All The Claims

1. A method of treating a subject for at least one syndrome selected from the group consisting of Parkinson’s disease and restless leg syndrome, wherein the method comprising:
orally administering a composition to the subject, wherein the composition comprises:
a bioreversible derivative of a compound of formula (I) or an enantiomer or salt or prodrug thereof,
wherein Ra is selected from the group consisting of H, 2-thiophen-2-ylethyl, and n-propyl; and
a pharmaceutically acceptable carrier,
wherein the bioreversible derivative has an intrinsic lipophilicity C log P value of about 7 to about 11.5.
2. The method of claim 1, wherein the bioreversible derivative has an intrinsic lipophilicity C log P value of about 8 to about 11, or about 8.5 to about 10.5.
3. The method of claim 1, wherein the compound of formula (I) is selected from the group consisting of (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol compound of formula (IA), (6S)-(+5-hydroxy-N-propyl-2-aminotetralin compound of formula (IB), 8-hydroxy-N,N-dipropyl-2-aminotetralin compound of formula (IC), 5-hydroxy-N,N-dipropyl-2-aminotetralin compound of formula (ID), and 7-hydroxy-N,N-dipropyl-2-aminotetralin compound of formula (1E).
4. The method of claim 1, wherein the bioreversible derivative has the following structure:
wherein
R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, aralkyl, acyl, alkoxycarbonyl, cycloalkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, acetal, ketal, \u2014C(O)NR2R3, \u2014C(O)NHR2, \u2014S(O)2R2, \u2014S(O)2OR2, \u2014P(O2H)OR2;
R2 and R3 are independently selected from the group consisting of H, C1-16 alkyl or alkenyl or alkynyl, C3-16 cycloalkyl or cycloalkenyl or cycloalkynl, benzyl, and phenyl.
5. The method of claim 1, wherein the bioreversible derivative has the following structure:
wherein
R1 is selected from the group of C6-14 alkylcarbonyl, C3-14 cycloalkylcarbonyl, benzoyl, \u2014C(O)NR2R3, and \u2014C(O)NHR2, and
R2 and R3 are independently selected from the group consisting of C1-12 alkylcarbonyl, and C3-12 cycloalkylcarbonyl.
6. The method of claim 1, wherein the bioreversible derivative or its salt, when administered to the subject, is cleaved, processed or metabolized to (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol, or a prodrug or metabolite thereof.
7.-14. (canceled)
15. A method of treating a subject in need of (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol therapy, the method comprising:
orally administering an oral unit dosage form to the subject to provide a daily dose of the (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol, or the prodrug or salt or enantiomer thereof, of about 0.5 mg to about 400 mg of the (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol equivalent, based on single unit or multiple unit oral dosing,
wherein the oral unit dosage form comprises a 5-hydroxy bioreversible derivative of (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol, or an enantiomer or salt or prodrug thereof and a pharmaceutically acceptable carrier, the 5-hydroxy bioreversible derivative having an intrinsic lipophilicity C log P value of about 7 to about 11.5.
16. The method of claim 15, wherein the oral unit dosage form provides a mean serum rotigotine or its metabolite Cmax value in the subject of at least about 0.04 ngml after single dose.
17. The method of claim 15, wherein the oral unit dosage form provides a mean serum rotigotine or its metabolite Cmaxmg value in the subject of at least about 1.0\xd710\u221210 ml\u22121.
18. The method of claim 15, wherein the oral unit dosage form provides a mean Css-maxmg value in the subject of at least about 2.5\xd710\u221210 ml\u22121.
19. The method of claim 15, wherein the oral unit dosage form provides a serum rotigotine or its metabolite Cavg value in the subject of at least about 0.04 ngml.
20. The method of claim 15,
wherein the dosage form provides a mean serum AUC0-24 of (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol of at least about 0.5 ng\xb7hr\xb7ml\u22121 after a single dose oral administration with a meal.
21. The method of claim 15, wherein the oral unit dosage form provides a mean serum (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol AUC0-24 per mg of the 5-hydroxy bioreversible derivative equivalent administered of at least about 1.25\xd710\u22129 hr. ml\u22121.
22. The method of claim 15, wherein
the oral unit dosage form provides a mean serum AUC0-24 of (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol of no greater than about 94 ng\xb7hr\xb7ml\u22121, upon single dose oral administration to the mammal subject.
23. The method of claim 15, wherein the oral unit dosage form is orally administered to the subject with a meal that comprises at least about 15 g of fat.
24. A method of treating a subject for at least one of the following symptoms: depression, pain, anxiety disorders, sexual dysfunctions, glaucoma, cognitive disorders, restless leg syndrome, restless limb disorder, neurodevelopmental type disorder, attention deficit hyperactivity syndrome (ADHS), attention deficit hyperactivity disorder (ADHD), hyperkinetic disorder, obsessive compulsive disorder, impulsive disorder, hyperprolactinemia, hyperprolactinoma, eating disorders, neurodegenerative disorder, Parkinson-associated movement disorders, dopa- and neuroleptic-inducedsensitive movement disorders, galactorrhea, ovarian hyperstimulation disorder, neuroleptic-induced (tardive) dyskinesia, dystonia, akathisia, Parkinson plus syndrome, and addiction to cocaine, alcohol, opiate or nicotine, the method comprising:
orally administering a composition to the subject, wherein the composition comprises:
a bioreversible derivative of hydroxy N-substituted-2-aminotetralin, or an enantiomer, or salt or prodrug thereof; and
a pharmaceutically acceptable carrier,
wherein the bioreversible derivative has an apparent lipophilicity log D7.4 value at pH 7.4 of about 4 to about 9, and
wherein upon oral administration of the composition to the subject, at least about 1% of the hydroxy N-substituted-2-aminotetralin equivalent dose is bioavailable as hydroxy N-substituted-2-aminotetralin to the subject.
25. The method of claim 24, wherein the hydroxy N-substituted-2-aminotetralin is selected from the group consisting of (S)-6-propyl(2-thiophen-2-ylethyl)amino-5,6,7,8-tetrahydronaphthalen-1-ol, (6S)-(\u2212)-5-hydroxy-N-propyl-2 amino tetralin, 5-hydroxy-N,N-dipropyl-2-aminotetralin (5-OH-DPAT), 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT), and 7-hydroxy-N,N-dipropyl-2-aminotetralin (7-OH-DPAT).
26.-28. (canceled)
29. The method of claim 24, wherein the composition is administered with a meal.
30. The method of claim 24, wherein the composition is administered with a meal that comprises at least about 15 g of fat.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for manufacturing a field emission device comprising:
forming a semiconductor film in the shape of a stripe over an insulating surface of a substrate;
forming an insulating film on the semiconductor film and the insulating surface;
forming a gate electrode in the shape of a stripe on the insulating film;
removing a portion of the gate electrode and a portion of the insulating film to expose the semiconductor film; and
irradiating a laser beam to the semiconductor film to form a conical convex portion.
2. A method according to claim 1, wherein the semiconductor film is doped with an impurity that imparts n-type.
3. A method according to claim 1, wherein the laser beam is a pulse oscillation laser beam.
4. A method according to claim 1, wherein an electron emission portion comprises the conical convex portion.
5. A method for manufacturing a field emission device comprising:
forming a first conductive film in the shape of a stripe over an insulating surface of a substrate;
forming a first insulating film on the insulating surface;
forming a semiconductor film on the first conductive film and the first insulating film;
processing the semiconductor film into a desired shape;
forming a second insulating film on the semiconductor film in the desired shape;
forming a second conductive film on the second insulating film;
removing a portion of the second conductive film and a portion of the second insulating film to expose the semiconductor film; and
irradiating a laser beam to the semiconductor film to form a conical convex portion.
6. A method according to claim 5, wherein the semiconductor film is etched into the desired shape and a portion of the semiconductor film in the desired shape is doped with an impurity that imparts n-type.
7. A method according to claim 5, wherein the laser beam is a pulse oscillation laser beam.
8. A method according to claim 5, wherein an electron emission portion comprises the conical convex portion.
9. A method for manufacturing a field emission device comprising:
forming a semiconductor film over an insulating surface of a substrate;
processing the semiconductor film into a desired shape;
forming a first insulating film on the semiconductor film in the desired shape;
forming a first conductive film on the first insulating film;
forming a second insulating film on the first conductive film and the first insulating film;
removing a portion of the first insulating film and a portion of the second insulating film to expose first and second portions of the semiconductor film;
forming a second conductive film to have contact with the first portion; and
irradiating a laser beam to the semiconductor film to form a conical convex portion in the second portion.
10. A method according to claim 9, wherein the semiconductor film is etched into the desired shape and a portion of the semiconductor film in the desired shape is doped with an impurity that imparts n-type.
11. A method according to claim 9, wherein the laser beam is a pulse oscillation laser beam.
12. A method according to claim 9, wherein an electron emission portion comprises the conical convex portion.
13. A method for manufacturing a field emission device comprising:
forming a semiconductor film over an insulating surface of a substrate;
adding a metal element to the semiconductor film;
performing a first process to crystallize the semiconductor film and segregate the metal element or metal suicide at a grain boundary of the crystallized semiconductor film; and
performing a second process in an atmosphere including gas including a semiconductor element to form a whiskers-shaped convex portion in the vicinity of a surface of the metal element or the metal silicide.
14. A method according to claim 13, wherein the metal element is added with one of application, PVD, and CVD.
15. A method according to claim 13, wherein the first process is one of heating at a temperature from 300 to 650\xb0 C. and irradiation of a laser beam.
16. A method according to claim 13, wherein the gas including the semiconductor element includes one of silane and poly-silane such as di-silane or tri-silane.
17. A method according to claim 13, wherein the second process is heat treatment at a temperature from 400 to 650\xb0 C.
18. A method according to claim 13, wherein the semiconductor film is doped with an impurity that imparts n-type.
19. A method according to claim 13, wherein the metal element is one of Au, Al, Li, Mg, Ni, Co, Pt, and Fe.
20. A method according to claim 13, wherein an electron emission portion comprises the whiskers-shaped conical convex portion.

1. An intrusion masquerade detection method comprising:
a computer applying a compression algorithm to user data to build user grammars associated with a user;
forming at least one model by storing said user grammars using a database;
applying said compression algorithm to at least one target block to calculate an estimated algorithmic minimum sufficient statistic;
searching a string of data from said target block for phrases matching user grammars contained in said at least one model;
sorting the user grammars so that longest phrases among said user grammars are applied first to an unclassified string;
converting each matching phrase to a variable-length code value by replacing each said matching phrase with a corresponding variable-length code value;
attributing a cost for phrases that are not found in the at least one model by quantifying the cost of explicitly representing symbols associated with those phrases;
determining a degree of fit between said target block and said at least one model based on said cost; and
detecting an intrusion masquerade based on said degree of fit.
2. The intrusion detection method of claim 1, wherein said searching is performed in real-time.
3. The intrusion detection method of claim 1,
wherein said variable-length code is a Huffman code, and
wherein said compression algorithm is a grammar-based compression algorithm that estimates Kolmogorov complexity and which forms compressive grammar based on Minimum Description Length (MDL) principles.
4. The intrusion detection method of claim 1,
wherein said forming at least one model is performed using a steepest descent method; and
wherein said at least one model comprises a healthy session model.
5. The intrusion detection method of claim 1, further comprising:
outputting an indication of an intrusion masquerade.
6. The intrusion detection method of claim 1,
wherein said detecting an intrusion masquerade includes calculating an inverse compression ratio over a time period for user data, and comparing said calculated inverse compression ratio to at least one inverse compression ratio associated with a compressed data set of at least one said model, and
wherein said detecting an intrusion masquerade event is based on a difference between said calculated inverse compression ratio and said inverse compression ratio associated with a compressed data set, said difference exceeding a threshold.
7. A machine-implemented grammar inference engine for intrusion detection, comprising:
a pre-processor apparatus that receives input data and is configured to output filtered data;
a grammar generator apparatus coupled to the pre-processor apparatus and configured to generate grammars associated with a user by applying a compression algorithm to the filtered data, to form at least one model by storing said user grammars using a database, and to apply said compression algorithm to at least one target block to calculate an estimated algorithmic minimum sufficient statistic;
a grammar applicator apparatus that searches a string of data from said at least one target block for phrases matching user grammars contained in said at least one model, sorts the user grammars so that longest phrases among said user grammars are applied first to an unclassified string, replaces each matching phrase with a variable-length code value, and attributes a cost for phrases that are not found in the at least one model by quantifying the cost of explicitly representing symbols associated with those phrases; and
a classifier apparatus coupled to the grammar applicator apparatus and to a post-processor apparatus, wherein the classifier apparatus receives said cost from said grammar applicator apparatus and decision criteria from said post-processor apparatus, wherein the classifier apparatus is configured to determine a degree of fit between said at least one target block and said at least one model based on said cost and said decision criteria, to detect an intrusion masquerade based on said degree of fit, and to output an indication of an intrusion masquerade,
wherein said post-processor apparatus assigns each portion of the input data to one of said models.
8. The grammar inference engine of claim 7, further comprising:
a grammar database coupled to the grammar applicator apparatus and to the grammar generator apparatus; and
an input database coupled to an output of the pre-processor apparatus,
wherein the grammar applicator apparatus is configured to receive filtered data processed by the pre-processor apparatus from the input database.
9. The grammar inference engine of claim 7, wherein said compression algorithm is a grammar-based compression algorithm that estimates Kolmogorov complexity and which forms compressive grammar based on Minimum Description Length (MDL) principles.
10. The grammar inference engine of claim 7, wherein the pre-processor is further configured to apply a sliding window protocol to segment portions of said input data.
11. A machine-readable medium upon which is embodied and stored a sequence of programmable instructions which, when executed by a processor, cause the processor to perform intrusion masquerade detection operations comprising:
applying a compression algorithm to user data to build user grammars associated with a user;
forming at least one model by storing said user grammars using a database;
applying said compression algorithm to at least one target block to calculate an estimated algorithmic minimum sufficient statistic;
searching a string of data from said target block for phrases matching user grammars contained in said at least one model;
attributing a cost for phrases that are not found in the at least one model by quantifying the cost of explicitly representing symbols associated with those phrases;
determining a degree of fit between said target block and said at least one model based on said cost; and
detecting an intrusion masquerade based on said degree of fit; and
outputting an indication of an intrusion masquerade.
12. The machine-readable medium of claim 11, wherein the operations further comprise:
sorting the user grammars so that longest phrases among said user grammars are applied first to an unclassified string.
13. The machine-readable medium of claim 12, wherein the operations further comprise:
replacing each matching phrase with a variable-length code value.
14. The machine-readable medium of claim 13, wherein said variable-length code is a Huffman code.
15. The machine-readable medium of claim 11, wherein said searching is performed in real-time.
16. The machine-readable medium of claim 11, wherein said forming at least one model is performed using a steepest descent method.
17. The machine-readable medium of claim 11, wherein said at least one model comprises a healthy session model.
18. The machine-readable medium of claim 11,
wherein said detecting an intrusion masquerade includes calculating an inverse compression ratio over a time period for user data, and comparing said calculated inverse compression ratio to at least one inverse compression ratio associated with a compressed data set of at least one said model, and
wherein said detecting an intrusion masquerade event is based on a difference between said calculated inverse compression ratio and said inverse compression ratio associated with a compressed data set, said difference exceeding a threshold.
19. The machine-readable medium of claim 11, wherein said compression algorithm is a grammar-based compression algorithm that estimates Kolmogorov complexity and which forms compressive grammar based on Minimum Description Length (MDL) principles.
20. The machine-readable medium of claim 11, wherein said target block comprises a plurality of information packets of an information system.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An electrical connector receptacle comprising:
a first housing portion;
a tongue extending from the first housing portion and fitted to snap into the first housing portion;
a plurality of contacts in the tongue, wherein a front portion of each of the plurality of contacts is angled such that a front edge is embedded in the tongue;
a shield around the first housing portion;
a mounting bracket attached to the shield;
a first metallic piece between the mounting bracket and the tongue and comprising a plurality of EMI contacts; and
a tape layer between the first metallic piece and the mounting bracket.
2. The connector receptacle of claim 1 wherein the connector receptacle is formed to mate with a second housing portion formed with a device enclosure.
3. The connector receptacle of claim 1 wherein the plurality of contacts comprises at least one ground contact, the ground contact longer than at least one other contact in the plurality of contacts.
4. The connector receptacle of claim 1 wherein the tape layer holds the first metallic piece to the mounting bracket during manufacturing.
5. The connector receptacle of claim 1 wherein the plurality of EMI contacts each has a dome-shaped top.
6. The connector receptacle of claim 1 wherein each of the plurality of EMI contacts has a spherical-shaped top.
7. The connector receptacle of claim 1 wherein each of the plurality of EMI contacts is at an end of a finger portion.
8. The connector receptacle of claim 1 further comprising a plurality of EMI tabs extending from the first housing portion.
9. An electronic device comprising:
a device enclosure, the device enclosure having an opening and forming a first portion of a housing for a connector receptacle; and
a connector receptacle, the connector receptacle comprising:
a second housing portion;
a tongue extending from the second housing portion and fitted to snap into the second housing portion;
a plurality of contacts in the tongue, wherein a front portion of each of the plurality of contacts is angled such that a front edge is embedded in the tongue;
an EMI tab strip including a plurality of EMI tabs extending from the second housing portion;
a shield around the first housing portion and in electrical contact with the EMI tab strip;
a mounting bracket attached to the shield; and
a first metallic piece between the mounting bracket and the tongue and comprising a plurality of EMI contacts, wherein each of the plurality of EMI contacts is at an end of a finger portion.
10. The electronic device of claim 9 wherein each of the plurality of EMI electromagnetic contacts has a spherical-shaped top.
11. The electronic device of claim 9 wherein the electronic device is a portable computing device.
12. The electronic device of claim 9 wherein the electronic device is a portable media player.
13. An electrical connector receptacle comprising:
a first housing portion;
a tongue extending from the first housing portion;
a plurality of contacts in the tongue;
a shield around the first housing portion;
a mounting bracket attached to the shield;
a first metallic piece between the mounting bracket and the tongue and comprising a plurality of EMI contacts, wherein each of the plurality of EMI contacts is at an end of a finger portion; and
a plurality of EMI tabs extending from the first housing portion, wherein each tab is located at an end of a beam, each of the beams attached to a strip, the strip located between the first housing portion and the shield.
14. The connector receptacle of claim 13 wherein the strip is laser welded to the shield.
15. The connector receptacle of claim 13 wherein the EMI tabs, beams, and strip are stamped from a plane of sheet metal, and when a connector insert is mated with the connector receptacle, the plurality of EMI tabs contact the connector insert and the beams deflect in a direction of the plane of sheet metal.
16. The connector receptacle of claim 13 wherein a front portion of each of the plurality of contacts is angled such that a front edge is embedded in the tongue.