analysis engine the healthcare claims stored in the database to identify a first and second group of patients satisfying the filter parameters input by the user; wherein the first group includes patients with claim data indicating use of the new drug and the second group includes patients with claim data indicating use of the comparator drug;
identifying a comparative occurrence of one or more existing medical conditions or new medical conditions in the first and second groups of patients;
calculating a probability value indicating a relative likelihood that a patient taking the new drug will have each of the one or more new or existing medical conditions in comparison to a likelihood that a patient taking the comparator drug will have each of the one or more new or existing medical conditions; and
displaying each new or existing medical condition and the probability value for the new drug and the comparator drug in accordance with one or more report parameters entered by the user.
5. The method according to claim 4, wherein the display
generated by the electronic user interface includes demographic characteristics, prevalence of diagnosis, prevalence of procedures, prevalence of drug class, or healthcare utilization.
6. The method according to claim 4, wherein the filter parameters include one or more diagnosis codes, procedure codes, drug categories, or demographic characteristics.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of recording information on a user recordable multi-layer record carrier having a plurality of information layers including at least a first information layer and a second information layer for storing information, the method comprising acts of:
receiving data content to be recorded on the user recordable multi-layer record carrier;
recording the data content on the user recordable multi-layer record carrier such that the data content is substantially evenly distributed between each of the plurality of information layers and recorded in compliance with a ROM (read only memory) record carrier standard, wherein portions of the data content are recorded in data areas of the first and second information layers such that the data areas are superjacent; and
shifting middle zone areas of at least the first and second information layers towards an inner radius of the disc such that inner radius data areas of the first and second information layers are filled with a portion of the recorded data content if the user recordable multi-layer record carrier is recorded with less than a full capacity of the user recordable multi-layer record carrier.
2. The method of claim 1, wherein the recordable multi-layer record carrier is an optical disk.
3. The method of claim 1, wherein recording comprises acts of dividing the received data content into portions of substantially equal size, and recording the portions of the data content to the data areas of the plurality of information layers.
4. The method of claim 3, wherein dividing the data content into portions of substantially equal size comprises an act of dividing the data content based on recording time.
5. The method of claim 3, wherein dividing the data content into portions of substantially equal size comprises an act of dividing the data content based on a size of the data content to be recorded.
6. The method of claim 1, wherein the data content is video data.
7. The method of claim 1, wherein the data content is audio data.
8. The method of claim 1, wherein the data content is audiovisual data.
9. A user recordable multi-layer record carrier, said record carrier comprising:
a plurality of information layers including at least a first information layer and a second information layer for storing data content recorded on the user recordable multi-layer record carrier such that the data content is substantially evenly distributed between each of the plurality of information layers and recorded in compliance with a ROM (read only memory) record carrier standard,
wherein portions of the data content are recorded in data areas of the first and second information layers such that the data areas are of substantially equal size and are superjacent and wherein middle zone areas of at least the first and second information layers are shifted towards an inner radius of the disc such that inner radius data areas of the first and second information layers are filled with a portion of the recorded data content if the user recordable multi-layer record carrier is recorded with less than a full capacity of the user recordable multi-layer record carrier.
10. A method of recording information on a user recordable multi-layer optical disc having a plurality of information layers, the method comprising acts of:
receiving data content to be recorded on the user recordable multi-layer optical disk; and
recording the data content in data areas of the plurality of information layers such that the data content is substantially evenly distributed between each of the plurality of information layers and recorded in compliance with a ROM (read only memory) record carrier standard,
wherein recording includes an act of shifting middle zone areas of the plurality of information layers towards an inner radius of the disc if the user recordable multi-layer optical disk is recorded with less than a full capacity of the user recordable multi-layer optical disk such that the data area of the plurality of information layers are (i) substantially equal size, (ii) substantially filled with a portion of the recorded data content and are (iii) spatially aligned.
11. The method of claim 10, wherein recording the data content comprises an act of dividing the data content into portions of substantially equal size, and recording the portions of the data content to the data areas of the plurality of information layers.
12. The method of claim 11, wherein dividing the data content into portions of substantially equal size comprises an act of dividing the data content based on recording time.
13. The method of claim 11, wherein dividing the data content into portions of substantially equal size comprises an act of dividing the data content based on a size of the data content to be recorded.
14. The method of claim 10, wherein the data content is video data.
15. The method of claim 10, wherein the data content is audio data.
16. The method of claim 10, wherein the data content is audiovisual data.

1. A critical temperature indicator comprising a closed vessel having sealed upper and lower ends, at least one of the ends being a transparent end, the vessel containing at least one meltable solid material, and at least one non-meltable solid float material of a lower density than the meltable solid material positioned below the meltable solid material within the vessel when the vessel is oriented in an upright position with the transparent end at the top, the meltable solid material being transformable into a liquid upon heating to some critical temperature of the meltable solid material to allow the float material to start floating up through the liquid for viewing of the float material at least through the transparent end at the top to show that the critical temperature has been reached.
2. The temperature indicator of claim 1 wherein the float material is a rigid closed cell foam, hollow glass, or plastic beads.
3. The temperature indicator of claim 1 wherein the float material is pigmented.
4. The temperature indicator of claim 1 wherein both sealed ends of the vessel are transparent, and the temperature indicator is reset for use after the liquid returns to the meltable solid material after cooling below the critical temperature by rotating or turning the temperature indicator upside down to reposition the float material below the meltable solid material.
5. The temperature indicator of claim 1 wherein the vessel is a transparent sealed vessel that is filled with a liquid at room temperature that becomes the meltable solid material at some critical temperature below room temperature, and the float material is placed inside the vessel before the ends of the vessel are sealed.
6. The temperature indicator of claim 1 which is mounted on a card that is rotatable 180\xb0to reposition the float material below the meltable solid material for reuse of the temperature indicator after the float material has floated up through the liquid and the liquid has cooled below the critical temperature and returned to the meltable solid material.
7. The temperature indicator of claim 1 wherein the float material partially moves up in the meltable solid material when the meltable solid material partially melts to indicate partial thawing of an other material surrounding at least a portion of the vessel when the vessel is inserted into the other material.
8. The temperature indicator of claim 1 wherein the vessel is a transparent sealed tube, and the meltable solid material is a material that melts above room temperature and is a cylindrical form that closely fits within the tube when in a solid state, and the float material has a smaller diameter than the tube.
9. The temperature indicator of claim 1 wherein the vessel is made of a high temperature material that will withstand cooking temperatures of at least 500\xb0 F.
10. The temperature indicator of claim 1 wherein the vessel has a transparent top to show interior critical temperatures of a shipping container when the vessel is placed in the shipping container with the top of the vessel viewable.
11. The temperature indicator of claim 1 wherein the vessel has a transparent top that protrudes from a food product for viewing of the top during cooking of the food product.
12. The temperature indicator of claim 1 which is rotatable or turnable upside down to reposition the float material below the meltable solid material for reuse of the temperature indicator after the float material has floated up through the liquid and the liquid has cooled below the critical temperature and returned to the meltable solid material.
13. The temperature indicator of claim 1 wherein a plurality of meltable solid materials each having different critical melt temperatures and a plurality of non-meltable solid float materials each having a density less than that of each of the meltable solid materials are alternately stacked one upon another within the vessel to give a number of different critical temperatures during heating of a food product in which the vessel is inserted.
14. The temperature indicator of claim 13 wherein the different float materials have different colors to indicate different temperatures when the different meltable solid materials melt and the different float materials start to float in the different melted solid materials.
15. The temperature indicator of claim 1 wherein the float material is a pigmented float material, and the vessel contains a thermal insulating gas on top of the meltable solid material which extends below the surface of an other material into which the vessel is inserted, whereby when the other material is heated and the meltable solid material reaches a critical temperature and becomes a liquid, the pigmented float material starts floating up through the liquid and rises into the gas.
16. The temperature indicator of claim 1 wherein permanent magnets are mounted on top and bottom surfaces of the float material.
17. The temperature indicator of claim 16 further comprising an audible alarm positioned in close proximity to the top of the vessel, and a switch that is activated by one of the permanent magnets when the meltable solid material becomes a liquid and the float material starts floating to the top of the liquid to cause the audible alarm to be sounded.
18. The temperature indicator of claim 17 wherein the vessel is turnable upside down with respect to the alarm to reposition the float material below the meltable solid material for reuse of the temperature indicator after the float material has floated up through the liquid and the liquid has cooled below the critical temperature and returned to the meltable solid material.
19. The temperature indicator of claim 17 that is incorporated in a lid of a pressure cooker or pot to indicate when a critical temperature has been reached during use.
20. The temperature indicator of claim 17 that is built into a handle of a pot lid or pressure cooker to indicate when a critical temperature has been reached during use.
21. The temperature indicator of claim 17 that is fitted with one or more of a plurality of cylinders that are selectively nestable together to change the wall thickness surrounding the temperature indicator to alter the length of time required for the temperature indicator to reach a critical temperature and activate the alarm.
22. A critical temperature indicator comprising a closed vessel having sealed upper and lower ends, at least the upper end being transparent, the vessel containing a meltable solid material and a non-meltable solid material on top of the meltable solid material when in a solid state, the non-meltable solid material having a higher density than the meltable solid material, the meltable solid material becoming a liquid upon heating to some critical temperature to allow the non-meltable solid material to sink to the bottom of the liquid in the vessel to show that the critical temperature has been reached or exceeded, wherein the non-meltable solid material is comprised of pigmented particulates, and wherein the pigmented particulates are on top of a cylinder of the meltable solid material, and a pigmented solid float material having a lower density than the meltable solid material and a different color than the pigmented particulates is below the cylinder of the meltable solid material, whereby upon heating of the temperature indicator to some critical temperature, the meltable solid material becomes a liquid and the pigmented particulates start to sink toward the bottom of the liquid and the float material starts to float up to the top of the liquid so that two color changes occur.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A process for the preparation of tertiary alcohols comprising reacting tertiary olefins having the same number of carbon atoms as the tertiary alcohols to be prepared with water in a heterogeneous reactive rectification in the presence of an acidic cation exchanger, the process being performed in the presence of structured catalytic multi-purpose packings which have sections serving for material separation and sections serving as second functionality elements, wherein said sections serving as second functionality elements have a compartmental structure in which said acidic cation exchanger is contained.
2. The process of claim 1, wherein the tertiary alcohols to be prepared are C4 to C8 alcohols.
3. The process of claim 2, wherein the alcohols to be prepared are C5 to C7 alcohols.
4. The process of claim 3, wherein the alcohol to be prepared is tertiary amyl alcohol and the tertiary olefin is isoamylene.
5. The process of claim 1 or 2, wherein the acidic cation exchanger is selected from the group consisting of a sulfonated phenol-formaldehyde resin, a sulfonated cumarone-indene condensation product, sulfonated polystyrene or a sulfonated styrene-divinylbenzene resin in their respect H* forms.
6. The process of claim 5, wherein the sulfonated styrene-divinylbenzene resin has a degree of cross-linking (divinylbenzene content) of from 2 to 65% by weight.
7. The process of claim 6, wherein the degree of cross-linking is from 8 to 25% by weight.
8. The process of claim 1, wherein the acidic cation exchanger is loaded with such an amount of total feed mixture of tertiary olefin and water that a liquid hourly space velocity of 0.05-1 | of feed mixture per liter of catalyst per hour, is achieved.
9. The process of claim 8, wherein the liquid hourly space velocity is 0.1-0.4 | of feed mixture per liter of catalyst per hour.
10. The process of claim 1, wherein the amount of water employed is superstoichiometric, equimolar or substoichiometric, based on the tertiary olefin.
11. The process of claim 10, where an excess of water of from 10 to 90 mole percent is employed.
12. The process of claim 11, wherein the excess of water is from 30 to 70 mole percent.
13. The process of claim 4, wherein an excess of water of from 40 to 50 mole percent, based on the isoamylene is used for the preparation of the tertiary amyl alcohol.
14. The process of claim 1, wherein the structured multi-purpose packings contain material separation elements and second functionality elements provided in alternate layers, the material separation elements have a profiled surface, and each of the second functionality elements having two or more closed chambers provided on top of each other and filled with the acidic cation exchanger, a space being provided between any two of the chambers, which space is bridged by a section conducting a liquid, the walls of the second functionality elements being constituted of metal-wire cloth.