All The Claims

What is claimed is:

1. An agonist antibody which specifically binds to the WSX receptor.
2. The antibody of claim 1 which specifically binds to human WSX receptor.
3. The antibody of claim 2 which specifically binds to human WSX receptor variant 13.2.
4. The antibody of claim 1 which binds WSX receptor with a Kd of no more than about 1108M.
5. The antibody of claim 4 which binds WSX receptor with a Kd of no more than about 1109M.
6. The antibody of claim 2 which also binds to murine WSX receptor.
7. The antibody of claim 1 which has an IC50 in a KIRA ELISA of about 0.5 gml or less.
8. The antibody of claim 7 which has an IC50 in a KIRA ELISA of about 0.2 gml or less.
9. The antibody of claim 8 which has an IC50 in a KIRA ELISA of about 0.1 g ml or less.
10. The antibody of claim 1 which has biological characteristics of antibody 2D7 (ATCC Accession Number ______).
11. The antibody of claim 10 which binds to the epitope on WSX receptor bound by antibody 2D7.
12. The antibody of claim 10 which has complementarity determining region (CDR) residues from antibody 2D7.
13. The antibody of claim 1 which has the biological characteristics of antibody 1G4 (ATCC Accession Number ______).
14. The antibody of claim 13 which binds to the epitope on WSX receptor bound by antibody 1G4.
15. The antibody of claim 13 which has complementarity determining region (CDR) residues from antibody 1G4.
16. The antibody of claim 1 which has the biological characteristics of antibody 1E11 (ATCC Accession Number ______).
17. The antibody of claim 16 which binds to the epitope on WSX receptor bound by antibody 1E11.
18. The antibody of claim 16 which has complementarity determining region (CDR) residues from antibody 1E11.
19. The antibody of claim 1 which has the biological characteristics of antibody 1C11 (ATCC Accession Number ______).
20. The antibody of claim 19 which binds to the epitope on WSX receptor bound by antibody 1C11.
21. The antibody of claim 19 which has complementarity determining region (CDR) residues from antibody 1C11.
22. The antibody of claim 1 comprising hypervariable region residues of clone 3 antibody (SEQ ID NO:48).
23. The antibody of claim 1 comprising hypervariable region residues of clone 4 antibody (SEQ ID NO:49).
24. The antibody of claim 1 comprising hypervariable region residues of clone 17 antibody (SEQ ID NO:50).
25. The antibody of claim 1 which is a monoclonal antibody.
26. The antibody of claim 1 which is a hum an antibody.
27. The antibody of claim 1 which is a humanized antibody.
28. The antibody of claim 1 which is a n antibody fragment.
29. The antibody fragment of claim 28 which is an F(ab)2.
30. A composition comprising the antibody of claim 1 and a physiologically acceptable carrier.
31. The composition of claim 30 which is sterile.
32. The composition of claim 31 which is lyophilized.
33. The composition of claim 30 further comprising a cytokine.
34. A method for activating the WSX receptor comprising exposing the WSX receptor to an amount of the antibody of claim 1 which is effective for activating the WSX receptor.
35. A method for enhancing proliferation or differentiation of a cell comprising the WSX receptor comprising exposing the cell to an amount of the antibody of claim 1 which is effective for enhancing proliferation or differentiation of the cell.
36. An isolated nucleic acid molecule encoding the antibody of claim 1.
37. A vector comprising the nucleic acid molecule of claim 36.
38. A host cell comprising the nucleic acid molecule of claim 36.
39. A method of producing an agonist antibody which specifically binds to the WSX receptor comprising culturing the host cell of claim 38 and recovering the antibody from the cell culture.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A slack adjuster, comprising:
a single housing extending from a first end to a second end;
a tension rod positioned within and extending a length from the first end of the housing that is moveable relative to the housing to change the length that extends from the housing;
a clutch assembly having a clutch positioned in the housing and engaged with the tension rod to control movement of the tension rod relative to the housing;
a control rod interconnected to the second end of the housing and moveable relative to the housing;
an overtravel assembly positioned in the housing and operatively connected to the clutch assembly and the control rod to set the length of the tension rod that extends from the first end of the housing.
2. The slack adjuster of claim 1, further comprising a rod guide having a first end enclosing the clutch and a second end enclosing the tension rod, wherein the rod guide is fixedly attached to an intermediate portion of the housing.
3. The slack adjuster of claim 2, further comprising a cap secured to the first end of the rod guide.
4. The slack adjuster of claim 3, wherein the clutch assembly further includes a pair of thrust bearings positioned on either side of the clutch and a spring engaging the cap and one of the thrust bearings.
5. The slack adjuster of claim 4, wherein the overtravel assembly comprises:
a first sleeve extending within the housing and having a first flange operatively connected to the clutch assembly;
a second sleeve extending within the first sleeve and having a second flange operatively connected to the control rod;
a spring positioned between the first flange of the first sleeve and the second flange of the second sleeve; and
a retaining ring engaging the second flange of the second sleeve and an inner surface of the first sleeve to retain the second sleeve in telescoping engagement with the first sleeve.
6. The slack adjuster of claim 5, wherein the overtravel assembly is interconnected to the clutch assembly by at least one pin.
7. The slack adjuster of claim 6, wherein the pin interconnects the first flange of the second sleeve to one of the thrust bearings.
8. The slack adjuster of claim 7, wherein the second sleeve of the overtravel assembly contacts an actuating tube that is attached to the control rod and positioned over the second end of the tension rod for axial movement into the second end of the housing.
9. The slack adjuster of claim 8, further comprising a cap enclosing the second end of the housing and having a bore permitting the second end of the tension rod and the actuating tube to pass into the housing.
10. The slack adjuster of claim 9, further comprising a wiper positioned in the second end of the housing in engagement with the actuating tube.
11. The slack adjuster of claim 10, further comprising a wear ring in the first end of the housing positioned about the tension rod.
12. The slack adjuster of claim 11, further comprising a plate fixedly connected to the tension rod and positioned against the cap of the rod guide.
13. The slack adjuster of claim 12, further comprising a spring assembly positioned in the housing between the plate of the tension rod and the first end of the housing.
14. The slack adjuster of claim 13, wherein the spring assembly comprises a pair of springs and a spring guide positioned therebetween.
15. The slack adjuster of claim 14, further comprising a wasp excluder permitting access to an interior portion of the housing.

1. A method of detecting particulate matter in an aerosol sample; said method comprising:
collecting a size-selected sample of airborne particulate material;
exposing the sample to electromagnetic excitation radiation having a plurality of selected wavelengths; and
detecting electromagnetic emission radiation emitted from the sample in response to the excitation radiation.
2. The method of claim 1 wherein said collecting comprises depositing airborne particulate material on a medium.
3. The method of claim 2 wherein said medium comprises a filter medium.
4. The method of claim 1 wherein said collecting comprises concentrating the particulate material.
5. The method of claim 4 wherein said concentrating comprises removing particles larger than a first threshold size.
6. The method of claim 5 wherein said first threshold size is about ten microns.
7. The method of claim 4 wherein said concentrating comprises removing particles smaller than a second threshold size.
8. The method of claim 7 wherein said second threshold size is about one micron.
9. The method of claim 4 wherein said concentrating comprises removing particles larger than a first threshold size and smaller than a second threshold size.
10. The method of claim 9 wherein said first threshold size is about ten microns and said second threshold size is about one micron.
11. The method of claim 1 wherein said exposing comprises exposing the sample sequentially to each of the plurality of selected wavelengths.
12. The method of claim 1 wherein said excitation radiation is ultraviolet radiation.
13. The method of claim 1 wherein said detecting comprises detecting radiation at each of a plurality of emission wavelengths.
14. The method of claim 13 wherein said detecting comprises detecting radiation simultaneously at each of the plurality of emission wavelengths.
15. The method of claim 1 further comprising analyzing emission radiation responsive to said detecting.
16. A system for detecting particulate matter in an aerosol sample; said system comprising:
means for collecting a size-selected sample of airborne particulate material;
means for exposing the sample to electromagnetic excitation radiation having a plurality of selected wavelengths; and
means for detecting electromagnetic emission radiation emitted from the sample in response to the excitation radiation.
17. The system of claim 16 wherein said means for collecting comprises means for depositing airborne particulate material on a medium.
18. The system of claim 17 wherein said medium comprises a filter medium.
19. The system of claim 16 wherein said means for collecting comprises means for concentrating the airborne particulate material.
20. The system of claim 19 wherein the means for concentrating comprises means for removing particles larger than a first threshold size.
21. The system of claim 20 wherein said first threshold size is about ten microns.
22. The system of claim 19 wherein said means for concentrating comprises means for removing particles smaller than a second threshold size.
23. The system of claim 22 wherein said second threshold size is about one micron.
24. The system of claim 19 wherein said means for concentrating comprises means for removing particles larger than a first threshold size and smaller than a second threshold size.
25. The system of claim 24 wherein said first threshold size is about ten microns and said second threshold size is about one micron.
26. The system of claim 19 wherein said means for concentrating comprises a virtual impactor.
27. The system of claim 16 wherein said means for exposing comprises a lamp and an ultraviolet filter.
28. The system of claim 16 wherein said means for exposing comprises an ultraviolet laser diode.
29. The system of claim 27 wherein said means for exposing comprises a lamp and a plurality of ultraviolet filters.
30. The system of claim 29 further comprising means for sequentially positioning each of said plurality of ultraviolet filters between said lamp and the sample.
31. The system of claim 30 wherein said means for sequentially positioning comprises an ultraviolet filter wheel and means for rotating said filter wheel.
32. The system of claim 16 wherein said means for detecting comprises a detector operative to detect ultraviolet radiation at a selected emission wavelength.
33. The system of claim 32 wherein said detector comprises a photomultiplier tube.
34. The system of claim 16 wherein said means for detecting comprises a plurality of detectors, each of said plurality of detectors operative to detect ultraviolet radiation at a selected one of a plurality of emission wavelengths.
35. The system of claim 34 wherein each of said plurality of detectors comprises a photomultiplier tube.
36. The system of claim 16 further comprising means for analyzing the detected emission radiation.
37. The system of claim 16 wherein said means for exposing comprises means for exposing the sample sequentially to each of the plurality of selected wavelengths.
38. The system of claim 16 wherein said means for exposing comprises means for exposing the sample sequentially to each of the plurality of selected wavelengths and wherein one of the plurality of selected wavelengths is selected to identify a specific interferent particle.
39. The system of claim 19 wherein operation of said means for concentrating the airborne particulate material results in increased sensitivity of said means for detecting.
40. A sensor system comprising:
a size-separation component operative to collect a sample of airborne particulate material and to deposit selected particulate matter from the sample having a size within a predetermined range on a medium;
a sensor component operative to expose the selected particulate matter to electromagnetic excitation radiation having a plurality of selected wavelengths and to detect electromagnetic emission radiation emitted from the selected particulate matter in response to the excitation radiation; and
an analyzer component operative to execute an analysis of the selected particulate matter using data representative of the emission radiation acquired by said sensor component.
41. The system of claim 40 wherein said size-separation component deposits the selected particulate matter on a filter medium.
42. The system of claim 41 wherein said size-separation component comprises a virtual impactor.
43. The system of claim 40 wherein said sensor component comprises an ultraviolet spectral fluorescence detector.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An electrical connector comprising:
a first contact comprising a first distal end;
a second contact comprising a first distal end, wherein the first and second contacts define a first linear array extending along a first direction; and
a third contact in a second linear array that is adjacent to the first linear array, the second linear array extending along the first direction, the third contact comprising a first distal end that is offset along the first direction relative to the first distal end of the first contact, wherein the first and third contacts form a differential signal pair, and
wherein the third contact is structurally identical to the first contact and is oriented 180\xb0 about an imaginary axis that extends in a direction perpendicular to the first direction.
2. The electrical connector of claim 1, wherein each of the first and second contacts are at least partially received in a first lead frame assembly, and wherein the third contact is at least partially received in a second lead frame assembly.
3. The electrical connector of claim 2, wherein the second lead frame assembly is structurally identical to the first lead frame assembly and is oriented 180\xb0 about the imaginary axis that extends in the direction perpendicular to the first direction.
4. The electrical connector of claim 2, wherein the second lead frame assembly abuts the first lead frame assembly.
5. The electrical connector of claim 4, wherein the first lead frame assembly comprises an indentation and the second lead frame assembly comprises a protrusion, and wherein the protrusion is received in the indentation.
6. The electrical connector of claim 5, wherein the protrusion extends from the first lead frame assembly and abuts a substrate when the electrical connector is electrically connected to the substrate.
7. The electrical connector of claim 4, further comprising a third lead frame assembly adjacent to and spaced apart from the second lead frame assembly.
8. The electrical connector of claim 1, wherein the connector is devoid of a grounding plane.
9. The electrical connector of claim 1, wherein the connector is devoid of ground contacts.
10. The electrical connector of claim 1, wherein the first contact comprises a first body extending between a first mating end and a first terminal end,
wherein the second contact comprises a second body extending between a second mating end and a second terminal end,
wherein the third contact comprises a third body extending between a third mating end and a third terminal end,
wherein the first and second bodies define a first plane, and
wherein the first and third bodies define a second plane that is perpendicular to the first plane.
11. The electrical connector of claim 1, further comprising:
a housing, wherein the first, second, and third contacts are received in the housing, and wherein the housing is disposed for flat rock tooling to connect the electric connector to a substrate.
12. A system, comprising:
a first electrical connector comprising,
a first contact comprising a first distal end;
a second contact comprising a first distal end, wherein the first and second contacts define a first linear array extending along a first direction;

a third contact in a second linear array that is adjacent to the first linear array, the second linear array extending along the first direction, the third contact comprising a first distal end that is offset along the first direction relative to the first distal end of the first contact, wherein the first and third contacts form a differential signal pair, wherein the third contact is structurally identical to the first contact and is oriented 180\xb0 about an imaginary axis that extends in a direction perpendicular to the first direction; and
a second electrical connector comprising,
a fourth contact electrically connected to the first contact; and
a fifth contact electrically connected to the third contact.
13. The system of claim 12, wherein the second connector further comprises a connector body, wherein the fourth and fifth contacts are at least partially received in the connector body and the fourth contact is adapted to be removed from the connector body while the fifth contact remains connected to a substrate.
14. The system of claim 12, further comprising:
a substrate comprising a first side and a second side opposite the first side, wherein the second connector is electrically connected to the first side of the substrate; and
a third connector electrically connected to the second side of the substrate, the third connector comprising a structure that is the same as the first connector, wherein the third connector is in a position that is oriented 90\xb0 relative to the first connector.
15. An electrical connector comprising:
a first contact comprising a first distal end;
a second contact comprising a first distal end, wherein the first and second contacts define a first linear array extending along a first direction; and
a third contact in a second linear array that is adjacent to the first linear array, the second linear array extending along the first direction, the third contact comprising a first distal end that is offset along the first direction relative to the first distal end of the first contact, wherein the first and third contacts form a differential signal pair,
wherein each of the first and second contacts are at least partially received in a first lead frame assembly,
wherein the third contact is at least partially received in a second lead frame assembly, and
wherein the second lead frame assembly is structurally identical to the first lead frame assembly and is oriented 180\xb0 about an imaginary axis that extends in a direction perpendicular to the first direction.
16. The electrical connector of claim 15, wherein the second lead frame assembly abuts the first lead frame assembly.
17. The electrical connector of claim 15, wherein the first lead frame assembly comprises an indentation and the second lead frame assembly comprises a protrusion, and wherein the protrusion is received in the indentation.
18. The electrical connector of claim 17, wherein the protrusion extends from the first lead frame assembly and abuts a substrate when the electrical connector is electrically connected to the substrate.
19. The electrical connector of claim 15, further comprising a third lead frame assembly adjacent to and spaced apart from the second lead frame assembly.
20. The electrical connector of claim 15, wherein the connector is devoid of a grounding plane.
21. The electrical connector of claim 15, wherein the connector is devoid of ground contacts.
22. The electrical connector of claim 15, wherein the first contact comprises a first body extending between a first mating end and a first terminal end,
wherein the second contact comprises a second body extending between a second mating end and a second terminal end,
wherein the third contact comprises a third body extending between a third mating end and a third terminal end,
wherein the first and second bodies define a first plane, and
wherein the first and third bodies define a second plane that is perpendicular to the first plane.
23. The electrical connector of claim 15, further comprising a housing, wherein the first, second, and third contacts are received in the housing, and wherein the housing is disposed for flat rock tooling to connect the electric connector to a substrate.