1. An isolated nucleic acid molecule comprising a nucleic acid sequence chosen from the group consisting of:
(a) a nucleic acid sequence encoding an immunoglobulin heavy chain polypeptide comprising a heavy chain variable region comprising complementarity determining regions (CDRs) having the amino acid sequences shown in residues 31\u201335, 50\u201366 and 99\u2013107 of SEQ ID NO: 2, wherein said polypeptide when operatively combined with an immunoglobulin light chain polypeptide comprising a light chain variable region comprising CDRs having the amino acid sequences shown in residues 24\u201334, 50\u201356 and 89\u201397 of SEQ ID NO: 7 forms an antigen-combining region that binds the \u03b1v subunit of \u03b1v\u03b23 and \u03b1v\u03b25; and
(b) a nucleic acid sequence that is fully complementary to the entirety of said nucleic acid sequence encoding an immunoglobulin heavy chain polypeptide.
2. The isolated nucleic acid molecule of claim 1, wherein said immunoglobulin heavy chain polypeptide comprises the amino acid sequence shown in SEQ ID NO: 2.
3. The isolated nucleic acid molecule of claim 2 having the sequence shown in SEQ ID NO: 1.
4. The isolated nucleic acid molecule of claim 1, wherein said immunoglobulin heavy chain polypeptide comprises the amino acid sequence shown in SEQ ID NO: 5.
5. The isolated nucleic acid molecule of claim 4 having the sequence shown in SEQ ID NO: 4.
6. A recombinant plasmid comprising the nucleic acid sequence of a nucleic acid molecule of claim 1.
7. An isolated host cell comprising the plasmid of claim 6.
8. An isolated nucleic acid molecule comprising a nucleic acid sequence chosen from the group consisting of:
(a) a nucleic acid sequence encoding an immunoglobulin light chain polypeptide comprising a light chain variable region comprising complementarity determining regions (CDRs) having the amino acid sequences shown in residues 24\u201334, 50\u201356 and 89\u201397 of SEQ ID NO: 7, wherein said polypeptide when operatively combined with an immunoglobulin heavy chain polypeptide comprising a heavy chain variable region comprising CDRs having the amino acid sequences shown in residues 31\u201335, 50\u201366 and 99\u2013107 of SEQ ID NO: 2 forms an antigen-combining region that binds the \u03b1v subunit of \u03b1v\u03b23 and \u03b1v\u03b25; and
(b) a nucleic acid sequence that is fully complementary to the entirety of said nucleic acid sequence encoding an immunoglobulin light chain polypeptide.
9. The isolated nucleic acid molecule of claim 8, wherein said immunoglobulin light chain polypeptide comprises the amino acid sequence shown in SEQ ID NO: 7.
10. The isolated nucleic acid molecule of claim 9 having the sequence shown in SEQ ID NO: 6.
11. The isolated nucleic acid molecule of claim 8, wherein said immunoglobulin light chain polypeptide comprises the amino acid sequence shown in SEQ ID NO: 10.
12. The isolated nucleic acid molecule of claim 11 having the sequence shown in SEQ ID NO: 9.
13. The isolated nucleic acid molecule of claim 8, wherein said immunoglobulin light chain polypeptide comprises the amino acid sequence shown in SEQ ID NO: 29.
14. The isolated nucleic acid molecule of claim 13 having the sequence shown in SEQ ID NO:28.
15. The isolated nucleic acid molecule of claim 8, wherein said immunoglobulin light chain polypeptide comprises the amino acid sequence shown in SEQ ID NO: 31.
16. The isolated nucleic acid molecule of claim 15 having the sequence shown in SEQ ID NO: 30.
17. A recombinant plasmid comprising the nucleic acid of claim 8.
18. An isolated host cell comprising the plasmid of claim 17.
19. An isolated host cell comprising a nucleic acid sequence encoding an immunoglobulin heavy chain polypeptide comprising a heavy chain variable region comprising complementarity determining regions (CDRs) having the amino acid sequences shown in residues 31\u201335, 50\u201366 and 99\u2013107 of SEQ ID NO: 2 and further comprising a nucleic acid sequence encoding an immunoglobulin light chain polypeptide comprising a light chain variable region comprising complementarity determining regions (CDRs) having the amino acid sequences shown in residues 24\u201334, 50\u201356 and 89\u201397 of SEQ ID NO: 7, wherein said immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide when operatively combined form an antigen-combining region that binds the \u03b1v subunit of \u03b1v\u03b23 and \u03b1v\u03b25.
20. A process for the production of an antibody that binds the \u03b1v subunit of \u03b1v\u03b23 and \u03b1v\u03b25 comprising culturing the host cell of claim 19 in a medium under suitable conditions of time and temperature and pH and recovering the antibody produced, wherein said antibody comprises said immunoglobulin heavy chain and immunoglobulin light chain polypeptides.
The claims below are in addition to those above.
All refrences to claims which appear below refer to the numbering after this setence.
1. A communication node for a communication system, comprising:
a transmitter for transmitting information relating to a radio resource that is allocated to a destined node;
a receiver for receiving communications on the allocated radio resource from the destined node; and
a controller configured to allocate radio resources and to control, based on communications on the allocated resource from the destined node, a data relaying process between the communication node and the destined node.
2. A communication node as claimed in claim 1, wherein the controller is configured to process a pilot obtained from a broadcasting by the destined node on the allocated radio resource.
3. A communication node as claimed in claim 1, configured to communicate information about the allocated radio resource to at least one relay node.
4. A communication node as claimed in claim 3, further configured to communicate information of at least one of a destined node identity and a quality of service (QoS) requirement to the at least one relay node.
5. A communication node as claimed in claim 1, configured to provide the information by broadcasting the information.
6. A communication node as claimed in claim 1, configured to instruct a lesser than available number of relay nodes to relay data to the destined node.
7. A communication node as claimed in claim 1, configured to send scheduling instructions to relay nodes for communication with the destined node.
8. A communication node as claimed in claim 1, configured to make at least one decision regarding relaying of data to the destined node based on communication by the destined node on the allocated radio resource before delivery of data to at least one relay node.
9. A communication node as claimed in claim 1, configured to determine, based on at least one of communication on the allocated radio resource and feedback information from at least one relay node, an appropriate manner of communication with the destined node.
10. A communication node as claimed in claim 9, configured to determine if data is communicated on a broadcast channel or a dedicated channel.
11. A communication node as claimed in claim 1, configured to broadcast a release relay process indication.
12. A communication node as claimed in claim 1, configured to allocate a radio subband resource for sole use by the destined node and to communicate on other subbands.
13. A communication node as claimed in claim 1, comprising a base station.
14. A relay node for a communicating system, comprising:
a receiver configured to receive information of a radio resource allocated to a destined node and communications on the allocated radio resource;
a transmitter configured to communicate with other nodes;
a controller configured to monitor for communications on the allocated resource by the destined node and to control relaying of data between the originating node and the destined node based on the monitoring.
15. A relay node as claimed in claim 14, wherein the controller is configured to determine information relating to a parameter indicative of the quality of the radio channel between the relay node and the destined node and to compare the parameter with a threshold.
16. A relay node as claimed in claim 15, wherein the controller is configured to determine a value of the parameter based on the communications on the allocated resource.
17. A relay node as claimed in claim 14, wherein the controller is configured to determine, based on communications on the allocated resource, at least one of:
if the relay node is capable of taking part in relaying of data to the destined node;
if the relay node needs to take part in relaying data between to the destined node; and
if the relay node shall refrain from relaying of data to the destined node.
18. A relay node as claimed in claim 14, wherein the controller is configured to determine, based on an acknowledgement message by the destined node, that relaying of data is not needed.
19. A relay node as claimed in claim 14, comprising a mobile user device.
20. A method for communicating data in a wireless communication system enabling relaying of data between an originating node and a destined node, comprising:
providing information of a radio resource allocated to the destined node;
monitoring for communications on the allocated resource from the destined node; and
controlling relaying of data between the originating node and the destined node based on the monitoring.
21. A method as claimed in claim 20, wherein the communications comprise broadcasting by the destined node on the allocated radio resource.
22. A method as claimed in claim 20, wherein the communications on the allocated resource comprise communication of a pilot signal.
23. A method as claimed in claim 20, comprising communicating information about the reserved radio resource to at least one relay node.
24. A method as claimed in claim 23, further comprising communication of information of at least one of a destined node identity and a quality of service (QoS) requirement.
25. A method as claimed in claim 20, wherein the providing of information comprises broadcasting the information.
26. A method as claimed in claim 20, comprising determining, at a relay node, based on communications on the allocated resource, at least one of:
if the relay node is capable of taking part in relaying of data between the originating node and the destined node;
if the relay node needs to take part in relaying data between the originating node and the destined node; and
if the relay node shall refrain from relaying of data between the originating node and the destined node.
27. A method as claimed in claim 20, comprising determining the quality of a radio channel between a relay node and the destined node based on the communications on the allocated resource.
28. A method as claimed in claim 27, comprising determining if achievable transmission bit-rate equals to or is greater than a threshold.
29. A method as claimed in claim 20, comprising instructing a lesser number of relay nodes than is available to relay data to the destined node.
30. A method as claimed in claim 20, comprising providing scheduling instructions by the originating node.
31. A method as claimed in claim 20, comprising making at least one decision regarding the relay process based on communication by the destined node on the allocated radio resource before delivery of data to at least one relay node.
32. A method as claimed in claim 20, comprising determining, based on at least one of communication on the allocated radio resource and feedback information from relay nodes, an appropriate manner of communication with the destined node.
33. A method as claimed in claim 20, comprising broadcasting from the originating node a release relay process indication.
34. A method as claimed in claim 20, comprising determining at a relay node based on an acknowledgement message by the destined node that the relaying of data can be released.
35. A method as claimed in claim 20, comprising allocating a radio subband resource for sole use by the destined node and allowing communications by at least one of the other nodes on other subbands.
36. A computer program comprising program code means adapted to perform any of steps of claim 20 when the program is run on a processor.
37. A computer program as claimed in claim 36, wherein the processor is for a station of a mobile communication system.
38. A communication system comprising:
a communication node comprising a transmitter configured to transmit information relating to a radio resource that is allocated to a destined node;
a receiver configured to receive communications on the allocated radio resource from the destined node; and
a controller configured to allocate radio resources and to control, based on communications on the allocated resource from the destined node, a data relaying process between the communication node and the destined node,
said communication system further comprising a relay node comprising a receiver configured to receive information of the radio resource allocated to the destined node and communications on the allocated radio resource;
a transmitter configured to communicate with other nodes; and
a controller configured to monitor for communications on the allocated resource by the destined node and to control relaying of data between an originating node and the destined node based on the monitoring.
39. A controller for a communications device, configured to monitor for communications on a radio resource that has been allocated to a destined node and to control relaying of data between an originating node and the destined node based on the monitoring.
40. A controller as claimed in claim 39, configured to monitor for a pilot signal by the destined node on the allocated radio resource, to determine a value of at least one channel characteristic based on the pilot signal, to compare the value with a threshold and to decide based on the comparison whether data is to be relayed to the destined node.